Impact of NOTCH1/FBXW7 mutations on outcome in pediatric T-cell acute lymphoblastic leukemia patients treated on the MRC UKALL 2003 trial

Prognostic Significance ofNOTCH1andFBXW7Mutations in Pediatric T-ALL

(2013) Yucel Erbilgin et al.   DISEASE MARKERS

Impact of complex NOTCH1 mutations on survival in paediatric T-cell leukaemia

(2012) Marcela Braga Mansur et al.   BMC CANCER

The genetic basis of early T-cell precursor acute lymphoblastic leukaemia

(2012) Jinghui Zhang et al.   NATURE

Sequential mutations in Notch1, Fbxw7, and Tp53 in radiation-induced mouse thymic lymphomas

(2011) K.-Y. Jen et al.   BLOOD

Whole transcriptome sequencing reveals recurrent NOTCH1 mutations in mantle cell lymphoma

(2011) R. Kridel et al.   BLOOD

Analysis of the chronic lymphocytic leukemia coding genome: role ofNOTCH1mutational activation

(2011) Giulia Fabbri et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia

(2011) Xose S. Puente et al.   NATURE

Shared acquired genomic changes in zebrafish and human T-ALL

(2011) L A Rudner et al.   ONCOGENE

Notch in T-ALL: new players in a complex disease

(2011) Ute Koch et al.   TRENDS IN IMMUNOLOGY

Molecular pathogenesis and targeted therapies for NOTCH1-induced T-cell acute lymphoblastic leukemia

(2010) Maddalena Paganin et al.   BLOOD REVIEWS

Asparaginase-related venous thrombosis in UKALL 2003- re-exposure to asparaginase is feasible and safe

(2010) Amrana Qureshi et al.   BRITISH JOURNAL OF HAEMATOLOGY

NOTCH mutations as prognostic markers in T-ALL

(2010) A Ferrando   LEUKEMIA

NOTCH1 and/or FBXW7 mutations predict for initial good prednisone response but not for improved outcome in pediatric T-cell acute lymphoblastic leukemia patients treated on DCOG or COALL protocols

(2010) L Zuurbier et al.   LEUKEMIA

NOTCH1 and FBXW7 mutations have a favorable impact on early response to treatment, but not on outcome, in children with T-cell acute lymphoblastic leukemia (T-ALL) treated on EORTC trials 58881 and 58951

(2010) E Clappier et al.   LEUKEMIA

The favorable effect of activating NOTCH1 receptor mutations on long-term outcome in T-ALL patients treated on the ALL–BFM 2000 protocol can be separated from FBXW7 loss of function

(2010) C Kox et al.   LEUKEMIA

High-resolution genomic profiling of childhood T-ALL reveals frequent copy-number alterations affecting the TGF-  and PI3K-AKT pathways and deletions at 6q15-16.1 as a genomic marker for unfavorable early treatment response

(2009) M. Remke et al.   BLOOD

FBXW7andNOTCH1mutations in childhood T cell acute lymphoblastic leukaemia and T cell non-Hodgkin lymphoma

(2009) Myoung-Ja Park et al.   BRITISH JOURNAL OF HAEMATOLOGY

NOTCH1 extracellular juxtamembrane expansion mutations in T-ALL

(2008) M. L. Sulis et al.   BLOOD

Structure of the Notch1-negative regulatory region: implications for normal activation and pathogenic signaling in T-ALL

(2008) W. R. Gordon et al.   BLOOD

Leukemia-associated NOTCH1 alleles are weak tumor initiators but accelerate K-ras–initiated leukemia

(2008) Mark Y. Chiang et al.   JOURNAL OF CLINICAL INVESTIGATION