Combined CSL and p53 downregulation promotes cancer-associated fibroblast activation

Periostin secreted by glioblastoma stem cells recruits M2 tumour-associated macrophages and promotes malignant growth

(2015) Wenchao Zhou et al.   NATURE CELL BIOLOGY

High burden and pervasive positive selection of somatic mutations in normal human skin

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Multifocal epithelial tumors and field cancerization: stroma as a primary determinant

(2014) G. Paolo Dotto   JOURNAL OF CLINICAL INVESTIGATION

The role of senescent cells in ageing

(2014) Jan M. van Deursen   NATURE

Mutant p53 Prolongs NF-κB Activation and Promotes Chronic Inflammation and Inflammation-Associated Colorectal Cancer

(2013) Tomer Cooks et al.   CANCER CELL

Identification of Two Distinct Carcinoma-Associated Fibroblast Subtypes with Differential Tumor-Promoting Abilities in Oral Squamous Cell Carcinoma

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The Hallmarks of Aging

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Non-Cell-Autonomous Tumor Suppression by p53

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Cigarette smoke metabolically promotes cancer, via autophagy and premature aging in the host stromal microenvironment

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A miR-34a-SIRT6 axis in the squamous cell differentiation network

(2013) Karine Lefort et al.   EMBO JOURNAL

Dynamic binding of RBPJ is determined by Notch signaling status

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Carcinoma-associated fibroblasts: Non-neoplastic tumour-promoting mesenchymal cells

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p53-dependent chemokine production by senescent tumor cells supports NKG2D-dependent tumor elimination by natural killer cells

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FGF Receptors: Cancer Biology and Therapeutics

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Influence of tumour micro-environment heterogeneity on therapeutic response

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Intravital Immunofluorescence for Visualizing the Microcirculatory and Immune Microenvironments in the Mouse Ear Dermis

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Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells

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Cell-Autonomous and Non-Cell-Autonomous Mechanisms of Transformation by Amplified FGFR1 in Lung Cancer

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Recent Developments in Myofibroblast Biology

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Fibroblast-Derived Dermal Matrix Drives Development of Aggressive Cutaneous Squamous Cell Carcinoma in Patients with Recessive Dystrophic Epidermolysis Bullosa

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Immune surveillance of senescent cells--biological significance in cancer- and non-cancer pathologies

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Multifocal Epithelial Tumors and Field Cancerization from Loss of Mesenchymal CSL Signaling

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p21WAF1 and tumourigenesis

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Perspective: Finding cancer's first principles

(2012) Robert Gatenby   NATURE

Bone Marrow-Derived Myofibroblasts Contribute to the Mesenchymal Stem Cell Niche and Promote Tumor Growth

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IRF6 is a mediator of Notch pro-differentiation and tumour suppressive function in keratinocytes

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p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype

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Tumor Suppressor and Aging Biomarker p16INK4aInduces Cellular Senescence without the Associated Inflammatory Secretory Phenotype

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Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression

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Prognostic gene-expression signature of carcinoma-associated fibroblasts in non-small cell lung cancer

(2011) R. Navab et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-κB-Dependent Manner

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Breast Carcinoma-Associated Fibroblasts Rarely Contain p53 Mutations or Chromosomal Aberrations

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Control of hair follicle cell fate by underlying mesenchyme through a CSL-Wnt5a-FoxN1 regulatory axis

(2010) B. Hu et al.   GENES & DEVELOPMENT

Opposing roles for calcineurin and ATF3 in squamous skin cancer

(2010) Xunwei Wu et al.   NATURE

Protein-binding assays in biological liquids using microscale thermophoresis

(2010) Christoph J. Wienken et al.   Nature Communications

The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism

(2009) Raphael Kopan et al.   CELL

Cytokine expression and signaling in drug-induced cellular senescence

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Involvement of stromal p53 in tumor-stroma interactions

(2009) Jair Bar et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

RAM-induced Allostery Facilitates Assembly of a Notch Pathway Active Transcription Complex

(2008) David R. Friedmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

EGFR signalling as a negative regulator of Notch1 gene transcription and function in proliferating keratinocytes and cancer

(2008) Vihren Kolev et al.   NATURE CELL BIOLOGY

Coevolution in the tumor microenvironment

(2008) Robert A Weinberg   NATURE GENETICS

Transcriptional control of human p53-regulated genes

(2008) Todd Riley et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Co-evolution of tumor cells and their microenvironment

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Mutational and Energetic Studies of Notch1 Transcription Complexes

(2007) Cristina Del Bianco et al.   JOURNAL OF MOLECULAR BIOLOGY