Potential implications of polyphenols on aging considering oxidative stress, inflammation, autophagy, and gut microbiota

Mango (Mangifera indica L.) polyphenols reduce IL-8, GRO, and GM-SCF plasma levels and increase Lactobacillus species in a pilot study in patients with inflammatory bowel disease

(2020) Hyemee Kim et al.   NUTRITION RESEARCH

Daily consumption of orange juice from Citrus sinensis L. Osbeck cv. Cara Cara and cv. Bahia differently affects Gut Microbiota Profiling as unveiled by an integrated meta-omics approach

(2019) Elisa Brasili et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

The flavonoid 4,4′-dimethoxychalcone promotes autophagy-dependent longevity across species

(2019) Didac Carmona-Gutierrez et al.   Nature Communications

Dietary Black Raspberries Impact the Colonic Microbiome and Phytochemical Metabolites in Mice

(2019) Junnan Gu et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Mitochondrial Permeability Uncouples Elevated Autophagy and Lifespan Extension

(2019) Ben Zhou et al.   CELL

Long-term every-other-day administration of DMAMCL has little effect on aging and age-associated physiological decline in mice

(2019) Zhaomeng Sun et al.   Aging-US

Computational aspects of Anthocyanidins and Anthocyanins: a review

(2019) Alessandro Sinopoli et al.   FOOD CHEMISTRY

Autophagy in aging and longevity

(2019) Shi Q. Wong et al.   HUMAN GENETICS

Hydroxytyrosol protects from aging process via AMPK and autophagy; a review of its effects on cancer, metabolic syndrome, osteoporosis, immune-mediated and neurodegenerative diseases

(2019) Rocío M. de Pablos et al.   PHARMACOLOGICAL RESEARCH

Resveratrol-mediated glycemic regulation is blunted by curcumin and is associated to modulation of gut microbiota

(2019) Navin Sreng et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Healthspan and lifespan extension by fecal microbiota transplantation into progeroid mice

(2019) Clea Bárcena et al.   NATURE MEDICINE

Resveratrol attenuates endothelial oxidative injury by inducing autophagy via the activation of transcription factor EB

(2019) Xi Zhou et al.   Nutrition & Metabolism

Modulation of Akt-p38-MAPK/Nrf2/SIRT1 and NF-κB pathways by wine pomace product in hyperglycemic endothelial cell line

(2019) Gisela Gerardi et al.   Journal of Functional Foods

Upregulation of the Autophagy Adaptor p62/SQSTM1 Prolongs Health and Lifespan in Middle-Aged Drosophila

(2019) Ricardo Aparicio et al.   Cell Reports

Recent Advances of Natural Polyphenols Activators for Keap1‐Nrf2 Signaling Pathway

(2019) yanping zhou et al.   CHEMISTRY & BIODIVERSITY

Gut microbiota in phytopharmacology: A comprehensive overview of concepts, reciprocal interactions, biotransformations and mode of actions

(2019) Priyankar Dey   PHARMACOLOGICAL RESEARCH

Neohesperidin prevents colorectal tumorigenesis by altering the gut microbiota

(2019) Yanling Gong et al.   PHARMACOLOGICAL RESEARCH

Mediterranean diet: The role of long-chain ω-3 fatty acids in fish; polyphenols in fruits, vegetables, cereals, coffee, tea, cacao and wine; probiotics and vitamins in prevention of stroke, age-related cognitive decline, and Alzheimer disease

(2019) G.C. Román et al.   REVUE NEUROLOGIQUE

Mechanisms of aging and potential role of selected polyphenols in extending healthspan

(2019) Gian Luigi Russo et al.   BIOCHEMICAL PHARMACOLOGY

What is responsible for antioxidant properties of polyphenolic compounds from plants?

(2019) Małgorzata Olszowy   PLANT PHYSIOLOGY AND BIOCHEMISTRY

Dietary polyphenols to combat the metabolic diseases via altering gut microbiota

(2019) Vemana Gowd et al.   TRENDS IN FOOD SCIENCE & TECHNOLOGY

Targeting autophagy-related protein kinases for potential therapeutic purpose

(2019) Honggang Xiang et al.   Acta Pharmaceutica Sinica B

Ageing, age-related diseases and oxidative stress: What to do next?

(2019) Jiao Luo et al.   AGEING RESEARCH REVIEWS

Dietary tea polyphenols induce changes in immune response and intestinal microbiota in Koi carp, cryprinus carpio

(2019) R. Zhang et al.   AQUACULTURE

Ferulic acid, a natural polyphenol, protects against osteoporosis by activating SIRT1 and NF-κB in neonatal rats with glucocorticoid-induced osteoporosis

(2019) Tingting Hou et al.   BIOMEDICINE & PHARMACOTHERAPY

Effects of long-term intake of anthocyanins from Lycium ruthenicum Murray on the organism health and gut microbiota in vivo

(2019) Yujia Peng et al.   FOOD RESEARCH INTERNATIONAL

Green tea polyphenols decrease weight gain, ameliorate alteration of gut microbiota, and mitigate intestinal inflammation in canines with high-fat-diet-induced obesity

(2019) Yu Li et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Resveratrol prolongs lifespan and improves 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced oxidative damage and behavioural deficits in Drosophila melanogaster

(2018) Amos O. Abolaji et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Polyphenols protect against age-associated apoptosis in female rat cochleae

(2018) Carolina Sánchez-Rodríguez et al.   BIOGERONTOLOGY

Flavonoid metabolism: the interaction of metabolites and gut microbiota

(2018) Kaeko Murota et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Cytoprotective Polyphenols Against Chronological Skin Aging and Cutaneous Photodamage

(2018) Sergio Davinelli et al.   CURRENT PHARMACEUTICAL DESIGN

Diet and Brain Health: Which Role for Polyphenols?

(2018) Vanessa Castelli et al.   CURRENT PHARMACEUTICAL DESIGN

The expression of autophagy-related proteins within the corpus luteum lifespan in pigs

(2018) M. Grzesiak et al.   DOMESTIC ANIMAL ENDOCRINOLOGY

Resveratrol reduces senescence-associated secretory phenotype by SIRT1/NF-κB pathway in gut of the annual fish Nothobranchius guentheri

(2018) Shan Liu et al.   FISH & SHELLFISH IMMUNOLOGY

Autophagy and oxidative stress in non-communicable diseases: A matter of the inflammatory state?

(2018) Daniel Peña-Oyarzun et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Endotoxemia Marker Lipopolysaccharide-Binding Protein is Reduced in Overweight-Obese Subjects Consuming Pomegranate Extract by Modulating the Gut Microbiota: A Randomized Clinical Trial

(2018) Antonio González-Sarrías et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Oleuropein Aglycone Protects against MAO-A-Induced Autophagy Impairment and Cardiomyocyte Death through Activation of TFEB

(2018) Caterina Miceli et al.   Oxidative Medicine and Cellular Longevity

AMP-Activated Protein Kinase Regulation of the NLRP3 Inflammasome during Aging

(2018) Mario D. Cordero et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

A recent review of citrus flavanone naringenin on metabolic diseases and its potential sources for high yield-production

(2018) Naymul Karim et al.   TRENDS IN FOOD SCIENCE & TECHNOLOGY

Dietary polyphenols: A novel strategy to modulate microbiota-gut-brain axis

(2018) Diana Serra et al.   TRENDS IN FOOD SCIENCE & TECHNOLOGY

Pomegranate peel polyphenols inhibits inflammation in LPS-induced RAW264.7 macrophages via the suppression of MAPKs activation

(2018) Lin Du et al.   Journal of Functional Foods

Cardioprotection of CAPE- o NO 2 against myocardial ischemia/reperfusion induced ROS generation via regulating the SIRT1/eNOS/NF-κB pathway in vivo and in vitro

(2018) Dejuan Li et al.   Redox Biology

Epigallocatechin-3-gallate promotes healthy lifespan through mitohormesis during early-to-mid adulthood in Caenorhabditis elegans

(2018) Li-Gui Xiong et al.   Redox Biology

Double knockout of Akt2 and AMPK predisposes cardiac aging without affecting lifespan: Role of autophagy and mitophagy

(2018) Shuyi Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Blueberry polyphenols extract as a potential prebiotic with anti-obesity effects on C57BL/6 J mice by modulating the gut microbiota

(2018) Xinyao Jiao et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

In Vitro Gut Metabolism of [U-13 C]-Quinic Acid, The Other Hydrolysis Product of Chlorogenic Acid

(2018) Martine Naranjo Pinta et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Reciprocal Interactions Between Resveratrol and Gut Microbiota Deepen Our Understanding of Molecular Mechanisms Underlying Its Health Benefits

(2018) Liang Shen et al.   TRENDS IN FOOD SCIENCE & TECHNOLOGY

Fisetin is a senotherapeutic that extends health and lifespan

(2018) Matthew J. Yousefzadeh et al.   EBioMedicine

Ginsenosides, catechins, quercetin and gut microbiota: Current evidence of challenging interactions

(2018) Rosaria Santangelo et al.   FOOD AND CHEMICAL TOXICOLOGY

Sinapic acid and resveratrol alleviate oxidative stress with modulation of gut microbiota in high-fat diet-fed rats

(2018) Chen Yang et al.   FOOD RESEARCH INTERNATIONAL

Modulation of Gut Microbiota by Lonicera caerulea L. Berry Polyphenols in a Mouse Model of Fatty Liver Induced by High Fat Diet

(2018) Shusong Wu et al.   MOLECULES

Targeting Autophagy in Aging and Aging-Related Cardiovascular Diseases

(2018) Jun Ren et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Crosstalk between mitochondrial dysfunction, oxidative stress, and age related neurodegenerative disease: Etiologies and therapeutic strategies

(2018) Hasnaa A. Elfawy et al.   LIFE SCIENCES

High-throughput assay comparison and standardization for metal chelating capacity screening: A proposal and application

(2017) Jânio Sousa Santos et al.   FOOD CHEMISTRY

Prebiotic effect of predigested mango peel on gut microbiota assessed in a dynamic in vitro model of the human colon (TIM-2)

(2017) Sonia G. Sáyago-Ayerdi et al.   FOOD RESEARCH INTERNATIONAL

Green tea polyphenols reduce obesity in high-fat diet-induced mice by modulating intestinal microbiota composition

(2017) Xiaojing Guo et al.   INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY

The modulatory effect of polyphenols from green tea, oolong tea and black tea on human intestinal microbiota in vitro

(2017) Hanyang Sun et al.   JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE

Chronic Silymarin, Quercetin and Naringenin Treatments Increase Monoamines Synthesis and Hippocampal Sirt1 Levels Improving Cognition in Aged Rats

(2017) F. Sarubbo et al.   Journal of Neuroimmune Pharmacology

Fisetin Reduces the Impact of Aging on Behavior and Physiology in the Rapidly Aging SAMP8 Mouse

(2017) Antonio Currais et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Resveratrol attenuates MPP+-induced mitochondrial dysfunction and cell apoptosis via AKT/GSK-3β pathway in SN4741 cells

(2017) Weijun Zeng et al.   NEUROSCIENCE LETTERS

Non-extractable polyphenols produce gut microbiota metabolites that persist in circulation and show anti-inflammatory and free radical-scavenging effects

(2017) Antonio González-Sarrías et al.   TRENDS IN FOOD SCIENCE & TECHNOLOGY

Regulation of life span by the gut microbiota in the short-lived African turquoise killifish

(2017) Patrick Smith et al.   eLife

A polyphenol-rich cranberry extract reverses insulin resistance and hepatic steatosis independently of body weight loss

(2017) Fernando F. Anhê et al.   Molecular Metabolism

Rutin protects rat articular chondrocytes against oxidative stress induced by hydrogen peroxide through SIRT1 activation

(2016) Ji-Young Na et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Deciphering hallmark processes of aging from interaction networks

(2016) Suchi Smita et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Resveratrol provides neuroprotection by inhibiting phosphodiesterases and regulating the cAMP/AMPK/SIRT1 pathway after stroke in rats

(2016) Dan Wan et al.   BRAIN RESEARCH BULLETIN

Purple sweet potato anthocyanin attenuates fat-induced mortality in Drosophila melanogaster

(2016) Lijun Wang et al.   EXPERIMENTAL GERONTOLOGY

The Modulatory Effect of Anthocyanins from Purple Sweet Potato on Human Intestinal Microbiota in Vitro

(2016) Xin Zhang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Structural implications of polyphenolic antioxidants

(2016) Kantappa Halake et al.   JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY

Mango polyphenolics reduce inflammation in intestinal colitis-involvement of the miR-126/PI3K/AKT/mTOR axis in vitro and in vivo

(2016) Hyemee Kim et al.   MOLECULAR CARCINOGENESIS

SIRT1 inhibits inflammatory response partly through regulation of NLRP3 inflammasome in vascular endothelial cells

(2016) Yanxiang Li et al.   MOLECULAR IMMUNOLOGY

Flavonoid metabolite 3-(3-hydroxyphenyl)propionic acid formed by human microflora decreases arterial blood pressure in rats

(2016) Iveta Najmanová et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Sirt1 is essential for resveratrol enhancement of hypoxia-induced autophagy in the type 2 diabetic nephropathy rat

(2016) Liqun Ma et al.   PATHOLOGY RESEARCH AND PRACTICE

Phenolic-enriched foods: sources and processing for enhanced health benefits

(2016) Gordon J. McDougall   PROCEEDINGS OF THE NUTRITION SOCIETY

Effects of polyphenols including curcuminoids, resveratrol, quercetin, pterostilbene, and hydroxypterostilbene on lymphocyte pro-inflammatory cytokine production of senior horses in vitro

(2016) Melissa H. Siard et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Curcumin targets the TFEB-lysosome pathway for induction of autophagy

(2016) Jianbin Zhang et al.   Oncotarget

Resveratrol serves as a protein-substrate interaction stabilizer in human SIRT1 activation

(2016) Xuben Hou et al.   Scientific Reports

Bifidobacteria and Butyrate-Producing Colon Bacteria: Importance and Strategies for Their Stimulation in the Human Gut

(2016) Audrey Rivière et al.   Frontiers in Microbiology

Dietary polyphenols, oxidative stress and antioxidant and anti-inflammatory effects

(2016) Hua Zhang et al.   Current Opinion in Food Science

Resveratrol and obesity: Can resveratrol relieve metabolic disturbances?

(2015) Marlies de Ligt et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Phosphatidylethanolamine positively regulates autophagy and longevity

(2015) P Rockenfeller et al.   CELL DEATH AND DIFFERENTIATION

Dietary Polyphenols Promote Growth of the Gut BacteriumAkkermansia muciniphilaand Attenuate High-Fat Diet–Induced Metabolic Syndrome

(2015) Diana E. Roopchand et al.   DIABETES

Effect of virgin olive oil and thyme phenolic compounds on blood lipid profile: implications of human gut microbiota

(2015) Sandra Martín-Peláez et al.   EUROPEAN JOURNAL OF NUTRITION

Ellagic acid prevents monocrotaline-induced pulmonary artery hypertension via inhibiting NLRP3 inflammasome activation in rats

(2015) Bing Tang et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Towards a more comprehensive concept for prebiotics

(2015) Laure B. Bindels et al.   Nature Reviews Gastroenterology & Hepatology

Neuroinflammation in the normal aging hippocampus

(2015) R.M. Barrientos et al.   NEUROSCIENCE

Oleuropein aglycone induces autophagy via the AMPK/mTOR signalling pathway: a mechanistic insight

(2015) Stefania Rigacci et al.   Oncotarget

Bioavailability of Dietary Polyphenols and Gut Microbiota Metabolism: Antimicrobial Properties

(2015) Laura Marín et al.   Biomed Research International

Review on microbiota and effectiveness of probiotics use in older

(2015) Mariangela Rondanelli   World Journal of Clinical Cases

Intravenous (−)-epicatechin reduces myocardial ischemic injury by protecting mitochondrial function

(2014) Katrina Go Yamazaki et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Rutin modulates ASC expression in NLRP3 inflammasome: a study in alcohol and cerulein-induced rat model of pancreatitis

(2014) Ravikumar Aruna et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Flavonoid Apigenin Inhibits Lipopolysaccharide-Induced Inflammatory Response through Multiple Mechanisms in Macrophages

(2014) Xiaoxuan Zhang et al.   PLoS One

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Canonical Nlrp3 Inflammasome Links Systemic Low-Grade Inflammation to Functional Decline in Aging

(2013) Yun-Hee Youm et al.   Cell Metabolism

The effect of resveratrol on longevity across species: a meta-analysis

(2012) K. L. Hector et al.   Biology Letters

Phenol-Based Antioxidants and the In Vitro Methods Used for Their Assessment

(2012) Brian D. Craft et al.   COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY

Quercetin and Allopurinol Ameliorate Kidney Injury in STZ-Treated Rats with Regulation of Renal NLRP3 Inflammasome Activation and Lipid Accumulation

(2012) Chuang Wang et al.   PLoS One

Histone acetyltransferases are crucial regulators in NF-κB mediated inflammation

(2011) Massimo Ghizzoni et al.   DRUG DISCOVERY TODAY

Protective effects of combination of quercetin and α-tocopherol on mitochondrial dysfunction and myocardial infarct size in isoproterenol-treated myocardial infarcted rats: Biochemical, transmission electron microscopic, and macroscopic enzyme mapping evi

(2010) V. R. Punithavathi et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Anti-inflammatory properties of a pomegranate extract and its metabolite urolithin-A in a colitis rat model and the effect of colon inflammation on phenolic metabolism☆

(2009) Mar Larrosa et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

The regulation of aging: does autophagy underlie longevity?

(2009) Tibor Vellai et al.   TRENDS IN CELL BIOLOGY

Molecular inflammation: Underpinnings of aging and age-related diseases

(2008) Hae Young Chung et al.   AGEING RESEARCH REVIEWS