Autophagy in aging and longevity

Microtubules Deform the Nuclear Membrane and Disrupt Nucleocytoplasmic Transport in Tau-Mediated Frontotemporal Dementia

(2019) Francesco Paonessa et al.   Cell Reports

Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease

(2019) Evandro F. Fang et al.   NATURE NEUROSCIENCE

Lysosomal Signaling Promotes Longevity by Adjusting Mitochondrial Activity

(2019) Prasanna V. Ramachandran et al.   DEVELOPMENTAL CELL

Watch What You (Self-) Eat: Autophagic Mechanisms that Modulate Metabolism

(2019) Vikramjit Lahiri et al.   Cell Metabolism

LncRNA NEAT1 promotes autophagy in MPTP-induced Parkinson's disease through stabilizing PINK1 protein

(2018) Wang Yan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

LncRNA DICER1-AS1 promotes the proliferation, invasion and autophagy of osteosarcoma cells via miR-30b/ATG5

(2018) Zenghui Gu et al.   BIOMEDICINE & PHARMACOTHERAPY

Nuclear-Import Receptors Reverse Aberrant Phase Transitions of RNA-Binding Proteins with Prion-like Domains

(2018) Lin Guo et al.   CELL

Effect of the LncRNA GAS5-MiR-23a-ATG3 Axis in Regulating Autophagy in Patients with Breast Cancer

(2018) Juan Gu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

The RNA binding protein tristetraprolin down-regulates autophagy in lung adenocarcinoma cells

(2018) Fei Dong et al.   EXPERIMENTAL CELL RESEARCH

Fisetin as a caloric restriction mimetic protects rat brain against aging induced oxidative stress, apoptosis and neurodegeneration

(2018) Sandeep Singh et al.   LIFE SCIENCES

Dysregulation of the epigenetic landscape of normal aging in Alzheimer’s disease

(2018) Raffaella Nativio et al.   NATURE NEUROSCIENCE

The coming of age of chaperone-mediated autophagy

(2018) Susmita Kaushik et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Autophagy as a promoter of longevity: insights from model organisms

(2018) Malene Hansen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

TFEB dysregulation as a driver of autophagy dysfunction in neurodegenerative disease: Molecular mechanisms, cellular processes, and emerging therapeutic opportunities

(2018) Constanza J. Cortes et al.   NEUROBIOLOGY OF DISEASE

The RNA face of phase separation

(2018) Magdalini Polymenidou   SCIENCE

A novel autophagy enhancer as a therapeutic agent against metabolic syndrome and diabetes

(2018) Hyejin Lim et al.   Nature Communications

LncRNA CAIF inhibits autophagy and attenuates myocardial infarction by blocking p53-mediated myocardin transcription

(2018) Cui-Yun Liu et al.   Nature Communications

A TFEB nuclear export signal integrates amino acid supply and glucose availability

(2018) Linxin Li et al.   Nature Communications

Nuclear Export Inhibition Enhances HLH-30/TFEB Activity, Autophagy, and Lifespan

(2018) Melissa J. Silvestrini et al.   Cell Reports

The effect of fasting or calorie restriction on autophagy induction: A review of the literature

(2018) Mohammad Bagherniya et al.   AGEING RESEARCH REVIEWS

Transcriptional and epigenetic profiling of nutrient-deprived cells to identify novel regulators of autophagy

(2018) J.G.C. Peeters et al.   Autophagy

The Mitochondrial Unfolded Protein Response Is Mediated Cell-Non-autonomously by Retromer-Dependent Wnt Signaling

(2018) Qian Zhang et al.   CELL

Emerging topics in C. elegans aging research: Transcriptional regulation, stress response and epigenetics

(2018) Martin S. Denzel et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Selective vulnerability in neurodegenerative diseases

(2018) Hongjun Fu et al.   NATURE NEUROSCIENCE

Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer’s Disease

(2018) Bahareh Eftekharzadeh et al.   NEURON

TFEB, a potential therapeutic target for osteoarthritis via autophagy regulation

(2018) Gang Zheng et al.   Cell Death & Disease

mTOR-dependent phosphorylation controls TFEB nuclear export

(2018) Gennaro Napolitano et al.   Nature Communications

Huntingtin Aggregation Impairs Autophagy, Leading to Argonaute-2 Accumulation and Global MicroRNA Dysregulation

(2018) Karolina Pircs et al.   Cell Reports

Epigenetic Regulation of Autophagy: A Path to the Control of Autoimmunity

(2018) Jessica C. Hargarten et al.   Frontiers in Immunology

Autophagy and aging: Maintaining the proteome through exercise and caloric restriction

(2018) Kurt A. Escobar et al.   AGING CELL

p62-mediated phase separation at the intersection of the ubiquitin-proteasome system and autophagy

(2018) Alberto Danieli et al.   JOURNAL OF CELL SCIENCE

Autophagy and Its Role in Protein Secretion: Implications for Cancer Therapy

(2018) Israel Cotzomi-Ortega et al.   MEDIATORS OF INFLAMMATION

N6-methyldeoxyadenine is a transgenerational epigenetic signal for mitochondrial stress adaptation

(2018) Chengchuan Ma et al.   NATURE CELL BIOLOGY

The lysosome as a cellular centre for signalling, metabolism and quality control

(2018) Rosalie E. Lawrence et al.   NATURE CELL BIOLOGY

DAF-16/FOXO and HLH-30/TFEB function as combinatorial transcription factors to promote stress resistance and longevity

(2018) Xin-Xuan Lin et al.   Nature Communications

Perturbations in Traffic: Aberrant Nucleocytoplasmic Transport at the Heart of Neurodegeneration

(2018) Birthe Fahrenkrog et al.   Cells

Autophagy and Microglia: Novel Partners in Neurodegeneration and Aging

(2017) Ainhoa Plaza-Zabala et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Chaperone-mediated autophagy and endosomal microautophagy: Jointed by a chaperone

(2017) Kumsal Tekirdag et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Beyond self-eating: The control of nonautophagic functions and signaling pathways by autophagy-related proteins

(2017) Ken Cadwell et al.   JOURNAL OF CELL BIOLOGY

The aging clock: circadian rhythms and later life

(2017) Suzanne Hood et al.   JOURNAL OF CLINICAL INVESTIGATION

Polyglutamine tracts regulate beclin 1-dependent autophagy

(2017) Avraham Ashkenazi et al.   NATURE

KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1

(2017) Rachel L. Wolfson et al.   NATURE

Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles

(2017) Lorenzo Galluzzi et al.   NATURE REVIEWS DRUG DISCOVERY

RNA sequencing reveals pronounced changes in the noncoding transcriptome of aging synaptosomes

(2017) Bei Jun Chen et al.   NEUROBIOLOGY OF AGING

Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities

(2017) Fiona M. Menzies et al.   NEURON

AMPK blocks starvation-inducible transgenerational defects inCaenorhabditis elegans

(2017) Emilie Demoinet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Running as a Key Lifestyle Medicine for Longevity

(2017) Duck-chul Lee et al.   PROGRESS IN CARDIOVASCULAR DISEASES

Antiaging Effect of Metformin on Brain in Naturally Aged and Accelerated Senescence Model of Rat

(2017) Geetika Garg et al.   REJUVENATION RESEARCH

Lysosomal cholesterol activates mTORC1 via an SLC38A9–Niemann-Pick C1 signaling complex

(2017) Brian M. Castellano et al.   SCIENCE

Autophagy Receptors and Neurodegenerative Diseases

(2017) Zhiqiang Deng et al.   TRENDS IN CELL BIOLOGY

Long non-coding RNAs involved in autophagy regulation

(2017) Lixian Yang et al.   Cell Death & Disease

Environmental stresses induce transgenerationally inheritable survival advantages via germline-to-soma communication in Caenorhabditis elegans

(2017) Saya Kishimoto et al.   Nature Communications

Caloric restriction improves health and survival of rhesus monkeys

(2017) Julie A. Mattison et al.   Nature Communications

Long Non-coding RNA H19 Induces Cerebral Ischemia Reperfusion Injury via Activation of Autophagy

(2017) Jue Wang et al.   Aging and Disease

Mitophagy in Parkinson’s Disease: Pathogenic and Therapeutic Implications

(2017) Fei Gao et al.   Frontiers in Neurology

The lysosomal storage disease continuum with ageing-related neurodegenerative disease

(2016) Emyr Lloyd-Evans et al.   AGEING RESEARCH REVIEWS

TFEB and TFE3: Linking Lysosomes to Cellular Adaptation to Stress

(2016) Nina Raben et al.   Annual Review of Cell and Developmental Biology

The Lysosome as a Regulatory Hub

(2016) Rushika M. Perera et al.   Annual Review of Cell and Developmental Biology

Telemetric control of peripheral lipophagy by hypothalamic autophagy

(2016) Nuria Martinez-Lopez et al.   Autophagy

Emerging connections between RNA and autophagy

(2016) Lisa B. Frankel et al.   Autophagy

Autophagy, lipophagy and lysosomal lipid storage disorders

(2016) Carl Ward et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Autophagy in the CNS and Periphery Coordinate Lipophagy and Lipolysis in the Brown Adipose Tissue and Liver

(2016) Nuria Martinez-Lopez et al.   Cell Metabolism

Role of AMPK in regulation of LC3 lipidation as a marker of autophagy in skeletal muscle

(2016) Andreas Mæchel Fritzen et al.   CELLULAR SIGNALLING

Aging is associated with hypermethylation of autophagy genes in macrophages

(2016) Hany Khalil et al.   Epigenetics

Role of chaperone-mediated autophagy in metabolism

(2016) Inmaculada Tasset et al.   FEBS Journal

Regulation of Liver Metabolism by Autophagy

(2016) Julio Madrigal-Matute et al.   GASTROENTEROLOGY

Transcriptional regulation of mammalian autophagy at a glance

(2016) Jens Füllgrabe et al.   JOURNAL OF CELL SCIENCE

AMPK–SKP2–CARM1 signalling cascade in transcriptional regulation of autophagy

(2016) Hi-Jai R. Shin et al.   NATURE

The Autophagy–Lysosomal Pathway in Neurodegeneration: A TFEB Perspective

(2016) Heidi Martini-Stoica et al.   TRENDS IN NEUROSCIENCES

Autophagy-mediated longevity is modulated by lipoprotein biogenesis

(2015) Nicole E. Seah et al.   Autophagy

Transcriptional and epigenetic regulation of autophagy in aging

(2015) Louis R Lapierre et al.   Autophagy

AMPK Activation of Muscle Autophagy Prevents Fasting-Induced Hypoglycemia and Myopathy during Aging

(2015) Adam L. Bujak et al.   Cell Metabolism

TDP-43 loss of function increases TFEB activity and blocks autophagosome-lysosome fusion

(2015) Q. Xia et al.   EMBO JOURNAL

Deacetylation of Nuclear LC3 Drives Autophagy Initiation under Starvation

(2015) Rui Huang et al.   MOLECULAR CELL

Phosphorylation of LC3 by the Hippo Kinases STK3/STK4 Is Essential for Autophagy

(2015) Deepti S. Wilkinson et al.   MOLECULAR CELL

Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans

(2015) Konstantinos Palikaras et al.   NATURE

Transcriptional control of autophagy–lysosome function drives pancreatic cancer metabolism

(2015) Rushika M. Perera et al.   NATURE

Nutrient-sensing mechanisms and pathways

(2015) Alejo Efeyan et al.   NATURE

Autophagy at the crossroads of catabolism and anabolism

(2015) Jasvinder Kaur et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease

(2015) Alicia M. Pickrell et al.   NEURON

Lysosomal signaling molecules regulate longevity in Caenorhabditis elegans

(2015) A. Folick et al.   SCIENCE

Mitochondrial dysfunction and mitophagy in Parkinson's: from familial to sporadic disease

(2015) Brent J. Ryan et al.   TRENDS IN BIOCHEMICAL SCIENCES

Presenilin 1 Maintains Lysosomal Ca2+ Homeostasis via TRPML1 by Regulating vATPase-Mediated Lysosome Acidification

(2015) Ju-Hyun Lee et al.   Cell Reports

A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning

(2015) Koray Kırlı et al.   eLife

Impact of the Circadian Clock on the Aging Process

(2015) Sara S. Fonseca Costa et al.   Frontiers in Neurology

Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila

(2014) Anne Simonsen et al.   Autophagy

The role of TOR in autophagy regulation from yeast to plants and mammals

(2014) Sandra Díaz-Troya et al.   Autophagy

Starvation-Induced Transgenerational Inheritance of Small RNAs in C. elegans

(2014) Oded Rechavi et al.   CELL

Regulation of autophagy by protein post-translational modification

(2014) Willayat Yousuf Wani et al.   LABORATORY INVESTIGATION

REST and stress resistance in ageing and Alzheimer’s disease

(2014) Tao Lu et al.   NATURE

Foxk proteins repress the initiation of starvation-induced atrophy and autophagy programs

(2014) Christopher John Bowman et al.   NATURE CELL BIOLOGY

Calorie Restriction in Mammals and Simple Model Organisms

(2014) Giusi Taormina et al.   Biomed Research International

XBP-1 Is a Cell-Nonautonomous Regulator of Stress Resistance and Longevity

(2013) Rebecca C. Taylor et al.   CELL

Regulation of Organismal Proteostasis by Transcellular Chaperone Signaling

(2013) Patricija van Oosten-Hawle et al.   CELL

XBP-1u suppresses autophagy by promoting the degradation of FoxO1 in cancer cells

(2013) Ying Zhao et al.   CELL RESEARCH

The RNA-binding Protein HuD Regulates Autophagosome Formation in Pancreatic β Cells by Promoting Autophagy-related Gene 5 Expression

(2013) Chongtae Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epigenetic Regulation of Autophagy by the Methyltransferase G9a

(2013) A. Artal-Martinez de Narvajas et al.   MOLECULAR AND CELLULAR BIOLOGY

The histone H4 lysine 16 acetyltransferase hMOF regulates the outcome of autophagy

(2013) Jens Füllgrabe et al.   NATURE

TFEB-mediated autophagy rescues midbrain dopamine neurons from  -synuclein toxicity

(2013) M. Decressac et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The TFEB orthologue HLH-30 regulates autophagy and modulates longevity in Caenorhabditis elegans

(2013) Louis R. Lapierre et al.   Nature Communications

Exercise induces autophagy in peripheral tissues and in the brain

(2012) Congcong He et al.   Autophagy

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Ageing as a Risk Factor for Disease

(2012) Teresa Niccoli et al.   CURRENT BIOLOGY

Nicotinamide-induced Mitophagy

(2012) So-young Jang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lysosomal storage disorders: The cellular impact of lysosomal dysfunction

(2012) Frances M. Platt et al.   JOURNAL OF CELL BIOLOGY

Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis

(2012) Congcong He et al.   NATURE

SQSTM1 mutations in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

(2012) E. Rubino et al.   NEUROLOGY

The histone H3 lysine 56 acetylation pathway is regulated by target of rapamycin (TOR) signaling and functions directly in ribosomal RNA biogenesis

(2012) Hongfeng Chen et al.   NUCLEIC ACIDS RESEARCH

SQSTM1 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis

(2011) Faisal Fecto   ARCHIVES OF NEUROLOGY

The autophagy initiating kinase ULK1 is regulated via opposing phosphorylation by AMPK and mTOR

(2011) Dan Egan et al.   Autophagy

FoxO transcription factors; Regulation by AKT and 14-3-3 proteins

(2011) Guri Tzivion et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Autophagy and Lipid Metabolism Coordinately Modulate Life Span in Germline-less C. elegans

(2011) Louis R. Lapierre et al.   CURRENT BIOLOGY

JNK regulates FoxO-dependent autophagy in neurons

(2011) P. Xu et al.   GENES & DEVELOPMENT

Autophagy Driven by a Master Regulator of Hematopoiesis

(2011) Y.-A. Kang et al.   MOLECULAR AND CELLULAR BIOLOGY

TFEB Links Autophagy to Lysosomal Biogenesis

(2011) C. Settembre et al.   SCIENCE

With TOR, Less Is More: A Key Role for the Conserved Nutrient-Sensing TOR Pathway in Aging

(2010) Pankaj Kapahi et al.   Cell Metabolism

Regulation of the autophagy protein LC3 by phosphorylation

(2010) Salvatore J. Cherra et al.   JOURNAL OF CELL BIOLOGY

Members of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans

(2010) Eric L. Greer et al.   NATURE

The genetics of ageing

(2010) Cynthia J. Kenyon   NATURE

Chronic high-fat diet in fathers programs β-cell dysfunction in female rat offspring

(2010) Sheau-Fang Ng et al.   NATURE

Autophagy and Metabolism

(2010) J. D. Rabinowitz et al.   SCIENCE

Regulation Mechanisms and Signaling Pathways of Autophagy

(2009) Congcong He et al.   Annual Review of Genetics

Age-Dependent Deterioration of Nuclear Pore Complexes Causes a Loss of Nuclear Integrity in Postmitotic Cells

(2009) Maximiliano A. D'Angelo et al.   CELL

Autophagy regulates lipid metabolism

(2009) Rajat Singh et al.   NATURE

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

(2009) David E. Harrison et al.   NATURE

Dynamics and diversity in autophagy mechanisms: lessons from yeast

(2009) Hitoshi Nakatogawa et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitochondrial Autophagy Is an HIF-1-dependent Adaptive Metabolic Response to Hypoxia

(2008) Huafeng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The FoxO code

(2008) D R Calnan et al.   ONCOGENE