Autophagy Function and Regulation in Kidney Disease

Suppression of autophagic activity by Rubicon is a signature of aging

(2019) Shuhei Nakamura et al.   Nature Communications

ATG5-mediated autophagy suppresses NF-κB signaling to limit epithelial inflammatory response to kidney injury

(2019) Xuan Peng et al.   Cell Death & Disease

Autophagy attenuates tubulointerstital fibrosis through regulating transforming growth factor-β and NLRP3 inflammasome signaling pathway

(2019) Sun Ah Nam et al.   Cell Death & Disease

Podocytes and autophagy: a potential therapeutic target in lupus nephritis

(2019) Xu-Jie Zhou et al.   Autophagy

Disrupted APOL1-miR193a Axis Dedifferentiates Podocytes through Autophagy Blockade in APOL1 Risk Milieu

(2019) Vinod Kumar et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Knockdown of periostin attenuates 5/6 nephrectomy‐induced intrarenal renin–angiotensin system activation, fibrosis, and inflammation in rats

(2019) Xiaohui Bian et al.   JOURNAL OF CELLULAR PHYSIOLOGY

FoxO3 activation in hypoxic tubules prevents chronic kidney disease

(2019) Ling Li et al.   JOURNAL OF CLINICAL INVESTIGATION

The protective effect of the TUG1/miR‑197/MAPK1 axis on lipopolysaccharide‑induced podocyte injury

(2019) Dong Zhao et al.   Molecular Medicine Reports

Atrasentan alleviates high glucose-induced podocyte injury by the microRNA-21/forkhead box O1 axis

(2019) Jie Wang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Elafibranor Inhibits Chronic Kidney Disease Progression in NASH Mice

(2019) Hung-Cheng Tsai et al.   Biomed Research International

Trehalose Protects against Insulin Resistance-Induced Tissue Injury and Excessive Autophagy in Skeletal Muscles and Kidney

(2019) Wei Yu et al.   CURRENT PHARMACEUTICAL DESIGN

Role of TFEB in autophagic modulation of ischemia reperfusion injury in mice kidney and protection by urolithin A

(2019) Ying Wang et al.   FOOD AND CHEMICAL TOXICOLOGY

Progranulin alleviates podocyte injury via regulating CAMKK/AMPK-mediated autophagy under diabetic conditions

(2019) Di Zhou et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Autophagy in Kidney Disease

(2019) Mary E. Choi   Annual Review of Physiology

Genetic Ablation of Calcium-independent Phospholipase A2γ Exacerbates Glomerular Injury in Adriamycin Nephrosis in Mice

(2019) Hanan Elimam et al.   Scientific Reports

Hypoxia-inducible factor prolyl hydroxylase inhibitor roxadustat (FG-4592) protects against cisplatin-induced acute kidney injury

(2018) Yunwen Yang et al.   CLINICAL SCIENCE

Mangiferin prevents diabetic nephropathy progression and protects podocyte function via autophagy in diabetic rat glomeruli

(2018) Xiaodan Wang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Protein kinase Cα drives fibroblast activation and kidney fibrosis by stimulating autophagic flux

(2018) Xian Xue et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TAK1 mediates excessive autophagy via p38 and ERK in cisplatin-induced acute kidney injury

(2018) Jun Zhou et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Advanced glycation end-products suppress autophagic flux in podocytes by activating mammalian target of rapamycin and inhibiting nuclear translocation of transcription factor EB

(2018) Xingchen Zhao et al.   JOURNAL OF PATHOLOGY

Corrigendum to Induction of autophagy reduces ischemia/reperfusion injury in steatotic rat livers [Journal of Surgical Research 216 (2017) 207–218]

(2018) Chunyi Kan et al.   JOURNAL OF SURGICAL RESEARCH

Cinacalcet-mediated activation of the CaMKKβ-LKB1-AMPK pathway attenuates diabetic nephropathy in db/db mice by modulation of apoptosis and autophagy

(2018) Ji Hee Lim et al.   Cell Death & Disease

Ischemic preconditioning attenuates ischemia/reperfusion-induced kidney injury by activating autophagy via the SGK1 signaling pathway

(2018) Ying Xie et al.   Cell Death & Disease

Activation of Ca2+-sensing receptor as a protective pathway to reduce Cadmium-induced cytotoxicity in renal proximal tubular cells

(2018) Jie Gu et al.   Scientific Reports

MicroRNA-22 Promotes Renal Tubulointerstitial Fibrosis by Targeting PTEN and Suppressing Autophagy in Diabetic Nephropathy

(2018) Yingying Zhang et al.   Journal of Diabetes Research

Increased autophagy is cytoprotective against podocyte injury induced by antibody and interferon-α in lupus nephritis

(2018) Yuan-yuan Qi et al.   ANNALS OF THE RHEUMATIC DISEASES

Activation of autophagy contributes to the renoprotective effect of postconditioning on acute kidney injury and renal fibrosis

(2018) Yaolin Song et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Pioglitazone Protects Against Renal Ischemia-Reperfusion Injury via the AMP-Activated Protein Kinase-Regulated Autophagy Pathway

(2018) Wenlin Chen et al.   Frontiers in Pharmacology

Effect of Klotho on autophagy clearance in tacrolimus-induced renal injury

(2018) Sun Woo Lim et al.   FASEB JOURNAL

SIRT3 Protects Against Acute Kidney Injury via AMPK/mTOR-Regulated Autophagy

(2018) Wenyu Zhao et al.   Frontiers in Physiology

FoxO1 Promotes Mitophagy in the Podocytes of Diabetic Male Mice via the PINK1/Parkin Pathway

(2017) Wen Li et al.   ENDOCRINOLOGY

Berberine enhances the AMPK activation and autophagy and mitigates high glucose-induced apoptosis of mouse podocytes

(2017) Yingli Jin et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Notoginsenoside R1 attenuates glucose-induced podocyte injury via the inhibition of apoptosis and the activation of autophagy through the PI3K/Akt/mTOR signaling pathway

(2017) Guodong Huang et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

High Endogenous Accumulation of ω-3 Polyunsaturated Fatty Acids Protect against Ischemia-Reperfusion Renal Injury through AMPK-Mediated Autophagy in Fat-1 Mice

(2017) Do Gwon et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Preconditioning of primary human renal proximal tubular epithelial cells without tryptophan increases survival under hypoxia by inducing autophagy

(2017) Theodoros Eleftheriadis et al.   INTERNATIONAL UROLOGY AND NEPHROLOGY

Adhesion-induced eosinophil cytolysis requires the receptor-interacting protein kinase 3 (RIPK3)–mixed lineage kinase-like (MLKL) signaling pathway, which is counterregulated by autophagy

(2017) Susanne Radonjic-Hoesli et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Forkhead box O3 (FoxO3) regulates kidney tubular autophagy following urinary tract obstruction

(2017) Ling Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Suppression of autophagic flux contributes to cardiomyocyte death by activation of necroptotic pathways

(2017) Makoto Ogasawara et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Janus Kinase 2 Regulates Transcription Factor EB Expression and Autophagy Completion in Glomerular Podocytes

(2017) Tamadher A. Alghamdi et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Shikonin-induced necroptosis is enhanced by the inhibition of autophagy in non-small cell lung cancer cells

(2017) Hyo-Jin Kim et al.   Journal of Translational Medicine

Transgenic expression of human APOL1 risk variants in podocytes induces kidney disease in mice

(2017) Pazit Beckerman et al.   NATURE MEDICINE

Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles

(2017) Lorenzo Galluzzi et al.   NATURE REVIEWS DRUG DISCOVERY

Endoplasmic reticulum stress, the unfolded protein response and autophagy in kidney diseases

(2017) Andrey V. Cybulsky   Nature Reviews Nephrology

Tailoring trehalose for biomedical and biotechnological applications

(2017) Mara K. O’Neill et al.   PURE AND APPLIED CHEMISTRY

Cadmium disrupts autophagic flux by inhibiting cytosolic Ca 2+ -dependent autophagosome-lysosome fusion in primary rat proximal tubular cells

(2017) Fei Liu et al.   TOXICOLOGY

Emerging Mechanisms in Initiating and Terminating Autophagy

(2017) Manuela Antonioli et al.   TRENDS IN BIOCHEMICAL SCIENCES

Apelin involved in progression of diabetic nephropathy by inhibiting autophagy in podocytes

(2017) Yu Liu et al.   Cell Death & Disease

mTORC1-independent TFEB activation via Akt inhibition promotes cellular clearance in neurodegenerative storage diseases

(2017) Michela Palmieri et al.   Nature Communications

Calpain mobilizes Atg9/Bif-1 vesicles from Golgi stacks upon autophagy induction by thapsigargin

(2017) Elena Marcassa et al.   Biology Open

Triptolide Restores Autophagy to Alleviate Diabetic Renal Fibrosis through the miR-141-3p/PTEN/Akt/mTOR Pathway

(2017) Xiao-yu Li et al.   Molecular Therapy-Nucleic Acids

Periostin function in communication with extracellular matrices

(2017) Akira Kudo et al.   Journal of Cell Communication and Signaling

Rhein Inhibits Autophagy in Rat Renal Tubular Cells by Regulation of AMPK/mTOR Signaling

(2017) Yue Tu et al.   Scientific Reports

Astragaloside IV protects against podocyte injury via SERCA2-dependent ER stress reduction and AMPKα-regulated autophagy induction in streptozotocin-induced diabetic nephropathy

(2017) Hengjiang Guo et al.   Scientific Reports

Atg5-mediated autophagy deficiency in proximal tubules promotes cell cycle G2/M arrest and renal fibrosis

(2016) Huiyan Li et al.   Autophagy

The ULK1 complex mediates MTORC1 signaling to the autophagy initiation machinery via binding and phosphorylating ATG14

(2016) Ji-Man Park et al.   Autophagy

Inhibition of BMI1 induces autophagy-mediated necroptosis

(2016) Anindya Dey et al.   Autophagy

Time-dependent dysregulation of autophagy: Implications in aging and mitochondrial homeostasis in the kidney proximal tubule

(2016) Takeshi Yamamoto et al.   Autophagy

Persistent activation of autophagy in kidney tubular cells promotes renal interstitial fibrosis during unilateral ureteral obstruction

(2016) Man J. Livingston et al.   Autophagy

Autophagy promotes ferroptosis by degradation of ferritin

(2016) Wen Hou et al.   Autophagy

Regulation of necrotic cell death: p53, PARP1 and cyclophilin D-overlapping pathways of regulated necrosis?

(2016) Yuan Ying et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Regulated cell death and adaptive stress responses

(2016) Lorenzo Galluzzi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Valproic acid attenuates renal fibrosis through the induction of autophagy

(2016) Koichiro Kawaoka et al.   Clinical and Experimental Nephrology

The Autophagy Machinery Controls Cell Death Switching between Apoptosis and Necroptosis

(2016) Megan L. Goodall et al.   DEVELOPMENTAL CELL

Autophagy activators suppress cystogenesis in an autosomal dominant polycystic kidney disease model

(2016) Ping Zhu et al.   HUMAN MOLECULAR GENETICS

Nutrient-regulated Phosphorylation of ATG13 Inhibits Starvation-induced Autophagy

(2016) Cindy Puente et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of subcellular calcium redistribution in regulating apoptosis and autophagy in cadmium-exposed primary rat proximal tubular cells

(2016) Fei Liu et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Activation of the transcription factor EB rescues lysosomal abnormalities in cystinotic kidney cells

(2016) Laura R. Rega et al.   KIDNEY INTERNATIONAL

Autophagy in acute kidney injury

(2016) Gur P. Kaushal et al.   KIDNEY INTERNATIONAL

Autophagy wins the 2016 Nobel Prize in Physiology or Medicine: Breakthroughs in baker's yeast fuel advances in biomedical research

(2016) Beth Levine et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy and Tubular Cell Death in the Kidney

(2016) Andrea Havasi et al.   SEMINARS IN NEPHROLOGY

An Overview of Pathways of Regulated Necrosis in Acute Kidney Injury

(2016) Jesper Kers et al.   SEMINARS IN NEPHROLOGY

Role of necroptosis in autophagy signaling during hepatic ischemia and reperfusion

(2016) Jeong-Min Hong et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Digesting the Expanding Mechanisms of Autophagy

(2016) Nicholas T. Ktistakis et al.   TRENDS IN CELL BIOLOGY

Ubiquitin-Dependent And Independent Signals In Selective Autophagy

(2016) Aliaksandr Khaminets et al.   TRENDS IN CELL BIOLOGY

Role of FOXO1 in aldosterone-induced autophagy: A compensatory protective mechanism related to podocyte injury

(2016) Bin Wang et al.   Oncotarget

NADPH oxidase promotes Parkinsonian phenotypes by impairing autophagic flux in an mTORC1-independent fashion in a cellular model of Parkinson’s disease

(2016) Rituraj Pal et al.   Scientific Reports

GADD34 Keeps the mTOR Pathway Inactivated in Endoplasmic Reticulum Stress Related Autophagy

(2016) Marianna Holczer et al.   PLoS One

Metformin Protects Against Cisplatin-Induced Tubular Cell Apoptosis and Acute Kidney Injury via AMPKα-regulated Autophagy Induction

(2016) Jianzhong Li et al.   Scientific Reports

Synergistic effect of apoptosis and necroptosis inhibitors in cisplatin-induced nephrotoxicity

(2015) Vivian Regina Tristão et al.   APOPTOSIS

Transcriptional and epigenetic regulation of autophagy in aging

(2015) Louis R Lapierre et al.   Autophagy

Necroptosis mediated by receptor interaction protein kinase 1 and 3 aggravates chronic kidney injury of subtotal nephrectomised rats

(2015) Yongjun Zhu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Heme oxygenase-1 enhances autophagy in podocytes as a protective mechanism against high glucose-induced apoptosis

(2015) Chenglong Dong et al.   EXPERIMENTAL CELL RESEARCH

Recent insights into cell death and autophagy

(2015) Brent E. Fitzwalter et al.   FEBS Journal

Autophagy and neurodegeneration

(2015) Rebecca A. Frake et al.   JOURNAL OF CLINICAL INVESTIGATION

Amino Acid Metabolism Inhibits Antibody-Driven Kidney Injury by Inducing Autophagy

(2015) Kapil Chaudhary et al.   JOURNAL OF IMMUNOLOGY

mTOR in health and in sickness

(2015) Dritan Liko et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Renal 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase Is an Important Determinant of AKI Severity after Ischemia-Reperfusion

(2015) E. K. Jackson et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

A Role for Tubular Necroptosis in Cisplatin-Induced AKI

(2015) Y. Xu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Megalin-Mediated Tubuloglomerular Alterations in High-Fat Diet-Induced Kidney Disease

(2015) S. Kuwahara et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Failed Tubule Recovery, AKI-CKD Transition, and Kidney Disease Progression

(2015) M. A. Venkatachalam et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Autophagy Induces Prosenescent Changes in Proximal Tubular S3 Segments

(2015) A. Baisantry et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates

(2015) Daniel F. Egan et al.   MOLECULAR CELL

PARP-1 promotes autophagy via the AMPK/mTOR pathway in CNE-2 human nasopharyngeal carcinoma cells following ionizing radiation, while inhibition of autophagy contributes to the radiation sensitization of CNE-2 cells

(2015) ZE-TAN CHEN et al.   Molecular Medicine Reports

Ursolic acid improves podocyte injury caused by high glucose

(2015) Li Xu et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Inhibition of autophagy sensitizes malignant pleural mesothelioma cells to dual PI3K/mTOR inhibitors

(2015) N Echeverry et al.   Cell Death & Disease

Sorafenib-induced defective autophagy promotes cell death by necroptosis

(2015) Pedram Kharaziha et al.   Oncotarget

Endoplasmic Reticulum Stress-Induced Autophagy Provides Cytoprotection from Chemical Hypoxia and Oxidant Injury and Ameliorates Renal Ischemia-Reperfusion Injury

(2015) Bhavya B. Chandrika et al.   PLoS One

Autophagy plays a protective role during zVAD-induced necrotic cell death

(2014) You-Tong Wu et al.   Autophagy

Dual Role of JNK1-mediated phosphorylation of Bcl-2 in autophagy and apoptosis regulation

(2014) Yongjie Wei et al.   Autophagy

p65/RelA binds and activates thebeclin 1promoter

(2014) Tamara Copetti et al.   Autophagy

Calpain inhibition mediates autophagy-dependent protection against polyglutamine toxicity

(2014) F M Menzies et al.   CELL DEATH AND DIFFERENTIATION

The link between acute kidney injury and chronic kidney disease

(2014) Linda Y. Belayev et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

ULK1 translocates to mitochondria and phosphorylates FUNDC1 to regulate mitophagy

(2014) W. Wu et al.   EMBO REPORTS

p38 signaling inhibits mTORC1-independent autophagy in senescent human CD8+ T cells

(2014) Sian M. Henson et al.   JOURNAL OF CLINICAL INVESTIGATION

Quercetin attenuates renal ischemia/reperfusion injury via an activation of AMP-activated protein kinase-regulated autophagy pathway

(2014) Bo-Lin Chen et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Ferrostatins Inhibit Oxidative Lipid Damage and Cell Death in Diverse Disease Models

(2014) Rachid Skouta et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Disruption of Renal Tubular Mitochondrial Quality Control by Myo-Inositol Oxygenase in Diabetic Kidney Disease

(2014) M. Zhan et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Regulated Cell Death in AKI

(2014) A. Linkermann et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Delayed Administration of a Single Dose of Lithium Promotes Recovery from AKI

(2014) H. Bao et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Autophagy Regulates TGF-  Expression and Suppresses Kidney Fibrosis Induced by Unilateral Ureteral Obstruction

(2014) Y. Ding et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Mixed Lineage Kinase Domain-like Protein MLKL Causes Necrotic Membrane Disruption upon Phosphorylation by RIP3

(2014) Huayi Wang et al.   MOLECULAR CELL

Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy

(2014) Joseph D. Mancias et al.   NATURE

Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo

(2014) William E. Dowdle et al.   NATURE CELL BIOLOGY

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

Self-consumption: the interplay of autophagy and apoptosis

(2014) Guillermo Mariño et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Fenofibrate Improves Renal Lipotoxicity through Activation of AMPK-PGC-1α in db/db Mice

(2014) Yu Ah Hong et al.   PLoS One

Trehalose, an mTOR Independent Autophagy Inducer, Alleviates Human Podocyte Injury after Puromycin Aminonucleoside Treatment

(2014) Yu-Lin Kang et al.   PLoS One

Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense

(2014) K. G. Lassen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mTORC1 maintains renal tubular homeostasis and is essential in response to ischemic stress

(2014) Florian Grahammer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synchronized renal tubular cell death involves ferroptosis

(2014) Andreas Linkermann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular mechanisms of regulated necrosis

(2014) Lorenzo Galluzzi et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

NAD+ and sirtuins in aging and disease

(2014) Shin-ichiro Imai et al.   TRENDS IN CELL BIOLOGY

RIPK3-Mediated Necroptosis Promotes Donor Kidney Inflammatory Injury and Reduces Allograft Survival

(2013) A. Lau et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Regulation of autophagy by mTOR-dependent and mTOR-independent pathways: autophagy dysfunction in neurodegenerative diseases and therapeutic application of autophagy enhancers

(2013) Sovan Sarkar   BIOCHEMICAL SOCIETY TRANSACTIONS

Differential Regulation of Distinct Vps34 Complexes by AMPK in Nutrient Stress and Autophagy

(2013) Joungmok Kim et al.   CELL

Obatoclax (GX15-070) triggers necroptosis by promoting the assembly of the necrosome on autophagosomal membranes

(2013) F Basit et al.   CELL DEATH AND DIFFERENTIATION

AMP Is a True Physiological Regulator of AMP-Activated Protein Kinase by Both Allosteric Activation and Enhancing Net Phosphorylation

(2013) Graeme J. Gowans et al.   Cell Metabolism

Autophagy and human diseases

(2013) Peidu Jiang et al.   CELL RESEARCH

The RIP1-Kinase Inhibitor Necrostatin-1 Prevents Osmotic Nephrosis and Contrast-Induced AKI in Mice

(2013) A. Linkermann et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Obesity-Mediated Autophagy Insufficiency Exacerbates Proteinuria-induced Tubulointerstitial Lesions

(2013) K. Yamahara et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Non-apoptotic effects of antiapoptotic agent zVAD-fmk in renal injury

(2013) Gur P. Kaushal et al.   KIDNEY INTERNATIONAL

Bax and Bak have critical roles in ischemic acute kidney injury in global and proximal tubule–specific knockout mouse models

(2013) Qingqing Wei et al.   KIDNEY INTERNATIONAL

Regulation of lipid accumulation by AMK-activated kinase in high fat diet–induced kidney injury

(2013) Anne-Emilie Declèves et al.   KIDNEY INTERNATIONAL

ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase

(2013) Ryan C. Russell et al.   NATURE CELL BIOLOGY

Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis

(2013) Zhenyu Cai et al.   NATURE CELL BIOLOGY

The ATM protein kinase: regulating the cellular response to genotoxic stress and more

(2013) Yosef Shiloh et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Autophagy in Human Health and Disease

(2013) Augustine M.K. Choi et al.   NEW ENGLAND JOURNAL OF MEDICINE

mTOR-Controlled Autophagy Requires Intracellular Ca2+ Signaling

(2013) Jean-Paul Decuypere et al.   PLoS One

Augmenting Autophagy to Treat Acute Kidney Injury during Endotoxemia in Mice

(2013) Gina M. Howell et al.   PLoS One

Autosis is a Na+,K+-ATPase-regulated form of cell death triggered by autophagy-inducing peptides, starvation, and hypoxia-ischemia

(2013) Y. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Two independent pathways of regulated necrosis mediate ischemia-reperfusion injury

(2013) A. Linkermann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy in Acute Kidney Injury

(2013) Man J. Livingston et al.   SEMINARS IN NEPHROLOGY

Autophagy as a Stress-Response and Quality-Control Mechanism: Implications for Cell Injury and Human Disease

(2012) Lyndsay Murrow et al.   Annual Review of Pathology-Mechanisms of Disease

Cleavage of Atg3 protein by caspase-8 regulates autophagy during receptor-activated cell death

(2012) Ozlem Oral et al.   APOPTOSIS

FOXO3 induces FOXO1-dependent autophagy by activating the AKT1 signaling pathway

(2012) Jingyi Zhou et al.   Autophagy

Autophagy plays a critical role in kidney tubule maintenance, aging and ischemia-reperfusion injury

(2012) Shuya Liu et al.   Autophagy

AMPK-dependent phosphorylation of ULK1 regulates ATG9 localization

(2012) Hildegard I.D. Mack et al.   Autophagy

AMPK activator AICAR ameliorates ischaemia reperfusion injury in the rat kidney

(2012) J Lempiäinen et al.   BRITISH JOURNAL OF PHARMACOLOGY

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

(2012) Liming Sun et al.   CELL

Proteolysis of Ambra1 during apoptosis has a role in the inhibition of the autophagic pro-survival response

(2012) V Pagliarini et al.   CELL DEATH AND DIFFERENTIATION

Phosphorylation of Atg5 by the Gadd45β–MEKK4-p38 pathway inhibits autophagy

(2012) E Keil et al.   CELL DEATH AND DIFFERENTIATION

SIRT1 Is Required for AMPK Activation and the Beneficial Effects of Resveratrol on Mitochondrial Function

(2012) Nathan L. Price et al.   Cell Metabolism

ROS-induced DNA damage and PARP-1 are required for optimal induction of starvation-induced autophagy

(2012) José Manuel Rodríguez-Vargas et al.   CELL RESEARCH

Involvement of autophagy in the pharmacological effects of the mTOR inhibitor everolimus in acute kidney injury

(2012) Shunsaku Nakagawa et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Autophagy Promotes Intracellular Degradation of Type I Collagen Induced by Transforming Growth Factor (TGF)-β1

(2012) Sung Il Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of Autophagy Rescues Palmitic Acid-induced Necroptosis of Endothelial Cells

(2012) Muhammad Jadoon Khan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tryptophan Depletion and the Kinase GCN2 Mediate IFN- -Induced Autophagy

(2012) S. Fougeray et al.   JOURNAL OF IMMUNOLOGY

Poly(ADP-ribose) polymerase 1 activation is required for cisplatin nephrotoxicity

(2012) Jinu Kim et al.   KIDNEY INTERNATIONAL

Autophagy in proximal tubules protects against acute kidney injury

(2012) Man Jiang et al.   KIDNEY INTERNATIONAL

Rip1 (Receptor-interacting protein kinase 1) mediates necroptosis and contributes to renal ischemia/reperfusion injury

(2012) Andreas Linkermann et al.   KIDNEY INTERNATIONAL

TRAIL induces autophagic protein cleavage through caspase activation in melanoma cell lines under arginine deprivation

(2012) Min You et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Caspase-3-Independent Internucleosomal DNA Fragmentation in Ischemic Acute Kidney Injury

(2012) Taiko Yoshida et al.   NEPHRON EXPERIMENTAL NEPHROLOGY

Aristolochic Acid I Induced Autophagy Extenuates Cell Apoptosis via ERK 1/2 Pathway in Renal Tubular Epithelial Cells

(2012) Youjia Zeng et al.   PLoS One

Autophagy Suppresses RIP Kinase-Dependent Necrosis Enabling Survival to mTOR Inhibition

(2012) Kevin Bray et al.   PLoS One

PARP-1 Modulation of mTOR Signaling in Response to a DNA Alkylating Agent

(2012) Chantal Éthier et al.   PLoS One

Nec-1 Protects against Nonapoptotic Cell Death in Cisplatin-Induced Kidney Injury

(2012) Vivian Regina Tristão et al.   RENAL FAILURE

Akt-Mediated Regulation of Autophagy and Tumorigenesis Through Beclin 1 Phosphorylation

(2012) R. C. Wang et al.   SCIENCE

Metabolic Stress in Autophagy and Cell Death Pathways

(2012) B. J. Altman et al.   Cold Spring Harbor Perspectives in Biology

Ins(1,4,5)P3receptor-mediated Ca2+signaling and autophagy induction are interrelated

(2011) Jean-Paul Decuypere et al.   Autophagy

Calpains — An elaborate proteolytic system

(2011) Yasuko Ono et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

Autophagy-deficient mice develop multiple liver tumors

(2011) A. Takamura et al.   GENES & DEVELOPMENT

Identification of Small Molecule Inhibitors of Phosphatidylinositol 3-Kinase and Autophagy

(2011) Thomas Farkas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of mTOR in podocyte function and diabetic nephropathy in humans and mice

(2011) Markus Gödel et al.   JOURNAL OF CLINICAL INVESTIGATION

mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy in mice

(2011) Ken Inoki et al.   JOURNAL OF CLINICAL INVESTIGATION

TNFα-Induced Necroptosis and Autophagy via Supression of the p38–NF-κB Survival Pathway in L929 Cells

(2011) Yuan-Chao Ye et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Autophagy Protects the Proximal Tubule from Degeneration and Acute Ischemic Injury

(2011) T. Kimura et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Inhibition of MTOR Disrupts Autophagic Flux in Podocytes

(2011) D. P. Cina et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Apoptosis and acute kidney injury

(2011) Andrea Havasi et al.   KIDNEY INTERNATIONAL

Role of AMPK-mTOR-Ulk1/2 in the Regulation of Autophagy: Cross Talk, Shortcuts, and Feedbacks

(2011) S. Alers et al.   MOLECULAR AND CELLULAR BIOLOGY

cIAPs Block Ripoptosome Formation, a RIP1/Caspase-8 Containing Intracellular Cell Death Complex Differentially Regulated by cFLIP Isoforms

(2011) Maria Feoktistova et al.   MOLECULAR CELL

Canonical and non-canonical autophagy: variations on a common theme of self-eating?

(2011) Patrice Codogno et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The role of autophagy in unilateral ureteral obstruction rat model

(2011) WAN-YOUNG KIM et al.   NEPHROLOGY

TFEB Links Autophagy to Lysosomal Biogenesis

(2011) C. Settembre et al.   SCIENCE

Autophagy Is a Component of Epithelial Cell Fate in Obstructive Uropathy

(2010) Ling Li et al.   AMERICAN JOURNAL OF PATHOLOGY

Cigarette smoke-induced autophagy is regulated by SIRT1–PARP-1-dependent mechanism: Implication in pathogenesis of COPD

(2010) Jae-woong Hwang et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

ATM engages the TSC2/mTORC1 signaling node to regulate autophagy

(2010) Angela Alexander et al.   Autophagy

Control of basal autophagy by calpain1 mediated cleavage of ATG5

(2010) Hong-Guang Xia et al.   Autophagy

ER stress negatively regulates AKT/TSC/mTOR pathway to enhance autophagy

(2010) Liang Qin et al.   Autophagy

Essential Regulation of Cell Bioenergetics by Constitutive InsP3 Receptor Ca2+ Transfer to Mitochondria

(2010) César Cárdenas et al.   CELL

The role of the Atg1/ULK1 complex in autophagy regulation

(2010) Noboru Mizushima   CURRENT OPINION IN CELL BIOLOGY

Chronic lithium treatment protects the rat kidney against ischemia/reperfusion injury: The role of nitric oxide and cyclooxygenase pathways

(2010) Saman Shafaat Talab et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Rilmenidine attenuates toxicity of polyglutamine expansions in a mouse model of Huntington's disease

(2010) C. Rose et al.   HUMAN MOLECULAR GENETICS

The dynamic interaction of AMBRA1 with the dynein motor complex regulates mammalian autophagy

(2010) Sabrina Di Bartolomeo et al.   JOURNAL OF CELL BIOLOGY

Endogenous HMGB1 regulates autophagy

(2010) Daolin Tang et al.   JOURNAL OF CELL BIOLOGY

Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney

(2010) Shinji Kume et al.   JOURNAL OF CLINICAL INVESTIGATION

Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice

(2010) Björn Hartleben et al.   JOURNAL OF CLINICAL INVESTIGATION

Induction of autophagy-dependent necroptosis is required for childhood acute lymphoblastic leukemia cells to overcome glucocorticoid resistance

(2010) Laura Bonapace et al.   JOURNAL OF CLINICAL INVESTIGATION

Autophagy and the Integrated Stress Response

(2010) Guido Kroemer et al.   MOLECULAR CELL

Chemical modulators of autophagy as biological probes and potential therapeutics

(2010) Angeleen Fleming et al.   Nature Chemical Biology

Renal fibrosis: novel insights into mechanisms and therapeutic targets

(2010) Peter Boor et al.   Nature Reviews Nephrology

Regulation of Mammalian Autophagy in Physiology and Pathophysiology

(2010) Brinda Ravikumar et al.   PHYSIOLOGICAL REVIEWS

SIRT1 Negatively Regulates the Mammalian Target of Rapamycin

(2010) Hiyaa Singhee Ghosh et al.   PLoS One

ATM Activation by Oxidative Stress

(2010) Z. Guo et al.   SCIENCE

Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria

(2010) E Wirawan et al.   Cell Death & Disease

To die or to live: the dual role of poly(ADP-ribose) polymerase-1 in autophagy and necrosis under oxidative stress and DNA damage

(2009) Qing Huang et al.   Autophagy

Poly(ADP-ribose) polymerase (PARP) inhibition counteracts multiple manifestations of kidney disease in long-term streptozotocin-diabetic rat model

(2009) Hanna Shevalye et al.   BIOCHEMICAL PHARMACOLOGY

Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation

(2009) YoungSik Cho et al.   CELL

Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α

(2009) Sudan He et al.   CELL

The inositol 1,4,5-trisphosphate receptor regulates autophagy through its interaction with Beclin 1

(2009) J M Vicencio et al.   CELL DEATH AND DIFFERENTIATION

Apoptosis blocks Beclin 1-dependent autophagosome synthesis: an effect rescued by Bcl-xL

(2009) S Luo et al.   CELL DEATH AND DIFFERENTIATION

Coordinated regulation of autophagy by p38α MAPK through mAtg9 and p38IP

(2009) Jemma L Webber et al.   EMBO JOURNAL

DAP-kinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy

(2009) Einat Zalckvar et al.   EMBO REPORTS

Mechanisms of cross-talk between the ubiquitin-proteasome and autophagy-lysosome systems

(2009) Viktor I. Korolchuk et al.   FEBS LETTERS

Caspase cleavage of Atg4D stimulates GABARAP-L1 processing and triggers mitochondrial targeting and apoptosis

(2009) V. M. S. Betin et al.   JOURNAL OF CELL SCIENCE

Ureteral obstruction as a model of renal interstitial fibrosis and obstructive nephropathy

(2009) Robert L. Chevalier et al.   KIDNEY INTERNATIONAL

Polycystin-1 Regulates Extracellular Signal-Regulated Kinase-Dependent Phosphorylation of Tuberin To Control Cell Size through mTOR and Its Downstream Effectors S6K and 4EBP1

(2009) G. Distefano et al.   MOLECULAR AND CELLULAR BIOLOGY

Endoplasmic reticulum stress induces autophagy in renal proximal tubular cells

(2009) T. Kawakami et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

A Gene Network Regulating Lysosomal Biogenesis and Function

(2009) Marco Sardiello et al.   SCIENCE

RIP3, an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis

(2009) D.-W. Zhang et al.   SCIENCE

Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009

(2008) G Kroemer et al.   CELL DEATH AND DIFFERENTIATION

JNK1-Mediated Phosphorylation of Bcl-2 Regulates Starvation-Induced Autophagy

(2008) Yongjie Wei et al.   MOLECULAR CELL

Novel targets for Huntington's disease in an mTOR-independent autophagy pathway

(2008) Andrea Williams et al.   Nature Chemical Biology

The pivotal role of c-Jun NH2-terminal kinase-mediated Beclin 1 expression during anticancer agents-induced autophagy in cancer cells

(2008) D-D Li et al.   ONCOGENE

The FoxO code

(2008) D R Calnan et al.   ONCOGENE

A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy

(2008) I. H. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA