Fenofibrate Improves Renal Lipotoxicity through Activation of AMPK-PGC-1α in db/db Mice
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Title
Fenofibrate Improves Renal Lipotoxicity through Activation of AMPK-PGC-1α in db/db Mice
Authors
Keywords
Kidneys, Diabetes mellitus, Oxidative stress, Apoptosis, Glucose, Small interfering RNAs, Quantitative analysis, Fatty acids
Journal
PLoS One
Volume 9, Issue 5, Pages e96147
Publisher
Public Library of Science (PLoS)
Online
2014-05-07
DOI
10.1371/journal.pone.0096147
References
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- (2012) Wei-Lu Chen et al. BIOCHEMICAL PHARMACOLOGY
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- (2012) David D. Moore Cell Metabolism
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- (2012) M. Y. Kim et al. DIABETOLOGIA
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- (2011) Munehiro Kitada et al. Experimental Diabetes Research
- Energy-sensing Factors Coactivator Peroxisome Proliferator-activated Receptor γ Coactivator 1-α (PGC-1α) and AMP-activated Protein Kinase Control Expression of Inflammatory Mediators in Liver
- (2011) Marcin Buler et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- High-fat diet-induced renal cell apoptosis and oxidative stress in spontaneously hypertensive rat are ameliorated by fenofibrate through the PPARα–FoxO3a–PGC-1α pathway
- (2011) Hyun Wha Chung et al. NEPHROLOGY DIALYSIS TRANSPLANTATION
- Interactions between the consumption of a high-fat diet and fasting in the regulation of fatty acid oxidation enzyme gene expression: an evaluation of potential mechanisms
- (2010) Bruce C. Frier et al. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
- The p65 subunit of NF-κB binds to PGC-1α, linking inflammation and metabolic disturbances in cardiac cells
- (2010) David Álvarez-Guardia et al. CARDIOVASCULAR RESEARCH
- Lipotoxicity in Diabetic Nephropathy: The Potential Role of Fatty Acid Oxidation
- (2010) M. Murea et al. Clinical Journal of the American Society of Nephrology
- New pharmacological treatments for improving renal outcomes in diabetes
- (2010) Anne-Emilie Declèves et al. Nature Reviews Nephrology
- The role of FOXO in the regulation of metabolism
- (2009) Danielle N. Gross et al. Current Diabetes Reports
- PGC-1α, SIRT1 and AMPK, an energy sensing network that controls energy expenditure
- (2009) Carles Cantó et al. CURRENT OPINION IN LIPIDOLOGY
- Peroxisome proliferator-activated receptor-α activator fenofibrate prevents high-fat diet-induced renal lipotoxicity in spontaneously hypertensive rats
- (2009) Seok Joon Shin et al. HYPERTENSION RESEARCH
- Mutual Dependence of Foxo3a and PGC-1α in the Induction of Oxidative Stress Genes
- (2009) Yolanda Olmos et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
- (2009) Carles Cantó et al. NATURE
- A PGC-1α-O-GlcNAc Transferase Complex Regulates FoxO Transcription Factor Activity in Response to Glucose
- (2008) Michael P. Housley et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- PPARα activators upregulate eNOS activity and inhibit cytokine-induced NF-κB activation through AMP-activated protein kinase activation
- (2008) Toshie Okayasu et al. LIFE SCIENCES
- ERRα: a metabolic function for the oldest orphan
- (2008) Josep A. Villena et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
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