mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy in mice

Role of mTOR in podocyte function and diabetic nephropathy in humans and mice

(2011) Markus Gödel et al.   JOURNAL OF CLINICAL INVESTIGATION

Insulin Signaling to the Glomerular Podocyte Is Critical for Normal Kidney Function

(2010) Gavin I. Welsh et al.   Cell Metabolism

The evolutionarily conserved TSC/Rheb pathway activates Notch in tuberous sclerosis complex and Drosophila external sensory organ development

(2010) Magdalena Karbowniczek et al.   JOURNAL OF CLINICAL INVESTIGATION

Mammalian target of rapamycin regulates murine and human cell differentiation through STAT3/p63/Jagged/Notch cascade

(2010) Jianhui Ma et al.   JOURNAL OF CLINICAL INVESTIGATION

Expression of Notch pathway proteins correlates with albuminuria, glomerulosclerosis, and renal function

(2010) Mariana Murea et al.   KIDNEY INTERNATIONAL

Current concepts in the pathogenesis of urea cycle disorders

(2010) Olivier Braissant   MOLECULAR GENETICS AND METABOLISM

Epithelial-Mesenchymal Transition and Podocyte Loss in Diabetic Kidney Disease

(2009) Kimberly Reidy et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Epithelial-Mesenchymal Transition as a Potential Explanation for Podocyte Depletion in Diabetic Nephropathy

(2009) Yukinari Yamaguchi et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Tubular Toxicity in Sirolimus- and Cyclosporine-Based Transplant Immunosuppression Strategies: An Ancillary Study From a Randomized Controlled Trial

(2009) Stefan Franz et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

The mTOR pathway is highly activated in diabetic nephropathy and rapamycin has a strong therapeutic potential

(2009) Hiroyuki Mori et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Critical Role for Hypothalamic mTOR Activity in Energy Balance

(2009) Hiroyuki Mori et al.   Cell Metabolism

Angiotensin II type 2 receptor deficiency aggravates renal injury and reduces survival in chronic kidney disease in mice

(2009) Ralf A. Benndorf et al.   KIDNEY INTERNATIONAL

Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis

(2009) Darren M Hutt et al.   Nature Chemical Biology

Rapamycin has dual opposing effects on proteinuric experimental nephropathies: is it a matter of podocyte damage?

(2009) J. Torras et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Epithelial-to-Mesenchymal Transition Is a Potential Pathway Leading to Podocyte Dysfunction and Proteinuria

(2008) Yingjian Li et al.   AMERICAN JOURNAL OF PATHOLOGY

Adipose-Specific Knockout of raptor Results in Lean Mice with Enhanced Mitochondrial Respiration

(2008) Pazit Polak et al.   Cell Metabolism

ER stress is associated with dedifferentiation and an epithelial-to-mesenchymal transition-like phenotype in PC Cl3 thyroid cells

(2008) Luca Ulianich et al.   JOURNAL OF CELL SCIENCE

Proteinuria and Hyperglycemia Induce Endoplasmic Reticulum Stress

(2008) M. T. Lindenmeyer et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The Notch pathway in podocytes plays a role in the development of glomerular disease

(2008) Thiruvur Niranjan et al.   NATURE MEDICINE

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

(2008) Y. Sancak et al.   SCIENCE