The ATM protein kinase: regulating the cellular response to genotoxic stress and more

ATM-dependent phosphorylation of heterogeneous nuclear ribonucleoprotein K promotes p53 transcriptional activation in response to DNA damage

(2013) Abdeladim Moumen et al.   CELL CYCLE

The p53 circuit board

(2012) Kelly D. Sullivan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

HIPK2: A tumour suppressor that controls DNA damage-induced cell fate and cytokinesis

(2012) Thomas G. Hofmann et al.   BIOESSAYS

The p53 mRNA-Mdm2 Interaction Controls Mdm2 Nuclear Trafficking and Is Required for p53 Activation following DNA Damage

(2012) Madhavsai Gajjar et al.   CANCER CELL

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Involvement of the nuclear proteasome activator PA28γ in the cellular response to DNA double-strand breaks

(2012) Adva Levy-Barda et al.   CELL CYCLE

Posttranslational control of telomere maintenance and the telomere damage response

(2012) Marieke H. Peuscher et al.   CELL CYCLE

ATM-dependent phosphorylation of the checkpoint clamp regulates repair pathways and maintains genomic stability

(2012) Min Hwa Shin et al.   CELL CYCLE

Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling

(2012) Paul D. Ray et al.   CELLULAR SIGNALLING

Mechanisms of replication fork protection: a safeguard for genome stability

(2012) Alessia Errico et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

ATR maintains select progenitors during nervous system development

(2012) Youngsoo Lee et al.   EMBO JOURNAL

Regulation of SIRT1 activity by genotoxic stress

(2012) J. Yuan et al.   GENES & DEVELOPMENT

Regulation of DNA cross-link repair by the Fanconi anemia/BRCA pathway

(2012) H. Kim et al.   GENES & DEVELOPMENT

DNA damage-dependent NF-κB activation: NEMO turns nuclear signaling inside out

(2012) Kevin W. McCool et al.   IMMUNOLOGICAL REVIEWS

New Insights into p53 Signaling and Cancer Cell Response to DNA Damage: Implications for Cancer Therapy

(2012) Razmik Mirzayans et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Kinase-dead ATM protein causes genomic instability and early embryonic lethality in mice

(2012) Kenta Yamamoto et al.   JOURNAL OF CELL BIOLOGY

Loss of ATM kinase activity leads to embryonic lethality in mice

(2012) Jeremy A. Daniel et al.   JOURNAL OF CELL BIOLOGY

Quantitative Proteomics Reveal ATM Kinase-dependent Exchange in DNA Damage Response Complexes

(2012) Serah Choi et al.   JOURNAL OF PROTEOME RESEARCH

Proteomic profiling of ATM kinase proficient and deficient cell lines upon blockage of proteasome activity

(2012) Valeria Marzano et al.   Journal of Proteomics

Sp1 Facilitates DNA Double-Strand Break Repair through a Nontranscriptional Mechanism

(2012) K. Beishline et al.   MOLECULAR AND CELLULAR BIOLOGY

Skp2 E3 Ligase Integrates ATM Activation and Homologous Recombination Repair by Ubiquitinating NBS1

(2012) Juan Wu et al.   MOLECULAR CELL

PIDD Death-Domain Phosphorylation by ATM Controls Prodeath versus Prosurvival PIDDosome Signaling

(2012) Kiyohiro Ando et al.   MOLECULAR CELL

ATM-Dependent Downregulation of USP7/HAUSP by PPM1G Activates p53 Response to DNA Damage

(2012) Svetlana V. Khoronenkova et al.   MOLECULAR CELL

Playing the End Game: DNA Double-Strand Break Repair Pathway Choice

(2012) J. Ross Chapman et al.   MOLECULAR CELL

Recognition, signaling, and repair of DNA double-strand breaks produced by ionizing radiation in mammalian cells: The molecular choreography

(2012) Larry H. Thompson   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Nuclear accumulation of HDAC4 in ATM deficiency promotes neurodegeneration in ataxia telangiectasia

(2012) Jiali Li et al.   NATURE MEDICINE

DNAPKcs-dependent arrest of RNA polymerase II transcription in the presence of DNA breaks

(2012) Tibor Pankotai et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The molecular basis of ATM-dependent dimerization of the Mdc1 DNA damage checkpoint mediator

(2012) Stephanie Jungmichel et al.   NUCLEIC ACIDS RESEARCH

Distinct roles for DNA-PK, ATM and ATR in RPA phosphorylation and checkpoint activation in response to replication stress

(2012) S. Liu et al.   NUCLEIC ACIDS RESEARCH

Phosphorylation of PNKP by ATM prevents its proteasomal degradation and enhances resistance to oxidative stress

(2012) Jason L. Parsons et al.   NUCLEIC ACIDS RESEARCH

Structural mechanism of the phosphorylation-dependent dimerization of the MDC1 forkhead-associated domain

(2012) Jinping Liu et al.   NUCLEIC ACIDS RESEARCH

Attractor Landscape Analysis Reveals Feedback Loops in the p53 Network That Control the Cellular Response to DNA Damage

(2012) M. Choi et al.   Science Signaling

The p53 network: cellular and systemic DNA damage responses in aging and cancer

(2012) H. Christian Reinhardt et al.   TRENDS IN GENETICS

DBC1 phosphorylation by ATM/ATR inhibits SIRT1 deacetylase in response to DNA damage

(2012) Laura Zannini et al.   Journal of Molecular Cell Biology

Competition between NBS1 and ATMIN Controls ATM Signaling Pathway Choice

(2012) Tianyi Zhang et al.   Cell Reports

Identification of the First ATRIP–Deficient Patient and Novel Mutations in ATR Define a Clinical Spectrum for ATR–ATRIP Seckel Syndrome

(2012) Tomoo Ogi et al.   PLoS Genetics

Akt: A Double-Edged Sword in Cell Proliferation and Genome Stability

(2012) Naihan Xu et al.   Journal of Oncology

A Role for Vascular Deficiency in Retinal Pathology in a Mouse Model of Ataxia-Telangiectasia

(2011) Dorit Raz-Prag et al.   AMERICAN JOURNAL OF PATHOLOGY

ATM and the Molecular Pathogenesis of Ataxia Telangiectasia

(2011) Peter J. McKinnon   Annual Review of Pathology-Mechanisms of Disease

ATR signalling: more than meeting at the fork

(2011) Edward A. Nam et al.   BIOCHEMICAL JOURNAL

Mitochondrial dysfunction in ataxia-telangiectasia

(2011) Y. A. Valentin-Vega et al.   BLOOD

New insights into the roles of ATM and DNA-PKcs in the cellular response to oxidative stress

(2011) Benjamin P.C. Chen et al.   CANCER LETTERS

Irreversible chromosome damage accumulates rapidly in the absence of ATM kinase activity

(2011) Jason S. White et al.   CELL CYCLE

ATM activation in the presence of oxidative stress 

(2011) Zhi Guo et al.   CELL CYCLE

ATM protein kinase: the linchpin of cellular defenses to stress

(2011) Shahzad Bhatti et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Eukaryotic DNA damage checkpoint activation in response to double-strand breaks

(2011) Karen Finn et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Emerging roles of DNA-PK besides DNA repair

(2011) Xianming Kong et al.   CELLULAR SIGNALLING

Differential function of NBS1 and ATR in neurogenesis

(2011) Zhongwei Zhou et al.   DNA REPAIR

Cytoplasmic ATM protein kinase: an emerging therapeutic target for diabetes, cancer and neuronal degeneration

(2011) Da-Qing Yang et al.   DRUG DISCOVERY TODAY

ATM-mediated phosphorylation of polynucleotide kinase/phosphatase is required for effective DNA double-strand break repair

(2011) Hava Segal-Raz et al.   EMBO REPORTS

Beyond ATM: The protein kinase landscape of the DNA damage response

(2011) Ariel Bensimon et al.   FEBS LETTERS

Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications

(2011) S. E. Polo et al.   GENES & DEVELOPMENT

Oligomerization of MDC1 Protein Is Important for Proper DNA Damage Response

(2011) Kuntian Luo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ATM Protein-dependent Phosphorylation of Rad50 Protein Regulates DNA Repair and Cell Cycle Control

(2011) Magtouf Gatei et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Malfunctioning DNA Damage Response (DDR) Leads to the Degeneration of Nigro-Striatal Pathway in Mouse Brain

(2011) Michal Kirshner et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Integrated Analysis of ATM Mediated Gene and Protein Expression Impacting Cellular Metabolism

(2011) Amrita K. Cheema et al.   JOURNAL OF PROTEOME RESEARCH

Aurora-B Mediated ATM Serine 1403 Phosphorylation Is Required for Mitotic ATM Activation and the Spindle Checkpoint

(2011) Chunying Yang et al.   MOLECULAR CELL

Regulation of Homologous Recombination by RNF20-Dependent H2B Ubiquitination

(2011) Kyosuke Nakamura et al.   MOLECULAR CELL

The ATM Kinase Induces MicroRNA Biogenesis in the DNA Damage Response

(2011) Xinna Zhang et al.   MOLECULAR CELL

Requirement of ATM-Dependent Monoubiquitylation of Histone H2B for Timely Repair of DNA Double-Strand Breaks

(2011) Lilach Moyal et al.   MOLECULAR CELL

Transcriptional modulation induced by ionizing radiation: p53 remains a central player

(2011) Sharon Rashi-Elkeles et al.   Molecular Oncology

Choosing the right path: Does DNA-PK help make the decision?

(2011) Jessica A. Neal et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Induction and repair of DNA double strand breaks: The increasing spectrum of non-homologous end joining pathways

(2011) Emil Mladenov et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

More than just a focus: The chromatin response to DNA damage and its role in genome integrity maintenance

(2011) Jiri Lukas et al.   NATURE CELL BIOLOGY

The MRE11 complex: starting from the ends

(2011) Travis H. Stracker et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Chfr and RNF8 synergistically regulate ATM activation

(2011) Jiaxue Wu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

KAP-1 phosphorylation regulates CHD3 nucleosome remodeling during the DNA double-strand break response

(2011) Aaron A Goodarzi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Endogenously induced DNA double strand breaks arise in heterochromatic DNA regions and require ataxia telangiectasia mutated and Artemis for their repair

(2011) Lisa Woodbine et al.   NUCLEIC ACIDS RESEARCH

Phosphorylation of polynucleotide kinase/ phosphatase by DNA-dependent protein kinase and ataxia-telangiectasia mutated regulates its association with sites of DNA damage

(2011) Angela E. Zolner et al.   NUCLEIC ACIDS RESEARCH

Absence of Wip1 partially rescues Atm deficiency phenotypes in mice

(2011) Y Darlington et al.   ONCOGENE

A Novel Role for ATM in Regulating Proteasome-Mediated Protein Degradation through Suppression of the ISG15 Conjugation Pathway

(2011) Laurence M. Wood et al.   PLoS One

Ataxia telangiectasia mutated (Atm) and DNA-PKcs kinases have overlapping activities during chromosomal signal joint formation

(2011) Eric J. Gapud et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Signals from the Nucleus: Activation of NF- B by Cytosolic ATM in the DNA Damage Response

(2011) K. Hadian et al.   Science Signaling

DNA double-strand break repair pathways, chromosomal rearrangements and cancer

(2011) Torben R. Kasparek et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The ATM protein kinase and cellular redox signaling: beyond the DNA damage response

(2011) Scott Ditch et al.   TRENDS IN BIOCHEMICAL SCIENCES

ATM-Dependent Chromatin Changes Silence Transcription In cis to DNA Double-Strand Breaks

(2010) Niraj M. Shanbhag et al.   CELL

ATM regulates Mre11-dependent DNA end-degradation and microhomology-mediated end joining

(2010) Elias A. Rahal et al.   CELL CYCLE

Inhibition of ATM kinase activity does not phenocopy ATM protein disruption

(2010) Serah Choi et al.   CELL CYCLE

The DNA-dependent protein kinase (DNA-PK): More than just a case of making ends meet?

(2010) Richard Hill et al.   CELL CYCLE

Differential localization of ATM is correlated with activation of distinct downstream signaling pathways

(2010) Angela Alexander et al.   CELL CYCLE

Targeting Hypoxic Cells through the DNA Damage Response

(2010) M. Olcina et al.   CLINICAL CANCER RESEARCH

The ZFHX3 (ATBF1) transcription factor induces PDGFRB, which activates ATM in the cytoplasm to protect cerebellar neurons from oxidative stress

(2010) T.-S. Kim et al.   Disease Models & Mechanisms

Coping with DNA double strand breaks

(2010) Kevin Hiom   DNA REPAIR

The influence of heterochromatin on DNA double strand break repair: Getting the strong, silent type to relax

(2010) Aaron A. Goodarzi et al.   DNA REPAIR

Regulation of DNA-damage responses and cell-cycle progression by the chromatin remodelling factor CHD4

(2010) Sophie E Polo et al.   EMBO JOURNAL

ATM activates the pentose phosphate pathway promoting anti-oxidant defence and DNA repair

(2010) Claudia Cosentino et al.   EMBO JOURNAL

Focus on histone variant H2AX: To be or not to be

(2010) Jingsong Yuan et al.   FEBS LETTERS

Autophosphorylation and ATM Activation

(2010) Sergei V. Kozlov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The NuRD chromatin–remodeling complex regulates signaling and repair of DNA damage

(2010) Godelieve Smeenk et al.   JOURNAL OF CELL BIOLOGY

The chromatin-remodeling factor CHD4 coordinates signaling and repair after DNA damage

(2010) Dorthe Helena Larsen et al.   JOURNAL OF CELL BIOLOGY

mTORC1 Signaling under Hypoxic Conditions Is Controlled by ATM-Dependent Phosphorylation of HIF-1α

(2010) Hakan Cam et al.   MOLECULAR CELL

The DNA Damage Response: Making It Safe to Play with Knives

(2010) Alberto Ciccia et al.   MOLECULAR CELL

SPIKE: a database of highly curated human signaling pathways

(2010) Arnon Paz et al.   NUCLEIC ACIDS RESEARCH

ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS

(2010) A. Alexander et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ATM Activation by Oxidative Stress

(2010) Z. Guo et al.   SCIENCE

ATM-Dependent and -Independent Dynamics of the Nuclear Phosphoproteome After DNA Damage

(2010) A. Bensimon et al.   Science Signaling

Cytoplasmic ATM in Neurons Modulates Synaptic Function

(2009) Jiali Li et al.   CURRENT BIOLOGY

PIKK-dependent phosphorylation of Mre11 induces MRN complex inactivation by disassembly from chromatin

(2009) Michela Di Virgilio et al.   DNA REPAIR

Common mechanisms of PIKK regulation

(2009) Courtney A. Lovejoy et al.   DNA REPAIR

Emerging common themes in regulation of PIKKs and PI3Ks

(2009) Harri Lempiäinen et al.   EMBO JOURNAL

Optimal function of the DNA repair enzyme TDP1 requires its phosphorylation by ATM and/or DNA-PK

(2009) Benu Brata Das et al.   EMBO JOURNAL

53BP1 promotes ATM activity through direct interactions with the MRN complex

(2009) Ji-Hoon Lee et al.   EMBO JOURNAL

ATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2

(2009) Andrea Beucher et al.   EMBO JOURNAL

Distinct roles of ATR and DNA-PKcs in triggering DNA damage responses in ATM-deficient cells

(2009) Nozomi Tomimatsu et al.   EMBO REPORTS

Autophosphorylation at serine 1981 stabilizes ATM at DNA damage sites

(2009) Sairei So et al.   JOURNAL OF CELL BIOLOGY

CtIP Links DNA Double-Strand Break Sensing to Resection

(2009) Zhongsheng You et al.   MOLECULAR CELL

Formation of Dynamic γ-H2AX Domains along Broken DNA Strands Is Distinctly Regulated by ATM and MDC1 and Dependent upon H2AX Densities in Chromatin

(2009) Velibor Savic et al.   MOLECULAR CELL

Single-Stranded DNA Orchestrates an ATM-to-ATR Switch at DNA Breaks

(2009) Bunsyo Shiotani et al.   MOLECULAR CELL

A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging

(2009) Matilde Murga et al.   NATURE GENETICS

The type 2C phosphatase Wip1: An oncogenic regulator of tumor suppressor and DNA damage response pathways

(2008) Xiongbin Lu et al.   CANCER AND METASTASIS REVIEWS

Aven-Dependent Activation of ATM Following DNA Damage

(2008) Jessie Yanxiang Guo et al.   CURRENT BIOLOGY

The neurological phenotype of ataxia-telangiectasia: Solving a persistent puzzle

(2008) Sharon Biton et al.   DNA REPAIR

Mre11–Rad50–Nbs1-dependent processing of DNA breaks generates oligonucleotides that stimulate ATM activity

(2008) Ali Jazayeri et al.   EMBO JOURNAL

Multiple autophosphorylation sites are dispensable for murine ATM activation in vivo

(2008) Jeremy A. Daniel et al.   JOURNAL OF CELL BIOLOGY

ATM Activation and Signaling under Hypoxic Conditions

(2008) Z. Bencokova et al.   MOLECULAR AND CELLULAR BIOLOGY

ATM Signaling Facilitates Repair of DNA Double-Strand Breaks Associated with Heterochromatin

(2008) Aaron A. Goodarzi et al.   MOLECULAR CELL

Functional interaction between FOXO3a and ATM regulates DNA damage response

(2008) Wen-Bin Tsai et al.   NATURE CELL BIOLOGY

Activation of ATM depends on chromatin interactions occurring before induction of DNA damage

(2008) Yong-Chul Kim et al.   NATURE CELL BIOLOGY

Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer

(2008) Martin F. Lavin   NATURE REVIEWS MOLECULAR CELL BIOLOGY

ATR: an essential regulator of genome integrity

(2008) Karlene A. Cimprich et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Activation of the Cellular DNA Damage Response in the Absence of DNA Lesions

(2008) E. Soutoglou et al.   SCIENCE