Ursolic acid improves podocyte injury caused by high glucose

Valproate attenuates the proteinuria, podocyte and renal injury by facilitating autophagy and inactivation of NF-κB/iNOS signaling in diabetic rat

(2015) Sabbir Khan et al.   BIOCHIMIE

Downregulation of miR-21 is Involved in Direct Actions of Ursolic Acid on the Heart: Implications for Cardiac Fibrosis and Hypertrophy

(2015) Xingli Dong et al.   Cardiovascular Therapeutics

High glucose enhances microRNA-26a to activate mTORC1 for mesangial cell hypertrophy and matrix protein expression

(2015) Nirmalya Dey et al.   CELLULAR SIGNALLING

Heme oxygenase-1 enhances autophagy in podocytes as a protective mechanism against high glucose-induced apoptosis

(2015) Chenglong Dong et al.   EXPERIMENTAL CELL RESEARCH

Loss of PTEN promotes podocyte cytoskeletal rearrangement, aggravating diabetic nephropathy

(2015) Jamie S Lin et al.   JOURNAL OF PATHOLOGY

Autophagy inhibition induces podocyte apoptosis by activating the pro-apoptotic pathway of endoplasmic reticulum stress

(2014) Li Fang et al.   EXPERIMENTAL CELL RESEARCH

Ursolic acid ameliorates carbon tetrachloride-induced oxidative DNA damage and inflammation in mouse kidney by inhibiting the STAT3 and NF-κB activities

(2014) Jie-Qiong Ma et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

A novel functional interplay between Progesterone Receptor-B and PTEN, via AKT, modulates autophagy in breast cancer cells

(2014) Francesca De Amicis et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Molecular mechanisms of diabetic kidney disease

(2014) Kimberly Reidy et al.   JOURNAL OF CLINICAL INVESTIGATION

HDAC4 blocks autophagy to trigger podocyte injury: non-epigenetic action in diabetic nephropathy

(2014) Qingqing Wei et al.   KIDNEY INTERNATIONAL

Rapamycin promotes podocyte autophagy and ameliorates renal injury in diabetic mice

(2014) Tangli Xiao et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

The antipsychotic agent chlorpromazine induces autophagic cell death by inhibiting the Akt/mTOR pathway in human U-87MG glioma cells

(2013) Soon Young Shin et al.   CARCINOGENESIS

Ursolic Acid Provides Kidney Protection in Diabetic Rats

(2013) Chen Ling et al.   CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL

miR-21 is a key therapeutic target for renal injury in a mouse model of type 2 diabetes

(2013) X. Zhong et al.   DIABETOLOGIA

Obesity-Mediated Autophagy Insufficiency Exacerbates Proteinuria-induced Tubulointerstitial Lesions

(2013) K. Yamahara et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Dysregulated Autophagy Contributes to Podocyte Damage in Fabry’s Disease

(2013) Max C. Liebau et al.   PLoS One

Autophagy Attenuates Diabetic Glomerular Damage through Protection of Hyperglycemia-Induced Podocyte Injury

(2013) Li Fang et al.   PLoS One

Rapamycin Upregulates Autophagy by Inhibiting the mTOR-ULK1 Pathway, Resulting in Reduced Podocyte Injury

(2013) Lingling Wu et al.   PLoS One

PTEN Increases Autophagy and Inhibits the Ubiquitin-Proteasome Pathway in Glioma Cells Independently of its Lipid Phosphatase Activity

(2013) Rajaa Errafiy et al.   PLoS One

Emerging role of autophagy in kidney function, diseases and aging

(2012) Tobias B. Huber et al.   Autophagy

MicroRNA-21 Orchestrates High Glucose-induced Signals to TOR Complex 1, Resulting in Renal Cell Pathology in Diabetes

(2011) Nirmalya Dey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ursolic Acid, a Pentacyclic Triterpene from Sambucus australis, Prevents Abdominal Adiposity in Mice Fed a High-Fat Diet

(2011) Vietla S. Rao et al.   JOURNAL OF MEDICINAL FOOD

Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice

(2010) Björn Hartleben et al.   JOURNAL OF CLINICAL INVESTIGATION

Anti-glycative effects of oleanolic acid and ursolic acid in kidney of diabetic mice

(2009) Zhi-hong Wang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

MicroRNA-21 protects from mesangial cell proliferation induced by diabetic nephropathy in db/db mice

(2009) Zheng Zhang et al.   FEBS LETTERS

TGF-β activates Akt kinase through a microRNA-dependent amplifying circuit targeting PTEN

(2009) Mitsuo Kato et al.   NATURE CELL BIOLOGY