Podocytes and autophagy: a potential therapeutic target in lupus nephritis

CD8 T cells and mTOR: new concepts and targets for systemic lupus erythematosus

(2018) David R Fernandez et al.   LANCET

Sirolimus in patients with clinically active systemic lupus erythematosus resistant to, or intolerant of, conventional medications: a single-arm, open-label, phase 1/2 trial

(2018) Zhi-Wei Lai et al.   LANCET

Evaluation of ATG5 polymorphisms in Italian patients with systemic lupus erythematosus: contribution to disease susceptibility and clinical phenotypes

(2018) C Ciccacci et al.   LUPUS

Cargo recognition and degradation by selective autophagy

(2018) Damián Gatica et al.   NATURE CELL BIOLOGY

Type I interferon in rheumatic diseases

(2018) Theresa L. Wampler Muskardin et al.   Nature Reviews Rheumatology

Blockade of Treg Cell Differentiation and Function by the Interleukin-21-Mechanistic Target of Rapamycin Axis Via Suppression of Autophagy in Patients With Systemic Lupus Erythematosus

(2018) Hiroshi Kato et al.   Arthritis & Rheumatology

A Rare Variant (rs933717) at FBXO31-MAP1LC3B in Chinese Is Associated With Systemic Lupus Erythematosus

(2018) Yuan-yuan Qi et al.   Arthritis & Rheumatology

Lupus Regulator Peptide P140 Represses B Cell Differentiation by Reducing HLA Class II Molecule Overexpression

(2018) Maud Wilhelm et al.   Arthritis & Rheumatology

Autophagy and Rheumatoid Arthritis: Current Knowledges and Future Perspectives

(2018) Marta Vomero et al.   Frontiers in Immunology

Increased autophagy is cytoprotective against podocyte injury induced by antibody and interferon-α in lupus nephritis

(2018) Yuan-yuan Qi et al.   ANNALS OF THE RHEUMATIC DISEASES

ATG5 is required for B cell polarization and presentation of particulate antigens

(2018) Florent Arbogast et al.   Autophagy

Lymphocyte Autophagy in Homeostasis, Activation, and Inflammatory Diseases

(2018) Florent Arbogast et al.   Frontiers in Immunology

Boosting mTOR-dependent autophagy via upstream TLR4-MyD88-MAPK signalling and downstream NF-κB pathway quenches intestinal inflammation and oxidative stress injury

(2018) Mingxia Zhou et al.   EBioMedicine

Autophagy limits activation of the inflammasomes

(2017) Michihiro Takahama et al.   IMMUNOLOGICAL REVIEWS

ORMDL3 Facilitates the Survival of Splenic B Cells via an ATF6α–Endoplasmic Reticulum Stress–Beclin1 Autophagy Regulatory Pathway

(2017) Jie Dang et al.   JOURNAL OF IMMUNOLOGY

Updates in Lupus Genetics

(2017) Yun Deng et al.   Current Rheumatology Reports

Loss of autophagy enhances MIF/macrophage migration inhibitory factor release by macrophages

(2016) Jacinta P. W. Lee et al.   Autophagy

Autophagy in Dendritic Cells and B Cells Is Critical for the Inflammatory State of TLR7-Mediated Autoimmunity

(2016) Chi G. Weindel et al.   JOURNAL OF IMMUNOLOGY

Autophagy in kidney disease and aging: lessons from rodent models

(2016) Olivia Lenoir et al.   KIDNEY INTERNATIONAL

Noncanonical autophagy inhibits the autoinflammatory, lupus-like response to dying cells

(2016) Jennifer Martinez et al.   NATURE

Notch-Hes-1 axis controls TLR7-mediated autophagic death of macrophage via induction of P62 in mice with lupus

(2016) Xiaojing Li et al.   Cell Death & Disease

Systemic lupus erythematosus

(2016) Arvind Kaul et al.   Nature Reviews Disease Primers

B cell autophagy mediates TLR7-dependent autoimmunity and inflammation

(2015) Chi G Weindel et al.   Autophagy

Modulation of inflammation by autophagy: Consequences for human disease

(2015) Romana T. Netea-Maier et al.   Autophagy

The Autoimmunity-Associated Gene CLEC16A Modulates Thymic Epithelial Cell Autophagy and Alters T Cell Selection

(2015) Cornelia Schuster et al.   IMMUNITY

Autoantibodies specific to D4GDI modulate Rho GTPase mediated cytoskeleton remodeling and induce autophagy in T lymphocytes

(2015) Cristiana Barbati et al.   JOURNAL OF AUTOIMMUNITY

Autophagy: a druggable process that is deregulated in aging and human disease

(2015) Guido Kroemer   JOURNAL OF CLINICAL INVESTIGATION

Rare Variants of ATG5 Are Likely to Be Associated With Chinese Patients With Systemic Lupus Erythematosus

(2015) Yue-miao Zhang et al.   MEDICINE

Autophagy is activated in systemic lupus erythematosus and required for plasmablast development

(2014) Alexander J Clarke et al.   ANNALS OF THE RHEUMATIC DISEASES

A pathogenic role for ER stress-induced autophagy and ER chaperone GRP78/BiP in T lymphocyte systemic lupus erythematosus

(2014) Won-Seok Lee et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Treatment of severe lupus nephritis: the new horizon

(2014) Tak Mao Chan   Nature Reviews Nephrology

Mechanisms and biological functions of autophagy in diseased and ageing kidneys

(2014) Sophie Fougeray et al.   Nature Reviews Nephrology

Role of alpha-synuclein in autophagy modulation of primary human T lymphocytes

(2014) T Colasanti et al.   Cell Death & Disease

Brief Report: Identification ofMTMR3as a Novel Susceptibility Gene for Lupus Nephritis in Northern Han Chinese by Shared-Gene Analysis With IgA Nephropathy

(2014) Xu-jie Zhou et al.   Arthritis & Rheumatology

Autophagy in Kidney Health and Disease

(2013) Zhibo Wang et al.   ANTIOXIDANTS & REDOX SIGNALING

Decreased apopto-phagocytic gene expression in the macrophages of systemic lupus erythematosus patients

(2013) G Majai et al.   LUPUS

Autophagy in Human Health and Disease

(2013) Augustine M.K. Choi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Influence of Atg5 Mutation in SLE Depends on Functional IL-10 Genotype

(2013) Patricia López et al.   PLoS One

End-Stage Renal Disease in African Americans With Lupus Nephritis Is Associated WithAPOL1

(2013) Barry I. Freedman et al.   Arthritis & Rheumatology

Meta-analysis Followed by Replication Identifies Loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as Associated with Systemic Lupus Erythematosus in Asians

(2012) Wanling Yang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Autophagy in immunity

(2012) Xu-Jie Zhou et al.   Autophagy

Macroautophagy is deregulated in murine and human lupus T lymphocytes

(2012) Frédéric Gros et al.   Autophagy

T lymphocytes from patients with systemic lupus erythematosus are resistant to induction of autophagy

(2012) Cristiano Alessandri et al.   FASEB JOURNAL

Genetic association of PRDM1-ATG5 intergenic region and autophagy with systemic lupus erythematosus in a Chinese population

(2011) X.-j. Zhou et al.   ANNALS OF THE RHEUMATIC DISEASES

A therapeutic peptide in lupus alters autophagic processes and stability of MHCII molecules in MRL/lpr B cells

(2011) Nicolas Page et al.   Autophagy

Systemic Lupus Erythematosus

(2011) George C. Tsokos   NEW ENGLAND JOURNAL OF MEDICINE

HSC70 blockade by the therapeutic peptide P140 affects autophagic processes and endogenous MHCII presentation in murine lupus

(2010) N. Page et al.   ANNALS OF THE RHEUMATIC DISEASES

The PI3K/Akt/mTOR pathway is activated in murine lupus nephritis and downregulated by rapamycin

(2010) Kostas Stylianou et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus

(2009) Vesela Gateva et al.   NATURE GENETICS

Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus

(2009) Jian-Wen Han et al.   NATURE GENETICS

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE

Rapamycin attenuates the severity of established nephritis in lupus-prone NZB/W F1 mice

(2008) S. L. Lui et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Mapping similarities in mTOR pathway perturbations in mouse lupus nephritis models and human lupus nephritis

(2008) Padmalatha S Reddy et al.   ARTHRITIS RESEARCH & THERAPY