Regulation of autophagy by mTOR-dependent and mTOR-independent pathways: autophagy dysfunction in neurodegenerative diseases and therapeutic application of autophagy enhancers

Characterization of Torin2, an ATP-Competitive Inhibitor of mTOR, ATM, and ATR

(2013) Q. Liu et al.   CANCER RESEARCH

Differential Regulation of Distinct Vps34 Complexes by AMPK in Nutrient Stress and Autophagy

(2013) Joungmok Kim et al.   CELL

Autophagy Enhancer Carbamazepine Alleviates Memory Deficits and Cerebral Amyloid-β Pathology in a Mouse Model of Alzheimer's Disease

(2013) Lixi Li et al.   Current Alzheimer Research

The Role of Lipids in the Control of Autophagy

(2013) Claudia Dall'Armi et al.   CURRENT BIOLOGY

Autophagy failure in Alzheimer's disease and the role of defective lysosomal acidification

(2013) Devin M. Wolfe et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Dysfunction of the autophagy/lysosomal degradation pathway is a shared feature of the genetic synucleinopathies

(2013) Claudia Manzoni et al.   FASEB JOURNAL

Inhibition of Autophagy via p53-Mediated Disruption of ULK1 in a SCA7 Polyglutamine Disease Model

(2013) Xin Yu et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

p62/SQSTM1 Differentially Removes the Toxic Mutant Androgen Receptor via Autophagy and Inclusion Formation in a Spinal and Bulbar Muscular Atrophy Mouse Model

(2013) H. Doi et al.   JOURNAL OF NEUROSCIENCE

Lithium in patients with amyotrophic lateral sclerosis (LiCALS): a phase 3 multicentre, randomised, double-blind, placebo-controlled trial

(2013)   LANCET NEUROLOGY

Autophagosomes form at ER–mitochondria contact sites

(2013) Maho Hamasaki et al.   NATURE

Identification of a candidate therapeutic autophagy-inducing peptide

(2013) Sanae Shoji-Kawata et al.   NATURE

Chemical modulation of chaperone-mediated autophagy by retinoic acid derivatives

(2013) Jaime Anguiano et al.   Nature Chemical Biology

Interplay of LRRK2 with chaperone-mediated autophagy

(2013) Samantha J Orenstein et al.   NATURE NEUROSCIENCE

Amino acid signalling upstream of mTOR

(2013) Jenna L. Jewell et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

p62/SQSTM1-Dependent Autophagy of Lewy Body-Like α-Synuclein Inclusions

(2013) Yoshihisa Watanabe et al.   PLoS One

Rapamycin Attenuates the Progression of Tau Pathology in P301S Tau Transgenic Mice

(2013) Sefika Ozcelik et al.   PLoS One

TFEB-mediated autophagy rescues midbrain dopamine neurons from  -synuclein toxicity

(2013) M. Decressac et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Frontotemporal Dementia: Implications for Understanding Alzheimer Disease

(2013) M. Goedert et al.   Cold Spring Harbor Perspectives in Medicine

Biochemistry of Amyloid  -Protein and Amyloid Deposits in Alzheimer Disease

(2013) C. L. Masters et al.   Cold Spring Harbor Perspectives in Medicine

Autophagy researchers

(2012)   Autophagy

Stimulation of autophagy reduces neurodegeneration in a mouse model of human tauopathy

(2012) Véronique Schaeffer et al.   BRAIN

The Hairpin-type Tail-Anchored SNARE Syntaxin 17 Targets to Autophagosomes for Fusion with Endosomes/Lysosomes

(2012) Eisuke Itakura et al.   CELL

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Trehalose Protects from Aggravation of Amyloid Pathology Induced by Isoflurane Anesthesia in APPswe Mutant Mice

(2012) Juan Perucho et al.   Current Alzheimer Research

Polyglutamine neurodegeneration: expanded glutamines enhance native functions

(2012) Harry T Orr   CURRENT OPINION IN GENETICS & DEVELOPMENT

Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC

(2012) Nicole C McKnight et al.   EMBO JOURNAL

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

(2012) Carmine Settembre et al.   EMBO JOURNAL

Differential Degradation of Full-length and Cleaved Ataxin-7 Fragments in a Novel Stable Inducible SCA7 Model

(2012) Xin Yu et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

A Role for Presenilins in Autophagy Revisited: Normal Acidification of Lysosomes in Cells Lacking PSEN1 and PSEN2

(2012) X. Zhang et al.   JOURNAL OF NEUROSCIENCE

Disrupted Autophagy Leads to Dopaminergic Axon and Dendrite Degeneration and Promotes Presynaptic Accumulation of  -Synuclein and LRRK2 in the Brain

(2012) L. G. Friedman et al.   JOURNAL OF NEUROSCIENCE

Rab GTPase-Activating Proteins in Autophagy: Regulation of Endocytic and Autophagy Pathways by Direct Binding to Human ATG8 Modifiers

(2012) D. Popovic et al.   MOLECULAR AND CELLULAR BIOLOGY

Bim Inhibits Autophagy by Recruiting Beclin 1 to Microtubules

(2012) Shouqing Luo et al.   MOLECULAR CELL

Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer's mouse model

(2012) J W Steele et al.   MOLECULAR PSYCHIATRY

Latrepirdine stimulates autophagy and reduces accumulation of α-synuclein in cells and in mouse brain

(2012) J W Steele et al.   MOLECULAR PSYCHIATRY

Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival

(2012) Alejo Efeyan et al.   NATURE

Autophagy modulation as a potential therapeutic target for diverse diseases

(2012) David C. Rubinsztein et al.   NATURE REVIEWS DRUG DISCOVERY

Molecular basis of physiological heart growth: fundamental concepts and new players

(2012) Marjorie Maillet et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

100 years of Lewy pathology

(2012) Michel Goedert et al.   Nature Reviews Neurology

Long-term oral lithium treatment attenuates motor disturbance in tauopathy model mice: Implications of autophagy promotion

(2012) Kohei Shimada et al.   NEUROBIOLOGY OF DISEASE

SQSTM1 mutations in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

(2012) E. Rubino et al.   NEUROLOGY

Autophagy-related proteins (p62, NBR1 and LC3) in intranuclear inclusions in neurodegenerative diseases

(2012) Fumiaki Mori et al.   NEUROSCIENCE LETTERS

Development of Purkinje cell degeneration in a knockin mouse model reveals lysosomal involvement in the pathogenesis of SCA6

(2012) T. Unno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Transcription Factor TFEB Links mTORC1 Signaling to Transcriptional Control of Lysosome Homeostasis

(2012) A. Roczniak-Ferguson et al.   Science Signaling

Chaperone-mediated autophagy: a unique way to enter the lysosome world

(2012) Susmita Kaushik et al.   TRENDS IN CELL BIOLOGY

PINK1-mediated phosphorylation of the Parkin ubiquitin-like domain primes mitochondrial translocation of Parkin and regulates mitophagy

(2012) Kahori Shiba-Fukushima et al.   Scientific Reports

Recent Advances in the Genetics of Parkinson's Disease

(2011) Ian Martin et al.   Annual Review of Genomics and Human Genetics

Microautophagy in mammalian cells: Revisiting a 40-year-old conundrum

(2011) Dalibor Mijaljica et al.   Autophagy

Overexpression of the autophagic beclin-1 protein clears mutant ataxin-3 and alleviates Machado–Joseph disease

(2011) Isabel Nascimento-Ferreira et al.   BRAIN

ESCRT functions in autophagy and associated disease

(2011) Tor Erik Rusten et al.   CELL CYCLE

p53 inhibits autophagy by interacting with the human ortholog of yeast Atg17, RB1CC1/FIP200

(2011) Eugenia Morselli et al.   CELL CYCLE

Redox modulation by S-nitrosylation contributes to protein misfolding, mitochondrial dynamics and neuronal synaptic damage in neurodegenerative diseases

(2011) T Nakamura et al.   CELL DEATH AND DIFFERENTIATION

Rap-linked cAMP signaling Epac proteins: Compartmentation, functioning and disease implications

(2011) Magali Breckler et al.   CELLULAR SIGNALLING

A small-molecule enhancer of autophagy decreases levels of Aβ and APP-CTF via Atg5-dependent autophagy pathway

(2011) Yuan Tian et al.   FASEB JOURNAL

α-Synuclein levels modulate Huntington's disease in mice

(2011) Silvia Corrochano et al.   HUMAN MOLECULAR GENETICS

Lafora bodies and neurological defects in malin-deficient mice correlate with impaired autophagy

(2011) Olga Criado et al.   HUMAN MOLECULAR GENETICS

Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP

(2011) Patricia Gómez-Suaga et al.   HUMAN MOLECULAR GENETICS

Autophagic substrate clearance requires activity of the syntaxin-5 SNARE complex

(2011) M. Renna et al.   JOURNAL OF CELL SCIENCE

Presenilin Is Necessary for Efficient Proteolysis through the Autophagy-Lysosome System in a  -Secretase-Independent Manner

(2011) K. M. Neely et al.   JOURNAL OF NEUROSCIENCE

Serine 403 Phosphorylation of p62/SQSTM1 Regulates Selective Autophagic Clearance of Ubiquitinated Proteins

(2011) Gen Matsumoto et al.   MOLECULAR CELL

Complex Inhibitory Effects of Nitric Oxide on Autophagy

(2011) Sovan Sarkar et al.   MOLECULAR CELL

Distinct Autophagosomal-Lysosomal Fusion Mechanism Revealed by Thapsigargin-Induced Autophagy Arrest

(2011) Ian G. Ganley et al.   MOLECULAR CELL

Lysosomal positioning coordinates cellular nutrient responses

(2011) Viktor I. Korolchuk et al.   NATURE CELL BIOLOGY

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Autophagy as a target for anticancer therapy

(2011) Filip Janku et al.   Nature Reviews Clinical Oncology

Rapamycin passes the torch: a new generation of mTOR inhibitors

(2011) Don Benjamin et al.   NATURE REVIEWS DRUG DISCOVERY

Autophagic degradation of tau in primary neurons and its enhancement by trehalose

(2011) Ulrike Krüger et al.   NEUROBIOLOGY OF AGING

BH3 mimetics activate multiple pro-autophagic pathways

(2011) S A Malik et al.   ONCOGENE

Dopaminergic Neuronal Loss, Reduced Neurite Complexity and Autophagic Abnormalities in Transgenic Mice Expressing G2019S Mutant LRRK2

(2011) David Ramonet et al.   PLoS One

Inducing Autophagy by Rapamycin Before, but Not After, the Formation of Plaques and Tangles Ameliorates Cognitive Deficits

(2011) Smita Majumder et al.   PLoS One

Autophagy and polyglutamine diseases

(2011) Maria Jimenez-Sanchez et al.   PROGRESS IN NEUROBIOLOGY

mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase

(2011) R. Zoncu et al.   SCIENCE

TFEB Links Autophagy to Lysosomal Biogenesis

(2011) C. Settembre et al.   SCIENCE

Epac: Defining a New Mechanism for cAMP Action

(2010) Martijn Gloerich et al.   Annual Review of Pharmacology and Toxicology

Calcium Dysregulation and Homeostasis of Neural Calcium in the Molecular Mechanisms of Neurodegenerative Diseases Provide Multiple Targets for Neuroprotection

(2010) Gregor Zündorf et al.   ANTIOXIDANTS & REDOX SIGNALING

A comprehensive glossary of autophagy-related molecules and processes

(2010) Daniel J. Klionsky et al.   Autophagy

Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits

(2010) Dun-Sheng Yang et al.   BRAIN

Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations

(2010) Ju-Hyun Lee et al.   CELL

Mitochondria Supply Membranes for Autophagosome Biogenesis during Starvation

(2010) Dale W. Hailey et al.   CELL

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

(2010) Yasemin Sancak et al.   CELL

Neurodegeneration by polyglutamine Atrophin is not rescued by induction of autophagy

(2010) I Nisoli et al.   CELL DEATH AND DIFFERENTIATION

The role of the Atg1/ULK1 complex in autophagy regulation

(2010) Noboru Mizushima   CURRENT OPINION IN CELL BIOLOGY

The Beclin 1 interactome

(2010) Congcong He et al.   CURRENT OPINION IN CELL BIOLOGY

Protein misfolding disorders and macroautophagy

(2010) Fiona M Menzies et al.   CURRENT OPINION IN CELL BIOLOGY

A Genome-Wide siRNA Screen Reveals Multiple mTORC1 Independent Signaling Pathways Regulating Autophagy under Normal Nutritional Conditions

(2010) Marta M. Lipinski et al.   DEVELOPMENTAL CELL

Rilmenidine attenuates toxicity of polyglutamine expansions in a mouse model of Huntington's disease

(2010) C. Rose et al.   HUMAN MOLECULAR GENETICS

Laforin, the most common protein mutated in Lafora disease, regulates autophagy

(2010) Carmen Aguado et al.   HUMAN MOLECULAR GENETICS

The Machado–Joseph disease-associated mutant form of ataxin-3 regulates parkin ubiquitination and stability

(2010) Thomas M. Durcan et al.   HUMAN MOLECULAR GENETICS

Antioxidants can inhibit basal autophagy and enhance neurodegeneration in models of polyglutamine disease

(2010) B. R. Underwood et al.   HUMAN MOLECULAR GENETICS

DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy

(2010) Kelly Jean Thomas et al.   HUMAN MOLECULAR GENETICS

Chemical Inducers of Autophagy That Enhance the Clearance of Mutant Proteins in Neurodegenerative Diseases

(2010) Maurizio Renna et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

α-Synuclein impairs macroautophagy: implications for Parkinson’s disease

(2010) Ashley R. Winslow et al.   JOURNAL OF CELL BIOLOGY

PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy

(2010) Noriyuki Matsuda et al.   JOURNAL OF CELL BIOLOGY

DJ-1, PINK1, and their effects on mitochondrial pathways

(2010) Mark R. Cookson   MOVEMENT DISORDERS

Network organization of the human autophagy system

(2010) Christian Behrends et al.   NATURE

Termination of autophagy and reformation of lysosomes regulated by mTOR

(2010) Li Yu et al.   NATURE

Plasma membrane contributes to the formation of pre-autophagosomal structures

(2010) Brinda Ravikumar et al.   NATURE CELL BIOLOGY

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

(2010) Sven Geisler et al.   NATURE CELL BIOLOGY

Chemical modulators of autophagy as biological probes and potential therapeutics

(2010) Angeleen Fleming et al.   Nature Chemical Biology

Effective and selective targeting of leukemia cells using a TORC1/2 kinase inhibitor

(2010) Matthew R Janes et al.   NATURE MEDICINE

Autophagy is defective in collagen VI muscular dystrophies and its reactivation rescues myofiber degeneration

(2010) Paolo Grumati et al.   NATURE MEDICINE

Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease

(2010) Marta Martinez-Vicente et al.   NATURE NEUROSCIENCE

Repeat expansion disease: progress and puzzles in disease pathogenesis

(2010) Albert R. La Spada et al.   NATURE REVIEWS GENETICS

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanisms of mitophagy

(2010) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Trehalose ameliorates dopaminergic and tau pathology in parkin deleted/tau overexpressing mice through autophagy activation

(2010) Jose A. Rodríguez-Navarro et al.   NEUROBIOLOGY OF DISEASE

17-AAG increases autophagic removal of mutant androgen receptor in spinal and bulbar muscular atrophy

(2010) Paola Rusmini et al.   NEUROBIOLOGY OF DISEASE

Lithium carbonate in amyotrophic lateral sclerosis: Lack of efficacy in a dose-finding trial

(2010) A. Chio et al.   NEUROLOGY

Regulation of Mammalian Autophagy in Physiology and Pathophysiology

(2010) Brinda Ravikumar et al.   PHYSIOLOGICAL REVIEWS

Mutations in CHMP2B in Lower Motor Neuron Predominant Amyotrophic Lateral Sclerosis (ALS)

(2010) Laura E. Cox et al.   PLoS One

Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease

(2010) Patricia Spilman et al.   PLoS One

Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease

(2010) M. M. Lipinski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of  -synuclein, and apoptotic cell death in aged mice

(2010) Y. Tong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Shaping Development of Autophagy Inhibitors with the Structure of the Lipid Kinase Vps34

(2010) S. Miller et al.   SCIENCE

An Autophagy-Enhancing Drug Promotes Degradation of Mutant  1-Antitrypsin Z and Reduces Hepatic Fibrosis

(2010) T. Hidvegi et al.   SCIENCE

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

(2010) D. F. Egan et al.   SCIENCE

Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy

(2010) E Morselli et al.   Cell Death & Disease

Deletion of the Huntingtin Polyglutamine Stretch Enhances Neuronal Autophagy and Longevity in Mice

(2010) Shuqiu Zheng et al.   PLoS Genetics

Treatment with lithium carbonate does not improve disease progression in two different strains of SOD1 mutant mice

(2009) Chiara Pizzasegola et al.   Amyotrophic Lateral Sclerosis

Autophagy induction by trehalose counter-acts cellular prion-infection

(2009) Yasmine Aguib et al.   Autophagy

Rapamycin inhibits mTORC1, but not completely

(2009) Carson C. Thoreen et al.   Autophagy

3D tomography reveals connections between the phagophore and endoplasmic reticulum

(2009) Päivi Ylä-Anttila et al.   Autophagy

TI-VAMP/VAMP7 and VAMP3/cellubrevin: two v-SNARE proteins involved in specific steps of the autophagy/multivesicular body pathways

(2009) Claudio Marcelo Fader et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Autophagy induction reduces mutant ataxin-3 levels and toxicity in a mouse model of spinocerebellar ataxia type 3

(2009) Fiona M. Menzies et al.   BRAIN

Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy

(2009) Paul Nicklin et al.   CELL

The inositol 1,4,5-trisphosphate receptor regulates autophagy through its interaction with Beclin 1

(2009) J M Vicencio et al.   CELL DEATH AND DIFFERENTIATION

Autophagy Is Required to Maintain Muscle Mass

(2009) Eva Masiero et al.   Cell Metabolism

Technical Challenges in Using Human Induced Pluripotent Stem Cells to Model Disease

(2009) Krishanu Saha et al.   Cell Stem Cell

mTOR and the control of whole body metabolism

(2009) Pazit Polak et al.   CURRENT OPINION IN CELL BIOLOGY

The IKK complex contributes to the induction of autophagy

(2009) Alfredo Criollo et al.   EMBO JOURNAL

Cytoplasmic retention of polyglutamine-expanded androgen receptor ameliorates disease via autophagy in a mouse model of spinal and bulbar muscular atrophy

(2009) Heather L. Montie et al.   HUMAN MOLECULAR GENETICS

LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model

(2009) Javier Alegre-Abarrategui et al.   HUMAN MOLECULAR GENETICS

Lafora progressive myoclonus epilepsy: A meta-analysis of reported mutations in the first decade following the discovery of theEPM2AandNHLRC1genes

(2009) Shweta Singh et al.   HUMAN MUTATION

ULK1·ATG13·FIP200 Complex Mediates mTOR Signaling and Is Essential for Autophagy

(2009) Ian G. Ganley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1

(2009) Carson C. Thoreen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

How do ESCRT proteins control autophagy?

(2009) T. E. Rusten et al.   JOURNAL OF CELL SCIENCE

Sequestosome 1/p62 links familial ALS mutant SOD1 to LC3 via an ubiquitin-independent mechanism

(2009) Jozsef Gal et al.   JOURNAL OF NEUROCHEMISTRY

Lithium induces clearance of protease resistant prion protein in prion-infected cells by induction of autophagy

(2009) Andreas Heiseke et al.   JOURNAL OF NEUROCHEMISTRY

Beclin 1 Gene Transfer Activates Autophagy and Ameliorates the Neurodegenerative Pathology in  -Synuclein Models of Parkinson's and Lewy Body Diseases

(2009) B. Spencer et al.   JOURNAL OF NEUROSCIENCE

Parkinson's disease

(2009) Andrew J Lees et al.   LANCET

Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy

(2009) Nao Hosokawa et al.   MOLECULAR BIOLOGY OF THE CELL

ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery

(2009) Chang Hwa Jung et al.   MOLECULAR BIOLOGY OF THE CELL

Autophagy Inhibition Compromises Degradation of Ubiquitin-Proteasome Pathway Substrates

(2009) Viktor I. Korolchuk et al.   MOLECULAR CELL

A Role for NBR1 in Autophagosomal Degradation of Ubiquitinated Substrates

(2009) Vladimir Kirkin et al.   MOLECULAR CELL

Hereditary parkinsonism: Parkinson disease look-alikes-An algorithm for clinicians to “PARK” genes and beyond

(2009) Christine Klein et al.   MOVEMENT DISORDERS

Autophagy regulates lipid metabolism

(2009) Rajat Singh et al.   NATURE

Induction of autophagy by spermidine promotes longevity

(2009) Tobias Eisenberg et al.   NATURE CELL BIOLOGY

A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formation

(2009) Mitsuko Hayashi-Nishino et al.   NATURE CELL BIOLOGY

Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1–phosphatidylinositol-3-kinase complex

(2009) Yun Zhong et al.   NATURE CELL BIOLOGY

Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages

(2009) Kohichi Matsunaga et al.   NATURE CELL BIOLOGY

Leucine-Rich Repeat Kinase 2 Regulates the Progression of Neuropathology Induced by Parkinson's-Disease-Related Mutant α-synuclein

(2009) Xian Lin et al.   NEURON

No Benefit from Chronic Lithium Dosing in a Sibling-Matched, Gender Balanced, Investigator-Blinded Trial Using a Standard Mouse Model of Familial ALS

(2009) Alan Gill et al.   PLoS One

Screen for Chemical Modulators of Autophagy Reveals Novel Therapeutic Inhibitors of mTORC1 Signaling

(2009) Aruna D. Balgi et al.   PLoS One

PINK1-dependent recruitment of Parkin to mitochondria in mitophagy

(2009) C. Vives-Bauza et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Active-Site Inhibitors of mTOR Target Rapamycin-Resistant Outputs of mTORC1 and mTORC2

(2009) Morris E Feldman et al.   PLOS BIOLOGY

Genomic investigation of α-synuclein multiplication and parkinsonism

(2008) Owen A. Ross et al.   ANNALS OF NEUROLOGY

Huntington's disease: from pathology and genetics to potential therapies

(2008) Sara Imarisio et al.   BIOCHEMICAL JOURNAL

Hypoxia signals autophagy in tumor cells via AMPK activity, independent of HIF-1, BNIP3 and BNIP3L

(2008) I Papandreou et al.   CELL DEATH AND DIFFERENTIATION

Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies

(2008) S Sarkar et al.   CELL DEATH AND DIFFERENTIATION

Dynein-dependent Movement of Autophagosomes Mediates Efficient Encounters with Lysosomes

(2008) Shunsuke Kimura et al.   CELL STRUCTURE AND FUNCTION

Huntington’s disease: degradation of mutant huntingtin by autophagy

(2008) Sovan Sarkar et al.   FEBS Journal

Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum

(2008) Elizabeth L. Axe et al.   JOURNAL OF CELL BIOLOGY

Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents

(2008) Michael Degtyarev et al.   JOURNAL OF CELL BIOLOGY

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

(2008) Derek Narendra et al.   JOURNAL OF CELL BIOLOGY

FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells

(2008) Taichi Hara et al.   JOURNAL OF CELL BIOLOGY

Rab5 modulates aggregation and toxicity of mutant huntingtin through macroautophagy in cell and fly models of Huntington disease

(2008) B. Ravikumar et al.   JOURNAL OF CELL SCIENCE

Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells

(2008) Edward D. Plowey et al.   JOURNAL OF NEUROCHEMISTRY

Motor Neuron Disease Occurring in a Mutant Dynactin Mouse Model Is Characterized by Defects in Vesicular Trafficking

(2008) F. M. Laird et al.   JOURNAL OF NEUROSCIENCE

Autophagy Induction and Autophagosome Clearance in Neurons: Relationship to Autophagic Pathology in Alzheimer's Disease

(2008) B. Boland et al.   JOURNAL OF NEUROSCIENCE

Kinase-Inactivated ULK Proteins Inhibit Autophagy via Their Conserved C-Terminal Domains Using an Atg13-Independent Mechanism

(2008) E. Y. W. Chan et al.   MOLECULAR AND CELLULAR BIOLOGY

Beclin 1 Forms Two Distinct Phosphatidylinositol 3-Kinase Complexes with Mammalian Atg14 and UVRAG

(2008) Eisuke Itakura et al.   MOLECULAR BIOLOGY OF THE CELL

Small molecule enhancers of autophagy for neurodegenerative diseases

(2008) Sovan Sarkar et al.   Molecular BioSystems

JNK1-Mediated Phosphorylation of Bcl-2 Regulates Starvation-Induced Autophagy

(2008) Yongjie Wei et al.   MOLECULAR CELL

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

(2008) Dana M. Gwinn et al.   MOLECULAR CELL

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE

Regulation of TORC1 by Rag GTPases in nutrient response

(2008) Eunjung Kim et al.   NATURE CELL BIOLOGY

Regulation of autophagy by cytoplasmic p53

(2008) Ezgi Tasdemir et al.   NATURE CELL BIOLOGY

Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking

(2008) Chengyu Liang et al.   NATURE CELL BIOLOGY

Novel targets for Huntington's disease in an mTOR-independent autophagy pathway

(2008) Andrea Williams et al.   Nature Chemical Biology

Lithium delays progression of amyotrophic lateral sclerosis

(2008) F. Fornai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase

(2008) Q. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The PINK1/Parkin pathway regulates mitochondrial morphology

(2008) A. C. Poole et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

(2008) Y. Sancak et al.   SCIENCE

The Itinerary of Autophagosomes: From Peripheral Formation to Kiss-and-Run Fusion with Lysosomes

(2008) Luca Jahreiss et al.   TRAFFIC

Regulation of macroautophagy by mTOR and Beclin 1 complexes

(2007) Sophie Pattingre et al.   BIOCHIMIE