mTORC1-independent TFEB activation via Akt inhibition promotes cellular clearance in neurodegenerative storage diseases
Published 2017 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
mTORC1-independent TFEB activation via Akt inhibition promotes cellular clearance in neurodegenerative storage diseases
Authors
Keywords
-
Journal
Nature Communications
Volume 8, Issue -, Pages 14338
Publisher
Springer Nature
Online
2017-02-06
DOI
10.1038/ncomms14338
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Transcription factor EB: from master coordinator of lysosomal pathways to candidate therapeutic target in degenerative storage diseases
- (2016) Marco Sardiello Annals of the New York Academy of Sciences
- Neurodegenerative diseases
- (2016) Marie-Thérèse Heemels NATURE
- Protein kinase C controls lysosome biogenesis independently of mTORC1
- (2016) Yang Li et al. NATURE CELL BIOLOGY
- Bridging the age spectrum of neurodegenerative storage diseases
- (2015) Barry Boland et al. BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
- Cell biology of the NCL proteins: What they do and don't do
- (2015) Jaime Cárcel-Trullols et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Glycogen Synthase Kinase-3 (GSK3) Inhibition Induces Prosurvival Autophagic Signals in Human Pancreatic Cancer Cells
- (2015) Benoît Marchand et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Autophagy and neurodegeneration
- (2015) Rebecca A. Frake et al. JOURNAL OF CLINICAL INVESTIGATION
- Neuronal-Targeted TFEB Accelerates Lysosomal Degradation of APP, Reducing A Generation and Amyloid Plaque Pathogenesis
- (2015) Q. Xiao et al. JOURNAL OF NEUROSCIENCE
- Lysosomal mTORC2/PHLPP1/Akt Regulate Chaperone-Mediated Autophagy
- (2015) Esperanza Arias et al. MOLECULAR CELL
- MTOR-independent, autophagic enhancer trehalose prolongs motor neuron survival and ameliorates the autophagic flux defect in a mouse model of amyotrophic lateral sclerosis
- (2014) Xiaojie Zhang et al. Autophagy
- Spatial Control of the TSC Complex Integrates Insulin and Nutrient Regulation of mTORC1 at the Lysosome
- (2014) Suchithra Menon et al. CELL
- Selective clearance of aberrant tau proteins and rescue of neurotoxicity by transcription factor EB
- (2014) V. A. Polito et al. EMBO Molecular Medicine
- Enhancing Astrocytic Lysosome Biogenesis Facilitates A Clearance and Attenuates Amyloid Plaque Pathogenesis
- (2014) Q. Xiao et al. JOURNAL OF NEUROSCIENCE
- Temsirolimus promotes autophagic clearance of amyloid-β and provides protective effects in cellular and animal models of Alzheimer's disease
- (2014) Teng Jiang et al. PHARMACOLOGICAL RESEARCH
- Effects of an oral allosteric AKT inhibitor (MK-2206) on human nasopharyngeal cancer in vitro and in vivo
- (2014) Yuanyuan Zhao et al. Drug Design Development and Therapy
- mTOR regulates tau phosphorylation and degradation: implications for Alzheimer's disease and other tauopathies
- (2013) Antonella Caccamo et al. AGING CELL
- Trehalose delays the progression of amyotrophic lateral sclerosis by enhancing autophagy in motoneurons
- (2013) Karen Castillo et al. Autophagy
- TFEB regulates lysosomal proteostasis
- (2013) Wensi Song et al. HUMAN MOLECULAR GENETICS
- Rapalogs and mTOR inhibitors as anti-aging therapeutics
- (2013) Dudley W. Lamming et al. JOURNAL OF CLINICAL INVESTIGATION
- Conditional Deletion of Atoh1 Reveals Distinct Critical Periods for Survival and Function of Hair Cells in the Organ of Corti
- (2013) T. Cai et al. JOURNAL OF NEUROSCIENCE
- Signal integration by mTORC1 coordinates nutrient input with biosynthetic output
- (2013) Christian C. Dibble et al. NATURE CELL BIOLOGY
- The role of autophagy in neurodegenerative disease
- (2013) Ralph A Nixon NATURE MEDICINE
- Neuroprotection and lifespan extension in Ppt1 −/− mice by NtBuHA: therapeutic implications for INCL
- (2013) Chinmoy Sarkar et al. NATURE NEUROSCIENCE
- TFEB-mediated autophagy rescues midbrain dopamine neurons from -synuclein toxicity
- (2013) M. Decressac et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB
- (2012) Jose A. Martina et al. Autophagy
- Stimulation of autophagy reduces neurodegeneration in a mouse model of human tauopathy
- (2012) Véronique Schaeffer et al. BRAIN
- The juvenile Batten disease protein, CLN3, and its role in regulating anterograde and retrograde post-Golgi trafficking
- (2012) Susan L Cotman et al. Clinical Lipidology
- A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB
- (2012) Carmine Settembre et al. EMBO JOURNAL
- Targeting the PI3K signaling pathway in cancer therapy
- (2012) Chandra Bartholomeusz et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- Rapamycin Delays Disease Onset and Prevents PrP Plaque Deposition in a Mouse Model of Gerstmann-Straussler-Scheinker Disease
- (2012) C. J. Cortes et al. JOURNAL OF NEUROSCIENCE
- Glycogen Synthase Kinase 3 Inhibition Promotes Lysosomal Biogenesis and Autophagic Degradation of the Amyloid- Precursor Protein
- (2012) C. Parr et al. MOLECULAR AND CELLULAR BIOLOGY
- Autophagy modulation as a potential therapeutic target for diverse diseases
- (2012) David C. Rubinsztein et al. NATURE REVIEWS DRUG DISCOVERY
- Autophagy activators rescue and alleviate pathogenesis of a mouse model with proteinopathies of the TAR DNA-binding protein 43
- (2012) I.-F. Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Akt-Mediated Regulation of Autophagy and Tumorigenesis Through Beclin 1 Phosphorylation
- (2012) R. C. Wang et al. SCIENCE
- The Transcription Factor TFEB Links mTORC1 Signaling to Transcriptional Control of Lysosome Homeostasis
- (2012) A. Roczniak-Ferguson et al. Science Signaling
- PGC-1 Rescues Huntington's Disease Proteotoxicity by Preventing Oxidative Stress and Promoting TFEB Function
- (2012) T. Tsunemi et al. Science Translational Medicine
- Transcriptional Activation of Lysosomal Exocytosis Promotes Cellular Clearance
- (2011) Diego L. Medina et al. DEVELOPMENTAL CELL
- Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways
- (2011) Michela Palmieri et al. HUMAN MOLECULAR GENETICS
- First-in-Man Clinical Trial of the Oral Pan-AKT Inhibitor MK-2206 in Patients With Advanced Solid Tumors
- (2011) Timothy A. Yap et al. JOURNAL OF CLINICAL ONCOLOGY
- TFEB Links Autophagy to Lysosomal Biogenesis
- (2011) C. Settembre et al. SCIENCE
- α-Synuclein impairs macroautophagy: implications for Parkinson’s disease
- (2010) Ashley R. Winslow et al. JOURNAL OF CELL BIOLOGY
- mTOR: from growth signal integration to cancer, diabetes and ageing
- (2010) Roberto Zoncu et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Trehalose ameliorates dopaminergic and tau pathology in parkin deleted/tau overexpressing mice through autophagy activation
- (2010) Jose A. Rodríguez-Navarro et al. NEUROBIOLOGY OF DISEASE
- Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease
- (2010) Patricia Spilman et al. PLoS One
- Neuronal ceroid lipofuscinoses
- (2008) Anu Jalanko et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- JNCL patients show marked brain volume alterations on longitudinal MRI in adolescence
- (2008) T. H. Autti et al. JOURNAL OF NEUROLOGY
- The function of CLN3P, the Batten disease protein
- (2008) Dinesh Rakheja et al. MOLECULAR GENETICS AND METABOLISM
- Autophagy fights disease through cellular self-digestion
- (2008) Noboru Mizushima et al. NATURE
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started