Melatonin Antioxidative Defense: Therapeutical Implications for Aging and Neurodegenerative Processes
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Title
Melatonin Antioxidative Defense: Therapeutical Implications for Aging and Neurodegenerative Processes
Authors
Keywords
Melatonin, Mitochondria, Free radicals, Oxidative stress, Aging, Parkinson’s disease, Alzheimer’s disease, Huntington’s disease, Amyotrophic lateral sclerosis, Stroke
Journal
NEUROTOXICITY RESEARCH
Volume 23, Issue 3, Pages 267-300
Publisher
Springer Nature
Online
2012-06-28
DOI
10.1007/s12640-012-9337-4
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Note: Only part of the references are listed.- Constant Illumination Induces Alzheimer-Like Damages with Endoplasmic Reticulum Involvement and the Protection of Melatonin
- (2017) Zhi-Qun Ling et al. JOURNAL OF ALZHEIMERS DISEASE
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- (2012) Dario Acuna Castroviejo et al. CURRENT TOPICS IN MEDICINAL CHEMISTRY
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- (2012) Matthis Synofzik et al. HUMAN MOLECULAR GENETICS
- Riluzole
- (2012) Alessandra Cifra et al. NEUROSCIENTIST
- Age-related changes in neuroendocrine rhythmic function in the rhesus macaque
- (2011) Henryk F. Urbanski et al. AGE
- Pathogenic protein seeding in alzheimer disease and other neurodegenerative disorders
- (2011) Mathias Jucker et al. ANNALS OF NEUROLOGY
- Bright Light Treatment in Elderly Patients With Nonseasonal Major Depressive Disorder
- (2011) Ritsaert Lieverse et al. ARCHIVES OF GENERAL PSYCHIATRY
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- (2011) Colm Cunningham BIOCHEMICAL SOCIETY TRANSACTIONS
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- (2011) Cecile Pagan et al. BMC Medical Genetics
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- (2011) M. D. Mediavilla et al. CURRENT MEDICINAL CHEMISTRY
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- (2011) Hugues Dardente JOURNAL OF NEUROENDOCRINOLOGY
- Inflammation in the early stages of neurodegenerative pathology
- (2011) Preeti J. Khandelwal et al. JOURNAL OF NEUROIMMUNOLOGY
- Hypoxia-Induced Cellular and Vascular Changes in the Nucleus Tractus Solitarius and Ventrolateral Medulla
- (2011) Charanjit Kaur et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
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- (2011) Natasa Dragicevic et al. JOURNAL OF PINEAL RESEARCH
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- (2011) Ming Che Tsai et al. JOURNAL OF PINEAL RESEARCH
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- (2011) Daniel P. Cardinali et al. JOURNAL OF PINEAL RESEARCH
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- (2010) C. Kaur et al. JOURNAL OF PINEAL RESEARCH
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- (2010) Arabinda Das et al. JOURNAL OF PINEAL RESEARCH
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- Review: Molecular pathogenesis of blood-brain barrier breakdown in acute brain injury
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- (2010) Yanning Cai et al. NEUROREPORT
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- (2010) Edward D. Hall et al. Neurotherapeutics
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- (2010) R. G. Stevens et al. OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
- International Union of Basic and Clinical Pharmacology. LXXV. Nomenclature, Classification, and Pharmacology of G Protein-Coupled Melatonin Receptors
- (2010) M. L. Dubocovich et al. PHARMACOLOGICAL REVIEWS
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- Melatonin: Signaling mechanisms of a pleiotropic agent
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- The Antiapoptotic Activity of Melatonin in Neurodegenerative Diseases
- (2009) Xin Wang CNS Neuroscience & Therapeutics
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- (2009) Alexander M. Mathes et al. CRITICAL CARE MEDICINE
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- (2009) P. A. Atanassova et al. JOURNAL OF NEUROENDOCRINOLOGY
- Delayed onset of the diurnal melatonin rise in patients with Huntington’s disease
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- (2009) Victor Tapias et al. JOURNAL OF NEUROSCIENCE RESEARCH
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