Different Human Copper-Zinc Superoxide Dismutase Mutants, SOD1G93A and SOD1H46R, Exert Distinct Harmful Effects on Gross Phenotype in Mice
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Title
Different Human Copper-Zinc Superoxide Dismutase Mutants, SOD1G93A and SOD1H46R, Exert Distinct Harmful Effects on Gross Phenotype in Mice
Authors
Keywords
Mouse models, Superoxide dismutase, Genetically modified animals, Genetics of disease, Amyotrophic lateral sclerosis, Phenotypes, Genetic engineering, Body weight
Journal
PLoS One
Volume 7, Issue 3, Pages e33409
Publisher
Public Library of Science (PLoS)
Online
2012-03-17
DOI
10.1371/journal.pone.0033409
References
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Note: Only part of the references are listed.- Effect of genetic background on phenotype variability in transgenic mouse models of amyotrophic lateral sclerosis: A window of opportunity in the search for genetic modifiers
- (2011) Terry D. Heiman-Patterson et al. Amyotrophic Lateral Sclerosis
- A comprehensive assessment of the SOD1G93A low-copy transgenic mouse, which models human amyotrophic lateral sclerosis
- (2011) A. Acevedo-Arozena et al. Disease Models & Mechanisms
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- (2011) Yasuhiro Yoshii et al. NEUROSCIENCE RESEARCH
- Guidelines for preclinical animal research in ALS/MND: A consensus meeting
- (2010) Albert C. Ludolph et al. Amyotrophic Lateral Sclerosis
- Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS
- (2010) Daryl A Bosco et al. NATURE NEUROSCIENCE
- Genetic background and gender effects on gross phenotypes in congenic lines of ALS2/alsin-deficient mice
- (2010) Shinji Hadano et al. NEUROSCIENCE RESEARCH
- Loss of ALS2/Alsin Exacerbates Motor Dysfunction in a SOD1H46R-Expressing Mouse ALS Model by Disturbing Endolysosomal Trafficking
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- (2008) Nathan C. Stam et al. EUROPEAN JOURNAL OF NEUROSCIENCE
- Interaction of Amyotrophic Lateral Sclerosis (ALS)-related Mutant Copper-Zinc Superoxide Dismutase with the Dynein-Dynactin Complex Contributes to Inclusion Formation
- (2008) Anna-Lena Ström et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis
- (2008) Koji Yamanaka et al. NATURE NEUROSCIENCE
- Physical Activity and Neuroprotection in Amyotrophic Lateral Sclerosis
- (2008) Mary E. McCrate et al. NEUROMOLECULAR MEDICINE
- Transgenics, toxicity and therapeutics in rodent models of mutant SOD1-mediated familial ALS
- (2008) B TURNER et al. PROGRESS IN NEUROBIOLOGY
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