An acetylation switch controls TDP-43 function and aggregation propensity
Published 2015 View Full Article
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Title
An acetylation switch controls TDP-43 function and aggregation propensity
Authors
Keywords
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Journal
Nature Communications
Volume 6, Issue 1, Pages -
Publisher
Springer Nature
Online
2015-01-05
DOI
10.1038/ncomms6845
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Note: Only part of the references are listed.- ALS-Linked Mutations Enlarge TDP-43-Enriched Neuronal RNA Granules in the Dendritic Arbor
- (2014) L. Liu-Yesucevitz et al. JOURNAL OF NEUROSCIENCE
- The crystal structure of TDP-43 RRM1-DNA complex reveals the specific recognition for UG- and TG-rich nucleic acids
- (2014) P.-H. Kuo et al. NUCLEIC ACIDS RESEARCH
- Acetylated Tau Neuropathology in Sporadic and Hereditary Tauopathies
- (2013) David J. Irwin et al. AMERICAN JOURNAL OF PATHOLOGY
- CDC7 inhibition blocks pathological TDP-43 phosphorylation and neurodegeneration
- (2013) Nicole F. Liachko et al. ANNALS OF NEUROLOGY
- Stages of pTDP-43 pathology in amyotrophic lateral sclerosis
- (2013) Johannes Brettschneider et al. ANNALS OF NEUROLOGY
- TDP-43 Phosphorylation by casein kinase Iε promotes oligomerization and enhances toxicity in vivo
- (2013) Darshana K. Choksi et al. HUMAN MOLECULAR GENETICS
- Acetylation of the KXGS motifs in tau is a critical determinant in modulation of tau aggregation and clearance
- (2013) Casey Cook et al. HUMAN MOLECULAR GENETICS
- Pathological mechanisms underlying TDP-43 driven neurodegeneration in FTLD-ALS spectrum disorders
- (2013) J. Janssens et al. HUMAN MOLECULAR GENETICS
- Molecular basis of UG-rich RNA recognition by the human splicing factor TDP-43
- (2013) Peter J Lukavsky et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Characterizing TDP-43 interaction with its RNA targets
- (2013) Amit Bhardwaj et al. NUCLEIC ACIDS RESEARCH
- Inhibition of TDP-43 Aggregation by Nucleic Acid Binding
- (2013) Yi-Chen Huang et al. PLoS One
- Brain expression level and activity of HDAC6 protein in neurodegenerative dementia
- (2012) Saori Odagiri et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Acetylated tau, a novel pathological signature in Alzheimer's disease and other tauopathies
- (2012) David J. Irwin et al. BRAIN
- Reducing HDAC6 ameliorates cognitive deficits in a mouse model for Alzheimer's disease
- (2012) Nambirajan Govindarajan et al. EMBO Molecular Medicine
- Loss of HDAC6, a novel CHIP substrate, alleviates abnormal tau accumulation
- (2012) Casey Cook et al. HUMAN MOLECULAR GENETICS
- RNA-binding ability of FUS regulates neurodegeneration, cytoplasmic mislocalization and incorporation into stress granules associated with FUS carrying ALS-linked mutations
- (2012) J. G. Daigle et al. HUMAN MOLECULAR GENETICS
- Parkin Ubiquitinates Tar-DNA Binding Protein-43 (TDP-43) and Promotes Its Cytosolic Accumulation via Interaction with Histone Deacetylase 6 (HDAC6)
- (2012) Michaeline L. Hebron et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Redox signalling directly regulates TDP-43 via cysteine oxidation and disulphide cross-linking
- (2011) Todd J Cohen et al. EMBO JOURNAL
- Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice
- (2011) Lionel M. Igaz et al. JOURNAL OF CLINICAL INVESTIGATION
- HDAC6 α-tubulin deacetylase: A potential therapeutic target in neurodegenerative diseases
- (2011) Guoyi Li et al. JOURNAL OF THE NEUROLOGICAL SCIENCES
- Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43
- (2011) Magdalini Polymenidou et al. NATURE NEUROSCIENCE
- Characterizing the RNA targets and position-dependent splicing regulation by TDP-43
- (2011) James R Tollervey et al. NATURE NEUROSCIENCE
- Accumulation of histone deacetylase 6, an aggresome-related protein, is specific to Lewy bodies and glial cytoplasmic inclusions
- (2011) Yasuo Miki et al. NEUROPATHOLOGY
- Hyperphosphorylation as a Defense Mechanism to Reduce TDP-43 Aggregation
- (2011) Huei-Ying Li et al. PLoS One
- TDP-43 functions and pathogenic mechanisms implicated in TDP-43 proteinopathies
- (2011) Todd J. Cohen et al. TRENDS IN MOLECULAR MEDICINE
- The acetylation of tau inhibits its function and promotes pathological tau aggregation
- (2011) Todd J. Cohen et al. Nature Communications
- TDP-43 and FUS/TLS: emerging roles in RNA processing and neurodegeneration
- (2010) C. Lagier-Tourenne et al. HUMAN MOLECULAR GENETICS
- Identification of Neuronal RNA Targets of TDP-43-containing Ribonucleoprotein Complexes
- (2010) Chantelle F. Sephton et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Disease-causing mutations in Parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy
- (2010) Joo-Yong Lee et al. JOURNAL OF CELL BIOLOGY
- Elevated expression of TDP-43 in the forebrain of mice is sufficient to cause neurological and pathological phenotypes mimicking FTLD-U
- (2010) Kuen-Jer Tsai et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Regulation of TDP-43 aggregation by phosphorylation andp62/SQSTM1
- (2010) Owen A. Brady et al. JOURNAL OF NEUROCHEMISTRY
- Cytoplasmic Mislocalization of TDP-43 Is Toxic to Neurons and Enhanced by a Mutation Associated with Familial Amyotrophic Lateral Sclerosis
- (2010) S. J. Barmada et al. JOURNAL OF NEUROSCIENCE
- Acetylation of Tau Inhibits Its Degradation and Contributes to Tauopathy
- (2010) Sang-Won Min et al. NEURON
- ALS-associated mutations in TDP-43 increase its stability and promote TDP-43 complexes with FUS/TLS
- (2010) S.-C. Ling et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- TDP-43 transgenic mice develop spastic paralysis and neuronal inclusions characteristic of ALS and frontotemporal lobar degeneration
- (2010) Hans Wils et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Phosphorylation of S409/410 of TDP-43 is a consistent feature in all sporadic and familial forms of TDP-43 proteinopathies
- (2009) Manuela Neumann et al. ACTA NEUROPATHOLOGICA
- Identification of casein kinase-1 phosphorylation sites on TDP-43
- (2009) Fuyuki Kametani et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Acetylation Targets Mutant Huntingtin to Autophagosomes for Degradation
- (2009) Hyunkyung Jeong et al. CELL
- Gain and loss of function of ALS-related mutations of TARDBP (TDP-43) cause motor deficits in vivo
- (2009) Edor Kabashi et al. HUMAN MOLECULAR GENETICS
- Mutations in TDP-43 link glycine-rich domain functions to amyotrophic lateral sclerosis
- (2009) G. S. Pesiridis et al. HUMAN MOLECULAR GENETICS
- Expression of TDP-43 C-terminal Fragmentsin VitroRecapitulates Pathological Features of TDP-43 Proteinopathies
- (2009) Lionel M. Igaz et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- TDP-43 Is Intrinsically Aggregation-prone, and Amyotrophic Lateral Sclerosis-linked Mutations Accelerate Aggregation and Increase Toxicity
- (2009) Brian S. Johnson et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- TDP-43 is recruited to stress granules in conditions of oxidative insult
- (2009) Claudia Colombrita et al. JOURNAL OF NEUROCHEMISTRY
- Global Analysis of TDP-43 Interacting Proteins Reveals Strong Association with RNA Splicing and Translation Machinery
- (2009) Brian D. Freibaum et al. JOURNAL OF PROTEOME RESEARCH
- Structural insights into TDP-43 in nucleic-acid binding and domain interactions
- (2009) P.-H. Kuo et al. NUCLEIC ACIDS RESEARCH
- TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration
- (2009) I. Wegorzewska et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions
- (2009) C. Choudhary et al. SCIENCE
- Phosphorylated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis
- (2008) Masato Hasegawa et al. ANNALS OF NEUROLOGY
- Disturbance of Nuclear and Cytoplasmic TAR DNA-binding Protein (TDP-43) Induces Disease-like Redistribution, Sequestration, and Aggregate Formation
- (2008) Matthew J. Winton et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Structural determinants of the cellular localization and shuttling of TDP-43
- (2008) Y. M. Ayala et al. JOURNAL OF CELL SCIENCE
- TDP-43, the signature protein of FTLD-U, is a neuronal activity-responsive factor
- (2008) I.-Fan Wang et al. JOURNAL OF NEUROCHEMISTRY
- TDP-43 regulates retinoblastoma protein phosphorylation through the repression of cyclin-dependent kinase 6 expression
- (2008) Y. M. Ayala et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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