Therapeutic Potential of Flavonoids in Pain and Inflammation: Mechanisms of Action, Pre-Clinical and Clinical Data, and Pharmaceutical Development
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Title
Therapeutic Potential of Flavonoids in Pain and Inflammation: Mechanisms of Action, Pre-Clinical and Clinical Data, and Pharmaceutical Development
Authors
Keywords
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Journal
MOLECULES
Volume 25, Issue 3, Pages 762
Publisher
MDPI AG
Online
2020-02-12
DOI
10.3390/molecules25030762
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Note: Only part of the references are listed.- Hesperidin methyl chalcone interacts with NFκB Ser276 and inhibits zymosan-induced joint pain and inflammation, and RAW 264.7 macrophage activation
- (2020) Fernanda S. Rasquel-Oliveira et al. INFLAMMOPHARMACOLOGY
- Targeting MAPK Pathways by Naringenin Modulates Microglia M1/M2 Polarization in Lipopolysaccharide-Stimulated Cultures
- (2019) Bei Zhang et al. Frontiers in Cellular Neuroscience
- Contribution of Nrf2 Modulation to the Mechanism of Action of Analgesic and Anti-inflammatory Drugs in Pre-clinical and Clinical Stages
- (2019) Larissa Staurengo-Ferrari et al. Frontiers in Pharmacology
- The citrus flavanone naringenin attenuates zymosan-induced mouse joint inflammation: induction of Nrf2 expression in recruited CD45+ hematopoietic cells
- (2019) Allan J. C. Bussmann et al. INFLAMMOPHARMACOLOGY
- Hesperidin as a Neuroprotective Agent: A Review of Animal and Clinical Evidence
- (2019) Marziyeh Hajialyani et al. MOLECULES
- Recent advances in topical delivery of flavonoids: A review
- (2019) Ruchika L. Nagula et al. JOURNAL OF CONTROLLED RELEASE
- Vitexin suppresses RANKL-induced osteoclastogenesis and prevents lipopolysaccharide (LPS)-induced osteolysis
- (2019) Jiawei Jiang et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Quercetin loaded nanoemulsion-based gel for rheumatoid arthritis: In vivo and in vitro studies
- (2019) Jayanti P. Gokhale et al. BIOMEDICINE & PHARMACOTHERAPY
- The specialised pro‐resolving lipid mediator maresin 1 reduces inflammatory pain with a long‐lasting analgesic effect
- (2019) Victor Fattori et al. BRITISH JOURNAL OF PHARMACOLOGY
- Safety and toxicity of silymarin, the major constituent of milk thistle extract: An updated review
- (2019) Vahid Soleimani et al. PHYTOTHERAPY RESEARCH
- Vitexin alleviates interleukin‐1β‐induced inflammatory responses in chondrocytes from osteoarthritis patients: Involvement of HIF‐1α pathway
- (2019) Hongpeng Yang et al. SCANDINAVIAN JOURNAL OF IMMUNOLOGY
- Galangin Suppresses Renal Inflammation via the Inhibition of NF-κB, PI3K/AKT and NLRP3 in Uric Acid Treated NRK-52E Tubular Epithelial Cells
- (2019) Hao Lu et al. Biomed Research International
- The granulopoietic cytokine granulocyte colony-stimulating factor (G-CSF) induces pain: analgesia by rutin
- (2019) Thacyana T. Carvalho et al. INFLAMMOPHARMACOLOGY
- Hesperidin inhibits synovial cell inflammation and macrophage polarization through suppression of the PI3K/AKT pathway in complete Freund's adjuvant-induced arthritis in mice
- (2019) Weizhong Qi et al. CHEMICO-BIOLOGICAL INTERACTIONS
- Quercetin conjugated with superparamagnetic iron oxide nanoparticles improves learning and memory better than free quercetin via interacting with proteins involved in LTP
- (2019) Elnaz Amanzadeh et al. Scientific Reports
- The Natural Flavonoid Naringenin Elicits Analgesia through Inhibition of NaV1.8 Voltage-Gated Sodium Channels
- (2019) Yuan Zhou et al. ACS Chemical Neuroscience
- Quercetin attenuates zymosan-induced arthritis in mice
- (2018) Carla F.S. Guazelli et al. BIOMEDICINE & PHARMACOTHERAPY
- Central and peripheral anti-hyperalgesic effects of diosmin in a neuropathic pain model in rats
- (2018) Azucena Ibeth Carballo-Villalobos et al. BIOMEDICINE & PHARMACOTHERAPY
- Protective effect of quercetin and rutin encapsulated liposomes on induced oxidative stress
- (2018) Claudia Bonechi et al. BIOPHYSICAL CHEMISTRY
- Protraction of neuropathic pain by morphine is mediated by spinal damage associated molecular patterns (DAMPs) in male rats
- (2018) Peter M. Grace et al. BRAIN BEHAVIOR AND IMMUNITY
- Formulation and evaluation of mixed polymeric micelles of quercetin for treatment of breast, ovarian, and multidrug resistant cancers
- (2018) Arjun Patra et al. International Journal of Nanomedicine
- Hesperidin Methylchalcone Suppresses Experimental Gout Arthritis in Mice by Inhibiting NF-κB Activation
- (2018) Kenji W. Ruiz-Miyazawa et al. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
- The flavonoid quercetin inhibits titanium dioxide (TiO 2 )-induced chronic arthritis in mice
- (2018) Sergio M. Borghi et al. JOURNAL OF NUTRITIONAL BIOCHEMISTRY
- Protective effects of apigenin on LPS-induced endometritis via activating Nrf2 signaling pathway
- (2018) Pei-Yue Jiang et al. MICROBIAL PATHOGENESIS
- Evaluation of the effect of topical chamomile (Matricaria chamomilla L.) oleogel as pain relief in migraine without aura: a randomized, double-blind, placebo-controlled, crossover study
- (2018) Arman Zargaran et al. NEUROLOGICAL SCIENCES
- Vitexin attenuates lipopolysaccharide-induced acute lung injury by controlling the Nrf2 pathway
- (2018) Ying Lu et al. PLoS One
- Flavonoids interfere with NLRP3 inflammasome activation
- (2018) Hyun Lim et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- The citrus flavanone naringenin reduces gout-induced joint pain and inflammation in mice by inhibiting the activation of NFκB and macrophage release of IL-1β
- (2018) Kenji W. Ruiz-Miyazawa et al. Journal of Functional Foods
- Spirodela polyrhiza and its Chemical Constituent Vitexin Exert Anti-Allergic Effect via ORAI1 Channel Inhibition
- (2018) Hyun Jong Kim et al. AMERICAN JOURNAL OF CHINESE MEDICINE
- Discovery of natural flavonoids as activators of Nrf2-mediated defense system: Structure-activity relationship and inhibition of intracellular oxidative insults
- (2018) Yan-Ru Li et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Effects of Tea Catechins on Alzheimer’s Disease: Recent Updates and Perspectives
- (2018) Kazuki Ide et al. MOLECULES
- Naringenin mitigates titanium dioxide (TiO2)-induced chronic arthritis in mice: role of oxidative stress, cytokines, and NFκB
- (2018) Marília F. Manchope et al. INFLAMMATION RESEARCH
- Trans-Chalcone Attenuates Pain and Inflammation in Experimental Acute Gout Arthritis in Mice
- (2018) Larissa Staurengo-Ferrari et al. Frontiers in Pharmacology
- Effects of supplementation with quercetin on plasma C-reactive protein concentrations: a systematic review and meta-analysis of randomized controlled trials
- (2017) M Mohammadi-Sartang et al. EUROPEAN JOURNAL OF CLINICAL NUTRITION
- Anti-inflammatory, antioxidant and anti-apoptotic activity of diosmin in acetic acid-induced ulcerative colitis
- (2017) AS Shalkami et al. HUMAN & EXPERIMENTAL TOXICOLOGY
- Akt Signaling Pathway in Macrophage Activation and M1/M2 Polarization
- (2017) Eleni Vergadi et al. JOURNAL OF IMMUNOLOGY
- Trans-chalcone added in topical formulation inhibits skin inflammation and oxidative stress in a model of ultraviolet B radiation skin damage in hairless mice
- (2017) Renata M. Martinez et al. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
- The therapeutic effect of silymarin in the treatment of nonalcoholic fatty disease
- (2017) Sheng Zhong et al. MEDICINE
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- (2017) Weiqun Lin et al. MOLECULAR NUTRITION & FOOD RESEARCH
- Antidiarrhoeic effect and dereplication of the aqueous extract of Annona crassiflora (Annonaceae)
- (2017) Camila Rodrigues Ferraz et al. NATURAL PRODUCT RESEARCH
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- (2017) Leandro Marcondes-Alves et al. NATURAL PRODUCT RESEARCH
- Vinpocetine reduces diclofenac-induced acute kidney injury through inhibition of oxidative stress, apoptosis, cytokine production, and NF-κB activation in mice
- (2017) Victor Fattori et al. PHARMACOLOGICAL RESEARCH
- trans-Chalcone, a flavonoid precursor, inhibits UV-induced skin inflammation and oxidative stress in mice by targeting NADPH oxidase and cytokine production
- (2017) Renata M. Martinez et al. PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
- Nociceptor Sensory Neuron–Immune Interactions in Pain and Inflammation
- (2017) Felipe A. Pinho-Ribeiro et al. TRENDS IN IMMUNOLOGY
- Encapsulation of flavonoids in liposomal delivery systems: the case of quercetin, kaempferol and luteolin
- (2017) Meigui Huang et al. Food & Function
- Apigenin in cancer therapy: anti-cancer effects and mechanisms of action
- (2017) Xiaohui Yan et al. Cell and Bioscience
- Pro-inflammatory cytokines involvement in the hesperidin antihyperalgesic effects at peripheral and central levels in a neuropathic pain model
- (2017) A. I. Carballo-Villalobos et al. INFLAMMOPHARMACOLOGY
- Quercetin Inhibits Inflammasome Activation by Interfering with ASC Oligomerization and Prevents Interleukin-1 Mediated Mouse Vasculitis
- (2017) Talita P. Domiciano et al. Scientific Reports
- Characterization and Metabolic Diversity of Flavonoids in Citrus Species
- (2017) Shouchuang Wang et al. Scientific Reports
- Quercetin ameliorates paclitaxel-induced neuropathic pain by stabilizing mast cells and subsequently blocking PKCε-dependent activation of TRPV1
- (2016) Wei Gao et al. ACTA PHARMACOLOGICA SINICA
- A phase 1 clinical trial of flavopiridol consolidation in chronic lymphocytic leukemia patients following chemoimmunotherapy
- (2016) Farrukh T. Awan et al. ANNALS OF HEMATOLOGY
- Effects of luteolin and quercetin 3-β- d -glucoside identified from Passiflora subpeltata leaves against acetaminophen induced hepatotoxicity in rats
- (2016) Saravanan Shanmugam et al. BIOMEDICINE & PHARMACOTHERAPY
- Hepatoprotective effect of trans-Chalcone on experimentally induced hepatic injury in rats: inhibition of hepatic inflammation and fibrosis
- (2016) Harsimran Singh et al. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
- Rutin ameliorates diabetic neuropathy by lowering plasma glucose and decreasing oxidative stress via Nrf2 signaling pathway in rats
- (2016) Ruifeng Tian et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Spinal cord oligodendrocyte-derived alarmin IL-33 mediates neuropathic pain
- (2016) Ana C. Zarpelon et al. FASEB JOURNAL
- Apigenin inhibits UVA-induced cytotoxicity in vitro and prevents signs of skin aging in vivo
- (2016) Sungjin Choi et al. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- Tea flavonoids for bone health: from animals to humans
- (2016) Chwan-Li Shen et al. JOURNAL OF INVESTIGATIVE MEDICINE
- The citrus flavonone naringenin reduces lipopolysaccharide-induced inflammatory pain and leukocyte recruitment by inhibiting NF-κB activation
- (2016) Felipe A. Pinho-Ribeiro et al. JOURNAL OF NUTRITIONAL BIOCHEMISTRY
- The Effect of Quercetin on Inflammatory Factors and Clinical Symptoms in Women with Rheumatoid Arthritis: A Double-Blind, Randomized Controlled Trial
- (2016) Fatemeh Javadi et al. JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION
- Nanoencapsulation of dietary flavonoid fisetin: Formulation and in vitro antioxidant and α-glucosidase inhibition activities
- (2016) Mario Sechi et al. Materials Science & Engineering C-Materials for Biological Applications
- Neuroprotective effects of vitexin against isoflurane-induced neurotoxicity by targeting the TRPV1 and NR2B signaling pathways
- (2016) Linlin Chen et al. Molecular Medicine Reports
- Anti‐Inflammatory Effect of Quercetin on RAW 264.7 Mouse Macrophages Induced with Polyinosinic‐Polycytidylic Acid
- (2016) Young‐Jin Kim et al. MOLECULES
- Preventive Effects of Catechins on Cardiovascular Disease
- (2016) Xiao-Qiang Chen et al. MOLECULES
- Synergistic antioxidant action of vitamin E and rutin SNEDDS in ameliorating oxidative stress in a Parkinson’s disease model
- (2016) Shrestha Sharma et al. NANOTECHNOLOGY
- Naringenin reduces inflammatory pain in mice
- (2016) Felipe A. Pinho-Ribeiro et al. NEUROPHARMACOLOGY
- Neutrophils and arthritis: Role in disease and pharmacological perspectives
- (2016) Victor Fattori et al. PHARMACOLOGICAL RESEARCH
- Topical formulation containing hesperidin methyl chalcone inhibits skin oxidative stress and inflammation induced by ultraviolet B irradiation
- (2016) Renata M. Martinez et al. PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
- Vitexin reduces neutrophil migration to inflammatory focus by down-regulating pro-inflammatory mediators via inhibition of p38, ERK1/2 and JNK pathway
- (2016) Suellen Iara Guirra Rosa et al. PHYTOMEDICINE
- (-)-Epigallocatechin-3-Gallate Antihyperalgesic Effect Associates With Reduced CX3CL1 Chemokine Expression in Spinal Cord
- (2016) Marc Bosch-Mola et al. PHYTOTHERAPY RESEARCH
- Quercetin Inhibits Peripheral and Spinal Cord Nociceptive Mechanisms to Reduce Intense Acute Swimming-Induced Muscle Pain in Mice
- (2016) Sergio M. Borghi et al. PLoS One
- Morphine paradoxically prolongs neuropathic pain in rats by amplifying spinal NLRP3 inflammasome activation
- (2016) Peter M. Grace et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Morphine enhances IL-1β release through toll-like receptor 4-mediated endocytic pathway in microglia
- (2016) Yongxin Liang et al. Purinergic Signalling
- Quercetin, Inflammation and Immunity
- (2016) Yao Li et al. Nutrients
- Pyrrolidine dithiocarbamate inhibits superoxide anion-induced pain and inflammation in the paw skin and spinal cord by targeting NF-κB and oxidative stress
- (2016) Felipe A. Pinho-Ribeiro et al. INFLAMMOPHARMACOLOGY
- Activation of PPARγ by a Natural Flavonoid Modulator, Apigenin Ameliorates Obesity-Related Inflammation Via Regulation of Macrophage Polarization
- (2016) Xiujing Feng et al. EBioMedicine
- Topical Formulation Containing Naringenin: Efficacy against Ultraviolet B Irradiation-Induced Skin Inflammation and Oxidative Stress in Mice
- (2016) Renata M. Martinez et al. PLoS One
- Naringenin Inhibits Superoxide Anion-Induced Inflammatory Pain: Role of Oxidative Stress, Cytokines, Nrf-2 and the NO−cGMP−PKG−KATPChannel Signaling Pathway
- (2016) Marília F. Manchope et al. PLoS One
- The superoxide anion donor, potassium superoxide, induces pain and inflammation in mice through production of reactive oxygen species and cyclooxygenase-2
- (2015) N.A. Maioli et al. BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
- Protective effects of the flavonoid hesperidin methyl chalcone in inflammation and pain in mice: Role of TRPV1, oxidative stress, cytokines and NF-κB
- (2015) Felipe A. Pinho-Ribeiro et al. CHEMICO-BIOLOGICAL INTERACTIONS
- Nonsteroidal Anti-inflammatory Drugs and Risk of Incident Heart Failure: A Systematic Review and Meta-analysis of Observational Studies
- (2015) Patompong Ungprasert et al. CLINICAL CARDIOLOGY
- Epigallocatechin-3-gallate treatment reduces thermal hyperalgesia after spinal cord injury by down-regulating RhoA expression in mice
- (2015) B. Álvarez-Pérez et al. EUROPEAN JOURNAL OF PAIN
- Condensed catechins and their potential health-benefits
- (2015) Toshiro Matsui EUROPEAN JOURNAL OF PHARMACOLOGY
- Opioid-Induced Central Immune Signaling: Implications for Opioid Analgesia
- (2015) Peter M. Grace et al. HEADACHE
- Anti-Inflammatory Effect of Apigenin on LPS-Induced Pro-Inflammatory Mediators and AP-1 Factors in Human Lung Epithelial Cells
- (2015) Rajeshwari H. Patil et al. INFLAMMATION
- Epigallocatechin-3-gallate attenuates bone cancer pain involving decreasing spinal Tumor Necrosis Factor-α expression in a mouse model
- (2015) Qingsong Li et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Apigenin, a potent suppressor of dendritic cell maturation and migration, protects against collagen-induced arthritis
- (2015) Xing Li et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Naringenin Inhibits UVB Irradiation-Induced Inflammation and Oxidative Stress in the Skin of Hairless Mice
- (2015) Renata M. Martinez et al. JOURNAL OF NATURAL PRODUCTS
- Naringenin inhibits dendritic cell maturation and has therapeutic effects in a murine model of collagen-induced arthritis
- (2015) Yi-Rong Li et al. JOURNAL OF NUTRITIONAL BIOCHEMISTRY
- Hesperidin methyl chalcone inhibits oxidative stress and inflammation in a mouse model of ultraviolet B irradiation-induced skin damage
- (2015) Renata M. Martinez et al. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
- Effect of hesperidin on neurobehavioral, neuroinflammation, oxidative stress and lipid alteration in intracerebroventricular streptozotocin induced cognitive impairment in mice
- (2015) Hayate Javed et al. JOURNAL OF THE NEUROLOGICAL SCIENCES
- Clinical activity of alvocidib (flavopiridol) in acute myeloid leukemia
- (2015) Joshua F. Zeidner et al. LEUKEMIA RESEARCH
- Naringenin neutralises oxidative stress and nerve growth factor discrepancy in experimental diabetic neuropathy
- (2015) Salim S. Al-Rejaie et al. NEUROLOGICAL RESEARCH
- Superoxide anion-induced pain and inflammation depends on TNFα/TNFR1 signaling in mice
- (2015) Fabiane Y. Yamacita-Borin et al. NEUROSCIENCE LETTERS
- Involvement of nuclear factor kappa B in the maintenance of persistent inflammatory hypernociception
- (2015) Guilherme R. Souza et al. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
- Hypericum perforatumReduces Paracetamol-Induced Hepatotoxicity and Lethality in Mice by Modulating Inflammation and Oxidative Stress
- (2015) Miriam S. N. Hohmann et al. PHYTOTHERAPY RESEARCH
- Jararhagin-induced mechanical hyperalgesia depends on TNF-α, IL-1β and NFκB in mice
- (2015) Camila R. Ferraz et al. TOXICON
- Quercetin Reduces Ehrlich Tumor-Induced Cancer Pain in Mice
- (2015) Cassia Calixto-Campos et al. Analytical Cellular Pathology
- Self-nanoemulsifying drug delivery system (SNEDDS) of the poorly water-soluble grapefruit flavonoid Naringenin: design, characterization,in vitroandin vivoevaluation
- (2014) Abdul Wadood Khan et al. DRUG DELIVERY
- Flavonoids Inhibit COX-1 and COX-2 Enzymes and Cytokine/Chemokine Production in Human Whole Blood
- (2014) Daniela Ribeiro et al. INFLAMMATION
- Understanding paracetamol-induced liver failure
- (2014) Fin Stolze Larsen et al. INTENSIVE CARE MEDICINE
- Quercetin reduces obesity-associated ATM infiltration and inflammation in mice: a mechanism including AMPKα1/SIRT1
- (2014) Jing Dong et al. JOURNAL OF LIPID RESEARCH
- Quercetin-Containing Self-Nanoemulsifying Drug Delivery System for Improving Oral Bioavailability
- (2014) Thanh Huyen Tran et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Hesperidin, a flavanoglycone attenuates experimental diabetic neuropathy via modulation of cellular and biochemical marker to improve nerve functions
- (2014) Asjad Visnagri et al. PHARMACEUTICAL BIOLOGY
- Green tea polyphenol treatment is chondroprotective, anti-inflammatory and palliative in a mouse posttraumatic osteoarthritis model
- (2014) Daniel J Leong et al. ARTHRITIS RESEARCH & THERAPY
- Review of the protective effects of rutin on the metabolic function as an important dietary flavonoid
- (2014) Hossein Hosseinzadeh et al. JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
- Diosmin protects against ethanol-induced hepatic injury via alleviation of inflammation and regulation of TNF-α and NF-κB activation
- (2013) Mir Tahir et al. ALCOHOL
- Preparation and characterization of inclusion complexes of naringenin with β-cyclodextrin or its derivative
- (2013) Li-Juan Yang et al. CARBOHYDRATE POLYMERS
- Enhancement of naringenin solution concentration by solid dispersion in cellulose derivative matrices
- (2013) Bin Li et al. CELLULOSE
- Enzogenol for cognitive functioning in traumatic brain injury: a pilot placebo-controlled RCT
- (2013) A. Theadom et al. EUROPEAN JOURNAL OF NEUROLOGY
- Antioxidant Effects of Quercetin and Naringenin Are Associated with Impaired Neutrophil Microbicidal Activity
- (2013) Francielli de Cássia Yukari Nishimura et al. Evidence-based Complementary and Alternative Medicine
- The relationship between the structure and biological actions of green tea catechins
- (2013) Cornelia Braicu et al. FOOD CHEMISTRY
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- (2013) Marcelo H. Napimoga et al. JOURNAL OF NATURAL PRODUCTS
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- (2013) Carla F. S. Guazelli et al. JOURNAL OF NATURAL PRODUCTS
- Vitexin Inhibits Inflammatory Pain in Mice by Targeting TRPV1, Oxidative Stress, and Cytokines
- (2013) Sergio M. Borghi et al. JOURNAL OF NATURAL PRODUCTS
- Nanoemulsions for delivery of flavonoids: formulation andin vitrorelease of rutin as model drug
- (2013) Ana S. Macedo et al. PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
- Anti-nociceptive effect of vitexin mediated by the opioid system in mice
- (2013) Ümide Demir Özkay et al. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
- Flavonoids, Flavonoid Subclasses and Breast Cancer Risk: A Meta-Analysis of Epidemiologic Studies
- (2013) Chang Hui et al. PLoS One
- Chemistry and Biological Activities of Flavonoids: An Overview
- (2013) Shashank Kumar et al. TheScientificWorldJOURNAL
- Generalized Anxiety Disorder (GAD)
- (2013) Stephanie Maxine Ross Holistic Nursing Practice
- Flavonoid Bioavailability and Attempts for Bioavailability Enhancement
- (2013) Surangi Thilakarathna et al. Nutrients
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- (2013) Katarzyna Orlicka et al. Therapeutic Advances in Chronic Disease
- Dietary intakes of berries and flavonoids in relation to cognitive decline
- (2012) Elizabeth E. Devore et al. ANNALS OF NEUROLOGY
- Citrus fruit and fabacea secondary metabolites potently and selectively block TRPM3
- (2012) I Straub et al. BRITISH JOURNAL OF PHARMACOLOGY
- Flavones induce neutrophil apoptosis by down-regulation of Mcl-1 via a proteasomal-dependent pathway
- (2012) Christopher D. Lucas et al. FASEB JOURNAL
- Barrier protective effects of rutin in LPS-induced inflammation in vitro and in vivo
- (2012) Wonhwa Lee et al. FOOD AND CHEMICAL TOXICOLOGY
- Anti-inflammatory activity of lipophilic epigallocatechin gallate (EGCG) derivatives in LPS-stimulated murine macrophages
- (2012) Ying Zhong et al. FOOD CHEMISTRY
- Effect of rikkunshito, a Japanese herbal medicine, on gastrointestinal symptoms and ghrelin levels in gastric cancer patients after gastrectomy
- (2012) Shuji Takiguchi et al. Gastric Cancer
- Hesperidin Prevents Retinal and Plasma Abnormalities in Streptozotocin-Induced Diabetic Rats
- (2012) Xiupu Shi et al. MOLECULES
- Habitual intake of dietary flavonoids and risk of Parkinson disease
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- Green tea extract reduces blood pressure, inflammatory biomarkers, and oxidative stress and improves parameters associated with insulin resistance in obese, hypertensive patients
- (2012) Pawel Bogdanski et al. NUTRITION RESEARCH
- Quercetin Is More Effective than Cromolyn in Blocking Human Mast Cell Cytokine Release and Inhibits Contact Dermatitis and Photosensitivity in Humans
- (2012) Zuyi Weng et al. PLoS One
- Which Sources of Flavonoids: Complex Diets or Dietary Supplements?
- (2012) Sarah Egert et al. Advances in Nutrition
- Rutin-Phospholipid Complex: An Innovative Technique in Novel Drug Delivery System- NDDS
- (2012) Devendra Singh et al. Current Drug Delivery
- Relationship between the structures of flavonoids and their NF-κB-dependent transcriptional activities
- (2011) Soon Young Shin et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Nuclear factor p65 interacts with Keap1 to repress the Nrf2-ARE pathway
- (2011) Miao Yu et al. CELLULAR SIGNALLING
- Trans-Chalcone prevents VEGF expression and retinal neovascularization in the ischemic retina
- (2011) Folami Lamoke et al. EXPERIMENTAL EYE RESEARCH
- Use of apigenin from Cordia dichotoma in the treatment of colitis
- (2011) Anjali B. Ganjare et al. FITOTERAPIA
- Rikkunshito Improves the Symptoms in Patients with Functional Dyspepsia, Accompanied by an Increase in the Level of Plasma Ghrelin
- (2011) Makoto Arai et al. HEPATO-GASTROENTEROLOGY
- Citrus Polyphenol Hesperidin Stimulates Production of Nitric Oxide in Endothelial Cells while Improving Endothelial Function and Reducing Inflammatory Markers in Patients with Metabolic Syndrome
- (2011) Stefano Rizza et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
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- (2011) Fabiana T.M.C. Vicentini et al. JOURNAL OF DERMATOLOGICAL SCIENCE
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- (2011) Cheng-Hsun Wu et al. JOURNAL OF FOOD SCIENCE
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- (2011) Fabricio O. Souto et al. JOURNAL OF NATURAL PRODUCTS
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- (2011) J. M. Calderon-Montano et al. MINI-REVIEWS IN MEDICINAL CHEMISTRY
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- (2011) Mari Hämäläinen et al. PLANTA MEDICA
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- (2011) Sanjay L. Dholakiya et al. TOXICOLOGY IN VITRO
- Potentiation of ghrelin signaling attenuates cancer anorexia–cachexia and prolongs survival
- (2011) N Fujitsuka et al. Translational Psychiatry
- Hesperidin contributes to the vascular protective effects of orange juice: a randomized crossover study in healthy volunteers
- (2010) Christine Morand et al. AMERICAN JOURNAL OF CLINICAL NUTRITION
- Habitual intake of flavonoid subclasses and incident hypertension in adults
- (2010) Aedín Cassidy et al. AMERICAN JOURNAL OF CLINICAL NUTRITION
- Quercetin supplementation and its effect on human monocyte gene expression profiles in vivo
- (2010) Inka Boomgaarden et al. BRITISH JOURNAL OF NUTRITION
- Pycnogenol: A blend of procyanidins with multifaceted therapeutic applications?
- (2010) Gabriele D'Andrea FITOTERAPIA
- Epigallocatechin-3-gallate inhibits mast cell degranulation, leukotriene C4 secretion, and calcium influx via mitochondrial calcium dysfunction
- (2010) Toshio Inoue et al. FREE RADICAL BIOLOGY AND MEDICINE
- Apigenin inhibits release of inflammatory mediators by blocking the NF-κB activation pathways in the HMC-1 cells
- (2010) Ok-Hwa Kang et al. IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
- Efficacy of Rikkunshito, a Traditional Japanese Medicine (Kampo), in Treating Functional Dyspepsia
- (2010) Hiroaki Kusunoki et al. INTERNAL MEDICINE
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- (2010) Satoko Akiyama et al. JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION
- What is this thing called pain?
- (2010) Clifford J. Woolf JOURNAL OF CLINICAL INVESTIGATION
- Immunosuppressive Effect of Quercetin on Dendritic Cell Activation and Function
- (2010) R.-Y. Huang et al. JOURNAL OF IMMUNOLOGY
- A Comprehensive Review of the Adverse Effects of Systemic Corticosteroids
- (2010) David M. Poetker et al. OTOLARYNGOLOGIC CLINICS OF NORTH AMERICA
- Morphine peripheral analgesia depends on activation of the PI3K /AKT/nNOS/NO/KATP signaling pathway
- (2010) T. M. Cunha et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Intravascular Danger Signals Guide Neutrophils to Sites of Sterile Inflammation
- (2010) B. McDonald et al. SCIENCE
- Role of interleukin-1β during pain and inflammation
- (2009) Ke Ren et al. BRAIN RESEARCH REVIEWS
- Quercetin reduces systolic blood pressure and plasma oxidised low-density lipoprotein concentrations in overweight subjects with a high-cardiovascular disease risk phenotype: a double-blinded, placebo-controlled cross-over study
- (2009) Sarah Egert et al. BRITISH JOURNAL OF NUTRITION
- Quercetin Reduces Inflammatory Pain: Inhibition of Oxidative Stress and Cytokine Production
- (2009) Daniel A. Valério et al. JOURNAL OF NATURAL PRODUCTS
- Flavonoids inhibit histamine release and expression of proinflammatory cytokines in mast cells
- (2008) Hyo-Hyun Park et al. ARCHIVES OF PHARMACAL RESEARCH
- NF-κB/p65 antagonizes Nrf2-ARE pathway by depriving CBP from Nrf2 and facilitating recruitment of HDAC3 to MafK
- (2008) Guang-Hui Liu et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Shared Principles in NF-κB Signaling
- (2008) Matthew S. Hayden et al. CELL
- Green Tea Catechins and Cardiovascular Health: An Update
- (2008) Pon Anandh Babu et al. CURRENT MEDICINAL CHEMISTRY
- Chemoprevention of Human Prostate Cancer by Green Tea Catechins: Two Years Later. A Follow-up Update
- (2008) Maurizio Brausi et al. EUROPEAN UROLOGY
- Cyclooxygenases 1 and 2 contribute to peroxynitrite-mediated inflammatory pain hypersensitivity
- (2008) Michael M. Ndengele et al. FASEB JOURNAL
- Catechin, epicatechin, quercetin, rutin and resveratrol in red grape: Content, in vitro antioxidant activity and interactions
- (2008) P. Iacopini et al. JOURNAL OF FOOD COMPOSITION AND ANALYSIS
- Naringenin has anti-inflammatory properties in macrophage and ex vivo human whole-blood models
- (2008) C. Bodet et al. JOURNAL OF PERIODONTAL RESEARCH
- A Catechin-rich Beverage Improves Obesity and Blood Glucose Control in Patients With Type 2 Diabetes
- (2008) Tomonori Nagao et al. Obesity
- Citrus fruit flavonoids influence on neutrophil apoptosis and oxidative metabolism
- (2008) Małgorzata Zielińska-Przyjemska et al. PHYTOTHERAPY RESEARCH
- Effect of pine bark extract (Pycnogenol®) on symptoms of knee osteoarthritis
- (2008) Peter Cisár et al. PHYTOTHERAPY RESEARCH
- Improved cognitive performance after dietary supplementation with aPinus radiatabark extract Formulation
- (2008) Andrew Pipingas et al. PHYTOTHERAPY RESEARCH
- Variations in C-reactive protein, plasma free radicals and fibrinogen values in patients with osteoarthritis treated with Pycnogenol®
- (2008) G. Belcaro et al. REDOX REPORT
- Prospective cohort comparison of flavonoid treatment in patients with resected colorectal cancer to prevent recurrence
- (2008) Harald Hoensch et al. WORLD JOURNAL OF GASTROENTEROLOGY
- Epigallocatechin gallate affects human dendritic cell differentiation and maturation
- (2007) Satomi Yoneyama et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
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