Article
Chemistry, Medicinal
Jeongjin Park, Dakyung Kim, Minhee Lee, Sangshin Han, Woojin Jun, Hyun Mook Jung, Yean Kyoung Koo, Gwi Hwan Na, Sang Hun Han, Jehee Han, Ok-Kyung Kim
Summary: This study found that enzyme-treated caviar powder extract (CV) can protect keratinocytes against oxidative stress and inflammation induced by UVB irradiation by increasing antioxidant enzyme activities, elevating sphingomyelin and hyaluronic acid levels, and reducing inflammatory cytokine production.
Article
Biochemistry & Molecular Biology
Yocasta Martinez-Alvarado, Eduardo Amezcua-Galvez, Judith Davila-Rodriguez, Ana Sandoval-Rodriguez, Marina Galicia-Moreno, Monica Almeida-Lopez, Silvia Lucano-Landeros, Arturo Santos, Hugo Christian Monroy-Ramirez, Juan Armendariz-Borunda
Summary: Ultraviolet radiation (UV) is the main cause of skin photodamage, which leads to histological degenerative changes and non-melanoma skin cancer. Retinoids have been commonly used to treat photoaging, but their adverse effects are recognized. Pirfenidone (PFD) has shown anti-inflammatory, antifibrogenic, and antioxidant properties. In this study, topical PFD was found to effectively reduce photodamage and inflammation in a UVB-induced model, making it a promising treatment for cell photodamage in humans. Clinical trials are needed to further investigate its potential.
Article
Medicine, Research & Experimental
Tomohisa Yoshimura, Chika Manabe, Yuki Inokuchi, Chikako Mutou, Tohru Nagahama, Shigeru Murakami
Summary: This study showed that oral supplementation with taurine can suppress UVB-induced wrinkle formation by regulating moisture content in the epidermis, suggesting potential beneficial effects of taurine on skin aging.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Eunjung Son, Yun Mi Lee, Seung-Hyung Kim, Dong-Seon Kim
Summary: This study assessed the effects of oral administration of processed ginseng leaves on photoaging. The results showed that oral administration of processed ginseng leaves can reduce skin wrinkles, inhibit the expression of collagen-degrading enzymes, and decrease levels of inflammatory cytokines.
Article
Agriculture, Multidisciplinary
Yannan Liu, Linlin Qu, Shichao Wan, Yingchun Li, Daidi Fan
Summary: In this study, it was found that ginsenoside Rk1 can attenuate oxidative stress and alleviate the inflammatory response. It can also inhibit collagen degradation by suppressing matrix metalloproteinases. Rk1 can suppress the PI3K/AKT/NF-kappa B signaling pathways and improve skin health. The evidence suggests that Rk1 can be applied as an effective natural antiphotoaging agent.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Wei-Sung Li, Shih-Chao Lin, Chien-Hui Chu, Yu-Kang Chang, Xiang Zhang, Chi-Chien Lin, Yu-Tang Tung
Summary: Naringenin exhibits anti-inflammatory and antioxidant properties, protecting the gastric mucosa in ethanol-induced damage models by reducing inflammation and oxidative stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Hye-Sun Lim, Kyeongno Yoon, Dong Hun Lee, Yong-Seok Lee, Jin Ho Chung, Gunhyuk Park
Summary: We have discovered that 20-hydroxyecdysone (20E), a steroid prohormone secreted by insects, can inhibit skin aging induced by UVB radiation. By inhibiting aldosterone synthase and reducing corticosterone levels, 20E reduces stress and protects against the decrease in collagen levels caused by UV radiation, making it a potential candidate for preventing skin aging.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Dakyung Kim, Eun-hye Choi, Ju Young Lee, Hye-Jeong See, Hye-Jin Kim, Yunhi Cho, Ok-Kyung Kim, Jeongmin Lee
Summary: This study investigated the protective effects of glucocerebroside-containing buttermilk concentrated powder (GCBM) on oxidative stress and photoaging in UVB-irradiated hairless mice. The results showed that dietary supplementation with GCBM increased antioxidant enzyme activity, reduced pro-inflammatory cytokine expression, inhibited wrinkle formation, and increased skin moisturization.
Article
Biochemistry & Molecular Biology
Sukjin Kim, Gwi Hwan Na, Hyun Mook Jung, Sang Hun Han, Jehee Han, Yean Kyoung Koo
Summary: This study investigated the anti-melanogenesis effects of enzyme-treated caviar extract (CV) in B16F10 cells and SKH-1 hairless mice. CV significantly decreased melanin production and activity of melanogenesis factors in B16F10 cells treated with IBMX. It also reduced the expression of melanogenesis proteins and factors in UVB-induced SKH-1 hairless mice. The results suggest the potential of CV as a skin whitening food supplement.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Liping Zhang, Kai Wang, Shaoxin Liang, Junhan Cao, Mengke Yao, Ling Qin, Changfeng Qu, Jinlai Miao
Summary: In this study, a & zeta;-carotene-like compound (CLC) was synthesized through the expression of three genes in the carotenoid pathway of Antarctic moss in Escherichia coli. The CLC was found to enhance skin antioxidant capacity, reduce inflammation, and mitigate skin damage induced by UVB radiation. This research provides a foundation for the application of CLC in functional food and medicine for skin resistance against UVB damage.
Article
Polymer Science
Cheolwoo Park, Jaeyoung Park, Won-Jin Kim, Woong Kim, Hyeonsook Cheong, Seok-Jun Kim
Summary: The study showed that malonic acid (MA) from Pinus densiflora protects against UVB-induced photoaging by reducing ROS levels and inhibiting skin inflammation.
Article
Biochemistry & Molecular Biology
Yejin Ahn, Min Guk Kim, Kyungae Jo, Ki-Bae Hong, Hyung Joo Suh
Summary: Sphingomyelin-containing milk phospholipids contribute to moisturizing the skin and reducing damage to the skin barrier caused by photoaging by maintaining hyaluronic acid content and reducing ROS levels.
Article
Integrative & Complementary Medicine
Manami Oyama, Kenta Murata, Misaki Ogata, Nina Fujita, Ryuji Takahashi
Summary: Saireito extract (SRT) has a protective effect against UVB-induced photodamage by attenuating inflammatory responses, improving extracellular matrix degradation, suppressing inflammatory cell infiltration, and inhibiting collagen degradation. SRT treatment can also inhibit UVB-induced upregulation of proinflammatory cytokines and improve lymphatic function.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2021)
Article
Multidisciplinary Sciences
Tava Shelan Nagapan, Wenna Nallance Lim, Ahmad Rohi Ghazali, Dayang Fredalina Basri
Summary: The study found that pterostilbene has a photoprotective effect on UVB-irradiated mouse skin by reducing skin redness, scaling, and epidermal thickness. Pterostilbene also showed anti-inflammatory and antioxidant properties, leading to decreased levels of MDA and increased levels of GSH and SOD in the skin.
Article
Dermatology
Liang Cao, Xueping Yue, Yonghui Zhao, Lixia Du, Zili Xie, Yi Yuan, Sha Zhang, Feng Li, Jing Feng, Hongzhen Hu
Summary: The study established a sunburn-related mouse model and found that TRPV1-positive dorsal root ganglion neurons are involved in broad-band UVB irradiation induced itch, while mast cells are not. Both genetic and pharmacological inhibition of TRPV1 function significantly alleviated the broad-band UVB irradiation-induced itch response.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Editorial Material
Biochemistry & Molecular Biology
Sergio Marques Borghi, Rubia Casagrande, Waldiceu Aparecido Verri
CURRENT MEDICINAL CHEMISTRY
(2023)
Article
Public, Environmental & Occupational Health
Rafaela Pires Erthal, Glaucia Eloisa Munhoz de Lion Siervo, Giovanna Fachetti Frigoli, Tiago Henrique Zaninelli, Waldiceu Aparecido Verri, Glaura Scantamburlo Alves Fernandes
Summary: This study found that low doses of malathion can impair sperm quality and function by downregulating gene expression, and can also damage the sperm's antioxidant profile during critical periods of development.
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
(2023)
Article
Pharmacology & Pharmacy
Sergio M. Borghi, Tiago H. Zaninelli, Telma Saraiva-Santos, Mariana M. Bertozzi, Renato D. R. Cardoso, Thacyana T. Carvalho, Camila R. Ferraz, Doumit Camilios-Neto, Fernando Q. Cunha, Thiago M. Cunha, Felipe A. Pinho-Ribeiro, Rubia Casagrande, Waldiceu A. Verri
Summary: In this study, the researchers investigated the effect of pentoxifylline (Ptx) on delayed-onset muscle soreness (DOMS) in untrained mice exposed to intense acute swimming exercise. They found that Ptx treatment reduced mechanical hyperalgesia caused by intense acute swimming in a dose-dependent manner. Ptx also inhibited neutrophil recruitment, oxidative stress, and cytokine production in the muscle tissue and spinal cord, as well as reduced glial cell activation in the spinal cord. These findings suggest that Ptx can alleviate pain in DOMS by targeting peripheral and spinal cord mechanisms.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Sergio M. Borghi, Tiago H. Zaninelli, Jessica B. Carra, Olivia K. Heintz, Marcela M. Baracat, Sandra R. Georgetti, Fabiana T. M. C. Vicentini, Waldiceu A. Verri, Rubia Casagrande
Summary: Asthma is a chronic disease characterized by allergic inflammatory reactions. Current treatment options have limitations and can have adverse effects, leading to poor management of the disease. Flavonoids, with their antioxidant and anti-inflammatory properties, have shown potential benefits for asthma treatment.
Article
Multidisciplinary Sciences
Felipe A. Pinho-Ribeiro, Liwen Deng, Dylan V. Neel, Ozge Erdogan, Himanish Basu, Daping Yang, Samantha Choi, Alec J. Walker, Simone Carneiro-Nascimento, Kathleen He, Glendon Wu, Beth Stevens, Kelly S. Doran, Dan Levy, Isaac M. Chiu
Summary: The meninges are innervated by sensory neurons that mediate pain and headache. Bacterial meningitis is a life-threatening infection that affects millions of people each year. The impact of pain and neuroimmune interactions on meningeal antibacterial defenses is unclear.
Article
Immunology
Telma Saraiva-Santos, Tiago H. Zaninelli, Marilia F. Manchope, Ketlem C. Andrade, Camila R. Ferraz, Mariana M. Bertozzi, Nayara A. Artero, Anelise Franciosi, Stephanie Badaro-Garcia, Larissa Staurengo-Ferrari, Sergio M. Borghi, Graziela S. Ceravolo, Avacir Casanova Andrello, Janaina Menezes Zanoveli, Michael S. Rogers, Rubia Casagrande, Felipe A. Pinho-Ribeiro, Waldiceu A. Verri Jr
Summary: LXA(4) has analgesic and anti-inflammatory effects in a model of prosthesis-induced joint inflammation and pain, mainly through reducing nuclear factor κB activation and modulating cytokine production.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Carina Z. Segato-Vendrameto, Camila Zanluca, Amanda Z. Zucoloto, Tiago H. Zaninelli, Mariana M. Bertozzi, Telma Saraiva-Santos, Camila R. Ferraz, Larissa Staurengo-Ferrari, Stephanie Badaro-Garcia, Marilia F. Manchope, Amanda M. Dionisio, Felipe A. Pinho-Ribeiro, Sergio M. Borghi, Ana Luiza Pamplona Mosimann, Rubia Casagrande, Juliano Bordignon, Victor Fattori, Claudia N. Duarte dos Santos, Waldiceu A. Verri
Summary: This article investigates therapeutic strategies against Chikungunya virus, finding that inhibiting viral proteins and using recombinant antibodies can alleviate virus-induced pain symptoms.
Article
Chemistry, Medicinal
Tiago H. Zaninelli, Sandra S. Mizokami, Mariana M. Bertozzi, Telma Saraiva-Santos, Felipe A. Pinho-Ribeiro, Gabriele Inacio de Oliveira, Renata Streck, Eduardo J. A. Araujo, Nilton S. Arakawa, Sergio M. Borghi, Rubia Casagrande, Waldiceu A. Verri
Summary: In this study, it was found that kaurenoic acid (KA), extracted from Sphagneticola trilobata, has analgesic properties and can be used for the treatment of neuropathic pain. KA inhibits neuropathic pain induced by chronic constriction injury (CCI) by activating the NO/cGMP/PKG/ATP-sensitive potassium channel signaling pathway. KA also reduces activation of sensory neurons and increases the levels of neuronal nitric oxide synthase (nNOS) and nitric oxide (NO) in dorsal root ganglion (DRG) neurons. These findings suggest that KA inhibits CCI neuropathic pain by activating the nNOS-NO pathway to silence nociceptive signaling.
Article
Biotechnology & Applied Microbiology
Marilia F. Manchope, Mariana M. Bertozzi, Sergio M. Borghi, Cintia L. Handa, Mariana A. Queiroz-Cancian, Camila R. Ferraz, Sandra S. Mizokami, Stephanie Badaro-Garcia, Ketlem C. Andrade, Tiago H. Zaninelli, Wilma A. Spinosa, Sandra R. Georgetti, Elza I. Ida, Waldiceu A. Verri, Rubia Casagrande
Summary: This study evaluates the biological activity of fermented and non-fermented defatted soybean flour (DSF) extracts in pain and inflammation. The results demonstrate that both fermented and non-fermented DSF extracts have analgesic and anti-inflammatory effects, with differences in the mechanism of action depending on the fungi used for fermentation.
FERMENTATION-BASEL
(2023)
Article
Microbiology
Vera Lucia Hideko Tatakihara, Aparecida Donizette Malvezi, Rito Santo Pereira, Bruno Fernando Cruz Lucchetti, Lucas Felipe Dos Santos, Rubens Cecchini, Lucy Megumi Yamauchi, Sueli Fumie Yamada-Ogatta, Katrina M. Miranda, Waldiceu A. Verri, Marli Cardoso Martins-Pinge, Phileno Pinge-Filho
Summary: This study found that a nitric oxide donor called Angeli's salt (AS) can reduce the number of parasites and the severity of Chagas disease in mice. In addition, AS treatment can enhance the antioxidant capacity of infected animals' red blood cells. These results suggest that AS could be a promising therapy for Chagas disease.
Article
Agriculture, Dairy & Animal Science
Suellen Miguez Gonzalez, Marcela Bortoletto Cerezetti, Larissa Zamparone Bergamo, Camila Rodrigues Ferraz, Waldiceu Aparecido Verri Jr, Marcelo Marcondes Seneda
Summary: The aim of this study was to evaluate oxidative stress in ovaries and corpus luteum (CL) of Bos taurus indicus females and the oxidant effect of CL in ovarian tissues. The results showed that luteal tissues had higher antioxidant activity than ovarian tissues, and there was no difference in antioxidant activity and oxidative stress between ovarian fragments obtained from different regions (with or without CL). The presence of CL in the ovaries did not influence oxidative stress or antioxidant potential.
ANIMAL REPRODUCTION
(2023)
Article
Chemistry, Multidisciplinary
Lucas Braganca Carvalho, Isabela Silva Godoy, Ana Cristina Preisler, Patricia Luiza de Freitas Proenca, Telma Saraiva-Santos, Waldiceu Aparecido Verri Jr, Halley Caixeta Oliveira, Giliardi Dalazen, Leonardo Fernandes Fraceto
Summary: In this study, zein nanoparticles associated with the herbicide atrazine were developed and their efficacy in weed control was evaluated. The nanoformulation showed good stability and encapsulation efficiency. It exhibited greater effectiveness against the target plant, Brassica juncea, even at low doses, without causing toxicity to the crop species. The nanoparticles were captured and accumulated in roots but had limited transportation to the shoot. The atrazine nanoencapsulation did not increase the mobility of the herbicide in the soil.
ENVIRONMENTAL SCIENCE-NANO
(2023)