Contribution of Nrf2 Modulation to the Mechanism of Action of Analgesic and Anti-inflammatory Drugs in Pre-clinical and Clinical Stages

Targeted therapy of esophageal squamous cell carcinoma: the NRF2 signaling pathway as target

(2018) Shaohua Ma et al.   Annals of the New York Academy of Sciences

Nrf2 as a therapeutic target for rheumatic diseases

(2018) María Luisa Ferrándiz et al.   BIOCHEMICAL PHARMACOLOGY

Fumaric acid esters in combination with a 6-week course of narrowband ultraviolet B provides an accelerated response compared with fumaric acid esters monotherapy in patients with moderate-to-severe plaque psoriasis: a randomized prospective clinical stud

(2018) S. Tzaneva et al.   BRITISH JOURNAL OF DERMATOLOGY

NRF2 and the Hallmarks of Cancer

(2018) Montserrat Rojo de la Vega et al.   CANCER CELL

DNA methylome and transcriptome alterations and cancer prevention by curcumin in colitis-accelerated colon cancer in mice

(2018) Yue Guo et al.   CARCINOGENESIS

“Keaping” a lid on lung cancer: the Keap1-Nrf2 pathway

(2018) Sarah A. Best et al.   CELL CYCLE

Psychosocial-Stress, Liver Regeneration and Weight Gain: a Conspicuous Pathophysiological Triad

(2018) Syeda Momna Ishtiaq et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Discovery of a head-to-tail cyclic peptide as the Keap1-Nrf2 protein-protein interaction inhibitor with high cell potency

(2018) Meng-Chen Lu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Glycyrrhizin ameliorates inflammatory pain by inhibiting microglial activation-mediated inflammatory response via blockage of the HMGB1-TLR4-NF-kB pathway

(2018) Xiaojuan Sun et al.   EXPERIMENTAL CELL RESEARCH

Rosmarinic acid attenuates β-amyloid-induced oxidative stress via Akt/GSK-3β/Fyn-mediated Nrf2 activation in PC12 cells

(2018) Hua Rong et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Crosstalk between Nrf2 and Inflammasomes

(2018) Paulina Hennig et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Hesperidin Methylchalcone Suppresses Experimental Gout Arthritis in Mice by Inhibiting NF-κB Activation

(2018) Kenji W. Ruiz-Miyazawa et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Lipoxin A4 inhibits UV radiation-induced skin inflammation and oxidative stress in mice

(2018) R.M. Martinez et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

The flavonoid quercetin inhibits titanium dioxide (TiO 2 )-induced chronic arthritis in mice

(2018) Sergio M. Borghi et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Aspirin suppresses neuronal apoptosis, reduces tissue inflammation, and restrains astrocyte activation by activating the Nrf2/HO-1 signaling pathway

(2018) Wang Wei et al.   NEUROREPORT

3-(1H-Benzo[d]imidazol-6-yl)-5-(4-fluorophenyl)-1,2,4-oxadiazole (DDO7232), a Novel Potent Nrf2/ARE Inducer, Ameliorates DSS-Induced Murine Colitis and Protects NCM460 Cells against Oxidative Stress via ERK1/2 Phosphorylation

(2018) Li-Li Xu et al.   Oxidative Medicine and Cellular Longevity

Anticancer Activity of Sulforaphane: The Epigenetic Mechanisms and the Nrf2 Signaling Pathway

(2018) Xuling Su et al.   Oxidative Medicine and Cellular Longevity

Epigenetics in osteoarthritis: Potential of HDAC inhibitors as therapeutics

(2018) Nazir M. Khan et al.   PHARMACOLOGICAL RESEARCH

Canonical and non-canonical mechanisms of Nrf2 activation

(2018) Carlos Alfredo Silva-Islas et al.   PHARMACOLOGICAL RESEARCH

Transcription Factor NRF2 as a Therapeutic Target for Chronic Diseases: A Systems Medicine Approach

(2018) Antonio Cuadrado et al.   PHARMACOLOGICAL REVIEWS

Celecoxib exerts protective effects in the vascular endothelium via COX-2-independent activation of AMPK-CREB-Nrf2 signalling

(2018) Fahad Al-Rashed et al.   Scientific Reports

Chemopreventive activity of sulforaphane

(2018) Xin Jiang et al.   Drug Design Development and Therapy

15d-PGJ2-loaded nanocapsules ameliorate experimental gout arthritis by reducing pain and inflammation in a PPAR-gamma-sensitive manner in mice

(2018) Kenji W. Ruiz-Miyazawa et al.   Scientific Reports

Role of Keap1-Nrf2 Signaling in Anhedonia Symptoms in a Rat Model of Chronic Neuropathic Pain: Improvement With Sulforaphane

(2018) Shan Li et al.   Frontiers in Pharmacology

Antitumor activity of sulforaphane in mice model of skin cancer via blocking sulfatase‐2

(2018) Abdullah Alyoussef et al.   EXPERIMENTAL DERMATOLOGY

Naringenin mitigates titanium dioxide (TiO2)-induced chronic arthritis in mice: role of oxidative stress, cytokines, and NFκB

(2018) Marília F. Manchope et al.   INFLAMMATION RESEARCH

Anti-Carcinogenic Glucosinolates in Cruciferous Vegetables and Their Antagonistic Effects on Prevention of Cancers

(2018) Prabhakaran Soundararajan et al.   MOLECULES

The Lipid Mediator Resolvin D1 Reduces the Skin Inflammation and Oxidative Stress Induced by UV Irradiation in Hairless Mice

(2018) Priscila Saito et al.   Frontiers in Pharmacology

Treating inflammation and infection in the 21st century: new hints from decoding resolution mediators and mechanisms

(2017) Charles N. Serhan   FASEB JOURNAL

Glucocorticoid receptor signaling represses the antioxidant response by inhibiting histone acetylation mediated by the transcriptional activator NRF2

(2017) Md. Morshedul Alam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Treatment with Sulforaphane Produces Antinociception and Improves Morphine Effects during Inflammatory Pain in Mice

(2017) Alejandro Redondo et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Activation of Nrf2/HO-1 Pathway by Glycogen Synthase Kinase-3β Inhibition Attenuates Renal Ischemia/Reperfusion Injury in Diabetic Rats

(2017) Xiaohua Shen et al.   KIDNEY & BLOOD PRESSURE RESEARCH

Systemic Activation of NRF2 Alleviates Lethal Autoimmune Inflammation in Scurfy Mice

(2017) Takuma Suzuki et al.   MOLECULAR AND CELLULAR BIOLOGY

Sulforaphane prevents bleomycin-induced pulmonary fibrosis in mice by inhibiting oxidative stress via nuclear factor erythroid 2-related factor-2 activation

(2017) Bingdi Yan et al.   Molecular Medicine Reports

A clinical drug library screen identifies clobetasol propionate as an NRF2 inhibitor with potential therapeutic efficacy in KEAP1 mutant lung cancer

(2017) E-J Choi et al.   ONCOGENE

Curcumin Protects Skin against UVB-Induced Cytotoxicity via the Keap1-Nrf2 Pathway: The Use of a Microemulsion Delivery System

(2017) Maya Ben Yehuda Greenwald et al.   Oxidative Medicine and Cellular Longevity

Nrf2 and NF-κB modulation by Plumbagin attenuates functional, behavioural and biochemical deficits in rat model of neuropathic pain

(2017) Vijay Arruri et al.   Pharmacological Reports

Fish oil omega-3 polyunsaturated fatty acids attenuate oxidative stress-induced DNA damage in vascular endothelial cells

(2017) Chiemi Sakai et al.   PLoS One

Correction: Lack of Effect of Oral Sulforaphane Administration on Nrf2 Expression in COPD: A Randomized, Double-Blind, Placebo Controlled Trial

(2017) Robert A. Wise et al.   PLoS One

The induction of the transcription factor Nrf2 enhances the antinociceptive effects of delta-opioid receptors in diabetic mice

(2017) Christina McDonnell et al.   PLoS One

Naringenin Ameliorates Behavioral Dysfunction and Neurological Deficits in a d-Galactose-Induced Aging Mouse Model Through Activation of PI3K/Akt/Nrf2 Pathway

(2017) Yan Zhang et al.   REJUVENATION RESEARCH

Nrf2 exerts cell-autonomous antifibrotic effects: compromised function in systemic sclerosis and therapeutic rescue with a novel heterocyclic chalcone derivative

(2017) Jun Wei et al.   Translational Research

Nociceptor Sensory Neuron–Immune Interactions in Pain and Inflammation

(2017) Felipe A. Pinho-Ribeiro et al.   TRENDS IN IMMUNOLOGY

Safety, pharmacokinetics, and pharmacodynamics of oral omaveloxolone (RTA 408), a synthetic triterpenoid, in a first-in-human trial of patients with advanced solid tumors

(2017) Ben Creelan et al.   OncoTargets and Therapy

Sulforaphane for the chemoprevention of bladder cancer: molecular mechanism targeted approach

(2017) Andrew Leone et al.   Oncotarget

Vanillic acid attenuates Aβ1-42-induced oxidative stress and cognitive impairment in mice

(2017) Faiz Ul Amin et al.   Scientific Reports

Anti-nociceptive and anti-inflammatory actions of sulforaphane in chronic constriction injury-induced neuropathic pain mice

(2017) Cheng Wang et al.   INFLAMMOPHARMACOLOGY

Therapeutic effect of ent -kaur-16-en-19-oic acid on neutrophilic lung inflammation and sepsis is mediated by Nrf2

(2016) Kyun Ha Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Efficacy and safety of LAS41008 (dimethyl fumarate) in adults with moderate-to-severe chronic plaque psoriasis: a randomized, double-blind, Fumaderm® - and placebo-controlled trial (BRIDGE)

(2016) U. Mrowietz et al.   BRITISH JOURNAL OF DERMATOLOGY

Severe recalcitrant cutaneous manifestations in systemic lupus erythematosus successfully treated with fumaric acid esters

(2016) A.M. Saracino et al.   BRITISH JOURNAL OF DERMATOLOGY

Prevention of Carcinogen-Induced Oral Cancer by Sulforaphane

(2016) J. E. Bauman et al.   Cancer Prevention Research

Dexamethasone improves redox state in ataxia telangiectasia cells by promoting an NRF2-mediated antioxidant response

(2016) Sara Biagiotti et al.   FEBS Journal

An overview of chemical inhibitors of the Nrf2-ARE signaling pathway and their potential applications in cancer therapy

(2016) Jiayu Zhu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Caffeic acid prevents acetaminophen-induced liver injury by activating the Keap1-Nrf2 antioxidative defense system

(2016) Chun Pang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Aspirin induces Nrf2-mediated transcriptional activation of haem oxygenase-1 in protection of human melanocytes from H2O2-induced oxidative stress

(2016) Zhe Jian et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Activation of the nuclear factor E2-related factor 2/anitioxidant response element alleviates the nitroglycerin-induced hyperalgesia in rats

(2016) Wei Di et al.   JOURNAL OF HEADACHE AND PAIN

Discovery and Development of Kelch-like ECH-Associated Protein 1. Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1:NRF2) Protein–Protein Interaction Inhibitors: Achievements, Challenges, and Future Directions

(2016) Zheng-Yu Jiang et al.   JOURNAL OF MEDICINAL CHEMISTRY

The citrus flavonone naringenin reduces lipopolysaccharide-induced inflammatory pain and leukocyte recruitment by inhibiting NF-κB activation

(2016) Felipe A. Pinho-Ribeiro et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

The Effect of Dietary Supplementation With Curcumin on Redox Status and Nrf2 Activation in Patients With Nondiabetic or Diabetic Proteinuric Chronic Kidney Disease: A Pilot Study

(2016) Angélica Saraí Jiménez-Osorio et al.   JOURNAL OF RENAL NUTRITION

Fumaric acid ester treatment in cutaneous lupus erythematosus (CLE): a prospective, open-label, phase II pilot study

(2016) A Kuhn et al.   LUPUS

Curcumin by down-regulating NF-kB and elevating Nrf2, reduces brain edema and neurological dysfunction after cerebral I/R

(2016) Wei Li et al.   MICROVASCULAR RESEARCH

Melatonin modulates glucocorticoid receptor mediated inhibition of antioxidant response and apoptosis in peripheral blood mononuclear cells

(2016) Amaresh Kumar Singh et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Capsaicin: Current Understanding of Its Mechanisms and Therapy of Pain and Other Pre-Clinical and Clinical Uses

(2016) Victor Fattori et al.   MOLECULES

The status of Nrf2-based therapeutics: current perspectives and future prospects

(2016) IrinaG Gazaryan et al.   Neural Regeneration Research

Naringenin reduces inflammatory pain in mice

(2016) Felipe A. Pinho-Ribeiro et al.   NEUROPHARMACOLOGY

An overview on the role of dietary phenolics for the treatment of cancers

(2016) Preethi G. Anantharaju et al.   Nutrition Journal

Role of Keap1-Nrf2 signaling in depression and dietary intake of glucoraphanin confers stress resilience in mice

(2016) Wei Yao et al.   Scientific Reports

Pyrrolidine dithiocarbamate inhibits superoxide anion-induced pain and inflammation in the paw skin and spinal cord by targeting NF-κB and oxidative stress

(2016) Felipe A. Pinho-Ribeiro et al.   INFLAMMOPHARMACOLOGY

Naringenin Inhibits Superoxide Anion-Induced Inflammatory Pain: Role of Oxidative Stress, Cytokines, Nrf-2 and the NO−cGMP−PKG−KATPChannel Signaling Pathway

(2016) Marília F. Manchope et al.   PLoS One

Nrf2 is essential for timely M phase entry of replicating hepatocytes during liver regeneration

(2015) Yuhong Zou et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Dissecting molecular cross-talk between Nrf2 and NF-κB response pathways

(2015) Joanna D. Wardyn et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Non-electrophilic modulators of the canonical Keap1/Nrf2 pathway

(2015) B.G. Richardson et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The superoxide anion donor, potassium superoxide, induces pain and inflammation in mice through production of reactive oxygen species and cyclooxygenase-2

(2015) N.A. Maioli et al.   BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH

Dimethyl fumarate and the oleanane triterpenoids, CDDO-imidazolide and CDDO-methyl ester, both activate the Nrf2 pathway but have opposite effects in the A/J model of lung carcinogenesis

(2015) Ciric To et al.   CARCINOGENESIS

Protective effects of the flavonoid hesperidin methyl chalcone in inflammation and pain in mice: Role of TRPV1, oxidative stress, cytokines and NF-κB

(2015) Felipe A. Pinho-Ribeiro et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Phospholipid oxidation generates potent anti-inflammatory lipid mediators that mimic structurally related pro-resolving eicosanoids by activating Nrf2

(2015) P. Bretscher et al.   EMBO Molecular Medicine

Nrf2—A regulator of keratinocyte redox signaling

(2015) Matthias Schäfer et al.   FREE RADICAL BIOLOGY AND MEDICINE

The involvement of p62–Keap1–Nrf2 antioxidative signaling pathway and JNK in the protection of natural flavonoid quercetin against hepatotoxicity

(2015) Li-Li Ji et al.   FREE RADICAL BIOLOGY AND MEDICINE

15-Deoxy-prostaglandin J2 anti-inflammation in a rat model of chronic obstructive pulmonary disease and human bronchial epithelial cells via Nrf2 activation

(2015) X.Y. Li et al.   GENETICS AND MOLECULAR RESEARCH

Curcumin inhibits superoxide anion-induced pain-like behavior and leukocyte recruitment by increasing Nrf2 expression and reducing NF-κB activation

(2015) Victor Fattori et al.   INFLAMMATION RESEARCH

Epigallocatechin-3-gallate attenuates bone cancer pain involving decreasing spinal Tumor Necrosis Factor-α expression in a mouse model

(2015) Qingsong Li et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Glycyrrhizin reduces HMGB1 secretion in lipopolysaccharide-activated RAW 264.7 cells and endotoxemic mice by p38/Nrf2-dependent induction of HO-1

(2015) Young Min Kim et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The effect of dimethyl fumarate on gene expression and the level of cytokines related to different T helper cell subsets in peripheral blood mononuclear cells of patients with psoriasis

(2015) Sahar Tahvili et al.   INTERNATIONAL JOURNAL OF DERMATOLOGY

Effects of Eicosapentaenoic Acid on the Cytoprotection Through Nrf2-Mediated Heme Oxygenase-1 in Human Endothelial Cells

(2015) Seung Eun Lee et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Vanillic Acid Inhibits Inflammatory Pain by Inhibiting Neutrophil Recruitment, Oxidative Stress, Cytokine Production, and NFκB Activation in Mice

(2015) Cássia Calixto-Campos et al.   JOURNAL OF NATURAL PRODUCTS

Cell-Permeable Peptide Targeting the Nrf2-Keap1 Interaction: A Potential Novel Therapy for Global Cerebral Ischemia

(2015) J. Tu et al.   JOURNAL OF NEUROSCIENCE

Promising cannabinoid-based therapies for Parkinson’s disease: motor symptoms to neuroprotection

(2015) Sandeep Vasant More et al.   Molecular Neurodegeneration

Epigallocatechin-3-Gallate Protects HUVECs from PM2.5-Induced Oxidative Stress Injury by Activating Critical Antioxidant Pathways

(2015) Guang-Zhao Yang et al.   MOLECULES

Bosentan, a mixed endothelin receptor antagonist, inhibits superoxide anion-induced pain and inflammation in mice

(2015) Karla G. G. Serafim et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Superoxide anion-induced pain and inflammation depends on TNFα/TNFR1 signaling in mice

(2015) Fabiane Y. Yamacita-Borin et al.   NEUROSCIENCE LETTERS

Ultraviolet-B protective effect of flavonoids from Eugenia Caryophylata on human dermal fibroblast cells

(2015) Purvi Bhatt et al.   Pharmacognosy Magazine

Regulation of the expression of renal drug transporters in KEAP1-knockdown human tubular cells

(2015) Hyuk-Sang Jeong et al.   TOXICOLOGY IN VITRO

Quercetin Reduces Ehrlich Tumor-Induced Cancer Pain in Mice

(2015) Cassia Calixto-Campos et al.   Analytical Cellular Pathology

Histone deacetylase inhibition activates Nrf2 and protects against osteoarthritis

(2015) Dawei Cai et al.   ARTHRITIS RESEARCH & THERAPY

Nrf2 status affects tumor growth, HDAC3 gene promoter associations, and the response to sulforaphane in the colon

(2015) Praveen Rajendran et al.   Clinical Epigenetics

Nuclear factor erythroid 2-related factor 2 (Nrf2) regulates airway epithelial barrier integrity

(2015) Yoshitaka Shintani et al.   ALLERGOLOGY INTERNATIONAL

Derivative of Bardoxolone Methyl, dh404, in an Inverse Dose-Dependent Manner Lessens Diabetes-Associated Atherosclerosis and Improves Diabetic Kidney Disease

(2014) S. M. Tan et al.   DIABETES

Keap1 inhibition attenuates glomerulosclerosis

(2014) Yoichi Miyazaki et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

The Nrf2 regulatory network provides an interface between redox and intermediary metabolism

(2014) John D. Hayes et al.   TRENDS IN BIOCHEMICAL SCIENCES

Nrf2 Activation Protects the Liver From Ischemia/Reperfusion Injury in Mice

(2013) Kazuhiro Kudoh et al.   ANNALS OF SURGERY

Role of Nrf2 in Oxidative Stress and Toxicity

(2013) Qiang Ma   Annual Review of Pharmacology and Toxicology

Are Reactive Oxygen Species Always Detrimental to Pathogens?

(2013) Claudia N. Paiva et al.   ANTIOXIDANTS & REDOX SIGNALING

Reactive Oxygen Species in Inflammation and Tissue Injury

(2013) Manish Mittal et al.   ANTIOXIDANTS & REDOX SIGNALING

Inhibition of fatty acid amide hydrolase activates Nrf2 signalling and induces heme oxygenase 1 transcription in breast cancer cells

(2013) H Li et al.   BRITISH JOURNAL OF PHARMACOLOGY

Proteomic Analysis of Ubiquitin Ligase KEAP1 Reveals Associated Proteins That Inhibit NRF2 Ubiquitination

(2013) B. E. Hast et al.   CANCER RESEARCH

Oncogenic functions of the transcription factor Nrf2

(2013) Irene Gañán-Gómez et al.   FREE RADICAL BIOLOGY AND MEDICINE

BRCA1 interacts with Nrf2 to regulate antioxidant signaling and cell survival

(2013) Chiara Gorrini et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Clinical efficacy of BG-12 (dimethyl fumarate) in patients with relapsing–remitting multiple sclerosis: subgroup analyses of the DEFINE study

(2013) Amit Bar-Or et al.   JOURNAL OF NEUROLOGY

Targeting the transcription factor Nrf2 to ameliorate oxidative stress and inflammation in chronic kidney disease

(2013) Stacey Ruiz et al.   KIDNEY INTERNATIONAL

Unknown

(2013) Rania Dayoub et al.   MOLECULAR MEDICINE

Natural product-derived pharmacological modulators of Nrf2/ARE pathway for chronic diseases

(2013) Hemant Kumar et al.   NATURAL PRODUCT REPORTS

Bardoxolone Methyl in Type 2 Diabetes and Stage 4 Chronic Kidney Disease

(2013) Dick de Zeeuw et al.   NEW ENGLAND JOURNAL OF MEDICINE

Peptide inhibitors of the Keap1–Nrf2 protein–protein interaction with improved binding and cellular activity

(2013) Rowena Hancock et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Neuroprotection by Curcumin in Ischemic Brain Injury Involves the Akt/Nrf2 Pathway

(2013) Jingxian Wu et al.   PLoS One

Microarray and Pathway Analysis Reveal Distinct Mechanisms Underlying Cannabinoid-Mediated Modulation of LPS-Induced Activation of BV-2 Microglial Cells

(2013) Ana Juknat et al.   PLoS One

Keap1-Knockdown Decreases Fasting-Induced Fatty Liver via Altered Lipid Metabolism and Decreased Fatty Acid Mobilization from Adipose Tissue

(2013) Jialin Xu et al.   PLoS One

A novel natural Nrf2 activator with PPARγ-agonist (monascin) attenuates the toxicity of methylglyoxal and hyperglycemia

(2013) Wei-Hsuan Hsu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The five Rs of glucocorticoid action during inflammation: ready, reinforce, repress, resolve, and restore

(2013) John M. Busillo et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer

(2013) Emilia Kansanen et al.   Redox Biology

Bardoxolone Brings Nrf2-Based Therapies to Light

(2012) Donna D. Zhang   ANTIOXIDANTS & REDOX SIGNALING

Sestrins Activate Nrf2 by Promoting p62-Dependent Autophagic Degradation of Keap1 and Prevent Oxidative Liver Damage

(2012) Soo Han Bae et al.   Cell Metabolism

A Phase I First-in-Human Trial of Bardoxolone Methyl in Patients with Advanced Solid Tumors and Lymphomas

(2012) D. S. Hong et al.   CLINICAL CANCER RESEARCH

Rosmarinic acid ameliorates acute liver damage and fibrogenesis in carbon tetrachloride-intoxicated mice

(2012) Robert Domitrović et al.   FOOD AND CHEMICAL TOXICOLOGY

Nrf2 promotes alveolar mitochondrial biogenesis and resolution of lung injury in Staphylococcus aureus pneumonia in mice

(2012) Janhavi Athale et al.   FREE RADICAL BIOLOGY AND MEDICINE

Kaurenoic Acid from Sphagneticola trilobata Inhibits Inflammatory Pain: Effect on Cytokine Production and Activation of the NO–Cyclic GMP–Protein Kinase G–ATP-Sensitive Potassium Channel Signaling Pathway

(2012) Sandra S. Mizokami et al.   JOURNAL OF NATURAL PRODUCTS

PALB2 Interacts with KEAP1 To Promote NRF2 Nuclear Accumulation and Function

(2012) J. Ma et al.   MOLECULAR AND CELLULAR BIOLOGY

Celecoxib pathways

(2012) Li Gong et al.   Pharmacogenetics and Genomics

Suppression of the Nrf2-Dependent Antioxidant Response by Glucocorticoids and 11β-HSD1-Mediated Glucocorticoid Activation in Hepatic Cells

(2012) Denise V. Kratschmar et al.   PLoS One

Desipramine Protects Neuronal Cell Death and Induces Heme Oxygenase-1 Expression in Mes23.5 Dopaminergic Neurons

(2012) Hsiao-Yun Lin et al.   PLoS One

The Anti-Inflammatory Effects of Dimethyl Fumarate in Astrocytes Involve Glutathione and Haem Oxygenase-1

(2011) Shao Xia Lin et al.   ASN Neuro

A novel strategy to activate cytoprotective genes in the injured brain

(2011) Jing Zhao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway

(2011) Ralf A. Linker et al.   BRAIN

Modification of Keap1 Cysteine Residues by Sulforaphane

(2011) Chenqi Hu et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Ameliorative effect of caffeic acid against inflammatory pain in rodents

(2011) Anurag Mehrotra et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Peptide inhibitors of the Keap1–Nrf2 protein–protein interaction

(2011) Rowena Hancock et al.   FREE RADICAL BIOLOGY AND MEDICINE

Histone deacetylase inhibition activates transcription factor Nrf2 and protects against cerebral ischemic damage

(2011) Bing Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution

(2011) Keiko Taguchi et al.   GENES TO CELLS

Rapid non-genomic effects of corticosteroids and their role in the central stress response

(2011) Femke L Groeneweg et al.   JOURNAL OF ENDOCRINOLOGY

Fumarates improve psoriasis and multiple sclerosis by inducing type II dendritic cells

(2011) Kamran Ghoreschi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Novel Chalcone Derivatives as Potent Nrf2 Activators in Mice and Human Lung Epithelial Cells

(2011) Vineet Kumar et al.   JOURNAL OF MEDICINAL CHEMISTRY

Peripheral reduction of β-amyloid is sufficient to reduce brain β-amyloid: Implications for Alzheimer's disease

(2011) J. Gregor Sutcliffe et al.   JOURNAL OF NEUROSCIENCE RESEARCH

NSAIDs inhibit neovascularization of choroid through HO-1-dependent pathway

(2011) Narimasa Yoshinaga et al.   LABORATORY INVESTIGATION

When antioxidants are bad

(2011) Rushika M. Perera et al.   NATURE

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

(2011) Gina M. DeNicola et al.   NATURE

NF-κB controls energy homeostasis and metabolic adaptation by upregulating mitochondrial respiration

(2011) Claudio Mauro et al.   NATURE CELL BIOLOGY

Bardoxolone Methyl and Kidney Function in CKD with Type 2 Diabetes

(2011) Pablo E. Pergola et al.   NEW ENGLAND JOURNAL OF MEDICINE

Maps and legends: The quest for dissociated ligands of the glucocorticoid receptor

(2011) Andrew R. Clark et al.   PHARMACOLOGY & THERAPEUTICS

Efficacy of Fumaric Acid Esters in the R6/2 and YAC128 Models of Huntington's Disease

(2011) Gisa Ellrichmann et al.   PLoS One

Proteomic Analysis Shows Synthetic Oleanane Triterpenoid Binds to mTOR

(2011) Mark M. Yore et al.   PLoS One

Targeting Nrf2 Signaling Improves Bacterial Clearance by Alveolar Macrophages in Patients with COPD and in a Mouse Model

(2011) C. J. Harvey et al.   Science Translational Medicine

Regulation of NF-E2-Related Factor 2 Signaling for Cancer Chemoprevention: Antioxidant Coupled with Antiinflammatory

(2010) Rong Hu et al.   ANTIOXIDANTS & REDOX SIGNALING

Cancer Chemoprevention Mechanisms Mediated Through the Keap1–Nrf2 Pathway

(2010) John D. Hayes et al.   ANTIOXIDANTS & REDOX SIGNALING

Discovery of the Negative Regulator of Nrf2, Keap1: A Historical Overview

(2010) Ken Itoh et al.   ANTIOXIDANTS & REDOX SIGNALING

Nrf2 deficiency influences susceptibility to steroid resistance via HDAC2 reduction

(2010) David Adenuga et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Pharmacokinetics of Oltipraz and Its Major Metabolite (RM) in Patients With Liver Fibrosis or Cirrhosis: Relationship With Suppression of Circulating TGF-β1

(2010) S G Kim et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Auranofin, a Gold(I)-Containing Antirheumatic Compound, Activates Keap1/Nrf2 Signaling via Rac1/iNOS Signal and Mitogen-Activated Protein Kinase Activation

(2010) Nam-Hoon Kim et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

A Noncanonical Mechanism of Nrf2 Activation by Autophagy Deficiency: Direct Interaction between Keap1 and p62

(2010) A. Lau et al.   MOLECULAR AND CELLULAR BIOLOGY

Omega-3 fatty acid oxidation products prevent vascular endothelial cell activation by coplanar polychlorinated biphenyls

(2010) Zuzana Majkova et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Nrf2: friend or foe for chemoprevention?

(2009) T. W. Kensler et al.   CARCINOGENESIS

Nrf2 Enhances Cell Proliferation and Resistance to Anticancer Drugs in Human Lung Cancer

(2009) S. Homma et al.   CLINICAL CANCER RESEARCH

The Nrf2-Antioxidant Response Element Signaling Pathway and Its Activation by Oxidative Stress

(2009) Truyen Nguyen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Guardian Recruits Cops: The p53-p21 Axis Delegates Prosurvival Duties to the Keap1-Nrf2 Stress Pathway

(2009) Michel B. Toledano   MOLECULAR CELL

Anti-Inflammatory and Proresolving Lipid Mediators

(2008) Charles N. Serhan et al.   Annual Review of Pathology-Mechanisms of Disease

Two-Step Mechanism of Induction of the Gene Expression of a Prototypic Cancer-Protective Enzyme by Diphenols

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Oral sulforaphane increases Phase II antioxidant enzymes in the human upper airway

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Redox-based regulation of signal transduction: Principles, pitfalls, and promises

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Sulforaphane targets pancreatic tumour-initiating cells by NF- B-induced antiapoptotic signalling

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Inhibition of glycogen synthase kinase by curcumin: Investigation by simulated molecular docking and subsequentin vitro/in vivoevaluation

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Carnosic acid, acatechol-typeelectrophilic compound, protects neurons bothin vitroandin vivothrough activation of the Keap1/Nrf2 pathway viaS-alkylation of targeted cysteines on Keap1

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