Journal
INFLAMMATION
Volume 39, Issue 1, Pages 138-147Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10753-015-0232-z
Keywords
apigenin; LPS; pro-inflammatory mediators; AP-1 factors; A549
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Funding
- University Grant Commission-Centre with Potential for Excellence in Particular Area (UGC-CPEPA) [8-2/2008(NS/PE)]
- Department of Science and Technology-Promotion of University Research and Scientific Excellence (DST-PURSE), New Delhi [SR/59/Z-23/2010/38 (c)]
- University Grant Commission-Basic Scientific Research (UGC-BSR), New Delhi
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Apigenin is one of the plant flavonoids present in fruits and vegetables, acting as an important nutraceutical component. It is recognized as a potential antioxidant, antimicrobial, and anti-inflammatory molecule. In the present study, the mechanism of anti-inflammatory action of apigenin on lipopolysaccharide (LPS)-induced pro-inflammatory cytokines and activator protein-1 (AP-1) factors in human lung A549 cells was investigated. The antiaEuroinflammatory activity of apigenin on LPS-induced inflammation was determined by analyzing the expression of pro-inflammatory cytokines, nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and different AP-1 factors. Apigenin significantly inhibited the LPS-induced expression of iNOS, COX-2, expression of pro-inflammatory cytokines (IL-1 beta, IL-2, IL-6, IL-8, and TNF-alpha), and AP-1 proteins (c-Jun, c-Fos, and JunB) including nitric oxide production. Study confirms the anti-inflammatory effect of apigenin by inhibiting the expression of inflammatory mediators and AP-1 factors involved in the inflammation and its importance in the treatment of lung inflammatory diseases.
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