Article
Nutrition & Dietetics
Chia-Ling Ho, Ning-Jo Kao, Ching- Lin, Tzu-Wen L. Cross, Shyh-Hsiang Lin
Summary: Alzheimer's disease is a common neurodegenerative disorder, with oxidative stress and mitochondrial biogenesis being implicated in its progression. Quercetin has been found to increase mitochondrial biogenesis and reduce oxidative stress-induced damage, showing promise in protecting neuronal cells.
Review
Plant Sciences
Narges Marefati, Vahideh Ghorani, Farzaneh Shakeri, Marzie Boskabady, Farzaneh Kianian, Ramin Rezaee, Mohammad Hosein Boskabady
Summary: Onion and its derivatives possess anti-inflammatory, antioxidant, and immunomodulatory effects, indicating their therapeutic value in treating diseases associated with oxidative stress, inflammation, and immune dysregulation.
PHARMACEUTICAL BIOLOGY
(2021)
Article
Plant Sciences
Rahmatullah Jan, Nari Kim, Seo-Ho Lee, Muhammad Aaqil Khan, Sajjad Asaf, Lubna, Jae-Ryoung Park, Saleem Asif, In-Jung Lee, Kyung-Min Kim
Summary: The study demonstrates that increased accumulation of flavonoids can enhance the tolerance of rice plants to combined salt and heat stress by regulating physiological, biochemical, and molecular mechanisms.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Immunology
Shun Wang, Xiaodi Jin, Hao Chen, Mingdong Han, Jiaxin Bao, Dong Niu, Yikang Wang, Rui Li, Zhiyong Wu, Jichang Li
Summary: In this study, a network pharmacological method was used to screen the active components of a traditional Chinese herbal remedy for treating chronic respiratory disease caused by Mycoplasma gallisepticum in chickens. The study focused on the mechanism of action of one of the screened components, quercetin. The results showed that quercetin played an essential role in attenuating MG-induced oxidative stress and activation of the TLR2/MyD88/NF-Kappa B pathway. Furthermore, it suppressed the inflammatory response by regulating the expression of cytokines. This study provides a strong rationale for using quercetin as a therapeutic strategy to inhibit MG infection-induced inflammatory damage and oxidative stress.
MICROBIAL PATHOGENESIS
(2023)
Article
Medicine, Research & Experimental
Shu-Huei Wang, Feng-Chiao Tsai, Heng-Huei Lin, Tse-Ya Yu, Chun-Heng Kuo, Hung-Yuan Li, Mao-Shin Lin
Summary: Oxidative stress plays a crucial role in the development of atherosclerosis and non-alcoholic fatty liver disease. Monoamine oxidase is a major source of oxidative stress in the vascular system and liver. Inhibition of monoamine oxidase B shows potential as a novel treatment for atherosclerosis and NAFLD.
Article
Pharmacology & Pharmacy
Janaine P. Oliveira, Fabiula F. Abreu, Jose Marcos M. Bispo, Anderson R. A. Cerqueira, Jose Ronaldo dos Santos, Cristiane B. B. Correa, Soraia K. P. Costa, Enilton A. A. Camargo
Summary: This study evaluated the effect of myrtenol on orofacial pain and inflammation. The results showed that myrtenol can alleviate orofacial pain and inflammation and is associated with the modulation of IL-1β levels in the trigeminal pathway and p38-MAPK in the trigeminal ganglia.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Miyuki Takashima, Christian Lalonde, Laura Ashley Olszanski, Feng-Qi Zhao
Summary: The study identified strong inflammatory responses and oxidative stress in mammary glands following endotoxin challenge, along with decreased metabolic processes. Various cytokines showed increased levels post-LPS treatment, providing potential markers for prevention and treatment of gram-negative bacteria-induced mastitis.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Chemistry, Applied
Marilia F. Manchope, Sandra S. Mizokami, Camila R. Ferraz, Sergio M. Borghi, Josiane A. Vignoli, Doumit Camilios-Neto, Nilton S. Arakawa, Sandra R. Georgetti, Waldiceu A. Verri, Rubia Casagrande
Summary: This study demonstrated the analgesic effect of the dried extract of the Brazilian native plant Pimenta pseudocaryophyllus in various models of inflammatory pain, and indicated that the mechanism of action may involve inhibiting neutrophil recruitment, oxidative stress, and cytokine production.
NATURAL PRODUCT RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Yijing Liao, Xi Mai, Xiaqing Wu, Xing Hu, Xiaoqiao Luo, Guowen Zhang
Summary: This study investigated the inhibitory mechanism of quercetin in acetylcholinesterase (AChE) and its neuroprotective effects on beta-amyloid(25-35)-induced oxidative stress injury in PC12 cells. Quercetin inhibited AChE in a reversible mixed manner and formed a stable complex through hydrogen bonding and van der Waals forces. Computational docking and molecular dynamics simulation confirmed the stability and mechanism of the quercetin-AChE complex. Quercetin exhibited neuroprotective effects by increasing glutathione level and reducing malondialdehyde content and reactive oxygen species levels. The combination of galantamine hydrobromide and quercetin showed synergistic inhibition effects. These findings provide insights into the development and application of quercetin in the dietary treatment of Alzheimer's disease.
Article
Medicine, Research & Experimental
Amira A. Sallam, Mohammed A. El-Magd, Mona M. Ahmed, Heba I. Ghamry, Mohammad Y. Alshahrani, Rabab A. Hegazy, Ahmed Magdy, Magdy F. Abou El-Fotoh
Summary: The study found that quercetin can alleviate neurotoxicity induced by multi-walled carbon nanotubes. This effect is achieved through antioxidant, anti-inflammatory, and antipyroptotic mechanisms.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Amira A. Sallam, Mona M. Ahmed, Mohammed A. El-Magd, Ahmed Magdy, Heba Ghamry, Mohammad Y. Alshahrani, Magdy F. Abou El-Fotoh
Summary: This study demonstrates that quercetin has protective effects against the immunotoxic, inflammatory, and oxidative effects caused by carbon nanotubes.
Article
Chemistry, Multidisciplinary
Sanchaita Mondal, Sujata Das, Pradip Kumar Mahapatra, Krishna Das Saha
Summary: In this study, we investigated the effectiveness of morin encapsulated chitosan nanoparticles (MCNPs) against arsenic induced liver damage in mice. The results showed that MCNPs significantly reduced the liver function indicators, improved hematological and serum biochemical parameters, and decreased arsenic deposition in mice treated with arsenic. In addition, MCNPs demonstrated antioxidant, antiapoptotic, and anti-inflammatory effects.
NANOSCALE ADVANCES
(2022)
Article
Biochemistry & Molecular Biology
Ivana F. Rosa, Ana P. B. Pecanha, Tabata R. B. Carvalho, Leonardo S. Alexandre, Vinicius G. Ferreira, Lucas B. Doretto, Beatriz M. Souza, Rafael T. Nakajima, Patrick da Silva, Ana P. Barbosa, Leticia Gomes-de-Pontes, Camila G. Bomfim, Glaucia M. Machado-Santelli, Antonio Condino-Neto, Cristiane R. Guzzo, Jean P. S. Peron, Magaiver Andrade-Silva, Niels O. S. Camara, Anali M. B. Garnique, Renata J. Medeiros, Fausto K. Ferraris, Leonardo J. G. Barcellos, Jose D. Correia-Junior, Jorge Galindo-Villegas, Monica F. R. Machado, Angela Castoldi, Susana L. Oliveira, Camila C. Costa, Marco A. A. Belo, Giovane Galdino, German G. Sgro, Natalia F. Bueno, Silas F. Eto, Flavio P. Veras, Bianca H. V. Fernandes, Paulo R. S. Sanches, Eduardo M. Cilli, Guilherme Malafaia, Rafael H. Nobrega, Aguinaldo S. Garcez, Emanuel Carrilho, Ives Charlie-Silva
Summary: The study investigates the potential effect of red photobiomodulation (PBM) as a therapy for COVID-19. The findings suggest that inflammation is a significant feature of the disease, and PBM can help regulate the inflammatory response. Metabolomics analysis also reveals shared impacts on metabolic pathways between PBM and COVID-19.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Lisa Schindler, Leon C. D. Smyth, Juergen Bernhagen, Mark B. Hampton, Nina Dickerhof
Summary: The study demonstrates that MIF plays a role in potentiating HOCl production in neutrophils in response to phagocytic stimuli, contributing to mediating the inflammatory response and enhancing host defense.
Article
Chemistry, Multidisciplinary
Qiming Pang, Cui Wang, Bangtao Li, Suli Zhang, Jiaoyang Li, Shuo Gu, Xueyu Shi
Summary: This study evaluated the effects of resveratrol loaded in copolymer nanoparticles on cerebral ischemia/reperfusion (I/R) injury in rats. The results showed that RES.CP.NPs could have neuroprotective effects through their antioxidant and anti-inflammatory activities, leading to improved neurological disability scores and decreased oxidative stress levels.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
Article
Immunology
Thaiane Pinto Moreira, Carla Daiane Ferreira de Sousa, Victor Rodrigues de Melo Costa, Celso Martins Queiroz-Junior, Franciele Martins Santos, Caio Santos Bonilha, Lisia Maria Esper, Mauricio Lacerda Nogueira, Thiago Mattar Cunha, Mauro Martins Teixeira, Vivian Vasconcelos Costa, Daniele da Gloria de Souza
Summary: This study describes a novel mouse model of CHIKV infection and evaluates the role of tumour necrosis factor in the disease's pathogenesis. It shows that TNF plays a dual role in viral clearance and driving tissue damage and hypernociception. Therefore, TNF inhibitors may have therapeutic benefits, but viral levels must be monitored and used in combination with antiviral drugs when treating CHIKV-infected patients.
Article
Cell Biology
Vanessa de Fatima Borges, Leticia Selinger Galant, Alexandre Kanashiro, Fernanda Vargas e Silva Castanheira, Valter Vinicius Silva Monteiro, Diego angelo Duarte, Filipe Camargo Rodrigues, Camila Meirelles de Souza Silva, Ayda Henriques Schneider, Guilherme Cesar Martelossi Cebinelli, Mikhael Haruo Fernandes de Lima, Joao Paulo de Biaso Viola, Thiago Mattar Cunha, Claudio Miguel da Costa Neto, Jose Carlos Farias Alves-Filho, Andre Sampaio Pupo, Fernando de Queiroz Cunha
Summary: This study investigated the effects of FK506 on sepsis immunopathology and found that FK506 treatment resulted in failed neutrophil migration, leading to increased bacteremia and systemic inflammatory response, causing higher organ damage and mortality rates.
INFLAMMATION RESEARCH
(2023)
Article
Public, Environmental & Occupational Health
Rafaela Pires Erthal, Glaucia Eloisa Munhoz de Lion Siervo, Giovanna Fachetti Frigoli, Tiago Henrique Zaninelli, Waldiceu Aparecido Verri, Glaura Scantamburlo Alves Fernandes
Summary: This study found that low doses of malathion can impair sperm quality and function by downregulating gene expression, and can also damage the sperm's antioxidant profile during critical periods of development.
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
(2023)
Review
Pharmacology & Pharmacy
Sergio M. Borghi, Tiago H. Zaninelli, Jessica B. Carra, Olivia K. Heintz, Marcela M. Baracat, Sandra R. Georgetti, Fabiana T. M. C. Vicentini, Waldiceu A. Verri, Rubia Casagrande
Summary: Asthma is a chronic disease characterized by allergic inflammatory reactions. Current treatment options have limitations and can have adverse effects, leading to poor management of the disease. Flavonoids, with their antioxidant and anti-inflammatory properties, have shown potential benefits for asthma treatment.
Article
Cell Biology
N. B. Amaral, T. S. Rodrigues, M. C. Giannini, M. I. Lopes, L. P. Bonjorno, P. I. S. O. Menezes, S. M. Dib, S. L. G. Gigante, M. N. Benatti, U. C. Rezek, L. L. Emrich-Filho, B. A. Sousa, S. C. L. Almeida, R. Luppino-Assad, F. P. Veras, A. H. Schneider, L. O. S. Leiria, L. D. Cunha, J. C. Alves-Filho, T. M. Cunha, E. Arruda, C. H. Miranda, A. Pazin-Filho, M. Auxiliadora-Martins, M. C. Borges, B. A. L. Fonseca, V. R. Bollela, C. M. Del-Ben, F. Q. Cunha, R. C. Santana, F. C. Vilar, D. S. Zamboni, P. Louzada-Junior, R. D. R. Oliveira
Summary: This study evaluated whether colchicine treatment was associated with the inhibition of NLRP3 inflammasome activation in patients with COVID-19. The results showed that colchicine reduced the need for supplemental oxygen and the length of hospitalization, and lowered the serum levels of Casp1p20 and IL-18 in the first two days of treatment.
INFLAMMATION RESEARCH
(2023)
Article
Immunology
Tamara S. Rodrigues, Camila C. S. Caetano, Keyla S. G. de Sa, Leticia Almeida, Amanda Becerra, Augusto Goncalves, Leticia de Sousa Lopes, Samuel Oliveira, Danielle P. A. Mascarenhas, Sabrina S. Batah, Bruna M. Silva, Giovanni F. Gomes, Ricardo Castro, Ronaldo B. Martins, Jonathan Avila, Fabiani G. Frantz, Thiago M. Cunha, Eurico Arruda, Fernando Q. Cunha, Helder Nakaya, Larissa D. Cunha, Alexandre T. Fabro, Paulo Louzada-Junior, Rene D. R. de Oliveira, Dario S. Zamboni
Summary: SARS-CoV-2 infection activates the NLRP3 inflammasome and leads to inflammation and severe COVID-19. Human caspase-4 (mouse caspase-11) is upregulated and activated by SARS-CoV-2, contributing to NLRP3 activation. In vivo studies using transgenic hACE2 humanized mice show that hACE2 Casp11(-/-) mice are protected from disease development, with reduced lung damage, clinical symptoms, and mortality. Analysis of human samples from fatal COVID-19 cases reveals the expression of CASP4 in patient lungs, which correlates with inflammasome components and inflammatory mediators. These findings suggest CASP4/11 as a potential target for therapeutic interventions in COVID-19.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Biochemistry & Molecular Biology
Cristina P. B. Melo, Priscila Saito, Renata M. M. Martinez, Larissa Staurengo-Ferrari, Ingrid C. C. Pinto, Camilla C. A. Rodrigues, Stephanie Badaro-Garcia, Josiane A. A. Vignoli, Marcela M. M. Baracat, Allan J. C. Bussmann, Sandra R. R. Georgetti, Waldiceu A. A. Verri, Rubia Casagrande
Summary: This study investigates the protective effect of AT-RvD1 on UVB-induced inflammation and oxidative stress in hairless mice. The results show that AT-RvD1 can restrict various inflammatory and oxidative stress markers and restore the skin's natural antioxidant defense. AT-RvD1 achieves this by upregulating the Nrf2 pathway and promoting the expression of ARE genes.
Article
Cell Biology
Carina Z. Segato-Vendrameto, Camila Zanluca, Amanda Z. Zucoloto, Tiago H. Zaninelli, Mariana M. Bertozzi, Telma Saraiva-Santos, Camila R. Ferraz, Larissa Staurengo-Ferrari, Stephanie Badaro-Garcia, Marilia F. Manchope, Amanda M. Dionisio, Felipe A. Pinho-Ribeiro, Sergio M. Borghi, Ana Luiza Pamplona Mosimann, Rubia Casagrande, Juliano Bordignon, Victor Fattori, Claudia N. Duarte dos Santos, Waldiceu A. Verri
Summary: This article investigates therapeutic strategies against Chikungunya virus, finding that inhibiting viral proteins and using recombinant antibodies can alleviate virus-induced pain symptoms.
Article
Chemistry, Medicinal
Tiago H. Zaninelli, Sandra S. Mizokami, Mariana M. Bertozzi, Telma Saraiva-Santos, Felipe A. Pinho-Ribeiro, Gabriele Inacio de Oliveira, Renata Streck, Eduardo J. A. Araujo, Nilton S. Arakawa, Sergio M. Borghi, Rubia Casagrande, Waldiceu A. Verri
Summary: In this study, it was found that kaurenoic acid (KA), extracted from Sphagneticola trilobata, has analgesic properties and can be used for the treatment of neuropathic pain. KA inhibits neuropathic pain induced by chronic constriction injury (CCI) by activating the NO/cGMP/PKG/ATP-sensitive potassium channel signaling pathway. KA also reduces activation of sensory neurons and increases the levels of neuronal nitric oxide synthase (nNOS) and nitric oxide (NO) in dorsal root ganglion (DRG) neurons. These findings suggest that KA inhibits CCI neuropathic pain by activating the nNOS-NO pathway to silence nociceptive signaling.
Article
Biotechnology & Applied Microbiology
Marilia F. Manchope, Mariana M. Bertozzi, Sergio M. Borghi, Cintia L. Handa, Mariana A. Queiroz-Cancian, Camila R. Ferraz, Sandra S. Mizokami, Stephanie Badaro-Garcia, Ketlem C. Andrade, Tiago H. Zaninelli, Wilma A. Spinosa, Sandra R. Georgetti, Elza I. Ida, Waldiceu A. Verri, Rubia Casagrande
Summary: This study evaluates the biological activity of fermented and non-fermented defatted soybean flour (DSF) extracts in pain and inflammation. The results demonstrate that both fermented and non-fermented DSF extracts have analgesic and anti-inflammatory effects, with differences in the mechanism of action depending on the fungi used for fermentation.
FERMENTATION-BASEL
(2023)
Review
Biochemistry & Molecular Biology
Fernanda S. S. Rasquel-Oliveira, Matheus Deroco Veloso da Silva, Geovana Martelossi-Cebinelli, Victor Fattori, Rubia Casagrande, Waldiceu A. A. Verri Jr
Summary: During infection, inflammation can be harmful when it becomes excessive or chronic. Specialized pro-resolving lipid mediators (SPMs), derived from omega-3 and -6 polyunsaturated fatty acids, play a crucial role in resolving inflammation and promoting a coordinated immune response against pathogens. SPMs regulate leukocyte influx, reduce cytokine and chemokine levels, enhance bacterial clearance, inhibit viral replication, stimulate tissue healing, and decrease antibiotic requirements. Understanding the biosynthesis and effects of SPMs in different infections could have important implications for developing new therapeutic strategies.
Article
Microbiology
Vera Lucia Hideko Tatakihara, Aparecida Donizette Malvezi, Rito Santo Pereira, Bruno Fernando Cruz Lucchetti, Lucas Felipe Dos Santos, Rubens Cecchini, Lucy Megumi Yamauchi, Sueli Fumie Yamada-Ogatta, Katrina M. Miranda, Waldiceu A. Verri, Marli Cardoso Martins-Pinge, Phileno Pinge-Filho
Summary: This study found that a nitric oxide donor called Angeli's salt (AS) can reduce the number of parasites and the severity of Chagas disease in mice. In addition, AS treatment can enhance the antioxidant capacity of infected animals' red blood cells. These results suggest that AS could be a promising therapy for Chagas disease.
Article
Agriculture, Dairy & Animal Science
Suellen Miguez Gonzalez, Marcela Bortoletto Cerezetti, Larissa Zamparone Bergamo, Camila Rodrigues Ferraz, Waldiceu Aparecido Verri Jr, Marcelo Marcondes Seneda
Summary: The aim of this study was to evaluate oxidative stress in ovaries and corpus luteum (CL) of Bos taurus indicus females and the oxidant effect of CL in ovarian tissues. The results showed that luteal tissues had higher antioxidant activity than ovarian tissues, and there was no difference in antioxidant activity and oxidative stress between ovarian fragments obtained from different regions (with or without CL). The presence of CL in the ovaries did not influence oxidative stress or antioxidant potential.
ANIMAL REPRODUCTION
(2023)
Article
Respiratory System
Flavio P. Veras, Giovanni F. Gomes, Bruna M. S. Silva, Diego B. Caetite, Cicero J. L. R. Almeida, Camila Meirelles S. Silva, Ayda H. Schneider, Emily S. Corneo, Caio S. Bonilha, Sabrina S. Batah, Ronaldo Martins, Eurico Arruda, Alexandre T. Fabro, Jose C. Alves-Filho, Thiago M. Cunha, Fernando Q. Cunha
Summary: COVID-19 is characterized by severe lung injury due to neutrophil infiltration and release of neutrophil extracellular traps (NETs). This study demonstrates that treatment with DNase I, which degrades NETs, improves clinical symptoms and reduces lung, heart, and kidney injuries in a COVID-19 mouse model.
RESPIRATORY RESEARCH
(2023)