Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation

Evolutionary Convergence of Pathway-Specific Enzyme Expression Stoichiometry

(2018) Jean-Benoît Lalanne et al.   CELL

Deciphering synergistic regulatory networks of microRNAs in hESCs and fibroblasts

(2018) Mousumi Sahu et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

miRNA targeting and alternative splicing in the stress response – events hosted by membrane-less compartments

(2018) Mariya M. Kucherenko et al.   JOURNAL OF CELL SCIENCE

Oncogenic role of microRNA-532‑5p in human colorectal cancer via targeting of the 5'UTR of RUNX3

(2018) Jiantao Zhang et al.   Oncology Letters

Exosomes from human umbilical cord blood accelerate cutaneous wound healing through miR-21-3p-mediated promotion of angiogenesis and fibroblast function

(2018) Yin Hu et al.   Theranostics

MicroRNAs: crucial regulators of placental development

(2018) Heyam Hayder et al.   REPRODUCTION

Alternative Polyadenylation Directs Tissue-Specific miRNA Targeting inCaenorhabditis elegansSomatic Tissues

(2017) Stephen M. Blazie et al.   GENETICS

Interplay between miRNAs and human diseases

(2017) Prosenjit Paul et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Exosomes derived from gemcitabine-resistant cells transfer malignant phenotypic traits via delivery of miRNA-222-3p

(2017) Feng Wei et al.   Molecular Cancer

Multivalent Recruitment of Human Argonaute by GW182

(2017) Elad Elkayam et al.   MOLECULAR CELL

An integrated expression atlas of miRNAs and their promoters in human and mouse

(2017) Derek de Rie et al.   NATURE BIOTECHNOLOGY

miRTarBase update 2018: a resource for experimentally validated microRNA-target interactions

(2017) Chih-Hung Chou et al.   NUCLEIC ACIDS RESEARCH

MicroRNAs and miRceptors: a new mechanism of action for intercellular communication

(2017) Muller Fabbri   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

VAMP3 and SNAP23 mediate the disturbed flow-induced endothelial microRNA secretion and smooth muscle hyperplasia

(2017) Juan-Juan Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activity-dependent spatially localized miRNA maturation in neuronal dendrites

(2017) Sivakumar Sambandan et al.   SCIENCE

The circular RNA circBIRC6 participates in the molecular circuitry controlling human pluripotency

(2017) Chun-Ying Yu et al.   Nature Communications

Post-transcriptional gene silencing mediated by microRNAs is controlled by nucleoplasmic Sfpq

(2017) Silvia Bottini et al.   Nature Communications

MicroRNA exocytosis by large dense-core vesicle fusion

(2017) Alican Gümürdü et al.   Scientific Reports

Resolving Subcellular miRNA Trafficking and Turnover at Single-Molecule Resolution

(2017) Sethuramasundaram Pitchiaya et al.   Cell Reports

Alternative Polyadenylation Directs Tissue-Specific miRNA Targeting inCaenorhabditis elegansSomatic Tissues

(2017) Stephen M. Blazie et al.   GENETICS

Synergic Functions of miRNAs Determine Neuronal Fate of Adult Neural Stem Cells

(2017) Meritxell Pons-Espinal et al.   Stem Cell Reports

Identification of miRNA Changes in Alzheimer's Disease Brain and CSF Yields Putative Biomarkers and Insights into Disease Pathways

(2017) John P. Cogswell et al.   JOURNAL OF ALZHEIMERS DISEASE

Dissecting miRNA gene repression on single cell level with an advanced fluorescent reporter system

(2017) Nicolas Lemus-Diaz et al.   Scientific Reports

Dynamic and Modularized MicroRNA Regulation and Its Implication in Human Cancers

(2017) Jiang Shu et al.   Scientific Reports

A dual inhibition: microRNA-552 suppresses both transcription and translation of cytochrome P450 2E1

(2016) Lingling Miao et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Evidence and potential in vivo functions for biofluid miRNAs: From expression profiling to functional testing

(2016) Hina Iftikhar et al.   BIOESSAYS

Circular RNAs: analysis, expression and potential functions

(2016) Steven P. Barrett et al.   DEVELOPMENT

Spatiotemporal Uncoupling of MicroRNA-Mediated Translational Repression and Target RNA Degradation Controls MicroRNP Recycling in Mammalian Cells

(2016) Mainak Bose et al.   MOLECULAR AND CELLULAR BIOLOGY

Impact of MicroRNA Levels, Target-Site Complementarity, and Cooperativity on Competing Endogenous RNA-Regulated Gene Expression

(2016) Rémy Denzler et al.   MOLECULAR CELL

A Specialized Mechanism of Translation Mediated by FXR1a-Associated MicroRNP in Cellular Quiescence

(2016) Syed I.A. Bukhari et al.   MOLECULAR CELL

Pairing beyond the Seed Supports MicroRNA Targeting Specificity

(2016) James P. Broughton et al.   MOLECULAR CELL

Understanding microRNA-mediated gene regulatory networks through mathematical modelling

(2016) Xin Lai et al.   NUCLEIC ACIDS RESEARCH

Intracellular and extracellular microRNA: An update on localization and biological role

(2016) Julia A. Makarova et al.   PROGRESS IN HISTOCHEMISTRY AND CYTOCHEMISTRY

MicroRNAs activate gene transcription epigenetically as an enhancer trigger

(2016) Min Xiao et al.   RNA Biology

Principles and Properties of Stress Granules

(2016) David S.W. Protter et al.   TRENDS IN CELL BIOLOGY

Target-dependent biogenesis of cognate microRNAs in human cells

(2016) Mainak Bose et al.   Nature Communications

Exosomal microRNA miR-1246 induces cell motility and invasion through the regulation of DENND2D in oral squamous cell carcinoma

(2016) Sujata Sakha et al.   Scientific Reports

mRNA Targeting to Endoplasmic Reticulum Precedes Ago Protein Interaction and MicroRNA (miRNA)-mediated Translation Repression in Mammalian Cells

(2015) Bahnisikha Barman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MicroRNA as Biomarkers and Diagnostics

(2015) Jin Wang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Exosome-mediated microRNA signaling from breast cancer cells is altered by the anti-angiogenesis agent docosahexaenoic acid (DHA)

(2015) Bethany N. Hannafon et al.   Molecular Cancer

Human Argonaute 2 Has Diverse Reaction Pathways on Target RNAs

(2015) Myung Hyun Jo et al.   MOLECULAR CELL

N6-methyladenosine marks primary microRNAs for processing

(2015) Claudio R. Alarcón et al.   NATURE

Towards a molecular understanding of microRNA-mediated gene silencing

(2015) Stefanie Jonas et al.   NATURE REVIEWS GENETICS

From guide to target: molecular insights into eukaryotic RNA-interference machinery

(2015) Jonathan J Ipsaro et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Control of the localization and function of a miRNA silencing component TNRC6A by Argonaute protein

(2015) Kenji Nishi et al.   NUCLEIC ACIDS RESEARCH

MicroRNA control of protein expression noise

(2015) J. M. Schmiedel et al.   SCIENCE

From guide to target: molecular insights into eukaryotic RNA-interference machinery

(2015) Jonathan J Ipsaro et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Regulation of miRNA strand selection: follow the leader?

(2014) Hedda A. Meijer et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Mirsynergy: detecting synergistic miRNA regulatory modules by overlapping neighbourhood expansion

(2014) Yue Li et al.   BIOINFORMATICS

Identifying microRNA targets in different gene regions

(2014) Wenlong Xu et al.   BMC BIOINFORMATICS

Cancer-Secreted miR-105 Destroys Vascular Endothelial Barriers to Promote Metastasis

(2014) Weiying Zhou et al.   CANCER CELL

MicroRNA Directly Enhances Mitochondrial Translation during Muscle Differentiation

(2014) Xiaorong Zhang et al.   CELL

Exosome Uptake through Clathrin-mediated Endocytosis and Macropinocytosis and Mediating miR-21 Delivery

(2014) Tian Tian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mammalian microtubule P-body dynamics are mediated by nesprin-1

(2014) Dipen Rajgor et al.   JOURNAL OF CELL BIOLOGY

Circulating microRNAs as markers of liver inflammation, fibrosis and cancer

(2014) Christoph Roderburg et al.   JOURNAL OF HEPATOLOGY

Global Analyses of the Effect of Different Cellular Contexts on MicroRNA Targeting

(2014) Jin-Wu Nam et al.   MOLECULAR CELL

Regulation of microRNA biogenesis

(2014) Minju Ha et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Argonaute-1 binds transcriptional enhancers and controls constitutive and alternative splicing in human cells

(2014) M. Allo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNAs in cancer: biomarkers, functions and therapy

(2014) Josie Hayes et al.   TRENDS IN MOLECULAR MEDICINE

The application of multiple miRNA response elements enables oncolytic adenoviruses to possess specificity to glioma cells

(2014) Weicheng Yao et al.   VIROLOGY

HDL-transferred microRNA-223 regulates ICAM-1 expression in endothelial cells

(2014) Fatiha Tabet et al.   Nature Communications

RNAi Factors Are Present and Active in Human Cell Nuclei

(2014) Keith T. Gagnon et al.   Cell Reports

Drosha Promotes Splicing of a Pre-microRNA-like Alternative Exon

(2014) Mallory A. Havens et al.   PLoS Genetics

Evidence for the biogenesis of more than 1,000 novel human microRNAs

(2014) Marc R Friedländer et al.   GENOME BIOLOGY

Competing endogenous RNAs (ceRNAs): new entrants to the intricacies of gene regulation

(2014) Reena V. Kartha et al.   Frontiers in Genetics

Mammalian 5′-Capped MicroRNA Precursors that Generate a Single MicroRNA

(2013) Mingyi Xie et al.   CELL

MicroRNAs in Human Placental Development and Pregnancy Complications

(2013) Guodong Fu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

MicroRNAs Transfer from Human Macrophages to Hepato-Carcinoma Cells and Inhibit Proliferation

(2013) A. Aucher et al.   JOURNAL OF IMMUNOLOGY

Structure of the PAN3 Pseudokinase Reveals the Basis for Interactions with the PAN2 Deadenylase and the GW182 Proteins

(2013) Mary Christie et al.   MOLECULAR CELL

MicroRNA miR-324-3p Induces Promoter-Mediated Expression of RelA Gene

(2013) Ashutosh Dharap et al.   PLoS One

miRNAs confer phenotypic robustness to gene networks by suppressing biological noise

(2013) Velia Siciliano et al.   Nature Communications

Roles for MicroRNAs in Conferring Robustness to Biological Processes

(2012) Margaret S. Ebert et al.   CELL

Argonaute Divides Its RNA Guide into Domains with Distinct Functions and RNA-Binding Properties

(2012) Liang Meng Wee et al.   CELL

Immune-related MicroRNAs are Abundant in Breast Milk Exosomes

(2012) Qi Zhou et al.   International Journal of Biological Sciences

Synaptosomes secrete and uptake functionally active microRNAs via exocytosis and endocytosis pathways

(2012) Jie Xu et al.   JOURNAL OF NEUROCHEMISTRY

Senescence is an endogenous trigger for microRNA-directed transcriptional gene silencing in human cells

(2012) Moussa Benhamed et al.   NATURE CELL BIOLOGY

An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration

(2012) Sabrina M Lehmann et al.   NATURE NEUROSCIENCE

A direct interaction between DCP1 and XRN1 couples mRNA decapping to 5′ exonucleolytic degradation

(2012) Joerg E Braun et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Majority of MicroRNAs Detectable in Serum and Saliva Is Concentrated in Exosomes

(2012) Alessia Gallo et al.   PLoS One

MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response

(2012) M. Fabbri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human TNRC6A is an Argonaute-navigator protein for microRNA-mediated gene silencing in the nucleus

(2012) K. Nishi et al.   RNA

Differential association of microRNAs with polysomes reflects distinct strengths of interactions with their mRNA targets

(2012) N. Molotski et al.   RNA

Extracellular miRNAs: the mystery of their origin and function

(2012) Andrey Turchinovich et al.   TRENDS IN BIOCHEMICAL SCIENCES

Secreted microRNAs: a new form of intercellular communication

(2012) Xi Chen et al.   TRENDS IN CELL BIOLOGY

MicroRNA-mediated mRNA Translation Activation in Quiescent Cells and Oocytes Involves Recruitment of a Nuclear microRNP

(2012) S. S. Truesdell et al.   Scientific Reports

The sufficient minimal set of miRNA seed types

(2011) Daniel C. Ellwanger et al.   BIOINFORMATICS

Cell-Secreted Vesicles in Equine Ovarian Follicular Fluid Contain miRNAs and Proteins: A Possible New Form of Cell Communication Within the Ovarian Follicle1

(2011) Juliano C. da Silveira et al.   BIOLOGY OF REPRODUCTION

Microtubule disruption targets HIF-1α mRNA to cytoplasmic P-bodies for translational repression

(2011) Marisa Carbonaro et al.   JOURNAL OF CELL BIOLOGY

Microvesicles secreted by macrophages shuttle invasion-potentiating microRNAs into breast cancer cells

(2011) Mei Yang et al.   Molecular Cancer

MicroRNA history: Discovery, recent applications, and next frontiers

(2011) Maria I. Almeida et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Chromatin-associated RNA interference components contribute to transcriptional regulation in Drosophila

(2011) Filippo M. Cernilogar et al.   NATURE

Global quantification of mammalian gene expression control

(2011) Björn Schwanhäusser et al.   NATURE

MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins

(2011) Kasey C. Vickers et al.   NATURE CELL BIOLOGY

Gene silencing by microRNAs: contributions of translational repression and mRNA decay

(2011) Eric Huntzinger et al.   NATURE REVIEWS GENETICS

Characterization of extracellular circulating microRNA

(2011) Andrey Turchinovich et al.   NUCLEIC ACIDS RESEARCH

Pre-microRNA and Mature microRNA in Human Mitochondria

(2011) Eric Barrey et al.   PLoS One

Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma

(2011) J. D. Arroyo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MiRNA-20a promotes osteogenic differentiation of human mesenchymal stem cells by co-regulating BMP signaling

(2011) Jin-fang Zhang et al.   RNA Biology

Posttranscriptional Upregulation by MicroRNAs

(2011) Shobha Vasudevan   Wiley Interdisciplinary Reviews-RNA

The MicroRNA Spectrum in 12 Body Fluids

(2010) J. A. Weber et al.   CLINICAL CHEMISTRY

Identification of homologous microRNAs in 56 animal genomes

(2010) Sung-Chou Li et al.   GENOMICS

Mechanisms of control of microRNA biogenesis

(2010) B. N. Davis et al.   JOURNAL OF BIOCHEMISTRY

Secretory Mechanisms and Intercellular Transfer of MicroRNAs in Living Cells

(2010) Nobuyoshi Kosaka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A dicer-independent miRNA biogenesis pathway that requires Ago catalysis

(2010) Sihem Cheloufi et al.   NATURE

Cell stress is related to re-localization of Argonaute 2 and to decreased RNA interference in human cells

(2010) Anke Detzer et al.   NUCLEIC ACIDS RESEARCH

Export of microRNAs and microRNA-protective protein by mammalian cells

(2010) Kai Wang et al.   NUCLEIC ACIDS RESEARCH

Multiple microRNAs modulate p21Cip1/Waf1 expression by directly targeting its 3′ untranslated region

(2010) S Wu et al.   ONCOGENE

Conserved vertebrate mir-451 provides a platform for Dicer-independent, Ago2-mediated microRNA biogenesis

(2010) J.-S. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Target RNA-Directed Trimming and Tailing of Small Silencing RNAs

(2010) S. L. Ameres et al.   SCIENCE

Making RISC

(2010) Tomoko Kawamata et al.   TRENDS IN BIOCHEMICAL SCIENCES

Multivesicular bodies associate with components of miRNA effector complexes and modulate miRNA activity

(2009) Derrick J. Gibbings et al.   NATURE CELL BIOLOGY

ATP-dependent human RISC assembly pathways

(2009) Mayuko Yoda et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A High-Resolution Structure of the Pre-microRNA Nuclear Export Machinery

(2009) C. Okada et al.   SCIENCE

Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases

(2008) Xi Chen et al.   CELL RESEARCH

Mouse ES cells express endogenous shRNAs, siRNAs, and other Microprocessor-independent, Dicer-dependent small RNAs

(2008) J. E. Babiarz et al.   GENES & DEVELOPMENT

MicroRNA-10a Binds the 5′UTR of Ribosomal Protein mRNAs and Enhances Their Translation

(2008) Ulf Andersson Ørom et al.   MOLECULAR CELL

A search for conserved sequences in coding regions reveals that the let-7 microRNA targets Dicer within its coding sequence

(2008) J. J. Forman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circulating microRNAs as stable blood-based markers for cancer detection

(2008) P. S. Mitchell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA