Article
Environmental Sciences
Yuyang Lei, Fangfang Li, Monika Mortimer, Zhi Li, Bi-Xia Peng, Minjie Li, Liang-Hong Guo, Guoqiang Zhuang
Summary: Antibiotics as emerging environmental contaminants have adverse effects on lipid metabolism, but the underlying toxicological mechanisms are still unclear.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Toxicology
Elvis Ticiani, Yong Pu, Madison White, Victoria Adomshick, Almudena Veiga-Lopez
Summary: Butyltins and phenyltins, widely used organometallic chemicals, have been found to stimulate adipogenic differentiation. Among them, tributyltin (TBT) is the most potent inducer, followed by triphenyltin (TPT) and dibutyltin (DBT). However, TPT and DBT can weaken the adipogenic effect of TBT. These findings indicate the antagonistic effects among organotins and the involvement of PPAR gamma signaling in their adipogenic outcomes.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Medicine, Research & Experimental
Renli Qi, Xu Han, Jing Wang, Xiaoyu Qiu, Qi Wang, Feiyun Yang
Summary: The study revealed that miR-489 is highly expressed in the fat tissue of mice, and its overexpression inhibits cell proliferation but promotes adipogenic differentiation and lipid accumulation. By targeting the Postn gene, miR-489 plays a crucial role in adipocyte differentiation and metabolism, which could potentially contribute to obesity treatment.
Article
Medicine, Research & Experimental
Phutthida Kongthitilerd, Elise Barras, Weiqiong Rong, Ansleigh Thibodeaux, Madison Rigdon, Shaomian Yao, Sirichai Adisakwattana, Tanyawan Suantawee, Henrique Cheng
Summary: The objective of this study was to elucidate the mechanism of cyanidin, the most abundant anthocyanin found in red-purple plants, in inhibiting adipocyte formation. The results demonstrated that cyanidin inhibits adipogenesis by activating the PLC-IP3 pathway and intracellular Ca2+ signaling. This study provides new insights into the anti-obesity effect of cyanidin.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Endocrinology & Metabolism
Viktoria B. Horvath, Eszter Soltesz-Katona, Eva Wisniewski, Aniko Rajki, Eszter Halasz, Balazs Enyedi, Laszlo Hunyady, Andras David Toth, Gergo Szanda
Summary: Lowering the expression level of G protein-coupled receptors can reduce proteasomal degradation and offer receptor levels comparable to endogenous CB1 receptors, thus minimizing potential signalling artefacts.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yifen Wang, Jie Zhang, Xueru Chu, Mengke Wang, Yongning Xin, Shousheng Liu
Summary: This study found that miR-146a-5p regulates the differentiation of 3T3-L1 cells by targeting the ErbB4 gene and modulating the ERK1/2/PPAR-gamma signaling pathway.
LIPIDS IN HEALTH AND DISEASE
(2022)
Article
Pharmacology & Pharmacy
Jamie J. Manning, Gabriel Rawcliffe, David B. Finlay, Michelle Glass
Summary: This study investigated the impact of phosphorylation modifications in a specific sequence of the CB1 receptor C-terminus on the translocation of Arrestin-2 and Arrestin-3. The results showed that these modifications partially contributed to the translocation of Arrestin, but complete inhibition was only achieved when all phosphorylation sites were mutated. Additionally, the dissociation of G proteins was also impaired proportionally to the extent of Arrestin translocation.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Neurosciences
Edgar Soria-Gomez, Antonio C. Pagano Zottola, Yamuna Mariani, Tifany Desprez, Massimo Barresi, Itziar Bonilla-del Rio, Carolina Muguruza, Morgane Le Bon-Jego, Francisca Julio-Kalajzic, Robyn Flynn, Geoffrey Terral, Ignacio Fernandez-Moncada, Laurie M. Robin, Jose F. Oliveira da Cruz, Simone Corinti, Yasmine Ould Amer, Julia Goncalves, Marjorie Varilh, Astrid Cannich, Bastien Redon, Zhe Zhao, Thierry Leste-Lasserre, Peggy Vincent, Tarson Tolentino-Cortes, Arnau Busquets-Garcia, Nagore Puente, Jaideep S. Bains, Etienne Hebert-Chatelain, Gabriel Barreda-Gomez, Francis Chaouloff, Alexander W. Lohman, Luis F. Callado, Pedro Grandes, Jerome Baufreton, Giovanni Marsicano, Luigi Bellocchio
Summary: Recent neuroscience advances have identified brain circuits as key players in controlling behavior, with evidence showing that activation of specific receptors at different subcellular locations can lead to distinct behavioral outcomes.
Article
Agriculture, Dairy & Animal Science
Zixuan Cheng, Xihe Li, Siqin Bao, Takahisa Yamada, Guifang Cao, Jianfeng Liu, Aorigele Chen, Bin Tong
Summary: Overexpression of CDC10 in bovine intramuscular preadipocytes and 3T3-L1 cells promotes adipocyte differentiation, while knockdown of CDC10 has the opposite effect. These findings provide new insights into the regulatory role of CDC10 in adipocytes in animals.
Article
Neurosciences
Catharine A. Mielnik, Kim S. Sugamori, David B. Finlay, Hayley H. A. Thorpe, Matthieu Schapira, Nirunthan Sivananthan, Chun Kit Li, Vincent M. Lam, Sean Harrington, Mostafa H. Abdelrahman, Laurent A. Trembleau, W. McIntyre Burnham, Jibran Y. Khokhar, Ali Salahpour, Amy J. Ramsey, Michelle Glass, Iain R. Greig, Ruth A. Ross
Summary: The endocannabinoid system plays a significant role in various psychiatric disorders, including schizophrenia. A CB1 receptor allosteric modulator, ABM300, has shown the ability to reduce behavioral deficits in transgenic models, particularly those with hyperdopaminergia.
NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Rensiqin Wu, Hui Wang, Jian Huangfu, Rui Xiao
Summary: Inhibition of A-FABP expression can increase cell proliferation activity and reduce PTEN expression in induced 3T3-L1 cells, suggesting A-FABP plays a crucial role in regulating AKT activity during adipocyte differentiation.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Shunsuke Kimura, Ai Tsuruma, Eisuke Kato
Summary: Expression of taste 2 receptor (T2R) genes has been observed in mouse white adipose tissue and 3T3-L1 adipocytes. Fasting and bitter compounds stimulation increases Tas2r expression in mouse white adipose tissue, while serum starvation and bitter compounds stimulation increases Tas2r gene expression in 3T3-L1 adipocytes. Tas2r126 may play a role in adipocyte differentiation, as suggested by RNA sequencing analysis and overexpression studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Antonio C. Pagano Zottola, Ilenia Severi, Astrid Cannich, Philippe Ciofi, Daniela Cota, Giovanni Marsicano, Antonio Giordano, Luigi Bellocchio
Summary: By activating the CB1 receptor, cannabinoids regulate mitochondrial physiology and energy metabolism in adipocytes through intracellular signaling pathways.
Article
Biochemistry & Molecular Biology
Daniel J. Nasrallah, Neil K. Garg
Summary: This study reports on the synthesis and characterization of two isomeric hexahydrocannabinols (HHCs), (9R)-HHC and (9S)-HHC, which are derivatives of known psychoactive cannabinoids. The researchers used hydrogen-atom transfer reduction to prepare the compounds, with (9R)-HHC being the major diastereomer. They also conducted cannabinoid receptor studies and found that (9R)-HHC has similar binding affinity and activity to Δ9-THC, while (9S)-HHC binds strongly to the receptors but displays reduced activity in functional assays. The variability in HHC isomer ratios found in commercially available products highlights the need for further research and systematic testing of new cannabinoids.
ACS CHEMICAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Raj Kamal Srivastava, Inigo Ruiz de Azua, Andrea Conrad, Martin Purrio, Beat Lutz
Summary: This study found that the deletion of CB1 in dbh-positive cells prevents diet-induced obesity through multiple mechanisms including increased sympathetic nervous system activity, reduced NPY activity, and decreased basal hypothalamic-pituitary-adrenal axis activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Francesco Russo, Guglielmina Chimienti, Caterina Clemente, Carla Ferreri, Antonella Orlando, Giuseppe Riezzo
EUROPEAN JOURNAL OF NUTRITION
(2017)
Article
Oncology
Michele Linsalata, Antonella Orlando, Valeria Tutino, Maria Notarnicola, Benedetta D'Attoma, Francesco Russo
INTERNATIONAL JOURNAL OF ONCOLOGY
(2015)
Article
Biotechnology & Applied Microbiology
Antonella Orlando, Michele Linsalata, Valeria Tutino, Benedetta D'Attoma, Maria Notarnicola, Francesco Russo
BIOMED RESEARCH INTERNATIONAL
(2015)
Article
Oncology
Antonella Orlando, Michele Linsalata, Francesco Russo
INTERNATIONAL JOURNAL OF ONCOLOGY
(2016)
Article
Gastroenterology & Hepatology
Francesco Russo, Guglielmina Chimienti, Michele Linsalata, Caterina Clemente, Antonella Orlando, Giuseppe Riezzo
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
(2017)
Article
Gastroenterology & Hepatology
Francesco Russo, Guglielmina Chimienti, Caterina Clemente, Giuseppe Riezzo, Benedetta D'Attoma, Manuela Martulli
JOURNAL OF CLINICAL GASTROENTEROLOGY
(2017)
Article
Food Science & Technology
Antonella Orlando, Michele Linsalata, Benedetta D'Attoma, Francesco Russo
JOURNAL OF FUNCTIONAL FOODS
(2017)
Article
Biotechnology & Applied Microbiology
Giuseppe Riezzo, Guglielmina Chimienti, Caterina Clemente, Benedetta D'Attoma, Antonella Orlando, Caterina Mammone Rinaldi, Francesco Russo
BIOMED RESEARCH INTERNATIONAL
(2017)
Article
Medicine, General & Internal
Anna Picca, Giuseppe Riezzo, Angela M. S. Lezza, Caterina Clemente, Vito Pesce, Antonella Orlando, Guglielmina Chimienti, Francesco Russo
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2018)
Article
Microbiology
Antonella Orlando, Michele Linsalata, Maria Notarnicola, Valeria Tutino, Francesco Russo
Letter
Medical Laboratory Technology
Michele Linsalata, Benedetta D'Attoma, Antonella Orlando, Vito Guerra, Francesco Russo
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2014)
Article
Biochemistry & Molecular Biology
Antonio Francavilla, Barbara Pesetti, Michele Barone, Annalisa Morgano, Fabiola Bovenga, Anna Napoli, Leonardo Resta, Francesco Russo, Michele Linsalata, Mario Minoia, Giusy Bianco, Angela Tafaro, Lorenzo Polimeno
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2014)
Review
Oncology
Michele Linsalata, Antonella Orlando, Francesco Russo
INTERNATIONAL JOURNAL OF ONCOLOGY
(2014)
Article
Gastroenterology & Hepatology
Ruggiero Francavilla, Lorenzo Polimeno, Antonella Demichina, Giovanni Maurogiovanni, Beatrice Principi, Giuseppe Scaccianoce, Enzo Ierardi, Francesco Russo, Giuseppe Riezzo, Alfredo Di Leo, Luciano Cavallo, Antonio Francavilla, James Versalovic
JOURNAL OF CLINICAL GASTROENTEROLOGY
(2014)