The Signaling of Cellular Senescence in Diabetic Nephropathy

Removal of Protein-Bound Uremic Toxins during Hemodialysis Using a Binding Competitor

(2019) Magdalena Madero et al.   Clinical Journal of the American Society of Nephrology

Atrasentan and renal events in patients with type 2 diabetes and chronic kidney disease (SONAR): a double-blind, randomised, placebo-controlled trial

(2019) Hiddo J L Heerspink et al.   LANCET

Improved dialytic removal of protein-bound uremic toxins by intravenous lipid emulsion in chronic kidney disease rats

(2019) Yuanyuan Shi et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

A large-scale CRISPR screen and identification of essential genes in cellular senescence bypass

(2019) Xuehui Liu et al.   Aging-US

Shortening of telomere length by metabolic factors in diabetes: protective effects of fenofibrate

(2019) Surya Shin Ichi Sutanto et al.   Journal of Cell Communication and Signaling

The RAGE/STAT5/autophagy axis regulates senescence in mesangial cells

(2019) Mai Shi et al.   CELLULAR SIGNALLING

Long term rapamycin treatment improves mitochondrial DNA quality in aging mice

(2018) Jason Bielas et al.   EXPERIMENTAL GERONTOLOGY

C-peptide prevents NF-κB from recruiting p300 and binding to the inos promoter in diabetic nephropathy

(2018) Yanning Li et al.   FASEB JOURNAL

Chlorogenic acid prevents diabetic nephropathy by inhibiting oxidative stress and inflammation through modulation of the Nrf2/HO-1 and NF-ĸB pathways

(2018) Liping Bao et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Wnt9a Promotes Renal Fibrosis by Accelerating Cellular Senescence in Tubular Epithelial Cells

(2018) Congwei Luo et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Increased podocyte Sirtuin-1 function attenuates diabetic kidney injury

(2018) Quan Hong et al.   KIDNEY INTERNATIONAL

Trans -resveratrol mitigates type 1 diabetes-induced oxidative DNA damage and accumulation of advanced glycation end products in glomeruli and tubules of rat kidneys

(2018) Heba Al-Hussaini et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Optineurin-mediated mitophagy protects renal tubular epithelial cells against accelerated senescence in diabetic nephropathy

(2018) Kehong Chen et al.   Cell Death & Disease

BRD4 regulates cellular senescence in gastric cancer cells via E2F/miR-106b/p21 axis

(2018) Xingchen Dong et al.   Cell Death & Disease

Stem cells and anti-aging genes: double-edged sword—do the same job of life extension

(2018) Mujib Ullah et al.   Stem Cell Research & Therapy

Preventive effect of Shenkang injection against high glucose-induced senescence of renal tubular cells

(2018) Biqiong Fu et al.   Frontiers of Medicine

Short-term sustained hyperglycaemia fosters an archetypal senescence-associated secretory phenotype in endothelial cells and macrophages

(2018) Francesco Prattichizzo et al.   Redox Biology

Effect of osthole on advanced glycation end products-induced renal tubular hypertrophy and role of klotho in its mechanism of action

(2018) Wei-Chih Kan et al.   PHYTOMEDICINE

Mutations of mitochondrial DNA are not major contributors to aging of fruit flies

(2018) Timo E. S. Kauppila et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of STAT3/mTOR-regulated autophagy in angiotensin II-induced senescence of human glomerular mesangial cells

(2018) Shuang Yang et al.   CELLULAR SIGNALLING

Telomere length as a potential biomarker of coronary artery disease

(2017) Joyeeta Bhattacharyya et al.   INDIAN JOURNAL OF MEDICAL RESEARCH

Involvement of PINK1/Parkin-mediated mitophagy in AGE-induced cardiomyocyte aging

(2017) Zhimin Zha et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

The Potential of iPSCs for the Treatment of Premature Aging Disorders

(2017) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Nicotinamide Mononucleotide, an NAD + Precursor, Rescues Age-Associated Susceptibility to AKI in a Sirtuin 1–Dependent Manner

(2017) Yi Guan et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Association between Soluble Klotho and Change in Kidney Function: The Health Aging and Body Composition Study

(2017) David A. Drew et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Structural and Functional Changes in Human Kidneys with Healthy Aging

(2017) Musab S. Hommos et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Klotho restoration via acetylation of Peroxisome Proliferation–Activated Receptor γ reduces the progression of chronic kidney disease

(2017) Wenjun Lin et al.   KIDNEY INTERNATIONAL

Senescent cells: an emerging target for diseases of ageing

(2017) Bennett G. Childs et al.   NATURE REVIEWS DRUG DISCOVERY

Triggering of inflammasome by impaired autophagy in response to acute experimental Parkinson’s disease

(2017) Sabrina Giacoppo et al.   NEUROREPORT

Natural antioxidants in the treatment and prevention of diabetic nephropathy; a potential approach that warrants clinical trials

(2017) Noori Al-Waili et al.   REDOX REPORT

Cellular senescence, senescence-associated secretory phenotype, and chronic kidney disease

(2017) Wen-Juan Wang et al.   Oncotarget

Protein-bound uremic toxins impaired mitochondrial dynamics and functions

(2017) Chiao-Yin Sun et al.   Oncotarget

Telomere attrition, kidney function, and prevalent chronic kidney disease in the United States

(2017) Moshen Mazidi et al.   Oncotarget

Human umbilical cord-derived mesenchymal stromal cells protect against premature renal senescence resulting from oxidative stress in rats with acute kidney injury

(2017) Camila Eleuterio Rodrigues et al.   Stem Cell Research & Therapy

The mitochondria-targeted antioxidant MitoQ ameliorated tubular injury mediated by mitophagy in diabetic kidney disease via Nrf2/PINK1

(2017) Li Xiao et al.   Redox Biology

A new role for oxidative stress in aging: The accelerated aging phenotype in Sod1−/ − mice is correlated to increased cellular senescence

(2017) Yiqiang Zhang et al.   Redox Biology

New Insights into the Mechanism of Action of Soluble Klotho

(2017) George D. Dalton et al.   Frontiers in Endocrinology

Senescent endothelial cells: Potential modulators of immunosenescence and ageing

(2016) Ia Pantsulaia et al.   AGEING RESEARCH REVIEWS

Differential regulation of autophagy and mitophagy in pulmonary diseases

(2016) Saurabh Aggarwal et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Radiation-Induced Loss of Salivary Gland Function Is Driven by Cellular Senescence and Prevented by IL6 Modulation

(2016) Y. Marmary et al.   CANCER RESEARCH

Mitochondrial ROS Produced via Reverse Electron Transport Extend Animal Lifespan

(2016) Filippo Scialò et al.   Cell Metabolism

Synbiotics Easing Renal Failure by Improving Gut Microbiology (SYNERGY): A Randomized Trial

(2016) M. Rossi et al.   Clinical Journal of the American Society of Nephrology

Ergothioneine oxidation in the protection against high-glucose induced endothelial senescence: Involvement of SIRT1 and SIRT6

(2016) Nunzia D’Onofrio et al.   FREE RADICAL BIOLOGY AND MEDICINE

Telomere attrition and diabetes mellitus

(2016) Yoshiaki Tamura et al.   Geriatrics & Gerontology International

Discovery of Klotho peptide antagonists against Wnt3 and Wnt3a target proteins using combination of protein engineering, protein–protein docking, peptide docking and molecular dynamics simulations

(2016) Shaher Bano Mirza et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Mitochondrial quality control in the diabetic heart

(2016) Qiangrong Liang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Calorie restriction as an intervention in ageing

(2016) Guillermo López-Lluch et al.   JOURNAL OF PHYSIOLOGY-LONDON

Inorganic Phosphate Activates the AKT/mTORC1 Pathway and Shortens the Life Span of an  -Klotho-Deficient Model

(2016) M. Kawai et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Epigenetic regulation of the thioredoxin-interacting protein (TXNIP) gene by hyperglycemia in kidney

(2016) Yang De Marinis et al.   KIDNEY INTERNATIONAL

Mitophagy plays a central role in mitochondrial ageing

(2016) Alan Diot et al.   MAMMALIAN GENOME

Autophagy maintains stemness by preventing senescence

(2016) Laura García-Prat et al.   NATURE

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

(2016) Darren J. Baker et al.   NATURE

“Inflammaging” as a Druggable Target: A Senescence-Associated Secretory Phenotype—Centered View of Type 2 Diabetes

(2016) Francesco Prattichizzo et al.   Oxidative Medicine and Cellular Longevity

Cardiorenal fibrosis and dysfunction in aging: Imbalance in mediators and regulators of collagen

(2016) S. Jeson Sangaralingham et al.   PEPTIDES

Epigenomic profiling reveals an association between persistence of DNA methylation and metabolic memory in the DCCT/EDIC type 1 diabetes cohort

(2016) Zhuo Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL

(2016) Reut Yosef et al.   Nature Communications

BRD4 Connects Enhancer Remodeling to Senescence Immune Surveillance

(2016) N. Tasdemir et al.   Cancer Discovery

Antioxidant Supplementation in the Treatment of Aging-Associated Diseases

(2016) Valeria Conti et al.   Frontiers in Pharmacology

Specific lipofuscin staining as a novel biomarker to detect replicative and stress-induced senescence. A method applicable in cryo-preserved and archival tissues

(2016) EA Georgakopoulou et al.   Aging-US

Inflammaging: disturbed interplay between autophagy and inflammasomes

(2016) Antero Salminen et al.   Aging-US

Impact of ER stress-regulated ATF4/p16 signaling on the premature senescence of renal tubular epithelial cells in diabetic nephropathy

(2015) Jun Liu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Indoxyl sulfate enhances IL-1β-induced E-selectin expression in endothelial cells in acute kidney injury by the ROS/MAPKs/NFκB/AP-1 pathway

(2015) Wen-Ching Shen et al.   ARCHIVES OF TOXICOLOGY

Temporal dynamics of PARK2/parkin and OPTN/optineurin recruitment during the mitophagy of damaged mitochondria

(2015) Yvette C Wong et al.   Autophagy

Suppression of the senescence-associated secretory phenotype (SASP) in human fibroblasts using small molecule inhibitors of p38 MAP kinase and MK2

(2015) Dauren Alimbetov et al.   BIOGERONTOLOGY

Anti-Inflamm-Aging Effects of Long-Term Caloric Restriction via Overexpression of SIGIRR to Inhibit NF-κB Signaling Pathway

(2015) Xiao-meng Xu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Intracellular Signaling of the Aging Suppressor Protein Klotho

(2015) M. Sopjani et al.   CURRENT MOLECULAR MEDICINE

Targeting HSP90 Ameliorates Nephropathy and Atherosclerosis Through Suppression of NF-κB and STAT Signaling Pathways in Diabetic Mice

(2015) Iolanda Lazaro et al.   DIABETES

Molecular Basis of Klotho: From Gene to Function in Aging

(2015) Yuechi Xu et al.   ENDOCRINE REVIEWS

Drivers of age-related inflammation and strategies for healthspan extension

(2015) Emily L. Goldberg et al.   IMMUNOLOGICAL REVIEWS

Advanced glycation end-products induced VEGF production and inflammatory responses in human synoviocytes via RAGE-NF-κB pathway activation

(2015) Ying-Ju Chen et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

The Histone Methyltransferase Enzyme Enhancer of Zeste Homolog 2 Protects against Podocyte Oxidative Stress and Renal Injury in Diabetes

(2015) F. S. Siddiqi et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Sustained Activation of Wnt/ -Catenin Signaling Drives AKI to CKD Progression

(2015) L. Xiao et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Anti-Inflammatory Role of MicroRNA-146a in the Pathogenesis of Diabetic Nephropathy

(2015) K. Bhatt et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Diabetes Induces Aberrant DNA Methylation in the Proximal Tubules of the Kidney

(2015) T. Marumo et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The Influence of CKD on Colonic Microbial Metabolism

(2015) R. Poesen et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Unknown

(2015) Sho-ichi Yamagishi et al.   MOLECULAR MEDICINE

Mechanism of phospho-ubiquitin-induced PARKIN activation

(2015) Tobias Wauer et al.   NATURE

The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

(2015) Michael Lazarou et al.   NATURE

Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

(2015) Jianhui Chang et al.   NATURE MEDICINE

Diabetic nephropathy: landmark clinical trials and tribulations

(2015) Gary C.W. Chan et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Glucose Oxidase Induces Cellular Senescence in Immortal Renal Cells through ILK by DownregulatingKlothoGene Expression

(2015) Nuria Troyano-Suárez et al.   Oxidative Medicine and Cellular Longevity

JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age

(2015) Ming Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protective Role of PGC-1α in Diabetic Nephropathy Is Associated with the Inhibition of ROS through Mitochondrial Dynamic Remodeling

(2015) Kaifeng Guo et al.   PLoS One

Senescent cells: SASPected drivers of age-related pathologies

(2014) Yossi Ovadya et al.   BIOGERONTOLOGY

Adverse Epigenetic Signatures by Histone Methyltransferase Set7 Contribute to Vascular Dysfunction in Patients With Type 2 Diabetes MellitusCLINICAL PERSPECTIVE

(2014) Francesco Paneni et al.   Circulation-Cardiovascular Genetics

Effect of Increasing Dietary Fiber on Plasma Levels of Colon-Derived Solutes in Hemodialysis Patients

(2014) T. L. Sirich et al.   Clinical Journal of the American Society of Nephrology

An Update on the Molecular Actions of Fenofibrate and Its Clinical Effects on Diabetic Retinopathy and Other Microvascular End Points in Patients With Diabetes

(2014) J. E. Noonan et al.   DIABETES

Hyperglycemia causes cellular senescence via a SGLT2- and p21-dependent pathway in proximal tubules in the early stage of diabetic nephropathy

(2014) Kento Kitada et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Diabetic kidney disease: from physiology to therapeutics

(2014) Carmen Mora-Fernández et al.   JOURNAL OF PHYSIOLOGY-LONDON

Disruption of Renal Tubular Mitochondrial Quality Control by Myo-Inositol Oxygenase in Diabetic Kidney Disease

(2014) M. Zhan et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Multiple Genes of the Renin-Angiotensin System Are Novel Targets of Wnt/ -Catenin Signaling

(2014) L. Zhou et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Klotho Prevents NFκB Translocation and Protects Endothelial Cell From Senescence Induced by Uremia

(2014) Paula Buendía et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Histone deacetylase 4 selectively contributes to podocyte injury in diabetic nephropathy

(2014) Xiaojie Wang et al.   KIDNEY INTERNATIONAL

Old blood stem cells feel the stress

(2014) Jiri Bartek et al.   NATURE

The role of senescent cells in ageing

(2014) Jan M. van Deursen   NATURE

Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice

(2014) Saul A Villeda et al.   NATURE MEDICINE

Rejuvenation of the muscle stem cell population restores strength to injured aged muscles

(2014) Benjamin D Cosgrove et al.   NATURE MEDICINE

p38 MAPK signaling underlies a cell-autonomous loss of stem cell self-renewal in skeletal muscle of aged mice

(2014) Jennifer D Bernet et al.   NATURE MEDICINE

Diabetic nephropathy—emerging epigenetic mechanisms

(2014) Mitsuo Kato et al.   Nature Reviews Nephrology

High Amylose Resistant Starch Diet Ameliorates Oxidative Stress, Inflammation, and Progression of Chronic Kidney Disease

(2014) Nosratola D. Vaziri et al.   PLoS One

End-stage renal disease and survival in people with diabetes: a national database linkage study

(2014) S. Bell et al.   QJM-AN INTERNATIONAL JOURNAL OF MEDICINE

PINK1 Loss-of-Function Mutations Affect Mitochondrial Complex I Activity via NdufA10 Ubiquinone Uncoupling

(2014) V. A. Morais et al.   SCIENCE

New Insights Into the FGF23-Klotho Axis

(2014) Hannes Olauson et al.   SEMINARS IN NEPHROLOGY

Mesenchymal stem cell treatment for chronic renal failure

(2014) Alfonso Eirin et al.   Stem Cell Research & Therapy

The impact of age-related dysregulation of the angiotensin system on mitochondrial redox balance

(2014) Ramya Vajapey et al.   Frontiers in Physiology

The Association Between Age and Nephrosclerosis on Renal Biopsy Among Healthy Adults

(2013) Andrew D. Rule   ANNALS OF INTERNAL MEDICINE

Updating the Mitochondrial Free Radical Theory of Aging: An Integrated View, Key Aspects, and Confounding Concepts

(2013) Gustavo Barja   ANTIOXIDANTS & REDOX SIGNALING

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Receptor for advanced glycation end-products promotes premature senescence of proximal tubular epithelial cells via activation of endoplasmic reticulum stress-dependent p21 signaling

(2013) Jun Liu et al.   CELLULAR SIGNALLING

FGF23 and Klotho in chronic kidney disease

(2013) Hannes Olauson et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Non-coding RNAs as direct and indirect modulators of epigenetic regulation

(2013) Veronica J Peschansky et al.   Epigenetics

Cellular senescence and the senescent secretory phenotype: therapeutic opportunities

(2013) Tamara Tchkonia et al.   JOURNAL OF CLINICAL INVESTIGATION

Protein-Bound Uremic Toxins Stimulate Crosstalk between Leukocytes and Vessel Wall

(2013) A. Pletinck et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Loss of Klotho Contributes to Kidney Injury by Derepression of Wnt/ -Catenin Signaling

(2013) L. Zhou et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Metabolomics Reveals Signature of Mitochondrial Dysfunction in Diabetic Kidney Disease

(2013) K. Sharma et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Losartan reverses permissive epigenetic changes in renal glomeruli of diabetic db/db mice

(2013) Marpadga A. Reddy et al.   KIDNEY INTERNATIONAL

Short-term calorie restriction protects against renal senescence of aged rats by increasing autophagic activity and reducing oxidative damage

(2013) Yi-Chun Ning et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Renal tubular Sirt1 attenuates diabetic albuminuria by epigenetically suppressing Claudin-1 overexpression in podocytes

(2013) Kazuhiro Hasegawa et al.   NATURE MEDICINE

Autophagy Attenuates Diabetic Glomerular Damage through Protection of Hyperglycemia-Induced Podocyte Injury

(2013) Li Fang et al.   PLoS One

Parkin overexpression during aging reduces proteotoxicity, alters mitochondrial dynamics, and extends lifespan

(2013) A. Rana et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA methylation age of human tissues and cell types

(2013) Steve Horvath   GENOME BIOLOGY

Neuronal ROS signaling rather than AMPK/sirtuin-mediated energy sensing links dietary restriction to lifespan extension

(2013) Sebastian Schmeisser et al.   Molecular Metabolism

Stat3 Contributes to Indoxyl Sulfate-Induced Inflammatory and Fibrotic Gene Expression and Cellular Senescence

(2012) Hidehisa Shimizu et al.   AMERICAN JOURNAL OF NEPHROLOGY

Aging, Cellular Senescence, and Cancer

(2012) Judith Campisi   Annual Review of Physiology

Losartan inhibits STAT1 activation and protects human glomerular mesangial cells from angiotensin II induced premature senescence

(2012) Sumin Jiao et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

mTOR Inhibition Prevents Epithelial Stem Cell Senescence and Protects from Radiation-Induced Mucositis

(2012) Ramiro Iglesias-Bartolome et al.   Cell Stem Cell

Distinguishing Hyperglycemic Changes by Set7 in Vascular Endothelial Cells

(2012) Jun Okabe et al.   CIRCULATION RESEARCH

Gene Silencing of the Mitochondrial Adaptor p66 Shc Suppresses Vascular Hyperglycemic Memory in Diabetes

(2012) Francesco Paneni et al.   CIRCULATION RESEARCH

Ageing as a Risk Factor for Disease

(2012) Teresa Niccoli et al.   CURRENT BIOLOGY

The Critical Role of Metabolic Pathways in Aging

(2012) N. Barzilai et al.   DIABETES

Prediabetic Nephropathy as an Early Consequence of the High-Calorie/High-Fat Diet: Relation to Oxidative Stress

(2012) Hanna Shevalye et al.   ENDOCRINOLOGY

Nuclear lamina defects cause ATM-dependent NF- B activation and link accelerated aging to a systemic inflammatory response

(2012) F. G. Osorio et al.   GENES & DEVELOPMENT

NF-κB inhibition delays DNA damage–induced senescence and aging in mice

(2012) Jeremy S. Tilstra et al.   JOURNAL OF CLINICAL INVESTIGATION

Normal and Pathologic Concentrations of Uremic Toxins

(2012) F. Duranton et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

KLOTHO methylation is linked to uremic toxins and chronic kidney disease

(2012) Guang-Huar Young et al.   KIDNEY INTERNATIONAL

Decreased renal α-Klotho expression in early diabetic nephropathy in humans and mice and its possible role in urinary calcium excretion

(2012) Osamu Asai et al.   KIDNEY INTERNATIONAL

Suppression of Klotho expression by protein-bound uremic toxins is associated with increased DNA methyltransferase expression and DNA hypermethylation

(2012) Chiao-Yin Sun et al.   KIDNEY INTERNATIONAL

mRNA Decay Factor AUF1 Maintains Normal Aging, Telomere Maintenance, and Suppression of Senescence by Activation of Telomerase Transcription

(2012) Adam R. Pont et al.   MOLECULAR CELL

Genome stability, progressive kidney failure and aging

(2012) Hannes Lans et al.   NATURE GENETICS

Treating diabetic nephropathy—still an unresolved issue

(2012) Mark E. Cooper   Nature Reviews Endocrinology

Functions of DNA methylation: islands, start sites, gene bodies and beyond

(2012) Peter A. Jones   NATURE REVIEWS GENETICS

Dexamethasone Reduces Sensitivity to Cisplatin by Blunting p53-Dependent Cellular Senescence in Non-Small Cell Lung Cancer

(2012) Haiyan Ge et al.   PLoS One

Specific mitochondrial DNA mutation in mice regulates diabetes and lymphoma development

(2012) O. Hashizume et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activated protein C ameliorates diabetic nephropathy by epigenetically inhibiting the redox enzyme p66Shc

(2012) F. Bock et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AMPK and mTOR in Cellular Energy Homeostasis and Drug Targets

(2011) Ken Inoki et al.   Annual Review of Pharmacology and Toxicology

Klotho Depletion Contributes to Increased Inflammation in Kidney of the db/db Mouse Model of Diabetes via RelA (Serine)536 Phosphorylation

(2011) Y. Zhao et al.   DIABETES

Implication of dysregulation of the canonical wingless-type MMTV integration site (WNT) pathway in diabetic nephropathy

(2011) T. Zhou et al.   DIABETOLOGIA

Epigenetics in Diabetic Kidney Disease

(2011) M. A. Reddy et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The Inflammatory Cytokines TWEAK and TNF  Reduce Renal Klotho Expression through NF B

(2011) J. A. Moreno et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Inhibition of inflammation by pentosan polysulfate impedes the development and progression of severe diabetic nephropathy in aging C57B6 mice

(2011) Jin Wu et al.   LABORATORY INVESTIGATION

STAT1 mediates cellular senescence induced by angiotensin II and H2O2 in human glomerular mesangial cells

(2011) Sumin Jiao et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

The ageing systemic milieu negatively regulates neurogenesis and cognitive function

(2011) Saul A. Villeda et al.   NATURE

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

Diabetes Mellitus, Fasting Glucose, and Risk of Cause-Specific Death

(2011)   NEW ENGLAND JOURNAL OF MEDICINE

Cumulative Inflammatory Load Is Associated with Short Leukocyte Telomere Length in the Health, Aging and Body Composition Study

(2011) Aoife O'Donovan et al.   PLoS One

Pathogenesis of diabetic nephropathy

(2011) Zemin Cao et al.   Journal of Diabetes Investigation

Pilot study of probiotic dietary supplementation for promoting healthy kidney function in patients with chronic kidney disease

(2010) Natarajan Ranganathan et al.   ADVANCES IN THERAPY

Two modes of mitochondrial dysfunction lead independently to lifespan extension in Caenorhabditis elegans

(2010) Wen Yang et al.   AGING CELL

Senescence and dysfunction of proximal tubular cells are associated with activated p53 expression by indoxyl sulfate

(2010) Hidehisa Shimizu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

HIV Infection, Inflammation, Immunosenescence, and Aging

(2010) Steven G. Deeks   Annual Review of Medicine

Angiotensin II blockade: a strategy to slow ageing by protecting mitochondria?

(2010) E. M. V. de Cavanagh et al.   CARDIOVASCULAR RESEARCH

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Indoxyl Sulfate-Induced Endothelial Dysfunction in Patients with Chronic Kidney Disease via an Induction of Oxidative Stress

(2010) M. Yu et al.   Clinical Journal of the American Society of Nephrology

Inhibition of Respiration Extends C. elegans Life Span via Reactive Oxygen Species that Increase HIF-1 Activity

(2010) Seung-Jae Lee et al.   CURRENT BIOLOGY

Enhanced Levels of microRNA-125b in Vascular Smooth Muscle Cells of Diabetic db/db Mice Lead to Increased Inflammatory Gene Expression by Targeting the Histone Methyltransferase Suv39h1

(2010) L. M. Villeneuve et al.   DIABETES

Angiotensin II revisited: new roles in inflammation, immunology and aging

(2010) Ariela Benigni et al.   EMBO Molecular Medicine

Effects of telmisartan and enalapril on renoprotection in patients with mild to moderate chronic kidney disease

(2010) Tsukasa Nakamura et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Dietary and genetic evidence for phosphate toxicity accelerating mammalian aging

(2010) Mutsuko Ohnishi et al.   FASEB JOURNAL

Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule

(2010) Ming Chang Hu et al.   FASEB JOURNAL

Decrease of Klotho in the Kidney of Streptozotocin-Induced Diabetic Rats

(2010) Meng-Fu Cheng et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney

(2010) Shinji Kume et al.   JOURNAL OF CLINICAL INVESTIGATION

Blockade of Wnt/ -Catenin Signaling by Paricalcitol Ameliorates Proteinuria and Kidney Injury

(2010) W. He et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Does Accumulation of Advanced Glycation End Products Contribute to the Aging Phenotype?

(2010) R. D. Semba et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

A potential link between phosphate and aging—Lessons from Klotho-deficient mice

(2010) Makoto Kuro-o   MECHANISMS OF AGEING AND DEVELOPMENT

Role of the JAK2/STAT pathway and losartan in human glomerular mesangial cell senescence

(2010) Wang   Molecular Medicine Reports

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Epigenetic modifications and human disease

(2010) Anna Portela et al.   NATURE BIOTECHNOLOGY

Charting histone modifications and the functional organization of mammalian genomes

(2010) Vicky W. Zhou et al.   NATURE REVIEWS GENETICS

 -Catenin mediates adriamycin-induced albuminuria and podocyte injury in adult mouse kidneys

(2010) E. Heikkila et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Endothelial Progenitor Cells Homing and Renal Repair in Experimental Renovascular Disease

(2010) Alejandro R. Chade et al.   STEM CELLS

A Mitochondrial Superoxide Signal Triggers Increased Longevity in Caenorhabditis elegans

(2010) Wen Yang et al.   PLOS BIOLOGY

Lifespan Extension by Preserving Proliferative Homeostasis in Drosophila

(2010) Benoît Biteau et al.   PLoS Genetics

Random Point Mutations with Major Effects on Protein-Coding Genes Are the Driving Force behind Premature Aging in mtDNA Mutator Mice

(2009) Daniel Edgar et al.   Cell Metabolism

C. elegans as Model for the Study of High Glucose- Mediated Life Span Reduction

(2009) A. Schlotterer et al.   DIABETES

Hyperglycemia Induces a Dynamic Cooperativity of Histone Methylase and Demethylase Enzymes Associated With Gene-Activating Epigenetic Marks That Coexist on the Lysine Tail

(2009) D. Brasacchio et al.   DIABETES

Disruption of the Ang II type 1 receptor promotes longevity in mice

(2009) Ariela Benigni et al.   JOURNAL OF CLINICAL INVESTIGATION

Telomere length and progression of diabetic nephropathy in patients with type 1 diabetes

(2009) F. Fyhrquist et al.   JOURNAL OF INTERNAL MEDICINE

Senescence of Cultured Porcine Coronary Arterial Endothelial Cells Is Associated with Accelerated Oxidative Stress and Activation of NFĸB

(2009) Mary Y.K. Lee et al.   JOURNAL OF VASCULAR RESEARCH

Combination therapy with paricalcitol and trandolapril reduces renal fibrosis in obstructive nephropathy

(2009) Xiaoyue Tan et al.   KIDNEY INTERNATIONAL

p-Cresyl sulfate serum concentrations in haemodialysis patients are reduced by the prebiotic oligofructose-enriched inulin

(2009) B. K. I. Meijers et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Glyoxalase-1 prevents mitochondrial protein modification and enhances lifespan in Caenorhabditis elegans

(2008) Michael Morcos et al.   AGING CELL

Klotho as a regulator of oxidative stress and senescence

(2008) Makoto Kuro-o   BIOLOGICAL CHEMISTRY

ABT-263: A Potent and Orally Bioavailable Bcl-2 Family Inhibitor

(2008) C. Tse et al.   CANCER RESEARCH

Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia

(2008) Assam El-Osta et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Telomere attrition is associated with inflammation, low fetuin-A levels and high mortality in prevalent haemodialysis patients

(2008) J. J. Carrero et al.   JOURNAL OF INTERNAL MEDICINE

Combination therapy with AT1 blocker and vitamin D analog markedly ameliorates diabetic nephropathy: Blockade of compensatory renin increase

(2008) Z. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Telomere length assessment: Biomarker of chronic oxidative stress?

(2007) Joyce M.J. Houben et al.   FREE RADICAL BIOLOGY AND MEDICINE