Mutations of mitochondrial DNA are not major contributors to aging of fruit flies

A multi-systemic mitochondrial disorder due to a dominant p.Y955H disease variant in DNA polymerase gamma

(2017) Triinu Siibak et al.   HUMAN MOLECULAR GENETICS

Latent mitochondrial DNA deletion mutations drive muscle fiber loss at old age

(2016) Allen Herbst et al.   AGING CELL

Long Oskar Controls Mitochondrial Inheritance in Drosophila melanogaster

(2016) Thomas Ryan Hurd et al.   DEVELOPMENTAL CELL

Replication Errors Made During Oogenesis Lead to Detectable De Novo mtDNA Mutations in Zebrafish Oocytes with a Low mtDNA Copy Number

(2016) Auke B. C. Otten et al.   GENETICS

Rapamycin enhances survival in a Drosophila model of mitochondrial disease

(2016) Adrienne Wang et al.   Oncotarget

Sex difference in pathology of the ageing gut mediates the greater response of female lifespan to dietary restriction

(2016) Jennifer C Regan et al.   eLife

Replication Errors Made During Oogenesis Lead to Detectable De Novo mtDNA Mutations in Zebrafish Oocytes with a Low mtDNA Copy Number

(2016) Auke B. C. Otten et al.   GENETICS

Mitochondrial diseases

(2016) Gráinne S. Gorman et al.   Nature Reviews Disease Primers

Promoting Health and Longevity through Diet: From Model Organisms to Humans

(2015) Luigi Fontana et al.   CELL

Loss of Drosophila i-AAA protease, dYME1L, causes abnormal mitochondria and apoptotic degeneration

(2015) Y Qi et al.   CELL DEATH AND DIFFERENTIATION

Mitochondrial disease in adults: what's old and what's new?

(2015) P. F. Chinnery   EMBO Molecular Medicine

MitoCarta2.0: an updated inventory of mammalian mitochondrial proteins

(2015) Sarah E. Calvo et al.   NUCLEIC ACIDS RESEARCH

Complementation between polymerase- and exonuclease-deficient mitochondrial DNA polymerase mutants in genomically engineered flies

(2015) Ana Bratic et al.   Nature Communications

MtDNA mutagenesis impairs elimination of mitochondria during erythroid maturation leading to enhanced erythrocyte destruction

(2015) K.J. Ahlqvist et al.   Nature Communications

Making Proteins in the Powerhouse

(2014) B. Martin Hällberg et al.   Cell Metabolism

NAD+-Dependent Activation of Sirt1 Corrects the Phenotype in a Mouse Model of Mitochondrial Disease

(2014) Raffaele Cerutti et al.   Cell Metabolism

A Drosophila model of mitochondrial disease caused by a complex I mutation that uncouples proton pumping from electron transfer

(2014) J. L. Burman et al.   Disease Models & Mechanisms

Exploring the physiology and pathology of aging in the intestine ofDrosophila melanogaster

(2014) Heinrich Jasper   INVERTEBRATE REPRODUCTION & DEVELOPMENT

Similar patterns of clonally expanded somatic mtDNA mutations in the colon of heterozygous mtDNA mutator mice and ageing humans

(2014) Holly L. Baines et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Maternally transmitted mitochondrial DNA mutations can reduce lifespan

(2014) Jaime M. Ross et al.   Scientific Reports

Oxidative Stress Is Not a Major Contributor to Somatic Mitochondrial DNA Mutations

(2014) Leslie S. Itsara et al.   PLoS Genetics

Clonal Expansion of Early to Mid-Life Mitochondrial DNA Point Mutations Drives Mitochondrial Dysfunction during Human Ageing

(2014) Laura C. Greaves et al.   PLoS Genetics

Mitochondrial mutations and aging: random drift is insufficient to explain the accumulation of mitochondrial deletion mutants in short-lived animals

(2013) Axel Kowald et al.   AGING CELL

Germline mitochondrial DNA mutations aggravate ageing and can impair brain development

(2013) Jaime M. Ross et al.   NATURE

Somatic mtDNA Mutation Spectra in the Aging Human Putamen

(2013) Siôn L. Williams et al.   PLoS Genetics

Mitochondrial DNA polymerase editing mutation, PolgD257A, disturbs stem-progenitor cell cycling in the small intestine and restricts excess fat absorption

(2012) Raymond G. Fox et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Somatic Progenitor Cell Vulnerability to Mitochondrial DNA Mutagenesis Underlies Progeroid Phenotypes in Polg Mutator Mice

(2012) Kati J. Ahlqvist et al.   Cell Metabolism

Intestinal barrier dysfunction links metabolic and inflammatory markers of aging to death in Drosophila

(2012) M. Rera et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drosophila EGFR pathway coordinates stem cell proliferation and gut remodeling following infection

(2011) Nicolas Buchon et al.   BMC BIOLOGY

Accumulating Mitochondrial DNA Mutations Drive Premature Hematopoietic Aging Phenotypes Distinct from Physiological Stem Cell Aging

(2011) Gudmundur L. Norddahl et al.   Cell Stem Cell

Differences in the accumulation of mitochondrial defects with age in mice and humans

(2011) Laura C. Greaves et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Human Disease Models in Drosophila melanogaster and the Role of the Fly in Therapeutic Drug Discovery

(2011) U. B. Pandey et al.   PHARMACOLOGICAL REVIEWS

Modes of Metabolic Compensation during Mitochondrial Disease Using the Drosophila Model of ATP6 Dysfunction

(2011) Alicia M. Celotto et al.   PLoS One

Ultra-Deep Sequencing of Mouse Mitochondrial DNA: Mutational Patterns and Their Origins

(2011) Adam Ameur et al.   PLoS Genetics

Somatic Mitochondrial DNA Mutations in Mammalian Aging

(2010) Nils-Göran Larsson   Annual Review of Biochemistry

Mitochondrial uncoupling and lifespan

(2010) Shona A. Mookerjee et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Mitochondrial dysfunction in Caenorhabditis elegans causes metabolic restructuring, but this is not linked to longevity

(2010) Steven Zuryn et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Lifespan Extension by Preserving Proliferative Homeostasis in Drosophila

(2010) Benoît Biteau et al.   PLoS Genetics

Perturbation of mitochondrial complex V alters the response to dietary restriction inDrosophila

(2009) Sepehr Bahadorani et al.   AGING CELL

Caloric restriction-induced life extension of rats and mice: A critique of proposed mechanisms

(2009) Edward J. Masoro   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

4E-BP Extends Lifespan upon Dietary Restriction by Enhancing Mitochondrial Activity in Drosophila

(2009) Brian M. Zid et al.   CELL

Random Point Mutations with Major Effects on Protein-Coding Genes Are the Driving Force behind Premature Aging in mtDNA Mutator Mice

(2009) Daniel Edgar et al.   Cell Metabolism

Extension of Drosophila Life Span by RNAi of the Mitochondrial Respiratory Chain

(2009) Jeffrey M. Copeland et al.   CURRENT BIOLOGY

Reactive oxygen species prime Drosophila haematopoietic progenitors for differentiation

(2009) Edward Owusu-Ansah et al.   NATURE

Quantification of Food Intake in Drosophila

(2009) Richard Wong et al.   PLoS One

Locating the stem cell niche and tracing hepatocyte lineages in human liver

(2008) Tariq G. Fellous et al.   HEPATOLOGY

Distinct mitochondrial retrograde signals control the G1-S cell cycle checkpoint

(2008) Edward Owusu-Ansah et al.   NATURE GENETICS

Manipulating the Metazoan Mitochondrial Genome with Targeted Restriction Enzymes

(2008) H. Xu et al.   SCIENCE

Mechanisms of Field Cancerization in the Human Stomach: The Expansion and Spread of Mutated Gastric Stem Cells

(2007) Stuart A.C. McDonald et al.   GASTROENTEROLOGY