Mitophagy plays a central role in mitochondrial ageing

Age-dependent accumulation of mitochondrial DNA deletions in the aortic root of atherosclerosis-prone apolipoprotein E-knockout mice

(2016) Feng Tian et al.   ARCHIVES OF GERONTOLOGY AND GERIATRICS

Mitochondrial content is central to nuclear gene expression: Profound implications for human health

(2016) Rebecca Muir et al.   BIOESSAYS

Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype

(2016) Christopher D. Wiley et al.   Cell Metabolism

Impaired mitochondrial degradation by autophagy in the skeletal muscle of the aged female interleukin 10 null mouse

(2016) Fred Ko et al.   EXPERIMENTAL GERONTOLOGY

Autophagy maintains stemness by preventing senescence

(2016) Laura García-Prat et al.   NATURE

Mitochondrial ROS production correlates with, but does not directly regulate lifespan in drosophila

(2016) Alberto Sanz et al.   Aging-US

Increased expression of Drosophila Sir 2 extends life span in a dose-dependent manner

(2016) Rachel Whitaker et al.   Aging-US

Transmission from centenarians to their offspring of mtDNA heteroplasmy revealed by ultra-deep sequencing

(2016) Cristina Giuliani et al.   Aging-US

Altered brain energetics induces mitochondrial fission arrest in Alzheimer’s Disease

(2016) Liang Zhang et al.   Scientific Reports

Programmed cell death in aging

(2015) John Tower   AGEING RESEARCH REVIEWS

Mitochondrial respiratory capacity and coupling control decline with age in human skeletal muscle

(2015) Craig Porter et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Stem cells, mitochondria and aging

(2015) Kati J. Ahlqvist et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mitochondria: Are they causal players in cellular senescence?

(2015) Clara Correia-Melo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mitochondria and the non-genetic origins of cell-to-cell variability: More is different

(2015) Raúl Guantes et al.   BIOESSAYS

The daily rhythms of mitochondrial gene expression and oxidative stress regulation are altered by aging in the mouse liver

(2015) Changxia Gong et al.   CHRONOBIOLOGY INTERNATIONAL

Iron-Starvation-Induced Mitophagy Mediates Lifespan Extension upon Mitochondrial Stress in C. elegans

(2015) Alfonso Schiavi et al.   CURRENT BIOLOGY

Association of telomere length and mitochondrial DNA copy number in a community sample of healthy adults

(2015) Audrey R. Tyrka et al.   EXPERIMENTAL GERONTOLOGY

Coenzyme Q–dependent mitochondrial respiratory chain activity in granulosa cells is reduced with aging

(2015) Assaf Ben-Meir et al.   FERTILITY AND STERILITY

Sod1 gene ablation in adult mice leads to physiological changes at the neuromuscular junction similar to changes that occur in old wild-type mice

(2015) Maxim V. Ivannikov et al.   FREE RADICAL BIOLOGY AND MEDICINE

Global variability in gene expression and alternative splicing is modulated by mitochondrial content

(2015) Raul Guantes et al.   GENOME RESEARCH

Mitochondrial Oxidative Stress, Mitochondrial DNA Damage and Their Role in Age-Related Vascular Dysfunction

(2015) Yuliya Mikhed et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Loss of Phagocytic and Antigen Cross-Presenting Capacity in Aging Dendritic Cells Is Associated with Mitochondrial Dysfunction

(2015) Claire A. Chougnet et al.   JOURNAL OF IMMUNOLOGY

Mitochondrial DNA Heteroplasmy Associations With Neurosensory and Mobility Function in Elderly Adults

(2015) Gregory J. Tranah et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Coenzyme Q Protects Against Age-Related Alveolar Bone Loss Associated to n-6 Polyunsaturated Fatty Acid Rich-Diets by Modulating Mitochondrial Mechanisms

(2015) Alfonso Varela-Lopez et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Mitochondrial Aging and Physical Decline: Insights From Three Generations of Women

(2015) Sadie L. Hebert et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

NRMT1 knockout mice exhibit phenotypes associated with impaired DNA repair and premature aging

(2015) Lindsay A. Bonsignore et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Mitochondrial and Nuclear Accumulation of the Transcription Factor ATFS-1 Promotes OXPHOS Recovery during the UPRmt

(2015) Amrita M. Nargund et al.   MOLECULAR CELL

Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans

(2015) Konstantinos Palikaras et al.   NATURE

Mistargeted mitochondrial proteins activate a proteostatic response in the cytosol

(2015) Lidia Wrobel et al.   NATURE

A nuclear role for the respiratory enzyme CLK-1 in regulating mitochondrial stress responses and longevity

(2015) Richard M. Monaghan et al.   NATURE CELL BIOLOGY

Metabolomic analysis of exercise effects in the POLG mitochondrial DNA mutator mouse brain

(2015) Joanne Clark-Matott et al.   NEUROBIOLOGY OF AGING

L-Lactate Protects Skin Fibroblasts against Aging-Associated Mitochondrial DysfunctionviaMitohormesis

(2015) Jaroslav Zelenka et al.   Oxidative Medicine and Cellular Longevity

A novel quantitative assay of mitophagy: Combining high content fluorescence microscopy and mitochondrial DNA load to quantify mitophagy and identify novel pharmacological tools against pathogenic heteroplasmic mtDNA

(2015) Alan Diot et al.   PHARMACOLOGICAL RESEARCH

Pleiotropic age-dependent effects of mitochondrial dysfunction on epidermal stem cells

(2015) Michael C. Velarde et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effect of aging on muscle mitochondrial substrate utilization in humans

(2015) Kitt Falk Petersen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vivo imaging of axonal transport of mitochondria in the diseased and aged mammalian CNS

(2015) Yuji Takihara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The epigenetics of aging and neurodegeneration

(2015) Roy Lardenoije et al.   PROGRESS IN NEUROBIOLOGY

Stem cells and healthy aging

(2015) M. A. Goodell et al.   SCIENCE

Asymmetric apportioning of aged mitochondria between daughter cells is required for stemness

(2015) P. Katajisto et al.   SCIENCE

To unite or divide: mitochondrial dynamics in the murine outer retina that preceded age related photoreceptor loss

(2015) Jaimie Hoh Kam et al.   Oncotarget

Mitochondrial morphology is altered in atrophied skeletal muscle of aged mice

(2015) Jean-Philippe Leduc-Gaudet et al.   Oncotarget

Simultaneous impairment of mitochondrial fission and fusion reduces mitophagy and shortens replicative lifespan

(2015) Dominik Bernhardt et al.   Scientific Reports

LON is the master protease that protects against protein aggregation in human mitochondria through direct degradation of misfolded proteins

(2015) Ayenachew Bezawork-Geleta et al.   Scientific Reports

Complex IV-deficientSurf1−/−mice initiate mitochondrial stress responses

(2014) Daniel A. Pulliam et al.   BIOCHEMICAL JOURNAL

Mito-protective autophagy is impaired in erythroid cells of aged mtDNA-mutator mice

(2014) XiuJie Li-Harms et al.   BLOOD

Defective Mitophagy in XPA via PARP-1 Hyperactivation and NAD+/SIRT1 Reduction

(2014) Evandro Fei Fang et al.   CELL

ROS Function in Redox Signaling and Oxidative Stress

(2014) Michael Schieber et al.   CURRENT BIOLOGY

Mitochondrial quality control and age-associated arterial stiffening

(2014) Thomas J. LaRocca et al.   EXPERIMENTAL GERONTOLOGY

Mitochondrial ultrastructure and markers of dynamics in hepatocytes from aged, calorie restricted mice fed with different dietary fats

(2014) Husam Khraiwesh et al.   EXPERIMENTAL GERONTOLOGY

Genetic and environmental exposures constrain epigenetic drift over the human life course

(2014) Sonia Shah et al.   GENOME RESEARCH

Sirt3 Protects Cortical Neurons against Oxidative Stress via Regulating Mitochondrial Ca2+ and Mitochondrial Biogenesis

(2014) Shu-Hui Dai et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Effects of Lithium on Age-related Decline in Mitochondrial Turnover and Function in Caenorhabditis elegans

(2014) Z. Y. Tam et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Modelling age-related metabolic disorders in the mouse

(2014) Michelle E. Goldsworthy et al.   MAMMALIAN GENOME

Age-Related Decrease in the Mitochondrial Sirtuin Deacetylase Sirt3 Expression Associated with ROS Accumulation in the Auditory Cortex of the Mimetic Aging Rat Model

(2014) Lingling Zeng et al.   PLoS One

Metformin promotes lifespan through mitohormesis via the peroxiredoxin PRDX-2

(2014) W. De Haes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of the mitochondrial unfolded protein response does not predict longevity in Caenorhabditis elegans

(2014) Christopher F. Bennett et al.   Nature Communications

AMPK Modulates Tissue and Organismal Aging in a Non-Cell-Autonomous Manner

(2014) Matthew Ulgherait et al.   Cell Reports

The SIRT1 Activator SRT1720 Extends Lifespan and Improves Health of Mice Fed a Standard Diet

(2014) Sarah J. Mitchell et al.   Cell Reports

Differential expression of sirtuin family members in the developing, adult, and aged rat brain

(2014) Elena Sidorova-Darmos et al.   Frontiers in Aging Neuroscience

Clonal Expansion of Early to Mid-Life Mitochondrial DNA Point Mutations Drives Mitochondrial Dysfunction during Human Ageing

(2014) Laura C. Greaves et al.   PLoS Genetics

A mitochondrially targeted compound delays aging in yeast through a mechanism linking mitochondrial membrane lipid metabolism to mitochondrial redox biology

(2014) Michelle T. Burstein et al.   Redox Biology

Regulation of MnSOD Enzymatic Activity by Sirt3 Connects the Mitochondrial Acetylome Signaling Networks to Aging and Carcinogenesis

(2013) Randa Tao et al.   ANTIOXIDANTS & REDOX SIGNALING

MitoTimer probe reveals the impact of autophagy, fusion, and motility on subcellular distribution of young and old mitochondrial protein and on relative mitochondrial protein age

(2013) Andrew W Ferree et al.   Autophagy

The accumulation of misfolded proteins in the mitochondrial matrix is sensed by PINK1 to induce PARK2/Parkin-mediated mitophagy of polarized mitochondria

(2013) Seok Min Jin et al.   Autophagy

Aberrant expression of SIRT3 is conversely correlated with the progression and prognosis of human gastric cancer

(2013) Bing Yang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Muscle Mitohormesis Promotes Longevity via Systemic Repression of Insulin Signaling

(2013) Edward Owusu-Ansah et al.   CELL

Actin Dynamics Affect Mitochondrial Quality Control and Aging in Budding Yeast

(2013) Ryo Higuchi et al.   CURRENT BIOLOGY

Sirt3 Regulates Metabolic Flexibility of Skeletal Muscle Through Reversible Enzymatic Deacetylation

(2013) E. Jing et al.   DIABETES

Oxidative stress response elicited by mitochondrial dysfunction: Implication in the pathophysiology of aging

(2013) Chih-Hao Wang et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Age-dependent mitochondrial energy dynamics in the mice heart: Role of superoxide dismutase-2

(2013) Kumuda C. Das et al.   EXPERIMENTAL GERONTOLOGY

Light–dark condition regulates sirtuin mRNA levels in the retina

(2013) Norimitsu Ban et al.   EXPERIMENTAL GERONTOLOGY

A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects

(2013) Joseph L. McClay et al.   HUMAN MOLECULAR GENETICS

Markers of Human Skeletal Muscle Mitochondrial Biogenesis and Quality Control: Effects of Age and Aerobic Exercise Training

(2013) Adam R. Konopka et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

SIRT3 Deacetylates and Activates OPA1 To Regulate Mitochondrial Dynamics during Stress

(2013) Sadhana A. Samant et al.   MOLECULAR AND CELLULAR BIOLOGY

SirT3 Regulates the Mitochondrial Unfolded Protein Response

(2013) L. Papa et al.   MOLECULAR AND CELLULAR BIOLOGY

Germline mitochondrial DNA mutations aggravate ageing and can impair brain development

(2013) Jaime M. Ross et al.   NATURE

The role of autophagy in neurodegenerative disease

(2013) Ralph A Nixon   NATURE MEDICINE

The roles of senescence and telomere shortening in cardiovascular disease

(2013) Frej Fyhrquist et al.   Nature Reviews Cardiology

Thymidine kinase and mtDNA depletion in human cardiomyopathy: epigenetic and translational evidence for energy starvation

(2013) Christopher A. Koczor et al.   PHYSIOLOGICAL GENOMICS

Continuous Aging of the Human DNA Methylome Throughout the Human Lifespan

(2013) Åsa Johansson et al.   PLoS One

The Effect of Pro-Inflammatory Conditioning and/or High Glucose on Telomere Shortening of Aging Fibroblasts

(2013) Klelia D. Salpea et al.   PLoS One

Dysregulation of Mitochondrial Quality Control Processes Contribute to Sarcopenia in a Mouse Model of Premature Aging

(2013) Anna-Maria Joseph et al.   PLoS One

Mitochondrial Autophagy Involving Renal Injury and Aging Is Modulated by Caloric Intake in Aged Rat Kidneys

(2013) Jing Cui et al.   PLoS One

Mathematical Modeling of the Role of Mitochondrial Fusion and Fission in Mitochondrial DNA Maintenance

(2013) Zhi Yang Tam et al.   PLoS One

Parkin overexpression during aging reduces proteotoxicity, alters mitochondrial dynamics, and extends lifespan

(2013) A. Rana et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial DNA Haplotypes Define Gene Expression Patterns in Pluripotent and Differentiating Embryonic Stem Cells

(2013) Richard D.W. Kelly et al.   STEM CELLS

Loss-of-SIRT1 function during vascular ageing: Hyperphosphorylation mediated by cyclin-dependent kinase 5

(2013) Bo Bai et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Evaluating and responding to mitochondrial dysfunction: the mitochondrial unfolded-protein response and beyond

(2013) Cole M. Haynes et al.   TRENDS IN CELL BIOLOGY

Increased Mammalian Lifespan and a Segmental and Tissue-Specific Slowing of Aging after Genetic Reduction of mTOR Expression

(2013) J. Julie Wu et al.   Cell Reports

DNA methylation age of human tissues and cell types

(2013) Steve Horvath   GENOME BIOLOGY

Coordinated changes in AHRR methylation in lymphoblasts and pulmonary macrophages from smokers

(2012) Martha M. Monick et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Sirt3 inhibits hepatocellular carcinoma cell growth through reducing Mdm2-mediated p53 degradation

(2012) Yuan-Yuan Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mitochondrial dynamics in yeast cell death and aging

(2012) Ralf J. Braun et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Mitochondria, maternal inheritance, and asymmetric fitness: Why males die younger

(2012) Jonci N. Wolff et al.   BIOESSAYS

The free-radical theory of ageing - older, wiser and still alive

(2012) Thomas B. L. Kirkwood et al.   BIOESSAYS

SIRT3 Is a Mitochondrial Tumor Suppressor: A Scientific Tale That Connects Aberrant Cellular ROS, the Warburg Effect, and Carcinogenesis

(2012) M. C. Haigis et al.   CANCER RESEARCH

Impaired Insulin/IGF1 Signaling Extends Life Span by Promoting Mitochondrial L-Proline Catabolism to Induce a Transient ROS Signal

(2012) Kim Zarse et al.   Cell Metabolism

Tightrope act: autophagy in stem cell renewal, differentiation, proliferation, and aging

(2012) Kanchan Phadwal et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Mitochondrial quality control: a matter of life and death for neurons

(2012) Elena I Rugarli et al.   EMBO JOURNAL

Mitochondrial regulation of epigenetics and its role in human diseases

(2012) Sheroy Minocherhomji et al.   Epigenetics

Genome-wide DNA hydroxymethylation changes are associated with neurodevelopmental genes in the developing human cerebellum

(2012) Tao Wang et al.   HUMAN MOLECULAR GENETICS

Universal heteroplasmy of human mitochondrial DNA

(2012) B. A. I. Payne et al.   HUMAN MOLECULAR GENETICS

Epigenome-wide association study in the European Prospective Investigation into Cancer and Nutrition (EPIC-Turin) identifies novel genetic loci associated with smoking

(2012) Natalie S. Shenker et al.   HUMAN MOLECULAR GENETICS

SIRT3 interacts with the daf-16 homolog FOXO3a in the Mitochondria, as well as increases FOXO3a Dependent Gene expression

(2012) Kristi Muldoon Jacobs et al.   International Journal of Biological Sciences

Metabolic Labeling Reveals Proteome Dynamics of Mouse Mitochondria

(2012) Tae-Young Kim et al.   MOLECULAR & CELLULAR PROTEOMICS

Accelerated aging as evidenced by increased telomere shortening and mitochondrial DNA depletion in patients with type 2 diabetes

(2012) Finny Monickaraj et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

The sirtuin SIRT6 regulates lifespan in male mice

(2012) Yariv Kanfi et al.   NATURE

Mutant SOD1G93A triggers mitochondrial fragmentation in spinal cord motor neurons: Neuroprotection by SIRT3 and PGC-1α

(2012) Wenjun Song et al.   NEUROBIOLOGY OF DISEASE

Mitochondrial DNA copy number is regulated in a tissue specific manner by DNA methylation of the nuclear-encoded DNA polymerase gamma A

(2012) Richard D. W. Kelly et al.   NUCLEIC ACIDS RESEARCH

CNS SIRT3 Expression Is Altered by Reactive Oxygen Species and in Alzheimer’s Disease

(2012) Heather J. M. Weir et al.   PLoS One

Distinct DNA methylomes of newborns and centenarians

(2012) H. Heyn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial Import Efficiency of ATFS-1 Regulates Mitochondrial UPR Activation

(2012) A. M. Nargund et al.   SCIENCE

Global DNA methylation levels are modulated by mitochondrial DNA variants

(2012) Dina Bellizzi et al.   Epigenomics

Fusion and Fission: Interlinked Processes Critical for Mitochondrial Health

(2011) David C. Chan   Annual Review of Genetics

SIRT3 Opposes Reprogramming of Cancer Cell Metabolism through HIF1α Destabilization

(2011) Lydia W.S. Finley et al.   CANCER CELL

The Cell-Non-Autonomous Nature of Electron Transport Chain-Mediated Longevity

(2011) Jenni Durieux et al.   CELL

The link between mitochondrial DNA hypervariable segment I heteroplasmy and ageing among genetically unrelated Latvians

(2011) Liana Pliss et al.   EXPERIMENTAL GERONTOLOGY

Neutral mitochondrial heteroplasmy and the influence of aging

(2011) Neal Sondheimer et al.   HUMAN MOLECULAR GENETICS

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

A novel role for mitochondria in regulating epigenetic modifications in the nucleus

(2010) Dominic Smiraglia et al.   CANCER BIOLOGY & THERAPY

SIRT3 Is a Mitochondria-Localized Tumor Suppressor Required for Maintenance of Mitochondrial Integrity and Metabolism during Stress

(2010) Hyun-Seok Kim et al.   CANCER CELL

Intrinsic Cooperation between p16INK4a and p21Waf1/Cip1 in the Onset of Cellular Senescence and Tumor Suppression In vivo

(2010) S. Takeuchi et al.   CANCER RESEARCH

Sirt3 Mediates Reduction of Oxidative Damage and Prevention of Age-Related Hearing Loss under Caloric Restriction

(2010) Shinichi Someya et al.   CELL

How increased oxidative stress promotes longevity and metabolic health: The concept of mitochondrial hormesis (mitohormesis)

(2010) Michael Ristow et al.   EXPERIMENTAL GERONTOLOGY

Human aging and somatic point mutations in mtDNA: a comparative study of generational differences (grandparents and grandchildren)

(2010) Anderson Nonato do Rosário Marinho et al.   GENETICS AND MOLECULAR BIOLOGY

Loss of MARCH5 mitochondrial E3 ubiquitin ligase induces cellular senescence through dynamin-related protein 1 and mitofusin 1

(2010) Y.-Y. Park et al.   JOURNAL OF CELL SCIENCE

Mitochondrial dysfunction as a cause of ageing

(2010) A. Trifunovic et al.   JOURNAL OF INTERNAL MEDICINE

The Matrix Peptide Exporter HAF-1 Signals a Mitochondrial UPR by Activating the Transcription Factor ZC376.7 in C. elegans

(2010) Cole M. Haynes et al.   MOLECULAR CELL

SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation

(2010) Matthew D. Hirschey et al.   NATURE

A Mitochondrial Superoxide Signal Triggers Increased Longevity in Caenorhabditis elegans

(2010) Wen Yang et al.   PLOS BIOLOGY

Effect of calorie restriction on the metabolic history of chronologically aging yeast

(2009) Alexander A. Goldberg et al.   EXPERIMENTAL GERONTOLOGY

Increasing organismal healthspan by enhancing mitochondrial protein quality control

(2009) Karin Luce et al.   NATURE CELL BIOLOGY

ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation

(2009) K. E. Wellen et al.   SCIENCE

Ydc1p ceramidase triggers organelle fragmentation, apoptosis and accelerated ageing in yeast

(2008) A. M. Aerts et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Endurance Exercise as a Countermeasure for Aging

(2008) I. R. Lanza et al.   DIABETES

Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

(2008) Gilad Twig et al.   EMBO JOURNAL

Mitochondrial dysfunction leads to reduced chronological lifespan and increased apoptosis in yeast

(2008) An M. Aerts et al.   FEBS LETTERS

Telomerase does not counteract telomere shortening but protects mitochondrial function under oxidative stress

(2008) S. Ahmed et al.   JOURNAL OF CELL SCIENCE

What causes mitochondrial DNA deletions in human cells?

(2008) Kim J Krishnan et al.   NATURE GENETICS

A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis

(2008) B.-H. Ahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA