NF-κB inhibition delays DNA damage–induced senescence and aging in mice

Aging, Rejuvenation, and Epigenetic Reprogramming: Resetting the Aging Clock

(2012) Thomas A. Rando et al.   CELL

Muscle-derived stem/progenitor cell dysfunction limits healthspan and lifespan in a murine progeria model

(2012) Mitra Lavasani et al.   Nature Communications

Quantification of Oxidative DNA Lesions in Tissues of Long-Evans Cinnamon Rats by Capillary High-Performance Liquid Chromatography−Tandem Mass Spectrometry Coupled with Stable Isotope-Dilution Method

(2011) Jin Wang et al.   ANALYTICAL CHEMISTRY

Physiological consequences of defects in ERCC1–XPF DNA repair endonuclease

(2011) Siobhán Q. Gregg et al.   DNA REPAIR

A mouse model of accelerated liver aging caused by a defect in DNA repair

(2011) Siobhán Q. Gregg et al.   HEPATOLOGY

Four faces of cellular senescence

(2011) Francis Rodier et al.   JOURNAL OF CELL BIOLOGY

Premature aging-related peripheral neuropathy in a mouse model of progeria

(2011) James R. Goss et al.   MECHANISMS OF AGEING AND DEVELOPMENT

The ageing systemic milieu negatively regulates neurogenesis and cognitive function

(2011) Saul A. Villeda et al.   NATURE

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

Systemic delivery of NEMO binding domain/IKKγ inhibitory peptide to young mdx mice improves dystrophic skeletal muscle histopathology

(2011) Daniel P. Reay et al.   NEUROBIOLOGY OF DISEASE

Mitochondria and the Autophagy-Inflammation-Cell Death Axis in Organismal Aging

(2011) D. R. Green et al.   SCIENCE

Nuclear initiated NF-κB signaling: NEMO and ATM take center stage

(2010) Shigeki Miyamoto   CELL RESEARCH

DNA-SCARS: distinct nuclear structures that sustain damage-induced senescence growth arrest and inflammatory cytokine secretion

(2010) F. Rodier et al.   JOURNAL OF CELL SCIENCE

Accelerated aging of intervertebral discs in a mouse model of progeria

(2010) Nam Vo et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

When Sirtuins and NF-κB Collide

(2009) Gioacchino Natoli   CELL

SIRT6 Links Histone H3 Lysine 9 Deacetylation to NF-κB-Dependent Gene Expression and Organismal Life Span

(2009) Tiara L.A. Kawahara et al.   CELL

Hypoxia-inducible factor 1α activates and is inhibited by unoccupied estrogen receptor β

(2009) Wonchung Lim et al.   FEBS LETTERS

Protocols to detect senescence-associated beta-galactosidase (SA-βgal) activity, a biomarker of senescent cells in culture and in vivo

(2009) Florence Debacq-Chainiaux et al.   Nature Protocols

Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span

(2009) C. Selman et al.   SCIENCE

Molecular inflammation: Underpinnings of aging and age-related diseases

(2008) Hae Young Chung et al.   AGEING RESEARCH REVIEWS

Shared Principles in NF-κB Signaling

(2008) Matthew S. Hayden et al.   CELL

8,5′-Cyclopurine-2′-deoxynucleosides in DNA: Mechanisms of formation, measurement, repair and biological effects

(2008) Pawel Jaruga et al.   DNA REPAIR

Akt-dependent regulation of NF- B is controlled by mTOR and Raptor in association with IKK

(2008) H. C. Dan et al.   GENES & DEVELOPMENT

Nuclear factor-kappa B signaling in skeletal muscle atrophy

(2008) Hong Li et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

ERCC1-XPF Endonuclease Facilitates DNA Double-Strand Break Repair

(2008) A. Ahmad et al.   MOLECULAR AND CELLULAR BIOLOGY

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

(2008) Jean-Philippe Coppé et al.   PLOS BIOLOGY

Delayed and Accelerated Aging Share Common Longevity Assurance Mechanisms

(2008) Björn Schumacher et al.   PLoS Genetics

Cell autonomous expression of inflammatory genes in biologically aged fibroblasts associated with elevated NF-kappaB activity

(2008) Andres Kriete et al.   Immunity & Ageing

Antiinflammatory and Antiatherogenic Effects of the NF-κB Inhibitor Acetyl-11-Keto-β-Boswellic Acid in LPS-Challenged ApoE −/− Mice

(2007) Clarisse Cuaz-Pérolin et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY