Gene Silencing of the Mitochondrial Adaptor p66 Shc Suppresses Vascular Hyperglycemic Memory in Diabetes

Methylglyoxal promotes oxidative stress and endothelial dysfunction

(2012) Cristina M. Sena et al.   PHARMACOLOGICAL RESEARCH

Endothelium Derived Nitric Oxide Synthase Negatively Regulates the PDGF-Survivin Pathway during Flow-Dependent Vascular Remodeling

(2012) Jun Yu et al.   PLoS One

Redox Regulation of Mitochondrial Function

(2011) Diane E. Handy et al.   ANTIOXIDANTS & REDOX SIGNALING

Oxidized Low-Density Lipoprotein Activates p66 Shc via Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1, Protein Kinase C-β, and c-Jun N-Terminal Kinase Kinase in Human Endothelial Cells

(2011) Yi Shi et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Homocysteine promotes human endothelial cell dysfunction via site-specific epigenetic regulation of p66shc

(2011) Cuk-Seong Kim et al.   CARDIOVASCULAR RESEARCH

Repression of P66Shc Expression by SIRT1 Contributes to the Prevention of Hyperglycemia-Induced Endothelial Dysfunction

(2011) Shuang Zhou et al.   CIRCULATION RESEARCH

Mitochondria in Apoptosis: Bcl-2 Family Members and Mitochondrial Dynamics

(2011) Jean-Claude Martinou et al.   DEVELOPMENTAL CELL

Beneficial effect of the oligomerized polyphenol oligonol on high glucose-induced changes in eNOS phosphorylation and dephosphorylation in endothelial cells

(2010) Xiao-Hong Zhang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Epigenetics

(2010) Mark E. Cooper et al.   CIRCULATION RESEARCH

Oxidative Stress and Diabetic Complications

(2010) Ferdinando Giacco et al.   CIRCULATION RESEARCH

Hyperglycaemia-induced impairment of endothelium-dependent vasorelaxation in rat mesenteric arteries is mediated by intracellular methylglyoxal levels in a pathway dependent on oxidative stress

(2010) O. Brouwers et al.   DIABETOLOGIA

Is oxidative stress a therapeutic target in cardiovascular disease?

(2010) Thomas Münzel et al.   EUROPEAN HEART JOURNAL

Intensive glycemic control and cardiovascular disease: an update

(2010) Aparna Brown et al.   Nature Reviews Cardiology

Poly(ADP-ribose) polymerase-1 (PARP-1) and its therapeutic implications

(2010) Rupinder K. Sodhi et al.   VASCULAR PHARMACOLOGY

Vitamins E and C in the Prevention of Cardiovascular Disease in Men

(2008) Howard D. Sesso   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia

(2008) Assam El-Osta et al.   JOURNAL OF EXPERIMENTAL MEDICINE

UKPDS and the Legacy Effect

(2008) John Chalmers et al.   NEW ENGLAND JOURNAL OF MEDICINE

Intensive Blood Glucose Control and Vascular Outcomes in Patients with Type 2 Diabetes

(2008)   NEW ENGLAND JOURNAL OF MEDICINE

Effects of Intensive Glucose Lowering in Type 2 Diabetes

(2008)   NEW ENGLAND JOURNAL OF MEDICINE

10-Year Follow-up of Intensive Glucose Control in Type 2 Diabetes

(2008) Rury R. Holman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Glucose Control and Vascular Complications in Veterans with Type 2 Diabetes

(2008) William Duckworth et al.   NEW ENGLAND JOURNAL OF MEDICINE

AGE-receptor-1 counteracts cellular oxidant stress induced by AGEs via negative regulation of p66shc-dependent FKHRL1 phosphorylation

(2007) Weijing Cai et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Final Common Molecular Pathways of Aging and Cardiovascular Disease

(2007) Francesco Cosentino et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY