Updating the Mitochondrial Free Radical Theory of Aging: An Integrated View, Key Aspects, and Confounding Concepts

The extreme longevity ofArctica islandicais associated with increased peroxidation resistance in mitochondrial membranes

(2012) Daniel Munro et al.   AGING CELL

Effects of aging and methionine restriction applied at old age on ROS generation and oxidative damage in rat liver mitochondria

(2012) Inés Sanchez-Roman et al.   BIOGERONTOLOGY

Testing the Oxidative Stress Hypothesis of Aging in Primate Fibroblasts: Is There a Correlation Between Species Longevity and Cellular ROS Production?

(2012) A. Csiszar et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study

(2012) Julie A. Mattison et al.   NATURE

Specific mitochondrial DNA mutation in mice regulates diabetes and lymphoma development

(2012) O. Hashizume et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Superoxide dismutase is dispensable for normal animal lifespan

(2012) J. M. Van Raamsdonk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activities of DNA base excision repair enzymes in liver and brain correlate with body mass, but not lifespan

(2011) Melissa M. Page et al.   AGE

Molecular and structural antioxidant defenses against oxidative stress in animals

(2011) Reinald Pamplona et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

An evolutionary comparative scan for longevity-related oxidative stress resistance mechanisms in homeotherms

(2011) Reinald Pamplona et al.   BIOGERONTOLOGY

Measurement of H2O2 within Living Drosophila during Aging Using a Ratiometric Mass Spectrometry Probe Targeted to the Mitochondrial Matrix

(2011) Helena M. Cochemé et al.   Cell Metabolism

The redox stress hypothesis of aging

(2011) Rajindar S. Sohal et al.   FREE RADICAL BIOLOGY AND MEDICINE

Forty percent methionine restriction lowers DNA methylation, complex I ROS generation, and oxidative damage to mtDNA and mitochondrial proteins in rat heart

(2011) Ines Sanchez-Roman et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Enhanced protein repair and recycling are not correlated with longevity in 15 vertebrate endotherm species

(2010) Kurtis D. Salway et al.   AGE

Antioxidant enzyme activities are not broadly correlated with longevity in 14 vertebrate endotherm species

(2010) Melissa M. Page et al.   AGE

Mitochondrial–nuclear epistasis: Implications for human aging and longevity

(2010) Gregory J. Tranah   AGEING RESEARCH REVIEWS

Resistance to experimental tumorigenesis in cells of a long-lived mammal, the naked mole-rat (Heterocephalus glaber)

(2010) Sitai Liang et al.   AGING CELL

Targeting the age-related occurrence, removal, and accumulation of molecular damage by hormesis

(2010) Suresh I. S. Rattan   Annals of the New York Academy of Sciences

Fluorescent Protein-Based Redox Probes

(2010) Andreas J. Meyer et al.   ANTIOXIDANTS & REDOX SIGNALING

Reactive Oxygen Species and Aging in Caenorhabditis elegans: Causal or Casual Relationship?

(2010) Jeremy Michael Van Raamsdonk et al.   ANTIOXIDANTS & REDOX SIGNALING

Sirt3 Mediates Reduction of Oxidative Damage and Prevention of Age-Related Hearing Loss under Caloric Restriction

(2010) Shinichi Someya et al.   CELL

How increased oxidative stress promotes longevity and metabolic health: The concept of mitochondrial hormesis (mitohormesis)

(2010) Michael Ristow et al.   EXPERIMENTAL GERONTOLOGY

A Network Perspective on Metabolism and Aging

(2010) Q. A. Soltow et al.   INTEGRATIVE AND COMPARATIVE BIOLOGY

Mitochondrial DNA sequences are present inside nuclear DNA in rat tissues and increase with age

(2010) Pilar Caro et al.   MITOCHONDRION

In vivo imaging of hydrogen peroxide production in a murine tumor model with a chemoselective bioluminescent reporter

(2010) G. C. Van de Bittner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The β-Blocker Atenolol Lowers the Longevity-Related Degree of Fatty Acid Unsaturation, Decreases Protein Oxidative Damage, and Increases Extracellular Signal-Regulated Kinase Signaling in the Heart of C57BL/6 Mice

(2010) Ines Sanchez-Roman et al.   REJUVENATION RESEARCH

Extending Healthy Life Span--From Yeast to Humans

(2010) L. Fontana et al.   SCIENCE

Is the oxidative stress theory of aging dead?

(2009) Viviana I. Pérez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Modulation of oxidative phosphorylation machinery signifies a prime mode of anti-ageing mechanism of calorie restriction in male rat liver mitochondria

(2009) Diksha Dani et al.   BIOGERONTOLOGY

Life Span Extension in Mice by Food Restriction Depends on an Energy Imbalance

(2009) Rajindar S. Sohal et al.   JOURNAL OF NUTRITION

Life-Span Extension in Mice by Preweaning Food Restriction and by Methionine Restriction in Middle Age

(2009) L. Sun et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Calorie restriction causes healthy life span extension in the filamentous fungus Podospora anserina

(2009) Anne D. van Diepeningen et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila

(2009) Richard C. Grandison et al.   NATURE

Hypersensitivity to contact inhibition provides a clue to cancer resistance of naked mole-rat

(2009) A. Seluanov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein stability and resistance to oxidative stress are determinants of longevity in the longest-living rodent, the naked mole-rat

(2009) V. I. Perez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys

(2009) R. J. Colman et al.   SCIENCE

The oxidative stress theory of aging: embattled or invincible? Insights from non-traditional model organisms

(2008) Rochelle Buffenstein et al.   AGE

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

Sites of generation of reactive oxygen species in homogenates of brain tissue determined with the use of respiratory substrates and inhibitors

(2008) Alexei P. Kudin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Lowered methionine ingestion as responsible for the decrease in rodent mitochondrial oxidative stress in protein and dietary restriction

(2008) Mónica López-Torres et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Forty percent and eighty percent methionine restriction decrease mitochondrial ROS generation and oxidative stress in rat liver

(2008) Pilar Caro et al.   BIOGERONTOLOGY

Effect of 40% restriction of dietary amino acids (except methionine) on mitochondrial oxidative stress and biogenesis, AIF and SIRT1 in rat liver

(2008) Pilar Caro et al.   BIOGERONTOLOGY

Against the oxidative damage theory of aging: superoxide dismutases protect against oxidative stress but have little or no effect on life span in Caenorhabditis elegans

(2008) R. Doonan et al.   GENES & DEVELOPMENT

Oxidative stress caused by blocking of mitochondrial Complex I H+ pumping as a link in aging/disease vicious cycle

(2008) Andrea Dlasková et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

A systematic look at an old problem

(2008) Thomas B. L. Kirkwood   NATURE

Lifespan and reproduction in Drosophila: New insights from nutritional geometry

(2008) K. P. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The links between membrane composition, metabolic rate and lifespan

(2006) A.J. Hulbert   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY