Cognitive dysfunction: A growing link between diabetes and Alzheimer's disease

Korean Thistle (Cirsium japonicum var. maackii (Maxim.) Matsum.): A Potential Dietary Supplement against Diabetes and Alzheimer’s Disease

(2019) Aditi Wagle et al.   MOLECULES

Early-Stage Alzheimer’s Disease Is Associated with Simultaneous Systemic and Central Nervous System Dysregulation of Insulin-Linked Metabolic Pathways

(2019) Suzanne M. de la Monte et al.   JOURNAL OF ALZHEIMERS DISEASE

ε3/4 genotype of the apolipoprotein E is associated with higher risk of Alzheimer's disease in patients with type 2 diabetes mellitus

(2019) Yi Tang et al.   GENE

Tannic acid as a natural antioxidant compound: Discovery of a potent metabolic enzyme inhibitor for a new therapeutic approach in diabetes and Alzheimer's disease

(2019) Fikret Türkan et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Advanced Glycation End Products Modulate Amyloidogenic APP Processing and Tau Phosphorylation: A Mechanistic Link between Glycation and the Development of Alzheimer’s Disease

(2018) Kedar Batkulwar et al.   ACS Chemical Neuroscience

Detection of the receptor for advanced glycation endproducts in neuronally-derived exosomes in plasma

(2018) Sierra A. Patterson et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The BET/BRD inhibitor JQ1 attenuates diabetes-induced cognitive impairment in rats by targeting Nox4-Nrf2 redox imbalance

(2018) Ershun Liang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Insulin is a potential antioxidant for diabetes-associated cognitive decline via regulating Nrf2 dependent antioxidant enzymes

(2018) Ying Song et al.   BIOMEDICINE & PHARMACOTHERAPY

Cyanidin-3- O -glucoside ameliorates diabetic nephropathy through regulation of glutathione pool

(2018) Yan Qin et al.   BIOMEDICINE & PHARMACOTHERAPY

The protective effect of formononetin on cognitive impairment in streptozotocin (STZ)-induced diabetic mice

(2018) Jinchun Wang et al.   BIOMEDICINE & PHARMACOTHERAPY

Gallic acid attenuates type I diabetic nephropathy in rats

(2018) Mayuresh Sudamrao Garud et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Global Prevalence of Type 2 Diabetes over the Next Ten Years (2018-2028)

(2018) AMY BRADSHAW KAISER et al.   DIABETES

IDF Diabetes Atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045

(2018) N.H. Cho et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Accumulation of advanced glycation end products is associated with macrovascular events and glycaemic control with microvascular complications in Type 2 diabetes mellitus

(2018) K. Yozgatli et al.   DIABETIC MEDICINE

HbA1c, diabetes and cognitive decline: the English Longitudinal Study of Ageing

(2018) Fanfan Zheng et al.   DIABETOLOGIA

DA5-CH, a novel GLP-1/GIP dual agonist, effectively ameliorates the cognitive impairments and pathology in the APP/PS1 mouse model of Alzheimer's disease

(2018) Yue Cao et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Secreted amyloid precursor protein alpha activates neuronal insulin receptors and prevents diabetes-induced encephalopathy

(2018) Brent D. Aulston et al.   EXPERIMENTAL NEUROLOGY

Gene therapy with the angiogenic neuropeptide secretoneurin ameliorates experimental diabetic neuropathy

(2018) Markus Theurl et al.   FASEB JOURNAL

Tau ablation in mice leads to pancreatic β cell dysfunction and glucose intolerance

(2018) Nadeeja Wijesekara et al.   FASEB JOURNAL

The diabetes drug liraglutide reverses cognitive impairment in mice and attenuates insulin receptor and synaptic pathology in a non-human primate model of Alzheimer's disease

(2018) Andre F Batista et al.   JOURNAL OF PATHOLOGY

Insulin resistance and cognitive test performance in elderly adults: National health and nutrition examination survey (NHANES)

(2018) Ayesha Z. Sherzai et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Fibroblast growth factor 1 ameliorates diabetic nephropathy by an anti-inflammatory mechanism

(2018) Guang Liang et al.   KIDNEY INTERNATIONAL

Thyroid hormone improves insulin signaling and reduces the activation of neurodegenerative pathway in the hippocampus of diabetic adult male rats

(2018) Fernanda Prieto-Almeida et al.   LIFE SCIENCES

The BACE1 product sAPPβ induces ER stress and inflammation and impairs insulin signaling

(2018) Gaia Botteri et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Etiology of type 2 diabetes and Alzheimer's disease: Exploring the mitochondria

(2018) Talisa K. Silzer et al.   MITOCHONDRION

Chrysophanol Relieves Cognition Deficits and Neuronal Loss Through Inhibition of Inflammation in Diabetic Mice

(2018) Xu Chu et al.   NEUROCHEMICAL RESEARCH

Liraglutide ameliorates cognitive decline by promoting autophagy via the AMP-activated protein kinase/mammalian target of rapamycin pathway in a streptozotocin-induced mouse model of diabetes

(2018) Fei-Juan Kong et al.   NEUROPHARMACOLOGY

Insulin-signaling Pathway Regulates the Degradation of Amyloid β-protein via Astrocytes

(2018) Naoki Yamamoto et al.   NEUROSCIENCE

Kidney protection effects of dihydroquercetin on diabetic nephropathy through suppressing ROS and NLRP3 inflammasome

(2018) Tao Ding et al.   PHYTOMEDICINE

Carnosic acid improves diabetic nephropathy by activating Nrf2/ARE and inhibition of NF-κB pathway

(2018) Zhisheng Xie et al.   PHYTOMEDICINE

Insulin treatment partially prevents cognitive and hippocampal alterations as well as glucocorticoid dysregulation in early-onset insulin-deficient diabetic rats

(2018) Nathalie Marissal-Arvy et al.   PSYCHONEUROENDOCRINOLOGY

Atorvastatin and insulin equally mitigate brain pathology in diabetic rats

(2018) Wasana Pratchayasakul et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Renoprotective effect of nifuroxazide in diabetes-induced nephropathy: impact on NFκB, oxidative stress, and apoptosis

(2018) Nehal M. Elsherbiny et al.   TOXICOLOGY MECHANISMS AND METHODS

Cinacalcet-mediated activation of the CaMKKβ-LKB1-AMPK pathway attenuates diabetic nephropathy in db/db mice by modulation of apoptosis and autophagy

(2018) Ji Hee Lim et al.   Cell Death & Disease

The beta secretase BACE1 regulates the expression of insulin receptor in the liver

(2018) Paul J. Meakin et al.   Nature Communications

Ligustrazine attenuates renal damage by inhibiting endoplasmic reticulum stress in diabetic nephropathy by inactivating MAPK pathways

(2018) Hongling Yang et al.   RSC Advances

Altered Insulin/Insulin-Like Growth Factor Signaling in a Comorbid Rat model of Ischemia and β-Amyloid Toxicity

(2018) Zareen Amtul et al.   Scientific Reports

Renoprotective effect of nifuroxazide in diabetes-induced nephropathy: impact on NFκB, oxidative stress, and apoptosis

(2018) Nehal M. Elsherbiny et al.   TOXICOLOGY MECHANISMS AND METHODS

Proteomic Analysis of Hippocampus and Cortex in Streptozotocin-Induced Diabetic Model Mice Showing Dementia

(2018) Kenji Matsuura et al.   Journal of Diabetes Research

Metformin treatment ameliorates diabetes-associated decline in hippocampal neurogenesis and memory via phosphorylation of insulin receptor substrate 1

(2018) Daisuke Tanokashira et al.   FEBS Open Bio

Novel subgroups of adult-onset diabetes and their association with outcomes: a data-driven cluster analysis of six variables

(2018) Emma Ahlqvist et al.   Lancet Diabetes & Endocrinology

Insulin-like growth factor receptor signaling regulates working memory, mitochondrial metabolism, and amyloid-β uptake in astrocytes

(2018) Sreemathi Logan et al.   Molecular Metabolism

Type 2 diabetes impairs odour detection, olfactory memory and olfactory neuroplasticity; effects partly reversed by the DPP-4 inhibitor Linagliptin

(2018) Grazyna Lietzau et al.   Acta Neuropathologica Communications

The Improving Effect of HL271, a Chemical Derivative of Metformin, a Popular Drug for Type II Diabetes Mellitus, on Aging-induced Cognitive Decline

(2018) Eunyoung Bang et al.   Experimental Neurobiology

A curcumin derivative J147 ameliorates diabetic peripheral neuropathy in streptozotocin (STZ)-induced DPN rat models through negative regulation AMPK on TRPA1

(2018) Juan Lv et al.   Acta Cirurgica Brasileira

The effects of safranal, a constitute of saffron, and metformin on spatial learning and memory impairments in type-1 diabetic rats: behavioral and hippocampal histopathological and biochemical evaluations

(2018) Fatemeh Delkhosh-Kasmaie et al.   BIOMEDICINE & PHARMACOTHERAPY

The Natural Rotenoid Deguelin Ameliorates Diabetic Neuropathy by Decreasing Oxidative Stress and Plasma Glucose Levels in Rats via the Nrf2 Signalling Pathway

(2018) Ji Chen et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Low glucagon-like peptide-1 (GLP-1) concentration in serum is indicative of mild cognitive impairment in type 2 diabetes patients

(2018) Peipei Wu et al.   CLINICAL NEUROLOGY AND NEUROSURGERY

Synergistic Exacerbation of Mitochondrial and Synaptic Dysfunction and Resultant Learning and Memory Deficit in a Mouse Model of Diabetic Alzheimer's Disease

(2018) Yongfu Wang et al.   JOURNAL OF ALZHEIMERS DISEASE

Evaluation of a combination digital retinal camera with spectral-domain optical coherence tomography (SD-OCT) that might be used for the screening of diabetic retinopathy with telemedicine: A pilot study

(2018) George E. Sanborn et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Anti-diabetic vanadyl complexes reduced Alzheimer’s disease pathology independent of amyloid plaque deposition

(2018) Yaqiong Dong et al.   Science China-Life Sciences

Neural correlates of liraglutide effects in persons at risk for Alzheimer’s disease

(2018) Kathleen T. Watson et al.   BEHAVIOURAL BRAIN RESEARCH

Metformin attenuates diabetes-induced tau hyperphosphorylation in vitro and in vivo by enhancing autophagic clearance

(2018) Jin-Liang Chen et al.   EXPERIMENTAL NEUROLOGY

Amyloid-β and islet amyloid pathologies link Alzheimer’s disease and type 2 diabetes in a transgenic model

(2017) Nadeeja Wijesekara et al.   FASEB JOURNAL

Association of Cerebrospinal Fluid (CSF) Insulin with Cognitive Performance and CSF Biomarkers of Alzheimer’s Disease

(2017) Stefan L.C. Geijselaers et al.   JOURNAL OF ALZHEIMERS DISEASE

Plasma Amyloid-β Peptides in Type 2 Diabetes: A Matched Case-Control Study

(2017) Kirsten E. Peters et al.   JOURNAL OF ALZHEIMERS DISEASE

Intranasal insulin treatment restores cognitive deficits and insulin signaling impairment induced by repeated methamphetamine exposure

(2017) Elmira Beirami et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

cAMP/PKA signaling pathway contributes to neuronal apoptosis via regulating IDE expression in a mixed model of type 2 diabetes and Alzheimer's disease

(2017) Huajie Li et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Insulin differentially affects the distribution kinetics of amyloid beta 40 and 42 in plasma and brain

(2017) Suresh Kumar Swaminathan et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The Research on the Relationship of RAGE, LRP-1, and Aβ Accumulation in the Hippocampus, Prefrontal Lobe, and Amygdala of STZ-Induced Diabetic Rats

(2017) Lou-Yan Ma et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Fenofibrate ameliorates diabetic retinopathy by modulating Nrf2 signaling and NLRP3 inflammasome activation

(2017) Qiuping Liu et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Dementia-like pathology in type-2 diabetes: A novel microRNA mechanism

(2017) Anuradha Kalani et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Molecular interaction between type 2 diabetes and Alzheimer’s disease through cross-seeding of protein misfolding

(2017) I Moreno-Gonzalez et al.   MOLECULAR PSYCHIATRY

MicroRNA therapeutics: towards a new era for the management of cancer and other diseases

(2017) Rajesha Rupaimoole et al.   NATURE REVIEWS DRUG DISCOVERY

Central insulin dysregulation and energy dyshomeostasis in two mouse models of Alzheimer's disease

(2017) Ramon Velazquez et al.   NEUROBIOLOGY OF AGING

Tau hyperphosphorylation in the brain of ob/ob mice is due to hypothermia: Importance of thermoregulation in linking diabetes and Alzheimer's disease

(2017) Maud Gratuze et al.   NEUROBIOLOGY OF DISEASE

Insulin deficiency results in reversible protein kinase A activation and tau phosphorylation

(2017) Judith M. van der Harg et al.   NEUROBIOLOGY OF DISEASE

Matrix metalloproteinase 14 modulates diabetes and Alzheimer’s disease cross-talk: a meta-analysis

(2017) Jack Cheng et al.   NEUROLOGICAL SCIENCES

New Horizons in Diabetic Neuropathy: Mechanisms, Bioenergetics, and Pain

(2017) Eva L. Feldman et al.   NEURON

Agmatine ameliorates type 2 diabetes induced-Alzheimer's disease-like alterations in high-fat diet-fed mice via reactivation of blunted insulin signalling

(2017) Somang Kang et al.   NEUROPHARMACOLOGY

Angiotensin-(1–7) administration attenuates Alzheimer’s disease-like neuropathology in rats with streptozotocin-induced diabetes via Mas receptor activation

(2017) Jin-Liang Chen et al.   NEUROSCIENCE

Ferulic acid attenuates diabetes-induced cognitive impairment in rats via regulation of PTP1B and insulin signaling pathway

(2017) Hao Wang et al.   PHYSIOLOGY & BEHAVIOR

Type 2 Diabetes Mellitus and Impaired Renal Function Are Associated With Brain Alterations and Poststroke Cognitive Decline

(2017) Einor Ben Assayag et al.   STROKE

Adiponectin controls the apoptosis and the expression of tight junction proteins in brain endothelial cells through AdipoR1 under beta amyloid toxicity

(2017) Juhyun Song et al.   Cell Death & Disease

Chronic diabetic states worsen Alzheimer neuropathology and cognitive deficits accompanying disruption of calcium signaling in leptin-deficient APP/PS1 mice

(2017) Shuai Zhang et al.   Oncotarget

Increased dementia risk predominantly in diabetes mellitus rather than in hypertension or hyperlipidemia: a population-based cohort study

(2017) Yen-Chun Fan et al.   Alzheimers Research & Therapy

The role of melatonin in the onset and progression of type 3 diabetes

(2017) Juhyun Song et al.   Molecular Brain

Antidiabetic Drugs in Alzheimer’s Disease: Mechanisms of Action and Future Perspectives

(2017) Grazia Daniela Femminella et al.   Journal of Diabetes Research

The BET/BRD inhibitor JQ1 improves brain plasticity in WT and APP mice

(2017) E Benito et al.   Translational Psychiatry

Capsaicin reduces Alzheimer-associated tau changes in the hippocampus of type 2 diabetes rats

(2017) Weijie Xu et al.   PLoS One

Insulin deprivation induces PP2A inhibition and tau hyperphosphorylation in hTau mice, a model of Alzheimer’s disease-like tau pathology

(2017) Maud Gratuze et al.   Scientific Reports

Erythropoietin ameliorates diabetes-associated cognitive dysfunction in vitro and in vivo

(2017) Meng Wang et al.   Scientific Reports

Vanillin Affects Amyloid Aggregation and Non-Enzymatic Glycation in Human Insulin

(2017) Clara Iannuzzi et al.   Scientific Reports

Increased susceptibility to metabolic dysregulation in a mouse model of Alzheimer's disease is associated with impaired hypothalamic insulin signaling and elevated BCAA levels

(2016) Henry H. Ruiz et al.   Alzheimers & Dementia

Cerebral perfusion alterations in type 2 diabetes and its relation to insulin resistance and cognitive dysfunction

(2016) Ying Cui et al.   Brain Imaging and Behavior

Resveratrol Improves Cognitive Impairment by Regulating Apoptosis and Synaptic Plasticity in Streptozotocin-Induced Diabetic Rats

(2016) Zhiyan Tian et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Subcutaneous administration of liraglutide ameliorates learning and memory impairment by modulating tau hyperphosphorylation via the glycogen synthase kinase-3β pathway in an amyloid β protein induced alzheimer disease mouse model

(2016) Liqin Qi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Rutin ameliorates diabetic neuropathy by lowering plasma glucose and decreasing oxidative stress via Nrf2 signaling pathway in rats

(2016) Ruifeng Tian et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Metformin Facilitates Amyloid-β Generation by β- and γ-Secretases via Autophagy Activation

(2016) Sung Min Son et al.   JOURNAL OF ALZHEIMERS DISEASE

Insulin Resistance is Associated with Increased Levels of Cerebrospinal Fluid Biomarkers of Alzheimer’s Disease and Reduced Memory Function in At-Risk Healthy Middle-Aged Adults

(2016) Siobhan M. Hoscheidt et al.   JOURNAL OF ALZHEIMERS DISEASE

Humans with Type-2 Diabetes Show Abnormal Long-Term Potentiation-Like Cortical Plasticity Associated with Verbal Learning Deficits

(2016) Peter J. Fried et al.   JOURNAL OF ALZHEIMERS DISEASE

Unraveling Alzheimer’s: Making Sense of the Relationship between Diabetes and Alzheimer’s Disease1

(2016) Melissa A. Schilling   JOURNAL OF ALZHEIMERS DISEASE

Insula and Inferior Frontal Gyrus’ Activities Protect Memory Performance Against Alzheimer’s Disease Pathology in Old Age

(2016) Feng Lin et al.   JOURNAL OF ALZHEIMERS DISEASE

Brain-Wide Insulin Resistance, Tau Phosphorylation Changes, and Hippocampal Neprilysin and Amyloid-  Alterations in a Monkey Model of Type 1 Diabetes

(2016) J. Morales-Corraliza et al.   JOURNAL OF NEUROSCIENCE

Novel Roles for the Insulin-Regulated Glucose Transporter-4 in Hippocampally Dependent Memory

(2016) Jiah Pearson-Leary et al.   JOURNAL OF NEUROSCIENCE

Blood glucose levels and cortical thinning in cognitively normal, middle-aged adults

(2016) Alexandra M.V. Wennberg et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Exendin-4 reduces tau hyperphosphorylation in type 2 diabetic rats via increasing brain insulin level

(2016) Yan Yang et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Progressive Neuronal Pathology and Synaptic Loss Induced by Prediabetes and Type 2 Diabetes in a Mouse Model of Alzheimer’s Disease

(2016) Juan Jose Ramos-Rodriguez et al.   MOLECULAR NEUROBIOLOGY

Metformin Attenuates Aβ Pathology Mediated Through Levamisole Sensitive Nicotinic Acetylcholine Receptors in a C. elegans Model of Alzheimer’s Disease

(2016) Waqar Ahmad et al.   MOLECULAR NEUROBIOLOGY

Hypothermia mediates age-dependent increase of tau phosphorylation in db/db mice

(2016) Noura B. El Khoury et al.   NEUROBIOLOGY OF DISEASE

Amylin–Aβ oligomers at atomic resolution using molecular dynamics simulations: a link between Type 2 diabetes and Alzheimer's disease

(2016) Michal Baram et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Elevated glucose and oligomeric β-amyloid disrupt synapses via a common pathway of aberrant protein S-nitrosylation

(2016) Mohd Waseem Akhtar et al.   Nature Communications

Distinct cognitive effects and underlying transcriptome changes upon inhibition of individual miRNAs in hippocampal neurons

(2016) Josephine Malmevik et al.   Scientific Reports

Unexpected partial correction of metabolic and behavioral phenotypes of Alzheimer’s APP/PSEN1 mice by gene targeting of diabetes/Alzheimer’s-related Sorcs1

(2016) Elysse M. Knight et al.   Acta Neuropathologica Communications

Type 3 Diabetes: Cross Talk between Differentially Regulated Proteins of Type 2 Diabetes Mellitus and Alzheimer’s Disease

(2016) Khyati Mittal et al.   Scientific Reports

High glucose upregulates BACE1-mediated Aβ production through ROS-dependent HIF-1α and LXRα/ABCA1-regulated lipid raft reorganization in SK-N-MC cells

(2016) Hyun Jik Lee et al.   Scientific Reports

Andrographolide ameliorates diabetic retinopathy by inhibiting retinal angiogenesis and inflammation

(2015) Zengyang Yu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Alzheimer's disease and type 2 diabetes-related alterations in brain mitochondria, autophagy and synaptic markers

(2015) Cristina Carvalho et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Effects of ageing and experimental diabetes on insulin-degrading enzyme expression in male rat tissues

(2015) Ekaterina G. Kochkina et al.   BIOGERONTOLOGY

Inflammatory Macrophages Promotes Development of Diabetic Encephalopathy

(2015) Beiyun Wang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

DPP-4 Inhibitor Linagliptin Attenuates Aβ-induced Cytotoxicity through Activation of AMPK in Neuronal Cells

(2015) Edy Kornelius et al.   CNS Neuroscience & Therapeutics

Proteomic research of high-glucose-activated endothelial microparticles and related proteins to Alzheimer’s disease

(2015) Lingyun Zu et al.   Diabetes & Vascular Disease Research

Update of mortality attributable to diabetes for the IDF Diabetes Atlas: Estimates for the year 2013

(2015) IDF Diabetes Atlas Group   DIABETES RESEARCH AND CLINICAL PRACTICE

Exenatide reduces TNF-α expression and improves hippocampal neuron numbers and memory in streptozotocin treated rats

(2015) Volkan Solmaz et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Age-dependent impairment of glucose tolerance in the 3xTg-AD mouse model of Alzheimer’s disease

(2015) Milene Vandal et al.   FASEB JOURNAL

Disrupted subject-specific gray matter network properties and cognitive dysfunction in type 1 diabetes patients with and without proliferative retinopathy

(2015) Eelco van Duinkerken et al.   HUMAN BRAIN MAPPING

Exendin-4, a Glucagon-Like Peptide-1 Receptor Agonist, Reduces Alzheimer Disease-Associated Tau Hyperphosphorylation in the Hippocampus of Rats With Type 2 Diabetes

(2015) Weijie Xu et al.   JOURNAL OF INVESTIGATIVE MEDICINE

Identification of diabetes-related dementia: Longitudinal perfusion SPECT and amyloid PET studies

(2015) Raita Fukasawa et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Central activation of PPAR-gamma ameliorates diabetes induced cognitive dysfunction and improves BDNF expression

(2015) Thiruchelvam Kariharan et al.   NEUROBIOLOGY OF AGING

White matter hyperintensities in middle-aged adults with childhood-onset type 1 diabetes

(2015) K. A. Nunley et al.   NEUROLOGY

Type 2 diabetes mellitus and biomarkers of neurodegeneration

(2015) Chris Moran et al.   NEUROLOGY

Insulin resistance-induced hyperglycemia decreased the activation of Akt/CREB in hippocampus neurons: Molecular evidence for mechanism of diabetes-induced cognitive dysfunction

(2015) Qiong Xiang et al.   NEUROPEPTIDES

Red peppers with moderate and severe pungency prevent the memory deficit and hepatic insulin resistance in diabetic rats with Alzheimer’s disease

(2015) Hye Yang et al.   Nutrition & Metabolism

Assessment of the therapeutic potential of hesperidin and proteomic resolution of diabetes-mediated neuronal fluctuations expediting Alzheimer’s disease

(2015) Sapna Khowal et al.   RSC Advances

Link between type 2 diabetes and Alzheimer’s disease: from epidemiology to mechanism and treatment

(2015) Xiaohua Li et al.   Clinical Interventions in Aging

Diabetes Mellitus Accelerates Aβ Pathology in Brain Accompanied by Enhanced GAβ Generation in Nonhuman Primates

(2015) Sachi Okabayashi et al.   PLoS One

Anti-Diabetes Drug Pioglitazone Ameliorates Synaptic Defects in AD Transgenic Mice by Inhibiting Cyclin-Dependent Kinase5 Activity

(2015) Jinan Chen et al.   PLoS One

Inflammation, Defective Insulin Signaling, and Mitochondrial Dysfunction as Common Molecular Denominators Connecting Type 2 Diabetes to Alzheimer Disease

(2014) F. G. De Felice et al.   DIABETES

Huperzine A Ameliorates Cognitive Deficits in Streptozotocin-Induced Diabetic Rats

(2014) Xiao-Yuan Mao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Insulin sensitizers improve learning and attenuate tau hyperphosphorylation and neuroinflammation in 3xTg-AD mice

(2014) Yang Yu et al.   JOURNAL OF NEURAL TRANSMISSION

Ghrelin-Attenuated Cognitive Dysfunction in Streptozotocin-induced Diabetic Rats

(2011) Lou-yan Ma et al.   ALZHEIMER DISEASE & ASSOCIATED DISORDERS

Deficient brain insulin signalling pathway in Alzheimer's disease and diabetes

(2011) Ying Liu et al.   JOURNAL OF PATHOLOGY

Comparison of Alzheimer A (1-40) and A (1-42) amyloid fibrils reveals similar protofilament structures

(2009) M. Schmidt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Defective insulin signaling pathway and increased glycogen synthase kinase-3 activity in the brain of diabetic mice: Parallels with Alzheimer's disease and correction by insulin

(2008) C.G. Jolivalt et al.   JOURNAL OF NEUROSCIENCE RESEARCH