Unraveling Alzheimer’s: Making Sense of the Relationship between Diabetes and Alzheimer’s Disease1

Intranasal Insulin Administration Dose-Dependently Modulates Verbal Memory and Plasma Amyloid-β in Memory-Impaired Older Adults

(2017) Mark A. Reger et al.   JOURNAL OF ALZHEIMERS DISEASE

In Vivo Seeding and Cross-Seeding of Localized Amyloidosis

(2015) Marie E. Oskarsson et al.   AMERICAN JOURNAL OF PATHOLOGY

Effects of ageing and experimental diabetes on insulin-degrading enzyme expression in male rat tissues

(2015) Ekaterina G. Kochkina et al.   BIOGERONTOLOGY

CALHM1 ion channel elicits amyloid-  clearance by insulin-degrading enzyme in cell lines and in vivo in the mouse brain

(2015) V. Vingtdeux et al.   JOURNAL OF CELL SCIENCE

Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice

(2015) Rebecca Deprez-Poulain et al.   Nature Communications

Insulin-degrading enzyme prevents α-synuclein fibril formation in a nonproteolytical manner

(2015) Sandeep K. Sharma et al.   Scientific Reports

Amylin at the interface between metabolic and neurodegenerative disorders

(2015) Thomas A. Lutz et al.   Frontiers in Neuroscience

Reduced insulin clearance and lower insulin-degrading enzyme expression in the liver might contribute to the thrifty phenotype of protein-restricted mice

(2014) Luiz F. Rezende et al.   BRITISH JOURNAL OF NUTRITION

Neuroinflammation and neurologic deficits in diabetes linked to brain accumulation of amylin

(2014) Sarah Srodulski et al.   Molecular Neurodegeneration

Intraperitoneal injection of the pancreatic peptide amylin potently reduces behavioral impairment and brain amyloid pathology in murine models of Alzheimer’s disease

(2014) H Zhu et al.   MOLECULAR PSYCHIATRY

Amylin and its analogs: a friend or foe for the treatment of Alzheimer's disease?

(2014) Wei Qiao Qiu et al.   Frontiers in Aging Neuroscience

Amylin deposition in the brain: A second amyloid in Alzheimer disease?

(2013) Kaleena Jackson et al.   ANNALS OF NEUROLOGY

Geniposide Regulates Insulin-Degrading Enzyme Expression to Inhibit the Cytotoxicity of Aβ1-42 in Cortical Neurons

(2013) Fei Yin et al.   CNS & Neurological Disorders-Drug Targets

Intranasal Insulin as a Treatment for Alzheimer’s Disease: A Review of Basic Research and Clinical Evidence

(2013) Jessica Freiherr et al.   CNS DRUGS

The Type 2 Diabetes-Associated Gene Ide Is Required for Insulin Secretion and Suppression of  -Synuclein Levels in  -Cells

(2013) P. Steneberg et al.   DIABETES

Neuroprotective effects of the amylin analogue pramlintide on Alzheimer's disease pathogenesis and cognition

(2013) Brittany L. Adler et al.   NEUROBIOLOGY OF AGING

Monetary Costs of Dementia in the United States

(2013) Michael D. Hurd et al.   NEW ENGLAND JOURNAL OF MEDICINE

Glial activation and post-synaptic neurotoxicity: The key events in Streptozotocin (ICV) induced memory impairment in rats

(2013) Shivika Rai et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Ginsenoside Rg1 Decreases Aβ1–42 Level by Upregulating PPARγ and IDE Expression in the Hippocampus of a Rat Model of Alzheimer's Disease

(2013) QianKun Quan et al.   PLoS One

Regulation of distinct pools of amyloid β-protein by multiple cellular proteases

(2013) Malcolm A Leissring et al.   Alzheimers Research & Therapy

Proteolytic Degradation of Amyloid  -Protein

(2013) T. Saido et al.   Cold Spring Harbor Perspectives in Medicine

Cross-Seeding of Misfolded Proteins: Implications for Etiology and Pathogenesis of Protein Misfolding Diseases

(2013) Rodrigo Morales et al.   PLoS Pathogens

Genetics of Alzheimer’s Disease

(2012) María Elisa Alonso Vilatela et al.   ARCHIVES OF MEDICAL RESEARCH

Brain Insulin Resistance and Deficiency as Therapeutic Targets in Alzheimers Disease

(2012) Suzanne M. de la Monte   Current Alzheimer Research

Diabetes: Have We Got It All Wrong?: Hyperinsulinism as the culprit: surgery provides the evidence

(2012) W. J. Pories et al.   DIABETES CARE

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

(2012) Konrad Talbot et al.   JOURNAL OF CLINICAL INVESTIGATION

Mechanisms Underlying Insulin Deficiency-Induced Acceleration of β-Amyloidosis in a Mouse Model of Alzheimer's Disease

(2012) Latha Devi et al.   PLoS One

Intranasal Insulin Therapy for Alzheimer Disease and Amnestic Mild Cognitive Impairment

(2011) Suzanne Craft   ARCHIVES OF NEUROLOGY

Contributions of Brain Insulin Resistance and Deficiency in Amyloid-Related Neurodegeneration in Alzheimerʼs Disease

(2011) Suzanne M. de la Monte   DRUGS

Aβ-Degrading Enzymes: Potential for Treatment of Alzheimer Disease

(2011) James Scott Miners et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

A critical role for IGF-II in memory consolidation and enhancement

(2011) Dillon Y. Chen et al.   NATURE

Deletion of Insulin-Degrading Enzyme Elicits Antipodal, Age-Dependent Effects on Glucose and Insulin Tolerance

(2011) Samer O. Abdul-Hay et al.   PLoS One

Diabetes induces changes in ILK, PINCH and components of related pathways in the spinal cord of rats

(2010) Y. Jiang et al.   BRAIN RESEARCH

The Roles of Streptozotocin Neurotoxicity and Neutral Endopeptidase in Murine Experimental Diabetic Neuropathy

(2010) Eric Davidson et al.   Experimental Diabetes Research

Insulin deficiency exacerbates cerebral amyloidosis and behavioral deficits in an Alzheimer transgenic mouse model

(2010) Xu Wang et al.   Molecular Neurodegeneration

Designed Inhibitors of Insulin-Degrading Enzyme Regulate the Catabolism and Activity of Insulin

(2010) Malcolm A. Leissring et al.   PLoS One

The irreversible binding of amyloid peptide substrates to insulin-degrading enzyme

(2010) Matías B. de Tullio et al.   Prion

The neuropathology of probable Alzheimer disease and mild cognitive impairment

(2009) Julie A. Schneider et al.   ANNALS OF NEUROLOGY

Cross Currents in Protein Misfolding Disorders: Interactions and Therapy

(2009) Rodrigo Morales et al.   CNS & Neurological Disorders-Drug Targets

Glucose inhibits the insulin-induced activation of the insulin-degrading enzyme in HepG2 cells

(2009) O. Pivovarova et al.   DIABETOLOGIA

Type 1 diabetes exaggerates features of Alzheimer's disease in APP transgenic mice

(2009) Corinne G. Jolivalt et al.   EXPERIMENTAL NEUROLOGY

Insulin-degrading enzyme is exported via an unconventional protein secretion pathway

(2009) Ji Zhao et al.   Molecular Neurodegeneration

Nitric oxide inhibits insulin-degrading enzyme activity and function through S-nitrosylation

(2008) Crystal M. Cordes et al.   BIOCHEMICAL PHARMACOLOGY

Insulin Resistance and Hyperinsulinemia: Is hyperinsulinemia the cart or the horse?

(2008) M. H. Shanik et al.   DIABETES CARE