The BET/BRD inhibitor JQ1 improves brain plasticity in WT and APP mice

The BET-Bromodomain Inhibitor JQ1 Reduces Inflammation and Tau Phosphorylation at Ser396 in the Brain of the 3xTg Model of Alzheimer's Disease

(2016) Marco Magistri et al.   Current Alzheimer Research

BET bromodomain inhibition promotes neurogenesis while inhibiting gliogenesis in neural progenitor cells

(2016) Jingjun Li et al.   Stem Cell Research

HDAC inhibitor–dependent transcriptome and memory reinstatement in cognitive decline models

(2015) Eva Benito et al.   JOURNAL OF CLINICAL INVESTIGATION

Autism-like syndrome is induced by pharmacological suppression of BET proteins in young mice

(2015) Josefa M. Sullivan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Epigenetic Readers of Lysine Acetylation Regulate Cocaine-Induced Plasticity

(2015) G. C. Sartor et al.   JOURNAL OF NEUROSCIENCE

BET protein Brd4 activates transcription in neurons and BET inhibitor Jq1 blocks memory in mice

(2015) Erica Korb et al.   NATURE NEUROSCIENCE

Long-term depression is differentially expressed in distinct lamina of hippocampal CA1 dendrites

(2015) Binu Ramachandran et al.   Frontiers in Cellular Neuroscience

The bromodomain protein inhibitor I-BET151 suppresses expression of inflammatory genes and matrix degrading enzymes in rheumatoid arthritis synovial fibroblasts

(2014) Kerstin Klein et al.   ANNALS OF THE RHEUMATIC DISEASES

HTSeq--a Python framework to work with high-throughput sequencing data

(2014) S. Anders et al.   BIOINFORMATICS

Epigenetic memory: the Lamarckian brain

(2014) A. Fischer   EMBO JOURNAL

BET Inhibitor JQ1 Blocks Inflammation and Bone Destruction

(2014) S. Meng et al.   JOURNAL OF DENTAL RESEARCH

Olfactory exposure to males, including men, causes stress and related analgesia in rodents

(2014) Robert E Sorge et al.   NATURE METHODS

Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders

(2014) Katrina J. Falkenberg et al.   NATURE REVIEWS DRUG DISCOVERY

Bromodomain and Extraterminal Domain Inhibitors (BETi) for Cancer Therapy: Chemical Modulation of Chromatin Structure

(2014) J. Qi   Cold Spring Harbor Perspectives in Biology

The Potential of HDAC Inhibitors as Cognitive Enhancers

(2013) Johannes Gräff et al.   Annual Review of Pharmacology and Toxicology

BET Protein Function Is Required for Inflammation: Brd2 Genetic Disruption and BET Inhibitor JQ1 Impair Mouse Macrophage Inflammatory Responses

(2013) A. C. Belkina et al.   JOURNAL OF IMMUNOLOGY

BET acetyl-lysine binding proteins control pathological cardiac hypertrophy

(2013) Jessica I. Spiltoir et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Regulation of NO Synthesis, Local Inflammation, and Innate Immunity to Pathogens by BET Family Proteins

(2013) S. Wienerroither et al.   MOLECULAR AND CELLULAR BIOLOGY

Targeting MYCN in Neuroblastoma by BET Bromodomain Inhibition

(2013) Alexandre Puissant et al.   Cancer Discovery

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Small-Molecule Inhibition of BRDT for Male Contraception

(2012) Martin M. Matzuk et al.   CELL

Epigenetic mechanisms in neurological disease

(2012) Mira Jakovcevski et al.   NATURE MEDICINE

Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks

(2012) Cole Trapnell et al.   Nature Protocols

Proteogenomic characterization and mapping of nucleosomes decoded by Brd and HP1 proteins

(2012) Gary LeRoy et al.   GENOME BIOLOGY

RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

(2011) Johannes Zuber et al.   NATURE

Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

(2011) Mark A. Dawson et al.   NATURE

Structural Basis for Acetylated Histone H4 Recognition by the Human BRD2 Bromodomain

(2010) Takashi Umehara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Suppression of inflammation by a synthetic histone mimic

(2010) Edwige Nicodeme et al.   NATURE

Selective inhibition of BET bromodomains

(2010) Panagis Filippakopoulos et al.   NATURE

Altered Histone Acetylation Is Associated with Age-Dependent Memory Impairment in Mice

(2010) S. Peleg et al.   SCIENCE

Targeting the correct HDAC(s) to treat cognitive disorders

(2010) André Fischer et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

ClueGO: a Cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networks

(2009) Gabriela Bindea et al.   BIOINFORMATICS

HDAC2 negatively regulates memory formation and synaptic plasticity

(2009) Ji-Song Guan et al.   NATURE

Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions

(2009) C. Choudhary et al.   SCIENCE