Type 2 diabetes impairs odour detection, olfactory memory and olfactory neuroplasticity; effects partly reversed by the DPP-4 inhibitor Linagliptin

Differential Expression of Interneuron Populations and Correlation with Amyloid-β Deposition in the Olfactory Cortex of an AβPP/PS1 Transgenic Mouse Model of Alzheimer's Disease

(2018) Daniel Saiz-Sanchez et al.   JOURNAL OF ALZHEIMERS DISEASE

Pentamethylquercetin Protects Against Diabetes-Related Cognitive Deficits in Diabetic Goto-Kakizaki Rats

(2018) Xian-Hui Li et al.   JOURNAL OF ALZHEIMERS DISEASE

Evidence for Cortical Neuronal Loss in Male Type 2 Diabetic Goto-Kakizaki Rats

(2018) Shafaat Hussain et al.   JOURNAL OF ALZHEIMERS DISEASE

Olfactory and gustatory functions in patients with non-complicated type 1 diabetes mellitus

(2017) Aytug Altundag et al.   EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY

Prevalence and Correlates of Olfactory Dysfunction in Old Age: A Population-Based Study

(2017) Janina Seubert et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Olfactory dysfunction in neurodegenerative diseases: is there a common pathological substrate?

(2017) Richard L Doty   LANCET NEUROLOGY

Brain GLP-1/IGF-1 Signaling and Autophagy Mediate Exendin-4 Protection Against Apoptosis in Type 2 Diabetic Rats

(2017) Emanuel Candeias et al.   MOLECULAR NEUROBIOLOGY

Early ciliary and prominin-1 dysfunctions precede neurogenesis impairment in a mouse model of type 2 diabetes

(2017) Tomás P. Bachor et al.   NEUROBIOLOGY OF DISEASE

Type 2 diabetes alters hippocampal gamma oscillations: A potential mechanism behind impaired cognition

(2017) Grazyna Lietzau et al.   PSYCHONEUROENDOCRINOLOGY

SGLT2-inhibitor and DPP-4 inhibitor improve brain function via attenuating mitochondrial dysfunction, insulin resistance, inflammation, and apoptosis in HFD-induced obese rats

(2017) Piangkwan Sa-nguanmoo et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Linagliptin treatment improves cerebrovascular function and remodeling and restores reduced cerebral perfusion in Type 2 diabetes

(2016) Trevor Hardigan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Gliptin-mediated neuroprotection against stroke requires chronic pretreatment and is independent of glucagon-like peptide-1 receptor

(2016) V. Darsalia et al.   DIABETES OBESITY & METABOLISM

Interneurons in the human olfactory system in Alzheimer's disease

(2016) Daniel Saiz-Sanchez et al.   EXPERIMENTAL NEUROLOGY

Impairment of synaptic development in the hippocampus of diabetic Goto-Kakizaki rats

(2016) Yuki Matsunaga et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Diabetes Impairs Wnt3 Protein-induced Neurogenesis in Olfactory Bulbs via Glutamate Transporter 1 Inhibition

(2016) Tamami Wakabayashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Linagliptin, a Dipeptidyl Peptidase-4 Inhibitor, Mitigates Cognitive Deficits and Pathology in the 3xTg-AD Mouse Model of Alzheimer’s Disease

(2016) Jayasankar Kosaraju et al.   MOLECULAR NEUROBIOLOGY

Olfactory memory in the old and very old: relations to episodic and semantic memory and APOE genotype

(2016) Maria Larsson et al.   NEUROBIOLOGY OF AGING

Type 2 diabetes-induced neuronal pathology in the piriform cortex of the rat is reversed by the GLP-1 receptor agonist exendin-4

(2016) Grazyna Lietzau et al.   Oncotarget

High Fructose Diet inducing diabetes rapidly impacts olfactory epithelium and behavior in mice

(2016) Sébastien Rivière et al.   Scientific Reports

Fus1 KO Mouse As a Model of Oxidative Stress-Mediated Sporadic Alzheimer's Disease: Circadian Disruption and Long-Term Spatial and Olfactory Memory Impairments

(2016) Guillermo Coronas-Samano et al.   Frontiers in Aging Neuroscience

Biomarkers for Early Diagnostic of Mild Cognitive Impairment in Type-2 Diabetes Patients: A Multicentre, Retrospective, Nested Case–Control Study

(2016) Zhi-Peng Xu et al.   EBioMedicine

Assessment of Olfactory Function in MAPT-Associated Neurodegenerative Disease Reveals Odor-Identification Irreproducibility as a Non-Disease-Specific, General Characteristic of Olfactory Dysfunction

(2016) Katerina Markopoulou et al.   PLoS One

Long-Lasting Metabolic Imbalance Related to Obesity Alters Olfactory Tissue Homeostasis and Impairs Olfactory-Driven Behaviors

(2015) Marie-Christine Lacroix et al.   CHEMICAL SENSES

DPP-4 Inhibitor Linagliptin Attenuates Aβ-induced Cytotoxicity through Activation of AMPK in Neuronal Cells

(2015) Edy Kornelius et al.   CNS Neuroscience & Therapeutics

Characterization and isolation of immature neurons of the adult mouse piriform cortex

(2015) A. Rubio et al.   Developmental Neurobiology

Sitagliptin, a dipeptidyl peptidase-4 inhibitor, improves recognition memory, oxidative stress and hippocampal neurogenesis and upregulates key genes involved in cognitive decline

(2015) V. A. Gault et al.   DIABETES OBESITY & METABOLISM

Olfactory dysfunction: its early temporal relationship and neural correlates in the pathogenesis of Alzheimer’s disease

(2015) Mak Adam Daulatzai   JOURNAL OF NEURAL TRANSMISSION

Hippocampal insulin resistance and cognitive dysfunction

(2015) Geert Jan Biessels et al.   NATURE REVIEWS NEUROSCIENCE

Loss of calbindin-D 28K is associated with the full range of tangle pathology within basal forebrain cholinergic neurons in Alzheimer's disease

(2015) Saman S. Ahmadian et al.   NEUROBIOLOGY OF AGING

New neurons from old beliefs in the adult piriform cortex? A Commentary on: “Occurrence of new neurons in the piriform cortex”

(2015) Juan Nacher et al.   Frontiers in Neuroanatomy

Potentials of incretin-based therapies in dementia and stroke in type 2 diabetes mellitus

(2015) Onno N Groeneveld et al.   Journal of Diabetes Investigation

Connectivity of Pathology: The Olfactory System as a Model for Network-Driven Mechanisms of Alzheimer’s Disease Pathogenesis

(2015) Katherine H. Franks et al.   Frontiers in Aging Neuroscience

Olfactory Dysfunction in Type 2 Diabetes Mellitus

(2014) E. Gouveri et al.   ANGIOLOGY

Dipeptidyl peptidase-4 inhibition by Pterocarpus marsupium and Eugenia jambolana ameliorates streptozotocin induced Alzheimer's disease

(2014) Jayasankar Kosaraju et al.   BEHAVIOURAL BRAIN RESEARCH

Interneurons, tau and amyloid-β in the piriform cortex in Alzheimer’s disease

(2014) Daniel Saiz-Sanchez et al.   Brain Structure & Function

Crucial role of calbindin-D28k in the pathogenesis of Alzheimer’s disease mouse model

(2014) S-Y Kook et al.   CELL DEATH AND DIFFERENTIATION

Relationship between olfactory dysfunction and cognitive impairment in elderly patients with type 2 diabetes mellitus

(2014) Haruna Sanke et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

A review of gliptins for 2014

(2014) André J Scheen   EXPERT OPINION ON PHARMACOTHERAPY

Hyperlipidemic Diet Causes Loss of Olfactory Sensory Neurons, Reduces Olfactory Discrimination, and Disrupts Odor-Reversal Learning

(2014) N. Thiebaud et al.   JOURNAL OF NEUROSCIENCE

Neuronal organization of olfactory bulb circuits

(2014) Shin Nagayama et al.   Frontiers in Neural Circuits

The functional significance of newly born neurons integrated into olfactory bulb circuits

(2014) Masayuki Sakamoto et al.   Frontiers in Neuroscience

Olfactory Assays for Mouse Models of Neurodegenerative Disease

(2014) Andrew M. Lehmkuhl et al.   Jove-Journal of Visualized Experiments

Dipeptidyl peptidase-4 inhibitors for the treatment of type 2 diabetes: comparison, efficacy and safety

(2013) Carolyn F Deacon et al.   EXPERT OPINION ON PHARMACOTHERAPY

GalR3 activation promotes adult neural stem cell survival in response to a diabeticmilieu

(2013) Shiva Mansouri et al.   JOURNAL OF NEUROCHEMISTRY

Saxagliptin: A dipeptidyl peptidase-4 inhibitor ameliorates streptozotocin induced Alzheimer's disease

(2013) Jayasankar Kosaraju et al.   NEUROPHARMACOLOGY

Neurons and circuits for odor processing in the piriform cortex

(2013) John M. Bekkers et al.   TRENDS IN NEUROSCIENCES

Diabetes drugs and neurological disorders: new views and therapeutic possibilities

(2013) Cesare Patrone et al.   Lancet Diabetes & Endocrinology

Inhibitory Interneuron Deficit Links Altered Network Activity and Cognitive Dysfunction in Alzheimer Model

(2012) Laure Verret et al.   CELL

The DPP-4 Inhibitor Linagliptin Counteracts Stroke in the Normal and Diabetic Mouse Brain: A Comparison With Glimepiride

(2012) V. Darsalia et al.   DIABETES

Diabetes, hyperglycaemia, and acute ischaemic stroke

(2012) Merel JA Luitse et al.   LANCET NEUROLOGY

Olfactory memory is impaired in a triple transgenic model of Alzheimer disease

(2011) Tommaso Cassano et al.   BEHAVIOURAL BRAIN RESEARCH

Pituitary adenylate cyclase-activating polypeptide counteracts the impaired adult neural stem cell viability induced by palmitate

(2011) Shiva Mansouri et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Properties of Doublecortin-(DCX)-Expressing Cells in the Piriform Cortex Compared to the Neurogenic Dentate Gyrus of Adult Mice

(2011) Friederike Klempin et al.   PLoS One

Disruption of odour quality coding in piriform cortex mediates olfactory deficits in Alzheimer's disease

(2010) W. Li et al.   BRAIN

Odor representations in mammalian cortical circuits

(2010) Jeffry S Isaacson   CURRENT OPINION IN NEUROBIOLOGY

Accelerated Progression From Mild Cognitive Impairment to Dementia in People With Diabetes

(2010) W. Xu et al.   DIABETES

Widespread deficits in adult neurogenesis precede plaque and tangle formation in the 3xTg mouse model of Alzheimer’s disease

(2010) Laura K. Hamilton et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Diverse Patterns of Odor Representation by Neurons in the Anterior Piriform Cortex of Awake Mice

(2010) C. Zhan et al.   JOURNAL OF NEUROSCIENCE

Central mechanisms of odour object perception

(2010) Jay A. Gottfried   NATURE REVIEWS NEUROSCIENCE

Branching out: mechanisms of dendritic arborization

(2010) Yuh-Nung Jan et al.   NATURE REVIEWS NEUROSCIENCE

Clinical significance of smell and taste disorders in patients with diabetes mellitus

(2009) Asami Naka et al.   EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY

Long-term inhibition of dipeptidyl peptidase-4 in Alzheimer’s prone mice

(2009) Michele D’Amico et al.   EXPERIMENTAL GERONTOLOGY

Driving fast-spiking cells induces gamma rhythm and controls sensory responses

(2009) Jessica A. Cardin et al.   NATURE

Diabetes, microvascular pathology and Alzheimer disease

(2009) Raj N. Kalaria   Nature Reviews Neurology

Odor Representations in Olfactory Cortex: “Sparse” Coding, Global Inhibition, and Oscillations

(2009) Cindy Poo et al.   NEURON

Impaired neurogenesis in adult type-2 diabetic rats

(2008) Bradley T. Lang et al.   BRAIN RESEARCH

Cognitive Dysfunction and Diabetes Mellitus

(2008) Christopher T. Kodl et al.   ENDOCRINE REVIEWS

Progressive impairment in olfactory working memory in a mouse model of Mild Cognitive Impairment

(2008) Jared W. Young et al.   NEUROBIOLOGY OF AGING