High glucose upregulates BACE1-mediated Aβ production through ROS-dependent HIF-1α and LXRα/ABCA1-regulated lipid raft reorganization in SK-N-MC cells

Activation of Protein Phosphatase 2B and Hyperphosphorylation of Tau in Alzheimer's Disease

(2018) Wei Qian et al.   JOURNAL OF ALZHEIMERS DISEASE

Plasma Membrane Injury Depends on Bilayer Lipid Composition in Alzheimer's Disease

(2018) Elisa Evangelisti et al.   JOURNAL OF ALZHEIMERS DISEASE

Memantine Inhibits Calpain-Mediated Truncation of GSK-3 Induced by NMDA: Implications in Alzheimer's Disease

(2017) Paloma Goñi-Oliver et al.   JOURNAL OF ALZHEIMERS DISEASE

PP2A Regulates Tau Phosphorylation Directly and also Indirectly via Activating GSK-3β

(2017) Wei Qian et al.   JOURNAL OF ALZHEIMERS DISEASE

Altered Kv2.1 functioning promotes increased excitability in hippocampal neurons of an Alzheimer’s disease mouse model

(2016) V Frazzini et al.   Cell Death & Disease

Effect of High Glucose Levels on Amyloid β Production in Retinas of Spontaneous Diabetes Mellitus Otsuka Long-Evans Tokushima Fatty Rats

(2015) Noriaki Nagai et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Hyperglycemia modulates extracellular amyloid-β concentrations and neuronal activity in vivo

(2015) Shannon L. Macauley et al.   JOURNAL OF CLINICAL INVESTIGATION

Oxygen-glucose deprivation regulates BACE1 expression through induction of autophagy in Neuro-2a/APP695 cells

(2015) Xiao-jiang Sun et al.   Neural Regeneration Research

Diabetes and Alzheimer Disease, Two Overlapping Pathologies with the Same Background: Oxidative Stress

(2015) Sergio Rosales-Corral et al.   Oxidative Medicine and Cellular Longevity

The roles of lipid and glucose metabolism in modulation of β-amyloid, tau, and neurodegeneration in the pathogenesis of Alzheimer disease

(2015) Naoyuki Sato et al.   Frontiers in Aging Neuroscience

Dietary regulation of PI3K/AKT/GSK-3β pathway in Alzheimer’s disease

(2014) Yasuko Kitagishi et al.   Alzheimers Research & Therapy

BACE1 inhibitor drugs in clinical trials for Alzheimer’s disease

(2014) Robert Vassar   Alzheimers Research & Therapy

Cleavage of GSK-3β by calpain counteracts the inhibitory effect of Ser9 phosphorylation on GSK-3β activity induced by H2O2

(2013) Ye Feng et al.   JOURNAL OF NEUROCHEMISTRY

High Glucose Promotes Aβ Production by Inhibiting APP Degradation

(2013) Yi Yang et al.   PLoS One

Transcriptional and post-transcriptional regulation of β-secretase

(2012) Elena Tamagno et al.   IUBMB LIFE

BACE1 is at the crossroad of a toxic vicious cycle involving cellular stress and β-amyloid production in Alzheimer’s disease

(2012) Linda Chami et al.   Molecular Neurodegeneration

Transcription of Liver X Receptor Is Down-Regulated by 15-Deoxy-Δ12,14-Prostaglandin J2 through Oxidative Stress in Human Neutrophils

(2012) Gonzalo Alba et al.   PLoS One

Amyloid Precursor Protein Processing and Alzheimer's Disease

(2011) Richard J. O'Brien et al.   Annual Review of Neuroscience

Rapamycin pre-treatment abrogates Tumour Necrosis Factor-α down-regulatory effects on LXR-α and PXR mRNA expression via inhibition of c-Jun N-terminal kinase 1 activation in HepG2 cells

(2011) Choy-Hoong Chew et al.   ELECTRONIC JOURNAL OF BIOTECHNOLOGY

Liver X Receptor-Retinoid X Receptor (LXR-RXR) Heterodimer Cistrome Reveals Coordination of LXR and AP1 Signaling in Keratinocytes

(2011) Qi Shen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

APP processing in Alzheimer's disease

(2011) Yun-wu Zhang et al.   Molecular Brain

Diabetes mellitus and Alzheimer's disease: shared pathology and treatment?

(2010) Kawser Akter et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Diabetes and Insulin in Regulation of Brain Cholesterol Metabolism

(2010) Ryo Suzuki et al.   Cell Metabolism

Genetic connections between neurological disorders and cholesterol metabolism

(2010) Ingemar Björkhem et al.   JOURNAL OF LIPID RESEARCH

Treatment of Erectile Dysfunction in the Obese Type 2 Diabetic ZDF Rat with Adipose Tissue-Derived Stem Cells

(2009) Maurice M. Garcia et al.   Journal of Sexual Medicine

Liver X Receptor Ligands Suppress Ubiquitination and Degradation of LXRα by Displacing BARD1/BRCA1

(2009) Kang Ho Kim et al.   MOLECULAR ENDOCRINOLOGY

Cell Signaling and Nuclear Receptors: New Opportunities for Molecular Pharmaceuticals in Liver Disease

(2007) Jeff L. Staudinger et al.   MOLECULAR PHARMACEUTICS

Glucose neurotoxicity

(2007) David R. Tomlinson et al.   NATURE REVIEWS NEUROSCIENCE