Amyloid-β Pathology andAPOEGenotype Modulate Retinoid X Receptor Agonist Activityin Vivo

Use of Genetic Variation as Biomarkers for Mild Cognitive Impairment and Progression of Mild Cognitive Impairment to Dementia

(2017) Christiane Reitz et al.   JOURNAL OF ALZHEIMERS DISEASE

Chemopreventive Effects of RXR-Selective Rexinoid Bexarotene on Intestinal Neoplasia of ApcMin/+ Mice

(2015) Naveena B. Janakiram et al.   NEOPLASIA

Sex modifies theAPOE-related risk of developing Alzheimer disease

(2014) Andre Altmann et al.   ANNALS OF NEUROLOGY

The Involvement of Lipids in Alzheimer's Disease

(2014) Wei Ling Florence Lim et al.   Journal of Genetics and Genomics

Target Engagement Analysis and Link to Pharmacodynamic Endpoint for a Novel Class of CNS-penetrant and Efficacious p38α MAPK Inhibitors

(2014) Adam D. Bachstetter et al.   Journal of Neuroimmune Pharmacology

Reversal of apoE4-Driven Brain Pathology and Behavioral Deficits by Bexarotene

(2014) A. Boehm-Cagan et al.   JOURNAL OF NEUROSCIENCE

Genetic Modulation of Soluble A  Rescues Cognitive and Synaptic Impairment in a Mouse Model of Alzheimer's Disease

(2014) S. W. Fowler et al.   JOURNAL OF NEUROSCIENCE

Soluble apoE/Aβ complex: mechanism and therapeutic target for APOE4-induced AD risk

(2014) Leon M Tai et al.   Molecular Neurodegeneration

Antiamyloid Therapy for Alzheimer's Disease — Are We on the Right Road?

(2014) Eric Karran et al.   NEW ENGLAND JOURNAL OF MEDICINE

Detection of Impaired Cognitive Function in Rat with Hepatosteatosis Model and Improving Effect of GLP-1 Analogs (Exenatide) on Cognitive Function in Hepatosteatosis

(2014) Oytun Erbaş et al.   TheScientificWorldJOURNAL

Ten-year Experience of Bexarotene Therapy for Cutaneous T-cell Lymphoma in Finland

(2013) L Väkevä et al.   ACTA DERMATO-VENEREOLOGICA

2013 Alzheimer's disease facts and figures

(2013)   Alzheimers & Dementia

Functional Impairment in Alcoholic Liver Disease and Non-alcoholic Fatty Liver Disease Is Significant and Persists over 3 Years of Follow-Up

(2013) Chris Elliott et al.   DIGESTIVE DISEASES AND SCIENCES

Relationships Between Diabetes and Cognitive Impairment

(2013) Suzanne M. de la Monte   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA

Binding of Apolipoprotein E Inhibits the Oligomer Growth of Amyloid-β Peptide in Solution as Determined by Fluorescence Cross-correlation Spectroscopy

(2013) Sonny Ly et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Levels of Soluble Apolipoprotein E/Amyloid-β (Aβ) Complex Are Reduced and Oligomeric Aβ Increased withAPOE4and Alzheimer Disease in a Transgenic Mouse Model and Human Samples

(2013) Leon M. Tai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Potential novel targets for Alzheimer pharmacotherapy: II. Update on secretase inhibitors and related approaches

(2013) J. A. Mikulca et al.   JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS

Modeling, Synthesis, and Biological Evaluation of Potential Retinoid X Receptor (RXR) Selective Agonists: Novel Analogues of 4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic Acid (Bexarotene) and (E)-3-(3-(1,2,3,4-tetrahydro-1,1,4,4,6-pentamethylnaphthalen-7-yl)-4-hydroxyphenyl)acrylic Acid (CD3254)

(2013) Peter W. Jurutka et al.   JOURNAL OF MEDICINAL CHEMISTRY

Treatment with bexarotene, a compound that increases apolipoprotein-E, provides no cognitive benefit in mutant APP/PS1 mice

(2013) Katherine D LaClair et al.   Molecular Neurodegeneration

APOE modulates the effect of estrogen therapy on Aβ accumulation EFAD-Tg mice

(2013) Jacqueline Kunzler et al.   NEUROSCIENCE LETTERS

Accelerated Cell Aging in Female APOE-ε4 Carriers: Implications for Hormone Therapy Use

(2013) Emily G. Jacobs et al.   PLoS One

ApoE influences amyloid-  (A ) clearance despite minimal apoE/A  association in physiological conditions

(2013) P. B. Verghese et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comment on "ApoE-Directed Therapeutics Rapidly Clear  -Amyloid and Reverse Deficits in AD Mouse Models"

(2013) N. F. Fitz et al.   SCIENCE

Gene Transfer of Human Apoe Isoforms Results in Differential Modulation of Amyloid Deposition and Neurotoxicity in Mouse Brain

(2013) E. Hudry et al.   Science Translational Medicine

Thyroid Dysfunction as an Unintended Side Effect of Anticancer Drugs

(2013) Francesco Torino et al.   THYROID

Understanding brain dysfunction in sepsis

(2013) Romain Sonneville et al.   Annals of Intensive Care

U.K. consensus statement on safe clinical prescribing of bexarotene for patients with cutaneous T-cell lymphoma

(2012) J.J. Scarisbrick et al.   BRITISH JOURNAL OF DERMATOLOGY

Differential Regulation of Amyloid-β Endocytic Trafficking and Lysosomal Degradation by Apolipoprotein E Isoforms

(2012) Jie Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

APOE4-specific Changes in Aβ Accumulation in a New Transgenic Mouse Model of Alzheimer Disease

(2012) Katherine L. Youmans et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

 -Amyloid Inhibits Protein Prenylation and Induces Cholesterol Sequestration by Impairing SREBP-2 Cleavage

(2012) A. Mohamed et al.   JOURNAL OF NEUROSCIENCE

Apolipoprotein E, Especially Apolipoprotein E4, Increases the Oligomerization of Amyloid   Peptide

(2012) T. Hashimoto et al.   JOURNAL OF NEUROSCIENCE

Amyloid-related imaging abnormalities in patients with Alzheimer's disease treated with bapineuzumab: a retrospective analysis

(2012) Reisa Sperling et al.   LANCET NEUROLOGY

ApoE-Directed Therapeutics Rapidly Clear  -Amyloid and Reverse Deficits in AD Mouse Models

(2012) P. E. Cramer et al.   SCIENCE

Modulation of RXR function through ligand design

(2011) Efrén Pérez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The effect of apolipoprotein E (ApoE) genotype on biomarkers of amyloidogenesis, tau pathology and neurodegeneration in Alzheimer's disease

(2011) Valerio Leoni   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Soluble Aβ oligomer production and toxicity

(2011) Megan E. Larson et al.   JOURNAL OF NEUROCHEMISTRY

Dynamic Analysis of Amyloid  -Protein in Behaving Mice Reveals Opposing Changes in ISF versus Parenchymal A  during Age-Related Plaque Formation

(2011) S. Hong et al.   JOURNAL OF NEUROSCIENCE

Amyloid-β42 alters apolipoprotein E solubility in brains of mice with five familial AD mutations

(2011) Katherine Lynn Youmans et al.   JOURNAL OF NEUROSCIENCE METHODS

Apolipoprotein E in Alzheimer's disease and other neurological disorders

(2011) Philip B Verghese et al.   LANCET NEUROLOGY

Resolving controversies on the path to Alzheimer's therapeutics

(2011) Dennis J Selkoe   NATURE MEDICINE

Effects of aromatase inhibition versus gonadectomy on hippocampal complex amyloid pathology in triple transgenic mice

(2011) Cassia R. Overk et al.   NEUROBIOLOGY OF DISEASE

Soluble amyloid  -protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration

(2011) M. Jin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human apoE Isoforms Differentially Regulate Brain Amyloid-  Peptide Clearance

(2011) J. M. Castellano et al.   Science Translational Medicine

Proposed mechanism for lipoprotein remodelling in the brain

(2010) Chunjiang Yu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

A novel approach for long-term oral drug administration in animal research

(2010) Cassia R. Overk et al.   JOURNAL OF NEUROSCIENCE METHODS

Bexarotene Induces Dyslipidemia by Increased Very Low-Density Lipoprotein Production and Cholesteryl Ester Transfer Protein-Mediated Reduction of High-Density Lipoprotein

(2009) Jitske de Vries-van der Weij et al.   ENDOCRINOLOGY

Human APOE Isoform-Dependent Effects on Brain  -Amyloid Levels in PDAPP Transgenic Mice

(2009) K. R. Bales et al.   JOURNAL OF NEUROSCIENCE

Decreased levels of PSD95 and two associated proteins and increased levels of BCl2and caspase 3 in hippocampus from subjects with amnestic mild cognitive impairment: Insights into their potential roles for loss of synapses and memory, accumulation of Aβ, and neurodegeneration in a prodromal stage of Alzheimer's disease

(2009) Rukhsana Sultana et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Soluble fibrillar oligomer levels are elevated in Alzheimer's disease brain and correlate with cognitive dysfunction

(2009) Jennifer L. Tomic et al.   NEUROBIOLOGY OF DISEASE

Oligomeric amyloid   associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques

(2009) R. M. Koffie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

apoE isoform–specific disruption of amyloid β peptide clearance from mouse brain

(2008) Rashid Deane et al.   JOURNAL OF CLINICAL INVESTIGATION

ApoE Promotes the Proteolytic Degradation of Aβ

(2008) Qingguang Jiang et al.   NEURON