The role of APOE in cerebrovascular dysfunction

Apolipoprotein E-Mimetic COG1410 Reduces Acute Vasogenic Edema following Traumatic Brain Injury

(2016) Fang Cao et al.   JOURNAL OF NEUROTRAUMA

The APOE4 allele shows opposite sex bias in microbleeds and Alzheimer's disease of humans and mice

(2016) Mafalda Cacciottolo et al.   NEUROBIOLOGY OF AGING

APOEε2 is associated with milder clinical and pathological Alzheimer disease

(2015) Alberto Serrano-Pozo et al.   ANNALS OF NEUROLOGY

Does apolipoprotein E genotype influence cognition in middle-aged individuals?

(2015) Gerardo Salvato   CURRENT OPINION IN NEUROLOGY

Effects ofAPOEpromoter polymorphism on the topological organization of brain structural connectome in nondemented elderly

(2015) Ni Shu et al.   HUMAN BRAIN MAPPING

Apolipoprotein E Inhibits Cerebrovascular Pericyte Mobility through a RhoA Protein-mediated Pathway

(2015) Caroline S. Casey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Accelerated pericyte degeneration and blood–brain barrier breakdown in apolipoprotein E4 carriers with Alzheimer’s disease

(2015) Matthew R Halliday et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

APOE-modulated Aβ-induced neuroinflammation in Alzheimer's disease: current landscape, novel data, and future perspective

(2015) Leon M. Tai et al.   JOURNAL OF NEUROCHEMISTRY

Impact of Apolipoprotein E4 Polymorphism on the Gray Matter Volume and the White Matter Integrity in Subjective Memory Impairment without White Matter Hyperintensities: Voxel-Based Morphometry and Tract-Based Spatial Statistics Study under 3-Tesla MRI

(2015) Young-Min Lee et al.   JOURNAL OF NEUROIMAGING

APOE ε4 Genotype and the Risk for Subjective Cognitive Impairment in Elderly Persons

(2015) Janina Krell-Roesch et al.   JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES

Apolipoprotein E, Carbon Dioxide Vasoreactivity, and Cognition in Older Adults: Effect of Hypertension

(2015) Ihab Hajjar et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Opposing effects of viral mediated brain expression of apolipoprotein E2 (apoE2) and apoE4 on apoE lipidation and Aβ metabolism in apoE4-targeted replacement mice

(2015) Jin Hu et al.   Molecular Neurodegeneration

Cerebral amyloid angiopathy and its co-occurrence with Alzheimer's disease and other cerebrovascular neuropathologic changes

(2015) Willa D. Brenowitz et al.   NEUROBIOLOGY OF AGING

APOE and cerebral amyloid angiopathy in community-dwelling older persons

(2015) Lei Yu et al.   NEUROBIOLOGY OF AGING

Effects of vascular risk factors and APOE  4 on white matter integrity and cognitive decline

(2015) R. Wang et al.   NEUROLOGY

Cerebral amyloid angiopathy with and without hemorrhage: Evidence for different disease phenotypes

(2015) A. Charidimou et al.   NEUROLOGY

Lack of Widespread BBB Disruption in Alzheimer’s Disease Models: Focus on Therapeutic Antibodies

(2015) Nga Bien-Ly et al.   NEURON

Apolipoprotein E-dependent load of white matter hyperintensities in Alzheimer’s disease: a voxel-based lesion mapping study

(2015) Katrin Morgen et al.   Alzheimers Research & Therapy

APOE Stabilization by Exercise Prevents Aging Neurovascular Dysfunction and Complement Induction

(2015) Ileana Soto et al.   PLOS BIOLOGY

Aβ immunotherapy for Alzheimer’s disease: effects on apoE and cerebral vasculopathy

(2014) Kenji Sakai et al.   ACTA NEUROPATHOLOGICA

APOE ε4 and risk for Alzheimer's disease: Do regionally distributed white matter hyperintensities play a role?

(2014) Adam M. Brickman et al.   Alzheimers & Dementia

Immunotherapy for Alzheimer's disease

(2014) Thomas Wisniewski et al.   BIOCHEMICAL PHARMACOLOGY

Cerebral Amyloid Angiopathy, Subcortical White Matter Disease and Dementia: Literature Review and Study in OPTIMA

(2014) Margaret Esiri et al.   BRAIN PATHOLOGY

APOε4 is associated with enhanced in vivo innate immune responses in human subjects

(2014) Stephen C. Gale et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

PPAR Agonist-Mediated Protection against HIV Tat-Induced Cerebrovascular Toxicity is Enhanced in MMP-9-Deficient Mice

(2014) Wen Huang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Human Apolipoprotein E ε4 Expression Impairs Cerebral Vascularization and Blood—Brain Barrier Function in Mice

(2014) Wael Alata et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

ApoE-Deficient Promotes Blood–Brain Barrier Disruption in Experimental Autoimmune Encephalomyelitis via Alteration of MMP-9

(2014) Minghua Zheng et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Resting-State Functional Connectivity Changes in Aging apoE4 and apoE-KO Mice

(2014) V. Zerbi et al.   JOURNAL OF NEUROSCIENCE

Soluble apoE/Aβ complex: mechanism and therapeutic target for APOE4-induced AD risk

(2014) Leon M Tai et al.   Molecular Neurodegeneration

ApoE and Aβ in Alzheimer’s Disease: Accidental Encounters or Partners?

(2014) Takahisa Kanekiyo et al.   NEURON

Clinical Predictors of Severe Cerebral Amyloid Angiopathy and Influence ofAPOEGenotype in Persons With Pathologically Verified Alzheimer Disease

(2014) John M. Ringman et al.   JAMA Neurology

White matter microstructure in late middle-age: Effects of apolipoprotein E4 and parental family history of Alzheimer's disease

(2014) Nagesh Adluru et al.   NeuroImage-Clinical

The ε4 genotype of apolipoprotein E and white matter integrity in Alzheimer's disease

(2013) Vanja Kljajevic et al.   Alzheimers & Dementia

Interaction of white matter hyperintensities (WMHs) and apolipoprotein E (APOE) genotypes on cognition in patients with amnestic mild cognitive impairment (aMCI)

(2013) Bora Yoon et al.   ARCHIVES OF GERONTOLOGY AND GERIATRICS

Do cardiovascular risk factors explain the link between white matter hyperintensities and brain volumes in old age? A population-based study

(2013) R. Wang et al.   EUROPEAN JOURNAL OF NEUROLOGY

The APOE ε4/ε4 Genotype Potentiates Vascular Fibrin(Ogen) Deposition in Amyloid-Laden Vessels in the Brains of Alzheimer's Disease Patients

(2013) Karin Hultman et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Reduction in DHA transport to the brain of mice expressing humanAPOE4compared toAPOE2

(2013) Milène Vandal et al.   JOURNAL OF NEUROCHEMISTRY

APOE associations with severe CAA-associated vasculopathic changes: collaborative meta-analysis

(2013) K. Rannikmae et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

APOE-ε2 and APOE-ε4 Correlate With Increased Amyloid Accumulation in Cerebral Vasculature

(2013) Peter T. Nelson et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

APOE Genotype Modifies the Relationship between Midlife Vascular Risk Factors and Later Cognitive Decline

(2013) Katherine J. Bangen et al.   Journal of Stroke & Cerebrovascular Diseases

Peroxisome Proliferator-activated Receptors and Alzheimer's Disease: Hitting the Blood–Brain Barrier

(2013) Juan M. Zolezzi et al.   MOLECULAR NEUROBIOLOGY

Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

(2013) Chia-Chen Liu et al.   Nature Reviews Neurology

Specific risk factors for microbleeds and white matter hyperintensities in Alzheimer's disease

(2013) Marije R. Benedictus et al.   NEUROBIOLOGY OF AGING

APOE genotype and MRI markers of cerebrovascular disease: Systematic review and meta-analysis

(2013) S. Schilling et al.   NEUROLOGY

Patterns of cerebral amyloid angiopathy define histopathological phenotypes in Alzheimer's disease

(2013) N. Allen et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Investigating the Association of ApoE Genotypes with Blood-Brain Barrier Dysfunction Measured by Cerebrospinal Fluid-Serum Albumin Ratio in a Cohort of Patients with Different Types of Dementia

(2013) André Karch et al.   PLoS One

Relationship Between Cyclophilin A Levels and Matrix Metalloproteinase 9 Activity in Cerebrospinal Fluid of Cognitively Normal Apolipoprotein E4 Carriers and Blood-Brain Barrier Breakdown

(2013) Matthew R. Halliday et al.   JAMA Neurology

Vascular risk factors, apolipoprotein E, and hippocampal decline on magnetic resonance imaging over a 10-year follow-up

(2012) Tom den Heijer et al.   Alzheimers & Dementia

Correlation Analysis of Capillary APOE, VEGF and eNOS Expression in Alzheimer Brains

(2012) J. Provias et al.   Current Alzheimer Research

APOE4-specific Changes in Aβ Accumulation in a New Transgenic Mouse Model of Alzheimer Disease

(2012) Katherine L. Youmans et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effect of Mild Cognitive Impairment and APOE Genotype on Resting Cerebral Blood Flow and its Association with Cognition

(2012) Christina E Wierenga et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Association Between White Matter Hyperintensity Severity and Cognitive Impairment According to the Presence of the Apolipoprotein E (APOE) ε4 Allele in the Elderly

(2012) Sang Joon Son et al.   JOURNAL OF CLINICAL PSYCHIATRY

Stimulation of the Retinoid X Receptor Facilitates Beta-Amyloid Clearance Across the Blood–Brain Barrier

(2012) Corbin Bachmeier et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Effect of plasma lipids, hypertension and APOE genotype on cognitive decline

(2012) Fumihiko Yasuno et al.   NEUROBIOLOGY OF AGING

A Multifaceted Role for apoE in the Clearance of Beta-Amyloid across the Blood-Brain Barrier

(2012) Corbin Bachmeier et al.   Neurodegenerative Diseases

APOE e4 polymorphism in young adults is associated with improved attention and indexed by distinct neural signatures

(2012) J.M. Rusted et al.   NEUROIMAGE

Effects of APOE on brain white matter microstructure in healthy adults

(2012) L. T. Westlye et al.   NEUROLOGY

Age-related differences in memory and executive functions in healthy APOE ɛ4 carriers: The contribution of individual differences in prefrontal volumes and systolic blood pressure

(2012) Andrew R. Bender et al.   NEUROPSYCHOLOGIA

Regional cerebral perfusion in patients with Alzheimer’s disease and mild cognitive impairment: effect of APOE Epsilon4 allele

(2012) Sun Mi Kim et al.   NEURORADIOLOGY

Disruption of Arterial Perivascular Drainage of Amyloid-β from the Brains of Mice Expressing the Human APOE ε4 Allele

(2012) Cheryl A. Hawkes et al.   PLoS One

Antioxidant Status and APOE Genotype As Susceptibility Factors for Neurodegeneration in Alzheimer's Disease and Vascular Dementia

(2012) Giancarlo Zito et al.   REJUVENATION RESEARCH

Volume of white matter hyperintensities in healthy adults: Contribution of age, vascular risk factors, and inflammation-related genetic variants

(2011) Naftali Raz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

APOE ε4 Is Associated With Exacerbation of Cognitive Decline in Patients With Multiple Sclerosis

(2011) Jiong Shi et al.   Cognitive and Behavioral Neurology

Apolipoprotein E Regulates the Integrity of Tight Junctions in an Isoform-dependent Manner in anin VitroBlood-Brain Barrier Model

(2011) Kazuchika Nishitsuji et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid-β protein modulates the perivascular clearance of neuronal apolipoprotein E in mouse models of Alzheimer’s disease

(2011) Harshvardhan Rolyan et al.   JOURNAL OF NEURAL TRANSMISSION

The apoE-mimetic Peptide, COG1410, Improves Functional Recovery in a Murine Model of Intracerebral Hemorrhage

(2011) Daniel T. Laskowitz et al.   Neurocritical Care

Cerebrovascular risk factors and preclinical memory decline in healthy APOE  4 homozygotes

(2011) R. J. Caselli et al.   NEUROLOGY

Longitudinal modeling of frontal cognition in APOE  4 homozygotes, heterozygotes, and noncarriers

(2011) R. J. Caselli et al.   NEUROLOGY

Human apoE Isoforms Differentially Regulate Brain Amyloid-  Peptide Clearance

(2011) J. M. Castellano et al.   Science Translational Medicine

Capillary cerebral amyloid angiopathy identifies a distinct APOE ε4-associated subtype of sporadic Alzheimer’s disease

(2010) Dietmar Rudolf Thal et al.   ACTA NEUROPATHOLOGICA

APOE ε4 Genotype and Longitudinal Changes in Cerebral Blood Flow in Normal Aging

(2010) Madhav Thambisetty et al.   ARCHIVES OF NEUROLOGY

Apolipoprotein E4allele in the normal elderly: neuropsychologic and brain MRI correlates

(2010) H. Schmidt et al.   CLINICAL GENETICS

The vascular contribution to Alzheimer's disease

(2010) Robin Altman et al.   CLINICAL SCIENCE

Association Study of Gene Polymorphisms Involved in Vascular Alterations in Elderly Hypertensives with Subjective Memory Complaints

(2010) Ghassan Watfa et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Effect of ApoE ε4 Allele on Visual Evoked Potentials and Resultant Flow Coupling in Patients With Alzheimer

(2010) Bernhard Rosengarten et al.   JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY

Interactive Effects of Apolipoprotein E Type 4 Genotype and Cerebrovascular Risk on Neuropsychological Performance and Structural Brain Changes

(2010) David Zade et al.   Journal of Stroke & Cerebrovascular Diseases

The effects of APOE-ε4 on the BOLD response

(2010) Aaron J. Trachtenberg et al.   NEUROBIOLOGY OF AGING

Differential effects of the APOE genotype on brain function across the lifespan

(2010) N. Filippini et al.   NEUROIMAGE

Insulin resistance is associated with the pathology of Alzheimer disease: The Hisayama Study

(2010) T. Matsuzaki et al.   NEUROLOGY

Amyloid load in nondemented brains correlates with APOE e4

(2010) Richard J. Caselli et al.   NEUROSCIENCE LETTERS

Prevalence and Risk Factors of Cerebral Microbleeds: An Update of the Rotterdam Scan Study

(2010) M. M. F. Poels et al.   STROKE

Genetic Determinants of White Matter Hyperintensities on Brain Scans

(2009) Lavinia Paternoster et al.   STROKE

Enhanced Risk for Alzheimer Disease in Persons With Type 2 Diabetes and APOE ε4

(2008) Fumiko Irie et al.   ARCHIVES OF NEUROLOGY

apoE isoform–specific disruption of amyloid β peptide clearance from mouse brain

(2008) Rashid Deane et al.   JOURNAL OF CLINICAL INVESTIGATION

Cerebral Small Vessel Disease-Induced Apolipoprotein E Leakage Is Associated With Alzheimer Disease and the Accumulation of Amyloid β-Protein in Perivascular Astrocytes

(2008) Sabrina Utter et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Meta-Analysis of APOE4 Allele and Outcome after Traumatic Brain Injury

(2008) Weidong Zhou et al.   JOURNAL OF NEUROTRAUMA

Cerebral perfusion and oxygenation differences in Alzheimer's disease risk

(2008) Adam S. Fleisher et al.   NEUROBIOLOGY OF AGING

Cerebral Cortical Arteriolar Angiopathy, Vascular Beta-Amyloid, Smooth Muscle Actin, Braak Stage, and APOE Genotype

(2008) Edward G. Stopa et al.   STROKE