Heterozygous PINK1 p.G411S increases risk of Parkinson’s disease via a dominant-negative mechanism

miR-27a and miR-27b regulate autophagic clearance of damaged mitochondria by targeting PTEN-induced putative kinase 1 (PINK1)

(2016) Jaekwang Kim et al.   Molecular Neurodegeneration

Somatic mtDNA variation is an important component of Parkinson's disease

(2016) Jonathan Coxhead et al.   NEUROBIOLOGY OF AGING

Disease relevance of phosphorylated ubiquitin (p-S65-Ub)

(2015) Fabienne C Fiesel et al.   Autophagy

Activation of the E3 ubiquitin ligase Parkin

(2015) Thomas R. Caulfield et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The genetics of Parkinson's disease

(2015) Stephen Mullin et al.   BRITISH MEDICAL BULLETIN

Disruption of the autoinhibited state primes the E3 ligase parkin for activation and catalysis

(2015) A. Kumar et al.   EMBO JOURNAL

A Ubl/ubiquitin switch in the activation of Parkin

(2015) V. Sauve et al.   EMBO JOURNAL

(Patho-)physiological relevance of PINK1-dependent ubiquitin phosphorylation

(2015) F. C. Fiesel et al.   EMBO REPORTS

Structural and Functional Impact of Parkinson Disease-Associated Mutations in the E3 Ubiquitin Ligase Parkin

(2015) Fabienne C. Fiesel et al.   HUMAN MUTATION

Phosphorylated ubiquitin chain is the genuine Parkin receptor

(2015) Kei Okatsu et al.   JOURNAL OF CELL BIOLOGY

The PINK1-PARKIN Mitochondrial Ubiquitylation Pathway Drives a Program of OPTN/NDP52 Recruitment and TBK1 Activation to Promote Mitophagy

(2015) Jin-Mi Heo et al.   MOLECULAR CELL

Mechanism of phospho-ubiquitin-induced PARKIN activation

(2015) Tobias Wauer et al.   NATURE

The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

(2015) Michael Lazarou et al.   NATURE

Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65

(2014) Agne Kazlauskaite et al.   BIOCHEMICAL JOURNAL

PINK1 Kinase Catalytic Activity Is Regulated by Phosphorylation on Serines 228 and 402

(2014) Liesbeth Aerts et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity

(2014) Lesley A. Kane et al.   JOURNAL OF CELL BIOLOGY

A specific subset of E2 ubiquitin-conjugating enzymes regulate Parkin activation and mitophagy differently

(2014) F. C. Fiesel et al.   JOURNAL OF CELL SCIENCE

Quantitative Proteomics Reveal a Feedforward Mechanism for Mitochondrial PARKIN Translocation and Ubiquitin Chain Synthesis

(2014) Alban Ordureau et al.   MOLECULAR CELL

Phenotypic variability of PINK1 expression: 12 Years' clinical follow-up of two Italian families

(2014) Lucia Ricciardi et al.   MOVEMENT DISORDERS

Ubiquitin is phosphorylated by PINK1 to activate parkin

(2014) Fumika Koyano et al.   NATURE

Early-onset Parkinson's disease due to PINK1 p.Q456X mutation – Clinical and functional study

(2014) Joanna Siuda et al.   PARKINSONISM & RELATED DISORDERS

Phosphorylation by PINK1 Releases the UBL Domain and Initializes the Conformational Opening of the E3 Ubiquitin Ligase Parkin

(2014) Thomas R. Caulfield et al.   PLoS Computational Biology

Phosphorylation of Mitochondrial Polyubiquitin by PINK1 Promotes Parkin Mitochondrial Tethering

(2014) Kahori Shiba-Fukushima et al.   PLoS Genetics

PINK1 is degraded through the N-end rule pathway

(2013) Koji Yamano et al.   Autophagy

Direct Conversion of Fibroblasts to Neurons by Reprogramming PTB-Regulated MicroRNA Circuits

(2013) Yuanchao Xue et al.   CELL

The dual functions of the extreme N-terminus of TDP-43 in regulating its biological activity and inclusion formation

(2013) Yong-Jie Zhang et al.   HUMAN MOLECULAR GENETICS

A Dimeric PINK1-containing Complex on Depolarized Mitochondria Stimulates Parkin Recruitment

(2013) Kei Okatsu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Monogenic Parkinson's disease and parkinsonism: Clinical phenotypes and frequencies of known mutations

(2013) Andreas Puschmann   PARKINSONISM & RELATED DISORDERS

Motion of transfer RNA from the A/T state into the A-site using docking and simulations

(2013) Thomas Caulfield et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Structure and Function of Parkin, PINK1, and DJ-1, the Three Musketeers of Neuroprotection

(2013) Jean-François Trempe et al.   Frontiers in Neurology

Analysis of the regulatory and catalytic domains of PTEN-induced kinase-1 (PINK1)

(2012) Chou Hung Sim et al.   HUMAN MUTATION

Systematic Review and UK-Based Study ofPARK2 (parkin), PINK1, PARK7 (DJ-1)andLRRK2in early-onset Parkinson's disease

(2012) Laura L. Kilarski et al.   MOVEMENT DISORDERS

PINK1 autophosphorylation upon membrane potential dissipation is essential for Parkin recruitment to damaged mitochondria

(2012) Kei Okatsu et al.   Nature Communications

PINK1-mediated phosphorylation of the Parkin ubiquitin-like domain primes mitochondrial translocation of Parkin and regulates mitophagy

(2012) Kahori Shiba-Fukushima et al.   Scientific Reports

PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65

(2012) C. Kondapalli et al.   Open Biology

Functional alteration of PARL contributes to mitochondrial dysregulation in Parkinson's disease

(2011) Guang Shi et al.   HUMAN MOLECULAR GENETICS

Phylogenetic and in silico structural analysis of the Parkinson disease-related kinase PINK1

(2011) Fernando Cardona et al.   HUMAN MUTATION

Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies

(2011)   LANCET

Association of LRRK2 exonic variants with susceptibility to Parkinson's disease: a case–control study

(2011) Owen A Ross et al.   LANCET NEUROLOGY

Template-based protein structure modeling using TASSERVMT

(2011) Hongyi Zhou et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

The PINK1/Parkin-mediated mitophagy is compromised by PD-associated mutations

(2010) Sven Geisler et al.   Autophagy

Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL

(2010) Seok Min Jin et al.   JOURNAL OF CELL BIOLOGY

Novel pathogenic LRRK2 p.Asn1437His substitution in familial Parkinson's disease

(2010) Jan O. Aasly et al.   MOVEMENT DISORDERS

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

(2010) Sven Geisler et al.   NATURE CELL BIOLOGY

Progression of subtle motor signs in PINK1 mutation carriers with mild dopaminergic deficit

(2010) C. Eggers et al.   NEUROLOGY

PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin

(2010) Derek P. Narendra et al.   PLOS BIOLOGY

Protein Structure Prediction by Pro-Sp3-TASSER

(2009) Hongyi Zhou et al.   BIOPHYSICAL JOURNAL

Multicenter Analysis of Glucocerebrosidase Mutations in Parkinson's Disease

(2009) E. Sidransky et al.   NEW ENGLAND JOURNAL OF MEDICINE

PINK1 Defect Causes Mitochondrial Dysfunction, Proteasomal Deficit and α-Synuclein Aggregation in Cell Culture Models of Parkinson's Disease

(2009) Wencheng Liu et al.   PLoS One

Performance of the Pro-sp3-TASSER server in CASP8

(2009) Hongyi Zhou et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Improving physical realism, stereochemistry, and side-chain accuracy in homology modeling: Four approaches that performed well in CASP8

(2009) Elmar Krieger et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

PINK1heterozygous rare variants: prevalence, significance and phenotypic spectrum

(2008) Roberta Marongiu et al.   HUMAN MUTATION

Biochemical aspects of the neuroprotective mechanism of PTEN-induced kinase-1 (PINK1)

(2008) Ryan D. Mills et al.   JOURNAL OF NEUROCHEMISTRY

Screening PARK genes for mutations in early-onset Parkinson's disease patients from Queensland, Australia

(2008) George D. Mellick et al.   PARKINSONISM & RELATED DISORDERS