Apolipoprotein E4 mediates insulin resistance-associated cerebrovascular dysfunction and the post-prandial response

Reversal of high fat diet-induced obesity improves glucose tolerance, inflammatory response, β-amyloid accumulation and cognitive decline in the APP/PSEN1 mouse model of Alzheimer's disease

(2017) Jennifer M. Walker et al.   NEUROBIOLOGY OF DISEASE

Apolipoprotein E4 and Insulin Resistance Interact to Impair Cognition and Alter the Epigenome and Metabolome

(2017) Lance A. Johnson et al.   Scientific Reports

Neuronutrition and Alzheimer's Disease

(2017) Balenahalli N. Ramesh et al.   JOURNAL OF ALZHEIMERS DISEASE

The role of APOE in cerebrovascular dysfunction

(2016) Leon M. Tai et al.   ACTA NEUROPATHOLOGICA

Brain fluorodeoxyglucose (FDG) PET in dementia

(2016) Takashi Kato et al.   AGEING RESEARCH REVIEWS

Alzheimer's Disease Genetic Risk Factor APOE-ε4 Also Affects Normal Brain Function

(2016) Amanda M. Di Battista et al.   Current Alzheimer Research

Insulin resistance, dyslipidemia, and apolipoprotein E interactions as mechanisms in cognitive impairment and Alzheimer's disease

(2016) Therese S Salameh et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Metabolic shifts toward fatty-acid usage and increased thermogenesis are associated with impaired adipogenesis in mice expressing human APOE4

(2016) J M Arbones-Mainar et al.   INTERNATIONAL JOURNAL OF OBESITY

Rapamycin rescues vascular, metabolic and learning deficits in apolipoprotein E4 transgenic mice with pre-symptomatic Alzheimer’s disease

(2016) Ai-Ling Lin et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Apolipoprotein E: from cardiovascular disease to neurodegenerative disorders

(2016) Robert W. Mahley   JOURNAL OF MOLECULAR MEDICINE-JMM

Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4·4 million participants

(2016)   LANCET

Pericytes of the neurovascular unit: key functions and signaling pathways

(2016) Melanie D Sweeney et al.   NATURE NEUROSCIENCE

A Dietary Treatment Improves Cerebral Blood Flow and Brain Connectivity in Aging apoE4 Mice

(2016) Maximilian Wiesmann et al.   NEURAL PLASTICITY

Amelioration of Metabolic Syndrome-Associated Cognitive Impairments in Mice via a Reduction in Dietary Fat Content or Infusion of Non-Diabetic Plasma

(2016) Lance A. Johnson et al.   EBioMedicine

Cerebral blood flow, blood supply, and cognition in Type 2 Diabetes Mellitus

(2016) Jacobus F. A. Jansen et al.   Scientific Reports

Vascular contributions to cognitive impairment and dementia including Alzheimer's disease

(2015) Heather M. Snyder et al.   Alzheimers & Dementia

Regional brain hypometabolism is unrelated to regional amyloid plaque burden

(2015) Andre Altmann et al.   BRAIN

Contrast-Enhanced Ultrasound Assessment of Impaired Adipose Tissue and Muscle Perfusion in Insulin-Resistant Mice

(2015) J. T. Belcik et al.   Circulation-Cardiovascular Imaging

Inflammation-associated declines in cerebral vasoreactivity and cognition in type 2 diabetes

(2015) Chen-Chih Chung et al.   NEUROLOGY

Effects of glucose load on cognitive functions in elderly people

(2015) N. L. van der Zwaluw et al.   NUTRITION REVIEWS

Shared Neuropathological Characteristics of Obesity, Type 2 Diabetes and Alzheimer’s Disease: Impacts on Cognitive Decline

(2015) Jennifer Walker et al.   Nutrients

Type 2 diabetes mellitus

(2015) Ralph A. DeFronzo et al.   Nature Reviews Disease Primers

Alzheimer's Disease, Cerebrovascular Disease, and the β-amyloid Cascade

(2014) Kie Honjo et al.   CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES

The APOE Genotype: Modification of Therapeutic Responses in Alzheimer's Disease

(2014) Angela Hanson et al.   CURRENT PHARMACEUTICAL DESIGN

Human Apolipoprotein E ε4 Expression Impairs Cerebral Vascularization and Blood—Brain Barrier Function in Mice

(2014) Wael Alata et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Apolipoprotein E (APOE) genotype regulates body weight and fatty acid utilization-Studies in gene-targeted replacement mice

(2014) Patricia Huebbe et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Capillary pericytes regulate cerebral blood flow in health and disease

(2014) Catherine N. Hall et al.   NATURE

The Apolipoprotein E Polymorphism rs7412 Associates with Body Fatness Independently of Plasma Lipids in Middle Aged Men

(2014) M. Teresa Tejedor et al.   PLoS One

Enhancement of Vasoreactivity and Cognition by Intranasal Insulin in Type 2 Diabetes

(2013) Vera Novak et al.   DIABETES CARE

Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

(2013) Chia-Chen Liu et al.   Nature Reviews Neurology

APOE genotype and MRI markers of cerebrovascular disease: Systematic review and meta-analysis

(2013) S. Schilling et al.   NEUROLOGY

Early Decline in Glucose Transport and Metabolism Precedes Shift to Ketogenic System in Female Aging and Alzheimer's Mouse Brain: Implication for Bioenergetic Intervention

(2013) Fan Ding et al.   PLoS One

Cerebrovascular Effects of Apolipoprotein E

(2013) Berislav V. Zlokovic   JAMA Neurology

Effect of Apolipoprotein E Genotype and Diet on Apolipoprotein E Lipidation and Amyloid Peptides

(2013) Angela J. Hanson et al.   JAMA Neurology

Brain Insulin Resistance and Deficiency as Therapeutic Targets in Alzheimers Disease

(2012) Suzanne M. de la Monte   Current Alzheimer Research

Projections of Type 1 and Type 2 Diabetes Burden in the U.S. Population Aged

(2012) G. Imperatore et al.   DIABETES CARE

Diabetic atherosclerosis in APOE*4 mice: synergy between lipoprotein metabolism and vascular inflammation

(2012) Lance A. Johnson et al.   JOURNAL OF LIPID RESEARCH

Dietary Omega 3 Polyunsaturated Fatty Acids and Alzheimers Disease: Interaction with Apolipoprotein E Genotype

(2011) P. Barberger-Gateau et al.   Current Alzheimer Research

Apolipoprotein E4 Exaggerates Diabetic Dyslipidemia and Atherosclerosis in Mice Lacking the LDL Receptor

(2011) L. A. Johnson et al.   DIABETES

Apolipoprotein E Regulates the Integrity of Tight Junctions in an Isoform-dependent Manner in anin VitroBlood-Brain Barrier Model

(2011) Kazuchika Nishitsuji et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The ε3 and ε4 Alleles of Human APOE Differentially Affect Tau Phosphorylation in Hyperinsulinemic and Pioglitazone Treated Mice

(2011) Alvina W. M. To et al.   PLoS One

APOE ε4 Genotype and Longitudinal Changes in Cerebral Blood Flow in Normal Aging

(2010) Madhav Thambisetty et al.   ARCHIVES OF NEUROLOGY

Increased Brain Fatty Acid Uptake in Metabolic Syndrome

(2010) A. Karmi et al.   DIABETES

In vivo optical imaging of revascularization after brain trauma in mice

(2010) Yali Jia et al.   MICROVASCULAR RESEARCH

Differential effects of the APOE genotype on brain function across the lifespan

(2010) N. Filippini et al.   NEUROIMAGE

Diabetes, Alzheimer disease, and vascular dementia: A population-based neuropathologic study

(2010) S. Ahtiluoto et al.   NEUROLOGY

The Role of Metabolic Disorders in Alzheimer Disease and Vascular Dementia

(2009) Suzanne Craft   ARCHIVES OF NEUROLOGY

Presence of the APOE ε4 allele modifies the relationship between type 2 diabetes and cognitive performance: the Maine–Syracuse Study

(2009) G. A. Dore et al.   DIABETOLOGIA

Genome-wide association studies in Alzheimer's disease

(2009) L. Bertram et al.   HUMAN MOLECULAR GENETICS

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

(2009) Denise Harold et al.   NATURE GENETICS

The Role of Apolipoprotein E in Alzheimer's Disease

(2009) Jungsu Kim et al.   NEURON

Astrocytes and the regulation of cerebral blood flow

(2009) Raymond C. Koehler et al.   TRENDS IN NEUROSCIENCES

Dietary Patterns Associated with Alzheimer’s Disease: Population Based Study

(2009) Katarzyna Gustaw-Rothenberg   International Journal of Environmental Research and Public Health

Enhanced Risk for Alzheimer Disease in Persons With Type 2 Diabetes and APOE ε4

(2008) Fumiko Irie et al.   ARCHIVES OF NEUROLOGY

Diet-induced insulin resistance impairs hippocampal synaptic plasticity and cognition in middle-aged rats

(2008) Alexis M. Stranahan et al.   HIPPOCAMPUS

Differential modulation of diet-induced obesity and adipocyte functionality by human apolipoprotein E3 and E4 in mice

(2008) J M Arbones-Mainar et al.   INTERNATIONAL JOURNAL OF OBESITY

Apolipoprotein E ɛ4 magnifies lifestyle risks for dementia: a population-based study

(2008) Miia Kivipelto et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Apolipoprotein E knock-out and knock-in mice: atherosclerosis, metabolic syndrome, and beyond: Fig. 1.

(2008) Avani A. Pendse et al.   JOURNAL OF LIPID RESEARCH