Clearance of beta-amyloid is facilitated by apolipoprotein E and circulating high-density lipoproteins in bioengineered human vessels

Apolipoprotein C-III is an Amyloid-β-Binding Protein and an Early Marker for Alzheimer's Disease

(2018) Yao-Hsiang Shih et al.   JOURNAL OF ALZHEIMERS DISEASE

High-density lipoproteins suppress Aβ-induced PBMC adhesion to human endothelial cells in bioengineered vessels and in monoculture

(2017) Jérôme Robert et al.   Molecular Neurodegeneration

ApoE, ApoE Receptors, and the Synapse in Alzheimer's Disease

(2017) Courtney Lane-Donovan et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Reconstituted high-density lipoproteins acutely reduce soluble brain Aβ levels in symptomatic APP/PS1 mice

(2016) Jérôme Robert et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Genes associated with Alzheimer's disease: an overview and current status

(2016) Mohan Giri et al.   Clinical Interventions in Aging

Distinct Contributions of Astrocytes and Pericytes to Neuroinflammation Identified in a 3D Human Blood-Brain Barrier on a Chip

(2016) Anna Herland et al.   PLoS One

Identification of a Chrysanthemic Ester as an Apolipoprotein E Inducer in Astrocytes

(2016) Jianjia Fan et al.   PLoS One

Nanoliposomes protect against human arteriole endothelial dysfunction induced by β-amyloid peptide

(2015) Seth Truran et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The neuropathology and cerebrovascular mechanisms of dementia

(2015) Limor Raz et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Three-Dimensional Blood-Brain Barrier Model for in vitro Studies of Neurovascular Pathology

(2015) Hansang Cho et al.   Scientific Reports

Cerebral Amyloid Angiopathy: Emerging Concepts

(2015) Masahito Yamada   Journal of Stroke

Plasma proteins predict conversion to dementia from prodromal disease

(2014) Abdul Hye et al.   Alzheimers & Dementia

The overlap between vascular disease and Alzheimer’s disease - lessons from pathology

(2014) Johannes Attems et al.   BMC Medicine

High-Density Lipoproteins and Cerebrovascular Integrity in Alzheimer’s Disease

(2014) Sophie Stukas et al.   Cell Metabolism

Clearance of Beta-Amyloid in the Brain

(2014) Masaki Ueno et al.   CURRENT MEDICINAL CHEMISTRY

Blood–brain barrier models and their relevance for a successful development of CNS drug delivery systems: A review

(2014) Joana Bicker et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Differences in amyloid-β clearance across mouse and human blood–brain barrier models: Kinetic analysis and mechanistic modeling

(2014) Hisham Qosa et al.   NEUROPHARMACOLOGY

Degradation of amyloid beta by human induced pluripotent stem cell-derived macrophages expressing Neprilysin-2

(2014) Koutaro Takamatsu et al.   Stem Cell Research

Intravenously Injected Human Apolipoprotein A‐I Rapidly Enters the Central Nervous System via the Choroid Plexus

(2014) Sophie Stukas et al.   Journal of the American Heart Association

Interleukin 6 Stimulates Endothelial Binding and Transport of High-Density Lipoprotein Through Induction of Endothelial Lipase

(2013) Jérôme Robert et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

High density lipoproteins and endothelial functions: mechanistic insights and alterations in cardiovascular disease

(2013) Meliana Riwanto et al.   JOURNAL OF LIPID RESEARCH

Isolation and expansion of human and mouse brain microvascular endothelial cells

(2013) Stefania E Navone et al.   Nature Protocols

A Three-Dimensional Engineered Artery Model for In Vitro Atherosclerosis Research

(2013) Jérôme Robert et al.   PLoS One

Epidemiology of Alzheimer Disease

(2013) R. Mayeux et al.   Cold Spring Harbor Perspectives in Medicine

Cerebrovascular Effects of Apolipoprotein E

(2013) Berislav V. Zlokovic   JAMA Neurology

Animal Models of Atherosclerosis

(2012) Godfrey S. Getz et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

BBB ON CHIP: microfluidic platform to mechanically and biochemically modulate blood-brain barrier function

(2012) L. M. Griep et al.   BIOMEDICAL MICRODEVICES

Characterization of a microfluidic in vitro model of the blood-brain barrier (μBBB)

(2012) Ross Booth et al.   LAB ON A CHIP

SyM-BBB: a microfluidic blood brain barrier model

(2012) Balabhaskar Prabhakarpandian et al.   LAB ON A CHIP

Prevention of β-amyloid induced toxicity in human iPS cell-derived neurons by inhibition of Cyclin-dependent kinases and associated cell cycle events

(2012) Xiaohong Xu et al.   Stem Cell Research

Cerebral Amyloid Angiopathy: A Systematic Review

(2011) Alessandro Biffi et al.   Journal of Clinical Neurology

Plasma lipid profiling across species for the identification of optimal animal models of human dyslipidemia

(2011) Wu Yin et al.   JOURNAL OF LIPID RESEARCH

Development of a three-dimensional, all-human in vitro model of the blood–brain barrier using mono-, co-, and tri-cultivation Transwell models

(2011) Kathryn Hatherell et al.   JOURNAL OF NEUROSCIENCE METHODS

Human apoE Isoforms Differentially Regulate Brain Amyloid-  Peptide Clearance

(2011) J. M. Castellano et al.   Science Translational Medicine

Association of Higher Levels of High-Density Lipoprotein Cholesterol in Elderly Individuals and Lower Risk of Late-Onset Alzheimer Disease

(2010) Christiane Reitz et al.   ARCHIVES OF NEUROLOGY

Relationship Between Low Levels of High-Density Lipoprotein Cholesterol and Dementia in the Elderly. The InChianti Study

(2010) G. Zuliani et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Insights into the pathogenesis and pathogenicity of cerebral amyloid angiopathy

(2009) Seth Love   Frontiers in Bioscience-Landmark

Human Brain Microvascular Endothelial Cells and Umbilical Vein Endothelial Cells Differentially Facilitate Leukocyte Recruitment and Utilize Chemokines for T Cell Migration

(2008) Shumei Man et al.   Clinical & Developmental Immunology

apoE isoform–specific disruption of amyloid β peptide clearance from mouse brain

(2008) Rashid Deane et al.   JOURNAL OF CLINICAL INVESTIGATION

Comparison of blood–brain barrier permeability assays: in situ brain perfusion, MDR1-MDCKII and PAMPA-BBB

(2008) Li Di et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Amyloid-  Dynamics Correlate with Neurological Status in the Injured Human Brain

(2008) D. L. Brody et al.   SCIENCE