Microglial inflammation and phagocytosis in Alzheimer's disease: Potential therapeutic targets
Published 2019 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Microglial inflammation and phagocytosis in Alzheimer's disease: Potential therapeutic targets
Authors
Keywords
-
Journal
BRITISH JOURNAL OF PHARMACOLOGY
Volume -, Issue -, Pages -
Publisher
Wiley
Online
2019-02-11
DOI
10.1111/bph.14618
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Peripheral complement interactions with amyloid β peptide in Alzheimer's disease: Polymorphisms, structure, and function of complement receptor 1
- (2018) Jenny U. Johansson et al. Alzheimers & Dementia
- High complement levels in astrocyte-derived exosomes of Alzheimer disease
- (2018) Edward J. Goetzl et al. ANNALS OF NEUROLOGY
- Innate Immunity and Neurodegeneration
- (2018) Larisa I. Labzin et al. Annual Review of Medicine
- Recent advances in inflammasome biology
- (2018) David E Place et al. CURRENT OPINION IN IMMUNOLOGY
- TREM2 Ameliorates Neuronal Tau Pathology Through Suppression of Microglial Inflammatory Response
- (2018) Teng Jiang et al. INFLAMMATION
- Toward a New Concept of Alzheimer’s Disease Models: A Perspective from Neuroinflammation
- (2018) Antonia Gutierrez et al. JOURNAL OF ALZHEIMERS DISEASE
- TREM2-activating antibodies abrogate the negative pleiotropic effects of the Alzheimer’s disease variant TREM2R47Hon murine myeloid cell function
- (2018) Qingwen Cheng et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Molecular basis for the loss-of-function effects of the Alzheimer’s disease–associated R47H variant of the immune receptor TREM2
- (2018) Athena Sudom et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Humanized TREM2 mice reveal microglia-intrinsic and -extrinsic effects of R47H polymorphism
- (2018) Wilbur M. Song et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Amyloid-beta modulates microglial responses by binding to the triggering receptor expressed on myeloid cells 2 (TREM2)
- (2018) Li Zhong et al. Molecular Neurodegeneration
- TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function
- (2018) Yingjun Zhao et al. NEURON
- Elevated TREM2 Gene Dosage Reprograms Microglia Responsivity and Ameliorates Pathological Phenotypes in Alzheimer’s Disease Models
- (2018) C.Y. Daniel Lee et al. NEURON
- Local apoptotic-like mechanisms underlie complement-mediated synaptic pruning
- (2018) Balázs A. Györffy et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Animal Models of the Sporadic Form of Alzheimer's Disease: Focus on the Disease and Not Just the Lesions1
- (2018) Khalid Iqbal et al. JOURNAL OF ALZHEIMERS DISEASE
- Targeting the NLRP3 inflammasome in inflammatory diseases
- (2018) Matthew S. J. Mangan et al. NATURE REVIEWS DRUG DISCOVERY
- A state of delirium: Deciphering the effect of inflammation on tau pathology in Alzheimer's disease
- (2017) Matthew Barron et al. EXPERIMENTAL GERONTOLOGY
- Neurophagy, the phagocytosis of live neurons and synapses by glia, contributes to brain development and disease
- (2017) Anna Vilalta et al. FEBS Journal
- Conditional eQTL analysis reveals allelic heterogeneity of gene expression
- (2017) Rick Jansen et al. HUMAN MOLECULAR GENETICS
- The P2X7 Receptor in Infection and Inflammation
- (2017) Francesco Di Virgilio et al. IMMUNITY
- The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases
- (2017) Susanne Krasemann et al. IMMUNITY
- Tauopathies: Mechanisms and Therapeutic Strategies
- (2017) Chen-Chen Tan et al. JOURNAL OF ALZHEIMERS DISEASE
- Microglia in Alzheimer’s disease
- (2017) David V. Hansen et al. JOURNAL OF CELL BIOLOGY
- Inflammasome activation and assembly at a glance
- (2017) Ankit Malik et al. JOURNAL OF CELL SCIENCE
- TREM2-Ligand Interactions in Health and Disease
- (2017) Daniel L. Kober et al. JOURNAL OF MOLECULAR BIOLOGY
- New concepts on the therapeutic control of complement anaphylatoxin receptors
- (2017) Owen A. Hawksworth et al. MOLECULAR IMMUNOLOGY
- Complement in clinical medicine: Clinical trials, case reports and therapy monitoring
- (2017) Daniel Ricklin et al. MOLECULAR IMMUNOLOGY
- TREM2 deficiency exacerbates tau pathology through dysregulated kinase signaling in a mouse model of tauopathy
- (2017) Shane M. Bemiller et al. Molecular Neurodegeneration
- TREM2 in Neurodegenerative Diseases
- (2017) Taylor R. Jay et al. Molecular Neurodegeneration
- Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer’s disease
- (2017) Carmen Venegas et al. NATURE
- Neurotoxic reactive astrocytes are induced by activated microglia
- (2017) Shane A. Liddelow et al. NATURE
- Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease
- (2017) Rebecca Sims et al. NATURE GENETICS
- Microglia emerge as central players in brain disease
- (2017) Michael W Salter et al. NATURE MEDICINE
- Transcriptomic analysis of purified human cortical microglia reveals age-associated changes
- (2017) Thais F Galatro et al. NATURE NEUROSCIENCE
- ADAM17 is the main sheddase for the generation of human triggering receptor expressed in myeloid cells (hTREM2) ectodomain and cleaves TREM2 after Histidine 157
- (2017) Dominik Feuerbach et al. NEUROSCIENCE LETTERS
- The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: updates and expansion to encompass the new guide to IMMUNOPHARMACOLOGY
- (2017) Simon D Harding et al. NUCLEIC ACIDS RESEARCH
- TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy
- (2017) Cheryl E. G. Leyns et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP/PS1 mice
- (2017) Qiaoqiao Shi et al. Science Translational Medicine
- Complement in the pathogenesis of Alzheimer’s disease
- (2017) B. Paul Morgan Seminars in Immunopathology
- TREM2/DAP12 Complex Regulates Inflammatory Responses in Microglia via the JNK Signaling Pathway
- (2017) Li Zhong et al. Frontiers in Aging Neuroscience
- Deaths from Alzheimer’s Disease — United States, 1999–2014
- (2017) Christopher A. Taylor et al. MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT
- The Cellular Phase of Alzheimer’s Disease
- (2016) Bart De Strooper et al. CELL
- Microglial genes regulating neuroinflammation in the progression of Alzheimer's disease
- (2016) Claudio Villegas-Llerena et al. CURRENT OPINION IN NEUROBIOLOGY
- sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early‐stage Alzheimer's disease and associate with neuronal injury markers
- (2016) Marc Suárez‐Calvet et al. EMBO Molecular Medicine
- Properdin: a tightly regulated critical inflammatory modulator
- (2016) Adam Z. Blatt et al. IMMUNOLOGICAL REVIEWS
- TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques
- (2016) Yaming Wang et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Disease Progression-Dependent Effects of TREM2 Deficiency in a Mouse Model of Alzheimer's Disease
- (2016) Taylor R. Jay et al. JOURNAL OF NEUROSCIENCE
- TREM2/DAP12 Signal Elicits Proinflammatory Response in Microglia and Exacerbates Neuropathic Pain
- (2016) M. Kobayashi et al. JOURNAL OF NEUROSCIENCE
- Role of Microglia in Neurological Disorders and Their Potentials as a Therapeutic Target
- (2016) Li Du et al. MOLECULAR NEUROBIOLOGY
- The road less traveled: Start-ups invest in novel approaches against neurodegeneration
- (2016) Shraddha Chakradhar NATURE MEDICINE
- Complement in disease: a defence system turning offensive
- (2016) Daniel Ricklin et al. Nature Reviews Nephrology
- A rare coding variant in TREM2 increases risk for Alzheimer's disease in Han Chinese
- (2016) Teng Jiang et al. NEUROBIOLOGY OF AGING
- TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy
- (2016) Peng Yuan et al. NEURON
- Chronic Infantile Neurological Cutaneous and Articular (CINCA) syndrome: a review
- (2016) Martina Finetti et al. Orphanet Journal of Rare Diseases
- Complement and microglia mediate early synapse loss in Alzheimer mouse models
- (2016) S. Hong et al. SCIENCE
- How neuroinflammation contributes to neurodegeneration
- (2016) R. M. Ransohoff SCIENCE
- Mechanism and Regulation of NLRP3 Inflammasome Activation
- (2016) Yuan He et al. TRENDS IN BIOCHEMICAL SCIENCES
- Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer’s disease in rodent models
- (2016) Michael J. D. Daniels et al. Nature Communications
- Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms
- (2016) Daniel L Kober et al. eLife
- Recent Advances of the NLRP3 Inflammasome in Central Nervous System Disorders
- (2016) Keren Zhou et al. Journal of Immunology Research
- Analysis of the Putative Role of CR1 in Alzheimer’s Disease: Genetic Association, Expression and Function
- (2016) Maria I. Fonseca et al. PLoS One
- TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model
- (2015) Yaming Wang et al. CELL
- Molecular mechanisms regulating NLRP3 inflammasome activation
- (2015) Eun-Kyeong Jo et al. Cellular & Molecular Immunology
- Compstatin: a C3-targeted complement inhibitor reaching its prime for bedside intervention
- (2015) Dimitrios C. Mastellos et al. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
- DAP12 Stabilizes the C-terminal Fragment of the Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) and Protects against LPS-induced Pro-inflammatory Response
- (2015) Li Zhong et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- TREM2 deficiency eliminates TREM2+inflammatory macrophages and ameliorates pathology in Alzheimer’s disease mouse models
- (2015) Taylor R. Jay et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Signaling pathways regulating neuron-glia interaction and their implications in Alzheimer's disease
- (2015) Hong Lian et al. JOURNAL OF NEUROCHEMISTRY
- Complement C3-Deficient Mice Fail to Display Age-Related Hippocampal Decline
- (2015) Q. Shi et al. JOURNAL OF NEUROSCIENCE
- Genetics ignite focus on microglial inflammation in Alzheimer’s disease
- (2015) Manasi Malik et al. Molecular Neurodegeneration
- A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases
- (2015) Rebecca C Coll et al. NATURE MEDICINE
- Inflammasomes: mechanism of action, role in disease and therapeutics
- (2015) Haitao Guo et al. NATURE MEDICINE
- The case for rejecting the amyloid cascade hypothesis
- (2015) Karl Herrup NATURE NEUROSCIENCE
- Do glia drive synaptic and cognitive impairment in disease?
- (2015) Won-Suk Chung et al. NATURE NEUROSCIENCE
- Alzheimer's disease is associated with low density of the long CR1 isoform
- (2015) Rachid Mahmoudi et al. NEUROBIOLOGY OF AGING
- Disease-Associated Mutations of TREM2 Alter the Processing of N-Linked Oligosaccharides in the Golgi Apparatus
- (2015) Ji-Seon Park et al. TRAFFIC
- TREM2 Protein Expression Changes Correlate with Alzheimer's Disease Neurodegenerative Pathologies in Post-Mortem Temporal Cortices
- (2014) Lih-Fen Lue et al. BRAIN PATHOLOGY
- Coding variants in TREM2 increase risk for Alzheimer's disease
- (2014) Sheng Chih Jin et al. HUMAN MOLECULAR GENETICS
- Activation and Regulation of Cellular Inflammasomes: Gaps in Our Knowledge for Central Nervous System Injury
- (2014) Juan Pablo de Rivero Vaccari et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- CR1 in Alzheimer's Disease
- (2014) Xi-Chen Zhu et al. MOLECULAR NEUROBIOLOGY
- Altered microglial response to Aβ plaques in APPPS1-21 mice heterozygous for TREM2
- (2014) Jason D Ulrich et al. Molecular Neurodegeneration
- Microglial phagocytosis of live neurons
- (2014) Guy C. Brown et al. NATURE REVIEWS NEUROSCIENCE
- Inflammasomes in the CNS
- (2014) John G. Walsh et al. NATURE REVIEWS NEUROSCIENCE
- Upregulation of TREM2 Ameliorates Neuropathology and Rescues Spatial Cognitive Impairment in a Transgenic Mouse Model of Alzheimer’s Disease
- (2014) Teng Jiang et al. NEUROPSYCHOPHARMACOLOGY
- TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis
- (2014) G. Kleinberger et al. Science Translational Medicine
- NLRP3 polymorphisms are associated with late-onset Alzheimer's disease in Han Chinese
- (2013) Meng-Shan Tan et al. JOURNAL OF NEUROIMMUNOLOGY
- Heterozygous TREM2 mutations in frontotemporal dementia
- (2013) Barbara Borroni et al. NEUROBIOLOGY OF AGING
- Functional Impairment of Microglia Coincides with Beta-Amyloid Deposition in Mice with Alzheimer-Like Pathology
- (2013) Grietje Krabbe et al. PLoS One
- Animal Models of Alzheimer Disease
- (2013) F. M. LaFerla et al. Cold Spring Harbor Perspectives in Medicine
- The Complement System: An Unexpected Role in Synaptic Pruning During Development and Disease
- (2012) Alexander H. Stephan et al. Annual Review of Neuroscience
- Inhibiting Alternative Pathway Complement Activation by Targeting the Factor D Exosite
- (2012) Kenneth J. Katschke et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study
- (2012) David H Cribbs et al. Journal of Neuroinflammation
- Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt–PCP–JNK pathway
- (2012) R Killick et al. MOLECULAR PSYCHIATRY
- NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice
- (2012) Michael T. Heneka et al. NATURE
- Genetic association of CR1 with Alzheimer's disease: A tentative disease mechanism
- (2012) Lili-Naz Hazrati et al. NEUROBIOLOGY OF AGING
- Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner
- (2012) Dorothy P. Schafer et al. NEURON
- Variant of TREM2 Associated with the Risk of Alzheimer's Disease
- (2012) Thorlakur Jonsson et al. NEW ENGLAND JOURNAL OF MEDICINE
- TREM2 Variants in Alzheimer's Disease
- (2012) Rita Guerreiro et al. NEW ENGLAND JOURNAL OF MEDICINE
- Constitutively Activated NLRP3 Inflammasome Causes Inflammation and Abnormal Skeletal Development in Mice
- (2012) Sheri L. Bonar et al. PLoS One
- Complement receptor 1 (CR1) and Alzheimer's disease
- (2011) Helen Crehan et al. IMMUNOBIOLOGY
- Blocking IL-1 Signaling Rescues Cognition, Attenuates Tau Pathology, and Restores Neuronal -Catenin Pathway Function in an Alzheimer's Disease Model
- (2011) M. Kitazawa et al. JOURNAL OF IMMUNOLOGY
- Complement in the brain
- (2011) Robert Veerhuis et al. MOLECULAR IMMUNOLOGY
- C1-Inhibitor: More Than a Serine Protease Inhibitor
- (2011) Sacha Zeerleder SEMINARS IN THROMBOSIS AND HEMOSTASIS
- TREM2- and DAP12-Dependent Activation of PI3K Requires DAP10 and Is Inhibited by SHIP1
- (2010) Q. Peng et al. Science Signaling
- Activation of Microglia by Amyloid Requires P2X7 Receptor Expression
- (2009) J. M. Sanz et al. JOURNAL OF IMMUNOLOGY
- Interleukin-1β enhances nucleotide-induced and α-secretase-dependent amyloid precursor protein processing in rat primary cortical neurons via up-regulation of the P2Y2receptor
- (2009) Qiongman Kong et al. JOURNAL OF NEUROCHEMISTRY
- Structural Insights into Formation of an Active Signaling Complex between Rac and Phospholipase C Gamma 2
- (2009) Tom D. Bunney et al. MOLECULAR CELL
- Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease
- (2009) Jean-Charles Lambert et al. NATURE GENETICS
- CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer
- (2009) Cameron R Stewart et al. NATURE IMMUNOLOGY
- Interleukin-1β up-regulates TACE to enhance α-cleavage of APP in neurons: resulting decrease in Aβ production
- (2008) Yuriko Tachida et al. JOURNAL OF NEUROCHEMISTRY
- Complement C3 Deficiency Leads to Accelerated Amyloid Plaque Deposition and Neurodegeneration and Modulation of the Microglia/Macrophage Phenotype in Amyloid Precursor Protein Transgenic Mice
- (2008) M. Maier et al. JOURNAL OF NEUROSCIENCE
- Complement Receptor 1: Disease associations and therapeutic implications
- (2008) Rohan Khera et al. MOLECULAR IMMUNOLOGY
- The NALP3 inflammasome is involved in the innate immune response to amyloid-β
- (2008) Annett Halle et al. NATURE IMMUNOLOGY
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now