Neurophagy, the phagocytosis of live neurons and synapses by glia, contributes to brain development and disease

Change in nomenclature for the immunologic synapse from Troxis Necrosis to trogocytosis

(2017) Samuel W. French   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Extrinsic Repair of Injured Dendrites as a Paradigm for Regeneration by Fusion inCaenorhabditis elegans

(2017) Meital Oren-Suissa et al.   GENETICS

GSK3B-mediated phosphorylation of MCL1 regulates axonal autophagy to promote Wallerian degeneration

(2017) Shuji Wakatsuki et al.   JOURNAL OF CELL BIOLOGY

Activated Microglia Desialylate and Phagocytose Cells via Neuraminidase, Galectin-3, and Mer Tyrosine Kinase

(2017) Koji Nomura et al.   JOURNAL OF IMMUNOLOGY

Sleep Loss Promotes Astrocytic Phagocytosis and Microglial Activation in Mouse Cerebral Cortex

(2017) Michele Bellesi et al.   JOURNAL OF NEUROSCIENCE

The role of peripheral immune cells in the CNS in steady state and disease

(2017) Marco Prinz et al.   NATURE NEUROSCIENCE

Errant gardeners: glial-cell-dependent synaptic pruning and neurodevelopmental disorders

(2017) Urte Neniskyte et al.   NATURE REVIEWS NEUROSCIENCE

TDP-43 Depletion in Microglia Promotes Amyloid Clearance but Also Induces Synapse Loss

(2017) Rosa C. Paolicelli et al.   NEURON

Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP/PS1 mice

(2017) Qiaoqiao Shi et al.   Science Translational Medicine

Reactive astrocytes function as phagocytes after brain ischemia via ABCA1-mediated pathway

(2017) Yosuke M. Morizawa et al.   Nature Communications

Extrinsic Repair of Injured Dendrites as a Paradigm for Regeneration by Fusion inCaenorhabditis elegans

(2017) Meital Oren-Suissa et al.   GENETICS

Galectin-3 released in response to traumatic brain injury acts as an alarmin orchestrating brain immune response and promoting neurodegeneration

(2017) Ping Kei Yip et al.   Scientific Reports

Myelin phagocytosis by astrocytes after myelin damage promotes lesion pathology

(2016) Gerald Ponath et al.   BRAIN

Dietary obesity reversibly induces synaptic stripping by microglia and impairs hippocampal plasticity

(2016) Shuai Hao et al.   BRAIN BEHAVIOR AND IMMUNITY

Microglial phagocytosis and activation underlying photoreceptor degeneration is regulated by CX3CL1-CX3CR1 signaling in a mouse model of retinitis pigmentosa

(2016) Matthew K. Zabel et al.   GLIA

Histamine induces microglia activation and dopaminergic neuronal toxicity via H1 receptor activation

(2016) Sandra M. Rocha et al.   Journal of Neuroinflammation

Megf10 Is a Receptor for C1Q That Mediates Clearance of Apoptotic Cells by Astrocytes

(2016) Tal Iram et al.   JOURNAL OF NEUROSCIENCE

A complement–microglial axis drives synapse loss during virus-induced memory impairment

(2016) Michael J. Vasek et al.   NATURE

Schizophrenia risk from complex variation of complement component 4

(2016) Aswin Sekar et al.   NATURE

TAM receptors regulate multiple features of microglial physiology

(2016) Lawrence Fourgeaud et al.   NATURE

Glucocorticoids Prevent Enterovirus 71 Capsid Protein VP1 Induced Calreticulin Surface Exposure by Alleviating Neuronal ER Stress

(2016) Dan-Dan Hu et al.   NEUROTOXICITY RESEARCH

Novel allele-dependent role for APOE in controlling the rate of synapse pruning by astrocytes

(2016) Won-Suk Chung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Xkr8 phospholipid scrambling complex in apoptotic phosphatidylserine exposure

(2016) Jun Suzuki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complement and microglia mediate early synapse loss in Alzheimer mouse models

(2016) S. Hong et al.   SCIENCE

Myelinosome formation represents an early stage of oligodendrocyte damage in multiple sclerosis and its animal model

(2016) Elisa Romanelli et al.   Nature Communications

Sculpting Neural Circuits by Axon and Dendrite Pruning

(2015) Martin M. Riccomagno et al.   Annual Review of Cell and Developmental Biology

SIRP/CD47 signaling in neurological disorders

(2015) Haiyue Zhang et al.   BRAIN RESEARCH

Sialylation of neurites inhibits complement-mediated macrophage removal in a human macrophage-neuron Co-Culture System

(2015) Bettina Linnartz-Gerlach et al.   GLIA

Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2)

(2015) Yuka Atagi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activated microglia cause reversible apoptosis of pheochromocytoma cells, inducing their cell death by phagocytosis

(2015) Tamara C. Hornik et al.   JOURNAL OF CELL SCIENCE

Complement C3-Deficient Mice Fail to Display Age-Related Hippocampal Decline

(2015) Q. Shi et al.   JOURNAL OF NEUROSCIENCE

Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) Deficiency Attenuates Phagocytic Activities of Microglia and Exacerbates Ischemic Damage in Experimental Stroke

(2015) M. Kawabori et al.   JOURNAL OF NEUROSCIENCE

Anterograde C1ql1 Signaling Is Required in Order to Determine and Maintain a Single-Winner Climbing Fiber in the Mouse Cerebellum

(2015) Wataru Kakegawa et al.   NEURON

Synaptic rearrangement following axonal injury: Old and new players

(2015) Aline Barroso Spejo et al.   NEUROPHARMACOLOGY

β-Asarone prevents autophagy and synaptic loss by reducing ROCK expression in asenescence-accelerated prone 8 mice

(2014) Yunbo Chen et al.   BRAIN RESEARCH

Mechanisms of developmental neurite pruning

(2014) Oren Schuldiner et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Inhibition of UDP/P2Y6purinergic signaling prevents phagocytosis of viable neurons by activated microgliain vitroandin vivo

(2014) Jonas J. Neher et al.   GLIA

Neurodegeneration by Activation of the Microglial Complement-Phagosome Pathway

(2014) L.-G. Bodea et al.   JOURNAL OF NEUROSCIENCE

Deficient neuron-microglia signaling results in impaired functional brain connectivity and social behavior

(2014) Yang Zhan et al.   NATURE NEUROSCIENCE

Microglial phagocytosis of live neurons

(2014) Guy C. Brown et al.   NATURE REVIEWS NEUROSCIENCE

Caspase-mediated cleavage of phospholipid flippase for apoptotic phosphatidylserine exposure

(2014) K. Segawa et al.   SCIENCE

Non-apoptotic role of caspase-3 in synapse refinement

(2014) Jin-Yuan Wang et al.   Neuroscience Bulletin

Microglia Play a Major Role in Direct Viral-Induced Demyelination

(2013) Dhriti Chatterjee et al.   Clinical & Developmental Immunology

Astrocytes engage unique molecular programs to engulf pruned neuronal debris from distinct subsets of neurons

(2013) O. E. Tasdemir-Yilmaz et al.   GENES & DEVELOPMENT

Siglec-h on activated microglia for recognition and engulfment of glioma cells

(2013) Jens Kopatz et al.   GLIA

Calcium-dependent Phospholipid Scramblase Activity of TMEM16 Protein Family Members

(2013) Jun Suzuki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Terminal Schwann Cells Participate in the Competition Underlying Neuromuscular Synapse Elimination

(2013) I. W. Smith et al.   JOURNAL OF NEUROSCIENCE

Microglia Regulate the Number of Neural Precursor Cells in the Developing Cerebral Cortex

(2013) C. L. Cunningham et al.   JOURNAL OF NEUROSCIENCE

Microglial CD33-Related Siglec-E Inhibits Neurotoxicity by Preventing the Phagocytosis-Associated Oxidative Burst

(2013) J. Claude et al.   JOURNAL OF NEUROSCIENCE

Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways

(2013) Won-Suk Chung et al.   NATURE

The Extent of Synaptic Stripping of Motoneurons after Axotomy Is Not Correlated to Activation of Surrounding Glia or Downregulation of Postsynaptic Adhesion Molecules

(2013) Alexander Berg et al.   PLoS One

Phagocytosis executes delayed neuronal death after focal brain ischemia

(2013) J. J. Neher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Janus-faced microglia: beneficial and detrimental consequences of microglial phagocytosis

(2013) Amanda Sierra et al.   Frontiers in Cellular Neuroscience

Primary phagocytosis of viable neurons by microglia activated with LPS or Aβ is dependent on calreticulin/LRP phagocytic signalling

(2012) Michael Fricker et al.   Journal of Neuroinflammation

MFG-E8 Mediates Primary Phagocytosis of Viable Neurons during Neuroinflammation

(2012) M. Fricker et al.   JOURNAL OF NEUROSCIENCE

Sialic Acid on the Neuronal Glycocalyx Prevents Complement C1 Binding and Complement Receptor-3-Mediated Removal by Microglia

(2012) B. Linnartz et al.   JOURNAL OF NEUROSCIENCE

Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

(2012) Dorothy P. Schafer et al.   NEURON

ROCK/Cdc42-mediated microglial motility and gliapse formation lead to phagocytosis of degenerating dopaminergic neurons in vivo

(2012) Carlos Barcia et al.   Scientific Reports

An angiogenic inhibitor, cyclic RGDfV, attenuates MPTP-induced dopamine neuron toxicity

(2011) Aditiben Patel et al.   EXPERIMENTAL NEUROLOGY

Neuronal Death Induced by Nanomolar Amyloid β Is Mediated by Primary Phagocytosis of Neurons by Microglia

(2011) Urte Neniskyte et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of Microglial Phagocytosis Is Sufficient To Prevent Inflammatory Neuronal Death

(2011) J. J. Neher et al.   JOURNAL OF IMMUNOLOGY

Microglial activation during acute cerebral infarction in the presence of diabetes mellitus

(2011) Gang Li et al.   NEUROLOGICAL SCIENCES

A neurodegenerative disease mutation that accelerates the clearance of apoptotic cells

(2011) A. W. Kao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synaptic Pruning by Microglia Is Necessary for Normal Brain Development

(2011) R. C. Paolicelli et al.   SCIENCE

Nerve injury-activated microglia engulf myelinated axons in a P2Y12 signaling-dependent manner in the dorsal horn

(2010) Mitsuyo Maeda et al.   GLIA

Alleviation of Neurotoxicity by Microglial Human Siglec-11

(2010) Y. Wang et al.   JOURNAL OF NEUROSCIENCE

Calcium-dependent phospholipid scrambling by TMEM16F

(2010) Jun Suzuki et al.   NATURE

Loss of the RhoGAP SRGP-1 promotes the clearance of dead and injured cells in Caenorhabditis elegans

(2010) Lukas J. Neukomm et al.   NATURE CELL BIOLOGY

NEW-ONSET REFRACTORY STATUS EPILEPTICUS WITH RESTRICTED DWI AND NEURONOPHAGIA IN THE PULVINAR

(2010) J. G. Boyd et al.   NEUROLOGY

Relationship between microglial activation and dopaminergic neuronal loss in the substantia nigra: a time course study in a 6-hydroxydopamine model of Parkinson’s disease

(2009) Lilia Marinova-Mutafchieva et al.   JOURNAL OF NEUROCHEMISTRY