Tauopathies: Mechanisms and Therapeutic Strategies

Genome-wide association study identifies MAPT locus influencing human plasma tau levels

(2017) Jason Chen et al.   NEUROLOGY

Spreading of Pathology in Alzheimer’s Disease

(2017) Zhong-Yue Lv et al.   NEUROTOXICITY RESEARCH

Involvement of tau phosphorylation in traumatic brain injury patients

(2016) W-J. Yang et al.   ACTA NEUROLOGICA SCANDINAVICA

A subcutaneous cellular implant for passive immunization against amyloid-β reduces brain amyloid and tau pathologies

(2016) Aurélien Lathuilière et al.   BRAIN

Alzheimer-related decrease in CYFIP2 links amyloid production to tau hyperphosphorylation and memory loss

(2016) Sachin Suresh Tiwari et al.   BRAIN

Tau PET patterns mirror clinical and neuroanatomical variability in Alzheimer’s disease

(2016) Rik Ossenkoppele et al.   BRAIN

miR‐132 loss de‐represses ITPKB and aggravates amyloid and TAU pathology in Alzheimer's brain

(2016) Evgenia Salta et al.   EMBO Molecular Medicine

Expression of A152T human tau causes age‐dependent neuronal dysfunction and loss in transgenic mice

(2016) Sumihiro Maeda et al.   EMBO REPORTS

Modifications of tau protein after cerebral ischemia and reperfusion in rats are similar to those occurring in Alzheimer’s disease – Hyperphosphorylation and cleavage of 4- and 3-repeat tau

(2016) Hiroki Fujii et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Serum Tau Fragments Predict Return to Play in Concussed Professional Ice Hockey Players

(2016) Pashtun Shahim et al.   JOURNAL OF NEUROTRAUMA

Alzheimer's disease

(2016) Philip Scheltens et al.   LANCET

Targeted Downregulation of dMyc Suppresses Pathogenesis of Human Neuronal Tauopathies in Drosophila by Limiting Heterochromatin Relaxation and Tau Hyperphosphorylation

(2016) Soram Idiyasan Chanu et al.   MOLECULAR NEUROBIOLOGY

Caspase-cleaved tau exhibits rapid memory impairment associated with tau oligomers in a transgenic mouse model

(2016) YoungDoo Kim et al.   NEUROBIOLOGY OF DISEASE

Plasma tau in Alzheimer disease

(2016) Niklas Mattsson et al.   NEUROLOGY

TREM2 modifies microglial phenotype and provides neuroprotection in P301S tau transgenic mice

(2016) Teng Jiang et al.   NEUROPHARMACOLOGY

Tauopathies as clinicopathological entities

(2016) David J. Irwin   PARKINSONISM & RELATED DISORDERS

Escitalopram attenuates β-amyloid-induced tau hyperphosphorylation in primary hippocampal neurons through the 5-HT1A receptor mediated Akt/GSK-3β pathway

(2016) Yan-Juan Wang et al.   Oncotarget

Tau accumulation impairs mitophagy via increasing mitochondrial membrane potential and reducing mitochondrial Parkin

(2016) Yu Hu et al.   Oncotarget

Reducing tau aggregates with anle138b delays disease progression in a mouse model of tauopathies

(2015) Jens Wagner et al.   ACTA NEUROPATHOLOGICA

PART is part of Alzheimer disease

(2015) Charles Duyckaerts et al.   ACTA NEUROPATHOLOGICA

Deep clinical and neuropathological phenotyping of Pick disease

(2015) David J. Irwin et al.   ANNALS OF NEUROLOGY

Reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain

(2015) Nicole Maphis et al.   BRAIN

Alzheimer's disease — Recent biomarker developments in relation to updated diagnostic criteria

(2015) Kina Höglund et al.   CLINICA CHIMICA ACTA

Tau imaging in neurodegenerative diseases

(2015) M. Dani et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Dysregulation of microRNA-219 promotes neurodegeneration through post-transcriptional regulation of tau

(2015) Ismael Santa-Maria et al.   JOURNAL OF CLINICAL INVESTIGATION

Tau Positron Emission Tomography (PET) Imaging: Past, Present, and Future

(2015) Manuela Ariza et al.   JOURNAL OF MEDICINAL CHEMISTRY

Escitalopram Ameliorates Forskolin-Induced Tau Hyperphosphorylation in HEK239/tau441 Cells

(2015) Qing-Guo Ren et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

NPAS4 Facilitates the Autophagic Clearance of Endogenous Tau in Rat Cortical Neurons

(2015) Wenhui Fan et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Pre-synaptic C-terminal truncated tau is released from cortical synapses in Alzheimer's disease

(2015) Sophie Sokolow et al.   JOURNAL OF NEUROCHEMISTRY

A Novel Tau Mutation in Exon 12, p.Q336H, Causes Hereditary Pick Disease

(2015) Pawel Tacik et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Tau imaging: early progress and future directions

(2015) Victor L Villemagne et al.   LANCET NEUROLOGY

Analysis of tau post-translational modifications in rTg4510 mice, a model of tau pathology

(2015) Lixin Song et al.   Molecular Neurodegeneration

Tau-driven 26S proteasome impairment and cognitive dysfunction can be prevented early in disease by activating cAMP-PKA signaling

(2015) Natura Myeku et al.   NATURE MEDICINE

Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits

(2015) Sang-Won Min et al.   NATURE MEDICINE

Depletion of microglia and inhibition of exosome synthesis halt tau propagation

(2015) Hirohide Asai et al.   NATURE NEUROSCIENCE

Tau and neurodegenerative disease: the story so far

(2015) Khalid Iqbal et al.   Nature Reviews Neurology

Genetic Disorders with Tau Pathology: A Review of the Literature and Report of Two Patients with Tauopathy and Positive Family Histories

(2015) Pawel Tacik et al.   Neurodegenerative Diseases

Invited review: Animal models of tauopathies and their implications for research/translation into the clinic

(2015) Simon Dujardin et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Invited review: Drug development for tauopathies

(2015) Fiona Grüninger   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Invited review: Prion-like transmission and spreading of tau pathology

(2015) Florence Clavaguera et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Invited review: Neuropathology of tauopathies: principles and practice

(2015) G. G. Kovacs   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Novel PET/SPECT Probes for Imaging of Tau in Alzheimer’s Disease

(2015) Hiroyuki Watanabe et al.   TheScientificWorldJOURNAL

Connecting the dots between tau dysfunction and neurodegeneration

(2015) Bess Frost et al.   TRENDS IN CELL BIOLOGY

Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer’s disease brain

(2015) Shuko Takeda et al.   Nature Communications

Assessing clinicopathological correlation in chronic traumatic encephalopathy: rationale and methods for the UNITE study

(2015) Jesse Mez et al.   Alzheimers Research & Therapy

Novel PET/SPECT Probes for Imaging of Tau in Alzheimer’s Disease

(2015) Hiroyuki Watanabe et al.   Scientific World Journal

PET Imaging of Tau Pathology in Alzheimer’s Disease and Tauopathies

(2015) Olga G. James et al.   Frontiers in Neurology

Cerebrospinal Fluid P-Tau181P: Biomarker for Improved Differential Dementia Diagnosis

(2015) Hanne Struyfs et al.   Frontiers in Neurology

Amyloid accelerates tau propagation and toxicity in a model of early Alzheimer’s disease

(2015) Amy M Pooler et al.   Acta Neuropathologica Communications

A Novel Triple Repeat Mutant Tau Transgenic Model That Mimics Aspects of Pick’s Disease and Fronto-Temporal Tauopathies

(2015) Edward Rockenstein et al.   PLoS One

Passive Immunization with Phospho-Tau Antibodies Reduces Tau Pathology and Functional Deficits in Two Distinct Mouse Tauopathy Models

(2015) Sethu Sankaranarayanan et al.   PLoS One

Primary age-related tauopathy (PART): a common pathology associated with human aging

(2014) John F. Crary et al.   ACTA NEUROPATHOLOGICA

Frontotemporal lobar degeneration: defining phenotypic diversity through personalized medicine

(2014) David J. Irwin et al.   ACTA NEUROPATHOLOGICA

VALIDATION OF A CASPASE-3 GENERATED TAU FRAGMENT AS A SERUM BIOMARKER OF BRAIN DAMAGE DUE TO STROKE: IMPLICATIONS FOR ALZHEIMER'S DISEASE

(2014) Dilek Inekci et al.   Alzheimers & Dementia

SULFORAPHANE PROMOTES THE DEGRADATION OF PHOSPHORYLATED TAU VIA THE INDUCTION OF AUTOPHAGY

(2014) Chulman Cho et al.   Alzheimers & Dementia

In vivo tau imaging: Obstacles and progress

(2014) Victor L. Villemagne et al.   Alzheimers & Dementia

Immunotherapy for Alzheimer's disease

(2014) Thomas Wisniewski et al.   BIOCHEMICAL PHARMACOLOGY

New perspectives on the role of tau in Alzheimer's disease. Implications for therapy

(2014) Miguel Medina et al.   BIOCHEMICAL PHARMACOLOGY

Axotrophin/MARCH7 acts as an E3 ubiquitin ligase and ubiquitinates tau protein in vitro impairing microtubule binding

(2014) Katharina Flach et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Phosphorylation regulates fibrillation of an aggregation core peptide in the second repeat of microtubule-binding domain of human tau

(2014) Masafumi Inoue et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Non-invasive assessment of Alzheimer’s disease neurofibrillary pathology using 18F-THK5105 PET

(2014) Nobuyuki Okamura et al.   BRAIN

Neuronal uptake of tau/pS422 antibody and reduced progression of tau pathology in a mouse model of Alzheimer‘s disease

(2014) Ludovic Collin et al.   BRAIN

Pathological stress granules in Alzheimer’s disease

(2014) Peter E.A. Ash et al.   BRAIN RESEARCH

Tau PET Imaging in Alzheimer’s Disease

(2014) Nobuyuki Okamura et al.   Current Neurology and Neuroscience Reports

MicroRNA-125b induces tau hyperphosphorylation and cognitive deficits in Alzheimer's disease

(2014) J. Banzhaf-Strathmann et al.   EMBO JOURNAL

The physiology and pathology of microtubule-associated protein tau

(2014) Jian-Zhi Wang et al.   Essays in Biochemistry

O-GlcNAc Modification of tau Directly Inhibits Its Aggregation without Perturbing the Conformational Properties of tau Monomers

(2014) Scott A. Yuzwa et al.   JOURNAL OF MOLECULAR BIOLOGY

Ionizing radiation causes increased tau phosphorylation in primary neurons

(2014) Li Li et al.   JOURNAL OF NEUROCHEMISTRY

SCM-198 inhibits microglial overactivation and attenuates Aβ1-40-induced cognitive impairments in rats via JNK and NF-кB pathways

(2014) Zhen-Yi Hong et al.   Journal of Neuroinflammation

Effect of taxoid and nontaxoid site microtubule-stabilizing agents on axonal transport of mitochondria in untransfected and ECFP-htau40-transfected rat cortical neurons in culture

(2014) Viswanath Das et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Folic acid inhibits tau phosphorylation through regulation of PP2A methylation in SH-SY5Y cells

(2014) W. Li et al.   Journal of Nutrition Health & Aging

Phosphorylation of protein Tau by GSK3β prolongs survival of bigenic Tau.P301L×GSK3β mice by delaying brainstem tauopathy

(2014) Natalia Crespo-Biel et al.   NEUROBIOLOGY OF DISEASE

Frontotemporal dementia with parkinsonism linked to chromosome 17 with theMAPT R406W mutation presenting with a broad distribution of abundant senile plaques

(2014) Chiho Ishida et al.   NEUROPATHOLOGY

Temsirolimus attenuates tauopathy in vitro and in vivo by targeting tau hyperphosphorylation and autophagic clearance

(2014) Teng Jiang et al.   NEUROPHARMACOLOGY

MicroRNA-922 promotes tau phosphorylation by downregulating ubiquitin carboxy-terminal hydrolase L1 (UCHL1) expression in the pathogenesis of Alzheimer’s disease

(2014) Z.-B. Zhao et al.   NEUROSCIENCE

p-Tau immunotherapy reduces soluble and insoluble tau in aged 3xTg-AD mice

(2014) Ken C. Walls et al.   NEUROSCIENCE LETTERS

Tau pathology involves protein phosphatase 2A in Parkinsonism-dementia of Guam

(2014) M. Arif et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Corticobasal degeneration initially developing motor versus non-motor symptoms: a comparative clinicopathological study

(2014) Chikako Ikeda et al.   Psychogeriatrics

Serum Biomarkers for Traumatic Brain Injury

(2014) Miriam D. Neher et al.   SOUTHERN MEDICAL JOURNAL

Targeting autophagy in neurodegenerative diseases

(2014) René L. Vidal et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Chronic traumatic encephalopathy: a spectrum of neuropathological changes following repetitive brain trauma in athletes and military personnel

(2014) Thor D Stein et al.   Alzheimers Research & Therapy

Identification of structural determinants on tau protein essential for its pathological function: novel therapeutic target for tau immunotherapy in Alzheimer’s disease

(2014) Eva Kontsekova et al.   Alzheimers Research & Therapy

First-in-man tau vaccine targeting structural determinants essential for pathological tau–tau interaction reduces tau oligomerisation and neurofibrillary degeneration in an Alzheimer’s disease model

(2014) Eva Kontsekova et al.   Alzheimers Research & Therapy

Acetylation: a new key to unlock tau’s role in neurodegeneration

(2014) Casey Cook et al.   Alzheimers Research & Therapy

Aβ and tau toxicities in Alzheimer’s are linked via oxidative stress-induced p38 activation: Protective role of vitamin E

(2014) E. Giraldo et al.   Redox Biology

Cell-based Models To Investigate Tau Aggregation

(2014) Sungsu Lim et al.   Computational and Structural Biotechnology Journal

Neuropathological characterization of two siblings carrying the MAPT S305S mutation demonstrates features resembling argyrophilic grain disease

(2013) Annica Rönnbäck et al.   ACTA NEUROPATHOLOGICA

The novel MAPT mutation K298E: mechanisms of mutant tau toxicity, brain pathology and tau expression in induced fibroblast-derived neurons

(2013) Mariangela Iovino et al.   ACTA NEUROPATHOLOGICA

Novel mutation in MAPT exon 13 (p.N410H) causes corticobasal degeneration

(2013) Naomi Kouri et al.   ACTA NEUROPATHOLOGICA

LRRK2 phosphorylates novel tau epitopes and promotes tauopathy

(2013) Rachel M. Bailey et al.   ACTA NEUROPATHOLOGICA

The role of autophagy in Alzheimer's disease

(2013) Miranda Orr et al.   Alzheimers & Dementia

Tau-aggregation inhibitor therapy for Alzheimer's disease

(2013) Claude M. Wischik et al.   BIOCHEMICAL PHARMACOLOGY

PTPA activates protein phosphatase-2A through reducing its phosphorylation at tyrosine-307 with upregulation of protein tyrosine phosphatase 1B

(2013) Yu Luo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Fractalkine activates NRF2/NFE2L2 and heme oxygenase 1 to restrain tauopathy-induced microgliosis

(2013) Isabel Lastres-Becker et al.   BRAIN

Olympic boxing is associated with elevated levels of the neuronal protein tau in plasma

(2013) Sanna Neselius et al.   BRAIN INJURY

Hyperphosphorylation of tau protein in the ipsilateral thalamus after focal cortical infarction in rats

(2013) Da-Wei Dong et al.   BRAIN RESEARCH

Autophagy Enhancer Carbamazepine Alleviates Memory Deficits and Cerebral Amyloid-β Pathology in a Mouse Model of Alzheimer's Disease

(2013) Lixi Li et al.   Current Alzheimer Research

Physiological release of endogenous tau is stimulated by neuronal activity

(2013) Amy M Pooler et al.   EMBO REPORTS

NAP Alpha-Aminoisobutyric Acid (IsoNAP)

(2013) Illana Gozes et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Tau pathology and neurodegeneration

(2013) Maria Grazia Spillantini et al.   LANCET NEUROLOGY

Targeting the mTOR Signaling Network for Alzheimer’s Disease Therapy

(2013) Chong Wang et al.   MOLECULAR NEUROBIOLOGY

Tau immunotherapy targets transcellular propagation

(2013) Monica Hoyos Flight   NATURE REVIEWS DRUG DISCOVERY

Autophagy in aging and neurodegenerative diseases: implications for pathogenesis and therapy

(2013) Chen-Chen Tan et al.   NEUROBIOLOGY OF AGING

Criteria for the diagnosis of corticobasal degeneration

(2013) M. J. Armstrong et al.   NEUROLOGY

Anti-Tau Antibodies that Block Tau Aggregate Seeding In Vitro Markedly Decrease Pathology and Improve Cognition In Vivo

(2013) Kiran Yanamandra et al.   NEURON

Phosphorylation of tau protein at sites Ser396-404is one of the earliest events in Alzheimer's disease and Down syndrome

(2013) S. Mondragón-Rodríguez et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Pallidonigroluysian atrophy associated with p.A152T variant in MAPT

(2013) Jonathan Graff-Radford et al.   PARKINSONISM & RELATED DISORDERS

Tau Passive Immunotherapy in Mutant P301L Mice: Antibody Affinity versus Specificity

(2013) Cristina d’Abramo et al.   PLoS One

Efficacy and Safety of A Liposome-Based Vaccine against Protein Tau, Assessed in Tau.P301L Mice That Model Tauopathy

(2013) Clara Theunis et al.   PLoS One

A Novel MAPT Mutation, G55R, in a Frontotemporal Dementia Patient Leads to Altered Tau Function

(2013) Abhinaya Iyer et al.   PLoS One

Tau degradation: The ubiquitin–proteasome system versus the autophagy-lysosome system

(2013) Min Jae Lee et al.   PROGRESS IN NEUROBIOLOGY

Anthraquinone-2-sulfonic acid (AQ2S) is A Novel Neurotherapeutic Agent

(2013) T C Jackson et al.   Cell Death & Disease

Interaction between the ubiquitin proteasome system, autophagy and progressive tauopathy in vivo

(2012) Natura Myeku et al.   Alzheimers & Dementia

Methylthioninium chloride (methylene blue) induces autophagy and attenuates tauopathy in vitro and in vivo

(2012) Erin E. Congdon et al.   Autophagy

Stimulation of autophagy reduces neurodegeneration in a mouse model of human tauopathy

(2012) Véronique Schaeffer et al.   BRAIN

The spectrum of disease in chronic traumatic encephalopathy

(2012) Ann C. McKee et al.   BRAIN

Targeting Phospho-Ser422 by Active Tau Immunotherapy in the THYTau22 Mouse Model: A Suitable Therapeutic Approach

(2012) Nadege Zommer et al.   Current Alzheimer Research

Loss of HDAC6, a novel CHIP substrate, alleviates abnormal tau accumulation

(2012) Casey Cook et al.   HUMAN MOLECULAR GENETICS

Inhibition of tau aggregation in a novel Caenorhabditis elegans model of tauopathy mitigates proteotoxicity

(2012) Chronis Fatouros et al.   HUMAN MOLECULAR GENETICS

Therapeutic Effects of Valproate Combined With Lithium Carbonate on MPTP-Induced Parkinsonism in Mice: Possible Mediation Through Enhanced Autophagy

(2012) Xue-zhong Li et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Extracellular Tau Levels Are Influenced by Variability in Tau That Is Associated with Tauopathies

(2012) Celeste M. Karch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Small Misfolded Tau Species Are Internalized via Bulk Endocytosis and Anterogradely and Retrogradely Transported in Neurons

(2012) Jessica W. Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Therapeutic strategies for tau mediated neurodegeneration

(2012) Y. Yoshiyama et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

The Microtubule-Stabilizing Agent, Epothilone D, Reduces Axonal Dysfunction, Neurotoxicity, Cognitive Deficits, and Alzheimer-Like Pathology in an Interventional Study with Aged Tau Transgenic Mice

(2012) B. Zhang et al.   JOURNAL OF NEUROSCIENCE

Contrasting Pathology of the Stress Granule Proteins TIA-1 and G3BP in Tauopathies

(2012) T. Vanderweyde et al.   JOURNAL OF NEUROSCIENCE

Mutations in the chromatin modifier gene KANSL1 cause the 17q21.31 microdeletion syndrome

(2012) David A Koolen et al.   NATURE GENETICS

Constitutive secretion of tau protein by an unconventional mechanism

(2012) Xiyun Chai et al.   NEUROBIOLOGY OF DISEASE

Neuropathology of the hippocampus in FTLD-Tau with Pick bodies: a study of the BrainNet Europe Consortium

(2012) G. G. Kovacs et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Tau as a therapeutic target in neurodegenerative disease

(2012) Diana S. Himmelstein et al.   PHARMACOLOGY & THERAPEUTICS

Trans-Synaptic Spread of Tau Pathology In Vivo

(2012) Li Liu et al.   PLoS One

Evaluation of [11C]N-Methyl Lansoprazole as a Radiopharmaceutical for PET Imaging of Tau Neurofibrillary Tangles

(2012) Xia Shao et al.   ACS Medicinal Chemistry Letters

Hypothermia-induced hyperphosphorylation: a new model to study tau kinase inhibitors

(2012) Alexis Bretteville et al.   Scientific Reports

Role of S5b/PSMD5 in Proteasome Inhibition Caused by TNF-α/NFκB in Higher Eukaryotes

(2012) Sang Mi Shim et al.   Cell Reports

Long-term oral lithium treatment attenuates motor disturbance by promoting autophagy in tauopathy model mice

(2011) Kohei Shimada   Alzheimers & Dementia

Neuropathological features of corticobasal degeneration presenting as corticobasal syndrome or Richardson syndrome

(2011) Naomi Kouri et al.   BRAIN

Valproate reduces tau phosphorylation via cyclin-dependent kinase 5 and glycogen synthase kinase 3 signaling pathways

(2011) Jiang-Ping Hu et al.   BRAIN RESEARCH BULLETIN

Loss of Medial Septum Cholinergic Neurons in THY-Tau22 Mouse Model: What Links with tau Pathology?

(2011) K. Belarbi et al.   Current Alzheimer Research

Evidence for Irreversible Inhibition of Glycogen Synthase Kinase-3β by Tideglusib

(2011) Juan Manuel Domínguez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Seeding of Normal Tau by Pathological Tau Conformers Drives Pathogenesis of Alzheimer-like Tangles

(2011) Jing L. Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stages of the Pathologic Process in Alzheimer Disease: Age Categories From 1 to 100 Years

(2011) Heiko Braak et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Tau oligomers impair memory and induce synaptic and mitochondrial dysfunction in wild-type mice

(2011) Cristian A Lasagna-Reeves et al.   Molecular Neurodegeneration

GSPE interferes with tau aggregation in vivo: implication for treating tauopathy

(2011) Ismael Santa-Maria et al.   NEUROBIOLOGY OF AGING

Oleuropein and derivatives from olives as Tau aggregation inhibitors

(2011) Anthony Daccache et al.   NEUROCHEMISTRY INTERNATIONAL

Role of ubiquitin–proteasome-mediated proteolysis in nervous system disease

(2010) Ashok N. Hegde et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

The Role of the Lipid Bilayer in Tau Aggregation

(2010) Shana Elbaum-Garfinkle et al.   BIOPHYSICAL JOURNAL

The role of the Atg1/ULK1 complex in autophagy regulation

(2010) Noboru Mizushima   CURRENT OPINION IN CELL BIOLOGY

Neuropathology of variants of progressive supranuclear palsy

(2010) Dennis W Dickson et al.   CURRENT OPINION IN NEUROLOGY

What features improve the accuracy of the clinical diagnosis of progressive supranuclear palsy-parkinsonism (PSP-P)?

(2010) David R Williams et al.   MOVEMENT DISORDERS

Enhancement of proteasome activity by a small-molecule inhibitor of USP14

(2010) Byung-Hoon Lee et al.   NATURE

Regulation of Tau Pathology by the Microglial Fractalkine Receptor

(2010) Kiran Bhaskar et al.   NEURON

Acetylation of Tau Inhibits Its Degradation and Contributes to Tauopathy

(2010) Sang-Won Min et al.   NEURON

A role for FKBP52 in Tau protein function

(2010) B. Chambraud et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sodium selenate mitigates tau pathology, neurodegeneration, and functional deficits in Alzheimer's disease models

(2010) J. van Eersel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy, a guardian against neurodegeneration

(2010) Moisés García-Arencibia et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Accumulation of Aspartic Acid421- and Glutamic Acid391-Cleaved Tau in Neurofibrillary Tangles Correlates With Progression in Alzheimer Disease

(2009) Gustavo Basurto-Islas et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Progressive supranuclear palsy: clinicopathological concepts and diagnostic challenges

(2009) David R Williams et al.   LANCET NEUROLOGY

Tor Directly Controls the Atg1 Kinase Complex To Regulate Autophagy

(2009) Y. Kamada et al.   MOLECULAR AND CELLULAR BIOLOGY

Argyrophilic grain disease

(2008) I. Ferrer et al.   BRAIN

A novel transgenic mouse expressing double mutant tau driven by its natural promoter exhibits tauopathy characteristics

(2008) Hanna Rosenmann et al.   EXPERIMENTAL NEUROLOGY

Extracellular tau promotes intracellular calcium increase through M1 and M3 muscarinic receptors in neuronal cells

(2008) A. Gómez-Ramos et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Microtubule-associated protein tau in development, degeneration and protection of neurons

(2008) Jian-Zhi Wang et al.   PROGRESS IN NEUROBIOLOGY

Haplotype-specific expression of the N-terminal exons 2 and 3 at the human MAPT locus

(2007) Tara M. Caffrey et al.   NEUROBIOLOGY OF AGING