Upregulation of TREM2 Ameliorates Neuropathology and Rescues Spatial Cognitive Impairment in a Transgenic Mouse Model of Alzheimer’s Disease

Temsirolimus promotes autophagic clearance of amyloid-β and provides protective effects in cellular and animal models of Alzheimer's disease

(2014) Teng Jiang et al.   PHARMACOLOGICAL RESEARCH

Structure, expression pattern and biological activity of molecular complex TREM-2/DAP12

(2013) Agnieszka Paradowska-Gorycka et al.   HUMAN IMMUNOLOGY

TREM2 in Alzheimer’s disease

(2013) Teng Jiang et al.   MOLECULAR NEUROBIOLOGY

Triggering receptor expressed on myeloid cells 2 knockdown exacerbates aging-related neuroinflammation and cognitive deficiency in senescence-accelerated mouse prone 8 mice

(2013) Teng Jiang et al.   NEUROBIOLOGY OF AGING

Alzheimer’s Disease Risk Gene CD33 Inhibits Microglial Uptake of Amyloid Beta

(2013) Ana Griciuc et al.   NEURON

Smoking exacerbates amyloid pathology in a mouse model of Alzheimer’s disease

(2013) Ines Moreno-Gonzalez et al.   Nature Communications

An Effector-Reduced Anti- -Amyloid (A ) Antibody with Unique A  Binding Properties Promotes Neuroprotection and Glial Engulfment of A 

(2012) O. Adolfsson et al.   JOURNAL OF NEUROSCIENCE

Variant TREM2 as Risk Factor for Alzheimer's Disease

(2012) Harald Neumann et al.   NEW ENGLAND JOURNAL OF MEDICINE

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

(2012) Thorlakur Jonsson et al.   NEW ENGLAND JOURNAL OF MEDICINE

TREM2 Variants in Alzheimer's Disease

(2012) Rita Guerreiro et al.   NEW ENGLAND JOURNAL OF MEDICINE

Amyloid beta impairs mitochondrial anterograde transport and degenerates synapses in Alzheimer's disease neurons

(2011) Marcus J. Calkins et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

TREM-2, triggering receptor expressed on myeloid cell-2, negatively regulates TLR responses in dendritic cells

(2011) Hiroaki Ito et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

TLR2 Is a Primary Receptor for Alzheimer's Amyloid   Peptide To Trigger Neuroinflammatory Activation

(2011) S. Liu et al.   JOURNAL OF IMMUNOLOGY

Soluble Aβ oligomer production and toxicity

(2011) Megan E. Larson et al.   JOURNAL OF NEUROCHEMISTRY

Autoimmune and inflammatory mechanisms of CNS damage

(2011) Minesh Kapadia et al.   PROGRESS IN NEUROBIOLOGY

Intraneuronal β-amyloid accumulation and synapse pathology in Alzheimer’s disease

(2010) Gunnar K. Gouras et al.   ACTA NEUROPATHOLOGICA

Dual Induction of TREM2 and Tolerance-Related Transcript, Tmem176b, in Amyloid Transgenic Mice: Implications for Vaccine-Based Therapies for Alzheimer's Disease

(2010) Benoit Melchior et al.   ASN Neuro

NSAIDs prevent, but do not reverse, neuronal cell cycle reentry in a mouse model of Alzheimer disease

(2009) Nicholas H. Varvel et al.   JOURNAL OF CLINICAL INVESTIGATION

A role for TREM2 ligands in the phagocytosis of apoptotic neuronal cells by microglia

(2009) Christine L. Hsieh et al.   JOURNAL OF NEUROCHEMISTRY

TREM2 is upregulated in amyloid plaque-associated microglia in aged APP23 transgenic mice

(2008) Stefanie Frank et al.   GLIA

Toll-like receptor 4-dependent upregulation of cytokines in a transgenic mouse model of Alzheimer's disease

(2008) Jing-Ji Jin et al.   Journal of Neuroinflammation