Signaling pathways regulating neuron-glia interaction and their implications in Alzheimer's disease

Astrocytes in Alzheimer's Disease: Emerging Roles in Calcium Dysregulation and Synaptic Plasticity

(2017) Adele J. Vincent et al.   JOURNAL OF ALZHEIMERS DISEASE

Neuroinflammation in Alzheimer's Disease: Mechanisms, Pathologic Consequences, and Potential for Therapeutic Manipulation

(2017) Kenneth Hensley   JOURNAL OF ALZHEIMERS DISEASE

L-Type Calcium Channel CaV 1.2 in Transgenic Mice Overexpressing Human AβPP751 with the London (V717I) and Swedish (K670M/N671L) Mutations

(2017) Michael Willis et al.   JOURNAL OF ALZHEIMERS DISEASE

Hesperidin ameliorates behavioral impairments and neuropathology of transgenic APP/PS1 mice

(2015) Chaoyun Li et al.   BEHAVIOURAL BRAIN RESEARCH

TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model

(2015) Yaming Wang et al.   CELL

Chondroitin sulfate proteoglycans impede myelination by oligodendrocytes after perinatal white matter injury

(2015) Ying-Ping Deng et al.   EXPERIMENTAL NEUROLOGY

Dual pathways mediate β-amyloid stimulated glutathione release from astrocytes

(2015) Bing Ye et al.   GLIA

The TNF-α/Nf-κB Signaling Pathway has a Key Role in Methamphetamine–Induced Blood–Brain Barrier Dysfunction

(2015) Vanessa Coelho-Santos et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Amyloid-β Activates Microglia and Regulates Protein Expression in a Manner Similar to Prions

(2015) Jian Tu et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

NFκB signaling drives pro-granulocytic astroglial responses to neuromyelitis optica patient IgG

(2015) Margaret E. Walker-Caulfield et al.   Journal of Neuroinflammation

Conditional Deletion of the Glutamate Transporter GLT-1 Reveals That Astrocytic GLT-1 Protects against Fatal Epilepsy While Neuronal GLT-1 Contributes Significantly to Glutamate Uptake into Synaptosomes

(2015) G. T. Petr et al.   JOURNAL OF NEUROSCIENCE

Lycopene abrogates Aβ(1–42)-mediated neuroinflammatory cascade in an experimental model of Alzheimer’s disease

(2015) Anand Kamal Sachdeva et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

Proteoglycan form and function: A comprehensive nomenclature of proteoglycans

(2015) Renato V. Iozzo et al.   MATRIX BIOLOGY

Nuclear pore complex remodeling by p75NTR cleavage controls TGF-β signaling and astrocyte functions

(2015) Christian Schachtrup et al.   NATURE NEUROSCIENCE

Disentangling calcium-driven astrocyte physiology

(2015) Dmitri A. Rusakov   NATURE REVIEWS NEUROSCIENCE

NFκB-Activated Astroglial Release of Complement C3 Compromises Neuronal Morphology and Function Associated with Alzheimer’s Disease

(2015) Hong Lian et al.   NEURON

Chondroitin Sulfate AcceleratesTrans-Golgi-to-Surface Transport of Proteoglycan Amyloid Precursor Protein

(2015) Deyan Mihov et al.   TRAFFIC

Astrocyte-Derived TGF-β1 Accelerates Disease Progression in ALS Mice by Interfering with the Neuroprotective Functions of Microglia and T Cells

(2015) Fumito Endo et al.   Cell Reports

The Role of the Tripartite Glutamatergic Synapse in the Pathophysiology of Alzheimer’s Disease

(2015) Carolyn C. Rudy et al.   Aging and Disease

Proteoglycans and neuronal migration in the cerebral cortex during development and disease

(2015) Nobuaki Maeda   Frontiers in Neuroscience

Protection of TGF-β1 against Neuroinflammation and Neurodegeneration in Aβ1–42-Induced Alzheimer’s Disease Model Rats

(2015) Jia-Hui Chen et al.   PLoS One

The Golgi-Localized γ-Ear-Containing ARF-Binding (GGA) Proteins Alter Amyloid-β Precursor Protein (APP) Processing through Interaction of Their GAE Domain with the Beta-Site APP Cleaving Enzyme 1 (BACE1)

(2015) Bjoern von Einem et al.   PLoS One

Astrocytic metabolic and inflammatory changes as a function of age

(2014) Tianyi Jiang et al.   AGING CELL

Aggravation of Alzheimer's disease due to the COX-2-mediated reciprocal regulation of IL-1β and Aβ between glial and neuron cells

(2014) Pu Wang et al.   AGING CELL

Apolipoprotein E increases cell association of amyloid-β 40 through heparan sulfate and LRP1 dependent pathways

(2014) Paul O’Callaghan et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

Complement and Its Receptors: New Insights into Human Disease

(2014) V. Michael Holers   Annual Review of Immunology

The role of neuronal versus astrocyte-derived heparan sulfate proteoglycans in brain development and injury: Table 1

(2014) Isabella Farhy Tselnicker et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Glia in the pathogenesis of neurodegenerative diseases

(2014) Alexei Verkhratsky et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Astrocyte transforming growth factor beta 1 promotes inhibitory synapse formation via CaM kinase II signaling

(2014) Luan Pereira Diniz et al.   GLIA

Astrocytic transforming growth factor-beta signaling reduces subacute neuroinflammation after stroke in mice

(2014) Egle Cekanaviciute et al.   GLIA

TGFβ produced by IL-10 redirected astrocytes attenuates microglial activation

(2014) Diana M. Norden et al.   GLIA

Overexpression of Heparanase Lowers the Amyloid Burden in Amyloid-β Precursor Protein Transgenic Mice

(2014) Charlotte B. Jendresen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Entrapment via Synaptic-Like Connections between NG2 Proteoglycan+ Cells and Dystrophic Axons in the Lesion Plays a Role in Regeneration Failure after Spinal Cord Injury

(2014) Angela R. Filous et al.   JOURNAL OF NEUROSCIENCE

IKK  Deficiency in Myeloid Cells Ameliorates Alzheimer's Disease-Related Symptoms and Pathology

(2014) Y. Liu et al.   JOURNAL OF NEUROSCIENCE

Activation of NF-κB Mediates Astrocyte Swelling and Brain Edema in Traumatic Brain Injury

(2014) Arumugam R. Jayakumar et al.   JOURNAL OF NEUROTRAUMA

The protease activity of transthyretin reverses the effect of pH on the amyloid-β protein/heparan sulfate proteoglycan interaction: A biochromatographic study

(2014) Ambre Geneste et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Valproic Acid Alleviates Memory Deficits and Attenuates Amyloid-β Deposition in Transgenic Mouse Model of Alzheimer’s Disease

(2014) Ai-Guo Xuan et al.   MOLECULAR NEUROBIOLOGY

Dysregulation of protein trafficking in neurodegeneration

(2014) Xin Wang et al.   Molecular Neurodegeneration

The impact of human and mouse differences in NOS2 gene expression on the brain’s redox and immune environment

(2014) Michael D Hoos et al.   Molecular Neurodegeneration

Increased mtDNA mutations with aging promotes amyloid accumulation and brain atrophy in the APP/Ld transgenic mouse model of Alzheimer’s disease

(2014) Lokesh Kukreja et al.   Molecular Neurodegeneration

Vascular and parenchymal amyloid pathology in an Alzheimer disease knock-in mouse model: interplay with cerebral blood flow

(2014) Hongmei Li et al.   Molecular Neurodegeneration

Diet and exercise orthogonally alter the gut microbiome and reveal independent associations with anxiety and cognition

(2014) Silvia S Kang et al.   Molecular Neurodegeneration

Ryanodine receptors: physiological function and deregulation in Alzheimer disease

(2014) Dolores Del Prete et al.   Molecular Neurodegeneration

Temporal gene profiling of the 5XFAD transgenic mouse model highlights the importance of microglial activation in Alzheimer’s disease

(2014) Véréna Landel et al.   Molecular Neurodegeneration

Models of β-amyloid induced Tau-pathology: the long and “folded” road to understand the mechanism

(2014) Ilie-Cosmin Stancu et al.   Molecular Neurodegeneration

Altered microglial response to Aβ plaques in APPPS1-21 mice heterozygous for TREM2

(2014) Jason D Ulrich et al.   Molecular Neurodegeneration

Neuronal and Astroglial TGFβ-Smad3 Signaling Pathways Differentially Regulate Dendrite Growth and Synaptogenesis

(2014) Chuan-Yong Yu et al.   NEUROMOLECULAR MEDICINE

Gliotransmitters Travel in Time and Space

(2014) Alfonso Araque et al.   NEURON

Microglia Induce Motor Neuron Death via the Classical NF-κB Pathway in Amyotrophic Lateral Sclerosis

(2014) Ashley E. Frakes et al.   NEURON

Montelukast targeting the cysteinyl leukotriene receptor 1 ameliorates Aβ1-42-induced memory impairment and neuroinflammatory and apoptotic responses in mice

(2014) Jin'e Lai et al.   NEUROPHARMACOLOGY

Icariin Ameliorates Neuropathological Changes, TGF-β1 Accumulation and Behavioral Deficits in a Mouse Model of Cerebral Amyloidosis

(2014) Zhi-Yuan Zhang et al.   PLoS One

TGF-β1 promotes cerebral cortex radial glia-astrocyte differentiation in vivo

(2014) Joice Stipursky et al.   Frontiers in Cellular Neuroscience

Versatility of the complement system in neuroinflammation, neurodegeneration and brain homeostasis

(2014) Franca Orsini et al.   Frontiers in Cellular Neuroscience

Aβ1–42 reduces P-glycoprotein in the blood–brain barrier through RAGE–NF-κB signaling

(2014) R Park et al.   Cell Death & Disease

Metabotropic P2Y1 receptor signalling mediates astrocytic hyperactivity in vivo in an Alzheimer’s disease mouse model

(2014) Andrea Delekate et al.   Nature Communications

Astrocytic A20 ameliorates experimental autoimmune encephalomyelitis by inhibiting NF-κB- and STAT1-dependent chemokine production in astrocytes

(2013) Xu Wang et al.   ACTA NEUROPATHOLOGICA

Ca2+-dependent endoplasmic reticulum stress correlates with astrogliosis in oligomeric amyloid β-treated astrocytes and in a model of Alzheimer's disease

(2013) Elena Alberdi et al.   AGING CELL

Aspirin-Triggered Lipoxin A4 Stimulates Alternative Activation of Microglia and Reduces Alzheimer Disease–Like Pathology in Mice

(2013) Rodrigo Medeiros et al.   AMERICAN JOURNAL OF PATHOLOGY

Striking reduction of amyloid plaque burden in an Alzheimer's mouse model after chronic administration of carmustine

(2013) Crystal D Hayes et al.   BMC Medicine

SnapShot: Genetics of Alzheimer’s Disease

(2013) Rita Guerreiro et al.   CELL

Antimalarial Drug Artemisinin Extenuates Amyloidogenesis and Neuroinflammation in APPswe/PS1dE9 Transgenic Mice via Inhibition of Nuclear Factor-κB and NLRP3 Inflammasome Activation

(2013) Jian-Quan Shi et al.   CNS Neuroscience & Therapeutics

Alzheimer´s Disease and Oxidative Stress: A Review

(2013) Miroslav Pohanka   CURRENT MEDICINAL CHEMISTRY

Chondroitin sulfate proteoglycans inhibit oligodendrocyte myelination through PTPσ

(2013) James C. Pendleton et al.   EXPERIMENTAL NEUROLOGY

β-amyloid and ATP-induced diffusional trapping of astrocyte and neuronal metabotropic glutamate type-5 receptors

(2013) Amulya Nidhi Shrivastava et al.   GLIA

Astrocytes play a key role in EAE pathophysiology by orchestrating in the CNS the inflammatory response of resident and peripheral immune cells and by suppressing remyelination

(2013) Roberta Brambilla et al.   GLIA

A critical role of astrocyte-mediated nuclear factor-κB-dependent inflammation in Huntington's disease

(2013) Han-Yun Hsiao et al.   HUMAN MOLECULAR GENETICS

Proteoglycans in the central nervous system: Role in development, neural repair, and Alzheimer's disease

(2013) Hao Cui et al.   IUBMB LIFE

cAMP Response Element-binding Protein (CREB) and Nuclear Factor κB Mediate the Tamoxifen-induced Up-regulation of Glutamate Transporter 1 (GLT-1) in Rat Astrocytes

(2013) Pratap Karki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Brain-wide pathway for waste clearance captured by contrast-enhanced MRI

(2013) Jeffrey J. Iliff et al.   JOURNAL OF CLINICAL INVESTIGATION

Complement in Immune and Inflammatory Disorders: Pathophysiological Mechanisms

(2013) D. Ricklin et al.   JOURNAL OF IMMUNOLOGY

IL-1β and TNF-α induce neurotoxicity through glutamate production: a potential role for neuronal glutaminase

(2013) Ling Ye et al.   JOURNAL OF NEUROCHEMISTRY

Deregulation of excitatory neurotransmission underlying synapse failure in Alzheimer's disease

(2013) Andrea C. Paula-Lima et al.   JOURNAL OF NEUROCHEMISTRY

Primary Hippocampal Neurons, Which Lack Four Crucial Extracellular Matrix Molecules, Display Abnormalities of Synaptic Structure and Function and Severe Deficits in Perineuronal Net Formation

(2013) M. Geissler et al.   JOURNAL OF NEUROSCIENCE

Cytotoxicity of Intracellular A 42 Amyloid Oligomers Involves Ca2+ Release from the Endoplasmic Reticulum by Stimulated Production of Inositol Trisphosphate

(2013) A. Demuro et al.   JOURNAL OF NEUROSCIENCE

Heparan sulfate proteoglycan as a cell-surface endocytosis receptor

(2013) Helena C. Christianson et al.   MATRIX BIOLOGY

IVIG immunotherapy protects against synaptic dysfunction in Alzheimer's disease through complement anaphylatoxin C5a-mediated AMPA-CREB-C/EBP signaling pathway

(2013) Bing Gong et al.   MOLECULAR IMMUNOLOGY

High Glucose Induces Reactive Oxygen Species-Dependent Matrix Metalloproteinase-9 Expression and Cell Migration in Brain Astrocytes

(2013) Hsi-Lung Hsieh et al.   MOLECULAR NEUROBIOLOGY

The synaptic maintenance problem: membrane recycling, Ca2+ homeostasis and late onset degeneration

(2013) Ilya Bezprozvanny et al.   Molecular Neurodegeneration

Sustained, neuron-specific IKK/NF-κB activation generates a selective neuroinflammatory response promoting local neurodegeneration with aging

(2013) Ayesha Maqbool et al.   Molecular Neurodegeneration

Immunotherapy for Alzheimer’s disease: hoops and hurdles

(2013) Cynthia A Lemere   Molecular Neurodegeneration

Cross-talk of membrane lipids and Alzheimer-related proteins

(2013) Jochen Walter et al.   Molecular Neurodegeneration

Blood–brain-barriers in aging and in Alzheimer’s disease

(2013) Fernanda Marques et al.   Molecular Neurodegeneration

TGF-β signaling regulates neuronal C1q expression and developmental synaptic refinement

(2013) Allison R Bialas et al.   NATURE NEUROSCIENCE

Differential Regulation of GLT-1/EAAT2 Gene Expression by NF-κB and N-myc in Male Mouse Brain During Postnatal Development

(2013) Rajaneesh Kumar Gupta et al.   NEUROCHEMICAL RESEARCH

Calcium dysregulation in relation to Alzheimer-type pathology in the ageing brain

(2013) C. Garwood et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Minimal NF-κB activity in neurons

(2013) S.J. Listwak et al.   NEUROSCIENCE

Heterogeneity of reactive astrocytes

(2013) Mark A. Anderson et al.   NEUROSCIENCE LETTERS

Oxidative Stress and the Pathogenesis of Alzheimer's Disease

(2013) Yan Zhao et al.   Oxidative Medicine and Cellular Longevity

α7 Nicotinic Receptor-Mediated Astrocytic Gliotransmitter Release: Aβ Effects in a Preclinical Alzheimer’s Mouse Model

(2013) Tiina Maria Pirttimaki et al.   PLoS One

Intricate interplay between astrocytes and motor neurons in ALS

(2013) H. P. Phatnani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Garbage Truck of the Brain

(2013) M. Nedergaard   SCIENCE

Sleep Drives Metabolite Clearance from the Adult Brain

(2013) L. Xie et al.   SCIENCE

Inflammation in Alzheimer Disease--A Brief Review of the Basic Science and Clinical Literature

(2013) T. Wyss-Coray et al.   Cold Spring Harbor Perspectives in Medicine

The Complement System: An Unexpected Role in Synaptic Pruning During Development and Disease

(2012) Alexander H. Stephan et al.   Annual Review of Neuroscience

Ketamine Inhibits Lipopolysaccharide-Induced Astrocytes Activation by Suppressing TLR4/NF-?B Pathway

(2012) Yuqing Wu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Activation of MAPK/PI3K/SMAD Pathways by TGF-β1 Controls Differentiation of Radial Glia into Astrocytes in vitro

(2012) Joice Stipursky et al.   DEVELOPMENTAL NEUROSCIENCE

Oligomers of beta-amyloid protein (Aβ1-42) induce the activation of cyclooxygenase-2 in astrocytes via an interaction with interleukin-1beta, tumour necrosis factor-alpha, and a nuclear factor kappa-B mechanism in the rat brain

(2012) I. Carrero et al.   EXPERIMENTAL NEUROLOGY

Scar-mediated inhibition and CSPG receptors in the CNS

(2012) Kartavya Sharma et al.   EXPERIMENTAL NEUROLOGY

Complement component C3 and complement receptor type 3 contribute to the phagocytosis and clearance of fibrillar Aβ by microglia

(2012) Hongjun Fu et al.   GLIA

Astrocyte-induced Synaptogenesis Is Mediated by Transforming Growth Factor β Signaling through Modulation of d-Serine Levels in Cerebral Cortex Neurons

(2012) Luan Pereira Diniz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Innate immunity in the central nervous system

(2012) Richard M. Ransohoff et al.   JOURNAL OF CLINICAL INVESTIGATION

Size and sulfation are critical for the effect of heparin on APP processing and Aβ production

(2012) Hao Cui et al.   JOURNAL OF NEUROCHEMISTRY

Transforming growth factor-β stimulates β amyloid uptake by microglia through Smad3-dependent mechanisms

(2012) Juan E. Tichauer et al.   JOURNAL OF NEUROSCIENCE RESEARCH

The calcium-sensing receptor: A novel Alzheimer's disease crucial target?

(2012) Ubaldo Armato et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Methylmercury induces CCL2 expression through activation of NF-^|^kappa;B in human 1321N1 astrocytes

(2012) Min-Seok Kim et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Loss of the Androgen Receptor Cofactor p44/WDR77 Induces Astrogliosis

(2012) B. Vincent et al.   MOLECULAR AND CELLULAR BIOLOGY

Reactive Astrogliosis after Spinal Cord Injury—Beneficial and Detrimental Effects

(2012) Soheila Karimi-Abdolrezaee et al.   MOLECULAR NEUROBIOLOGY

IκBα deficiency in brain leads to elevated basal neuroinflammation and attenuated response following traumatic brain injury: implications for functional recovery

(2012) Hong Lian et al.   Molecular Neurodegeneration

Intercellular (Mis)communication in Neurodegenerative Disease

(2012) Gwenn A. Garden et al.   NEURON

Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

(2012) Dorothy P. Schafer et al.   NEURON

Inhibition of human astrocyte and microglia neurotoxicity by calcium channel blockers

(2012) Sadayuki Hashioka et al.   NEUROPHARMACOLOGY

Deconstructing the perineuronal net: Cellular contributions and molecular composition of the neuronal extracellular matrix

(2012) K.A. Giamanco et al.   NEUROSCIENCE

TGF-β induced by interleukin-34-stimulated microglia regulates microglial proliferation and attenuates oligomeric amyloid β neurotoxicity

(2012) Di Ma et al.   NEUROSCIENCE LETTERS

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid  

(2012) J. J. Iliff et al.   Science Translational Medicine

Increased expression of the homologue of enhancer-of-split 1 protects neurons from beta amyloid neurotoxicity and hints at an alternative role for transforming growth factor beta1 as a neuroprotector

(2012) Pedro J Chacón et al.   Alzheimers Research & Therapy

Quantifying the Uncertainty of Spontaneous Ca2+ Oscillations in Astrocytes: Particulars of Alzheimer's Disease

(2011) J. Riera et al.   BIOPHYSICAL JOURNAL

Tetrandrine attenuates spatial memory impairment and hippocampal neuroinflammation via inhibiting NF-κB activation in a rat model of Alzheimer's disease induced by amyloid-β(1–42)

(2011) Fu-Qian He et al.   BRAIN RESEARCH

APP physiological and pathophysiological functions: insights from animal models

(2011) Qinxi Guo et al.   CELL RESEARCH

Chondroitin sulfate proteoglycans regulate astrocyte-dependent synaptogenesis and modulate synaptic activity in primary embryonic hippocampal neurons

(2011) Martin Pyka et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Extracellular matrix and cell signalling: the dynamic cooperation of integrin, proteoglycan and growth factor receptor

(2011) Soo-Hyun Kim et al.   JOURNAL OF ENDOCRINOLOGY

Cautionary notes on the use of NF-κB p65 and p50 antibodies for CNS studies

(2011) Miles Herkenham et al.   Journal of Neuroinflammation

Nuclear Factor- B Contributes to Neuron-Dependent Induction of Glutamate Transporter-1 Expression in Astrocytes

(2011) M. Ghosh et al.   JOURNAL OF NEUROSCIENCE

Amyloid  -Induced Death in Neurons Involves Glial and Neuronal Hemichannels

(2011) J. A. Orellana et al.   JOURNAL OF NEUROSCIENCE

A Requirement for Nuclear Factor- B in Developmental and Plasticity-Associated Synaptogenesis

(2011) M. C. H. Boersma et al.   JOURNAL OF NEUROSCIENCE

Complement in the brain

(2011) Robert Veerhuis et al.   MOLECULAR IMMUNOLOGY

Disruption of the NF-κB/IκBα Autoinhibitory Loop Improves Cognitive Performance and Promotes Hyperexcitability of Hippocampal Neurons

(2011) David J Shim et al.   Molecular Neurodegeneration

Biology and pathophysiology of the amyloid precursor protein

(2011) Hui Zheng et al.   Molecular Neurodegeneration

Oxidative Stress and Cell Membranes in the Pathogenesis of Alzheimer's Disease

(2011) Paul H. Axelsen et al.   PHYSIOLOGY

Regulation of neural process growth, elaboration and structural plasticity by NF-κB

(2011) Humberto Gutierrez et al.   TRENDS IN NEUROSCIENCES

Calcium Dysregulation and Homeostasis of Neural Calcium in the Molecular Mechanisms of Neurodegenerative Diseases Provide Multiple Targets for Neuroprotection

(2010) Gregor Zündorf et al.   ANTIOXIDANTS & REDOX SIGNALING

A Meta-Analysis of Cytokines in Alzheimer's Disease

(2010) Walter Swardfager et al.   BIOLOGICAL PSYCHIATRY

Contributions of astrocytes to synapse formation and maturation — Potential functions of the perisynaptic extracellular matrix

(2010) Andreas Faissner et al.   BRAIN RESEARCH REVIEWS

Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals

(2010) Jason J. Corneveaux et al.   HUMAN MOLECULAR GENETICS

Transforming Growth Factor β2 Level is Elevated in Neurons of Alzheimer's Disease Brains

(2010) Atsushi Noguchi et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Amyloid-β Protein Oligomer at Low Nanomolar Concentrations Activates Microglia and Induces Microglial Neurotoxicity

(2010) Izumi Maezawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Microglial activation depends on beta-amyloid conformation: role of the formylpeptide receptor 2

(2010) Tony Heurtaux et al.   JOURNAL OF NEUROCHEMISTRY

TGF-β1 blockade of microglial chemotaxis toward Aβ aggregates involves SMAD signaling and down-regulation of CCL5

(2010) Wei-Chao Huang et al.   Journal of Neuroinflammation

Fibrinogen Triggers Astrocyte Scar Formation by Promoting the Availability of Active TGF-  after Vascular Damage

(2010) C. Schachtrup et al.   JOURNAL OF NEUROSCIENCE

Membrane Biophysics and Mechanics in Alzheimer's Disease

(2010) Xiaoguang Yang et al.   MOLECULAR NEUROBIOLOGY

Defective feedback regulation of NF- B underlies Sjogren's syndrome in mice with mutated  B enhancers of the I B  promoter

(2010) B. Peng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complement in neuroprotection and neurodegeneration

(2010) Vijay Yanamadala et al.   TRENDS IN MOLECULAR MEDICINE

Astrocytes: biology and pathology

(2009) Michael V. Sofroniew et al.   ACTA NEUROPATHOLOGICA

Amyloid β-Peptide Directly Induces Spontaneous Calcium Transients, Delayed Intercellular Calcium Waves and Gliosis in Rat Cortical Astrocytes

(2009) Siu-Kei Chow et al.   ASN Neuro

Proteoglycans: from structural compounds to signaling molecules

(2009) Liliana Schaefer et al.   CELL AND TISSUE RESEARCH

Calcium-Sensing Receptor (CaSR) in Human Brains Pathophysiology: Roles in Late-Onset Alzheimers Disease (LOAD)

(2009) Anna Chiarini et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Inactivation of astroglial NF-κB promotes survival of retinal neurons following ischemic injury

(2009) Galina Dvoriantchikova et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Receptor-associated Protein Interacts with Amyloid-β Peptide and Promotes Its Cellular Uptake

(2009) Takahisa Kanekiyo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Treatment with a C5aR Antagonist Decreases Pathology and Enhances Behavioral Performance in Murine Models of Alzheimer's Disease

(2009) M. I. Fonseca et al.   JOURNAL OF IMMUNOLOGY

Bioactive TGF-β can associate with lipoproteins and is enriched in those containing apolipoprotein E3

(2009) Ina Tesseur et al.   JOURNAL OF NEUROCHEMISTRY

Unique aspects of transcriptional regulation in neurons - nuances in NFkappaB and Sp1-related factors

(2009) Xianrong R. Mao et al.   Journal of Neuroinflammation

Amyloid Precursor Protein Regulates Cav1.2 L-type Calcium Channel Levels and Function to Influence GABAergic Short-Term Plasticity

(2009) L. Yang et al.   JOURNAL OF NEUROSCIENCE

Neuroscience: Glia — more than just brain glue

(2009) Nicola J. Allen et al.   NATURE

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

(2009) Jean-Charles Lambert et al.   NATURE GENETICS

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

(2009) Denise Harold et al.   NATURE GENETICS

Immune Activation in Brain Aging and Neurodegeneration: Too Much or Too Little?

(2009) Kurt M. Lucin et al.   NEURON

Synchronous Hyperactivity and Intercellular Calcium Waves in Astrocytes in Alzheimer Mice

(2009) K. V. Kuchibhotla et al.   SCIENCE

Amyloid Goes Global

(2009) I. Bezprozvanny   Science Signaling

Complement-Derived Anaphylatoxin C3a Regulates In Vitro Differentiation and Migration of Neural Progenitor Cells

(2009) Noriko Shinjyo et al.   STEM CELLS

Tripartite synapses: astrocytes process and control synaptic information

(2009) Gertrudis Perea et al.   TRENDS IN NEUROSCIENCES

NF- B in the Nervous System

(2009) B. Kaltschmidt et al.   Cold Spring Harbor Perspectives in Biology

Amyloid-β peptide induces temporal membrane biphasic changes in astrocytes through cytosolic phospholipase A2

(2008) Jacob B. Hicks et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Non-Smad pathways in TGF-β signaling

(2008) Ying E Zhang   CELL RESEARCH

Synergistic Signaling from Extracellular Matrix–Growth Factor Complexes

(2008) Richard A.F. Clark   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Complement C3 and C4 expression in C1q sufficient and deficient mouse models of Alzheimer’s disease

(2008) Jun Zhou et al.   JOURNAL OF NEUROCHEMISTRY

Increased intraneuronal resting [Ca2+] in adult Alzheimer’s disease mice

(2008) José R. Lopez et al.   JOURNAL OF NEUROCHEMISTRY

Plaque complement activation and cognitive loss in Alzheimer's disease

(2008) David A Loeffler et al.   Journal of Neuroinflammation

Complement C3 Deficiency Leads to Accelerated Amyloid   Plaque Deposition and Neurodegeneration and Modulation of the Microglia/Macrophage Phenotype in Amyloid Precursor Protein Transgenic Mice

(2008) M. Maier et al.   JOURNAL OF NEUROSCIENCE

C1q, the recognition subcomponent of the classical pathway of complement, drives microglial activation

(2008) Katrin Färber et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Role of complement anaphylatoxin receptors (C3aR, C5aR) in the development of the rat cerebellum

(2008) Magalie Bénard et al.   MOLECULAR IMMUNOLOGY

Inflammatory changes are tightly associated with neurodegeneration in the brain and spinal cord of the APP/PS1KI mouse model of Alzheimer's disease

(2008) Oliver Wirths et al.   NEUROBIOLOGY OF AGING

Aβ Plaques Lead to Aberrant Regulation of Calcium Homeostasis In Vivo Resulting in Structural and Functional Disruption of Neuronal Networks

(2008) Kishore V. Kuchibhotla et al.   NEURON

The Mystery and Magic of Glia: A Perspective on Their Roles in Health and Disease

(2008) Ben A. Barres   NEURON

TGF-β1 is increased in a transgenic mouse model of familial Alzheimer's disease and causes neuronal apoptosis

(2007) Pradeep Salins et al.   NEUROSCIENCE LETTERS

The Transforming Growth Factor-βs

(2003) Martina Böttner et al.   JOURNAL OF NEUROCHEMISTRY