Local apoptotic-like mechanisms underlie complement-mediated synaptic pruning

Progranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia via Complement Activation

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Complement and microglia mediate early synapse loss in Alzheimer mouse models

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Pentraxins Coordinate Excitatory Synapse Maturation and Circuit Integration of Parvalbumin Interneurons

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Proteomic screening of glutamatergic mouse brain synaptosomes isolated by fluorescence activated sorting

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C1q Binds Phosphatidylserine and Likely Acts as a Multiligand-Bridging Molecule in Apoptotic Cell Recognition

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Synucleins Regulate the Kinetics of Synaptic Vesicle Endocytosis

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Local Pruning of Dendrites and Spines by Caspase-3-Dependent and Proteasome-Limited Mechanisms

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A Dramatic Increase of C1q Protein in the CNS during Normal Aging

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TGF-β signaling regulates neuronal C1q expression and developmental synaptic refinement

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Long-term depression: a cell biological view

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Compartmentalized Calcium Transients Trigger Dendrite Pruning in Drosophila Sensory Neurons

(2013) T. Kanamori et al.   SCIENCE

The Complement System: An Unexpected Role in Synaptic Pruning During Development and Disease

(2012) Alexander H. Stephan et al.   Annual Review of Neuroscience

Synaptic cell adhesion molecule-2 and collapsin response mediator protein-2 are novel members of the matrix metalloproteinase-9 degradome

(2012) Malgorzata Bajor et al.   JOURNAL OF NEUROCHEMISTRY

Analysis of synaptic vesicle endocytosis in synaptosomes by high-content screening

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Apoptotic and non-apoptotic roles of caspases in neuronal physiology and pathophysiology

(2012) Bradley T. Hyman et al.   NATURE REVIEWS NEUROSCIENCE

Critical role of neuronal pentraxin 1 in mitochondria-mediated hypoxic–ischemic neuronal injury

(2012) Md Al Rahim et al.   NEUROBIOLOGY OF DISEASE

Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

(2012) Dorothy P. Schafer et al.   NEURON

Complement in the brain

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Synaptic Pruning by Microglia Is Necessary for Normal Brain Development

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Caspase-3 Activation via Mitochondria Is Required for Long-Term Depression and AMPA Receptor Internalization

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Suppression of the Intrinsic Apoptosis Pathway by Synaptic Activity

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Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer's disease

(2010) Marcello D'Amelio et al.   NATURE NEUROSCIENCE

Axonal Dynamics of Excitatory and Inhibitory Neurons in Somatosensory Cortex

(2010) Sally A. Marik et al.   PLOS BIOLOGY

C1q enhances microglial clearance of apoptotic neurons and neuronal blebs, and modulates subsequent inflammatory cytokine production

(2009) Deborah A. Fraser et al.   JOURNAL OF NEUROCHEMISTRY

Experience-dependent structural synaptic plasticity in the mammalian brain

(2009) Anthony Holtmaat et al.   NATURE REVIEWS NEUROSCIENCE

C1q: the perfect complement for a synaptic feast?

(2008) V. Hugh Perry et al.   NATURE REVIEWS NEUROSCIENCE