Properdin: a tightly regulated critical inflammatory modulator

Disturbed sialic acid recognition on endothelial cells and platelets in complement attack causes atypical hemolytic uremic syndrome

(2016) S. Hyvarinen et al.   BLOOD

Serum properdin consumption as a biomarker of C5 convertase dysregulation in C3 glomerulopathy

(2016) F. Corvillo et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

The membrane attack complex as an inflammatory trigger

(2016) B. Paul Morgan   IMMUNOBIOLOGY

Mutations in Complement Factor H Impair Alternative Pathway Regulation on Mouse Glomerular Endothelial Cellsin Vitro

(2016) Markus A. Loeven et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Properdin-Mediated C5a Production Enhances Stable Binding of Platelets to Granulocytes in Human Whole Blood

(2016) Adam Z. Blatt et al.   JOURNAL OF IMMUNOLOGY

Anti-complement activity of the Ixodes scapularis salivary protein Salp20

(2016) Dennis E. Hourcade et al.   MOLECULAR IMMUNOLOGY

The many faces of Mac-1 in autoimmune disease

(2015) Florencia Rosetti et al.   IMMUNOLOGICAL REVIEWS

Binding of Complement Factor H to PorB3 and NspA Enhances Resistance of Neisseria meningitidis to Anti-Factor H Binding Protein Bactericidal Activity

(2015) Serena Giuntini et al.   INFECTION AND IMMUNITY

Properdin Regulation of Complement Activation Affects Colitis in Interleukin 10 Gene–Deficient Mice

(2015) Umang Jain et al.   INFLAMMATORY BOWEL DISEASES

Properdin Contributes to Allergic Airway Inflammation through Local C3a Generation

(2015) Yuan Wang et al.   JOURNAL OF IMMUNOLOGY

Factor H–Related Protein 5 Interacts with Pentraxin 3 and the Extracellular Matrix and Modulates Complement Activation

(2015) Ádám I. Csincsi et al.   JOURNAL OF IMMUNOLOGY

Properdin Provides Protection fromCitrobacter rodentium–Induced Intestinal Inflammation in a C5a/IL-6–Dependent Manner

(2015) Umang Jain et al.   JOURNAL OF IMMUNOLOGY

Complement Factor H-Related 5-Hybrid Proteins Anchor Properdin and Activate Complement at Self-Surfaces

(2015) Q. Chen et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

An extended mini-complement factor H molecule ameliorates experimental C3 glomerulopathy

(2015) Eva-Maria Nichols et al.   KIDNEY INTERNATIONAL

Complement and platelets: Mutual interference in the immune network

(2015) Cornelia Speth et al.   MOLECULAR IMMUNOLOGY

Contact activation of C3 enables tethering between activated platelets and polymorphonuclear leukocytes via CD11b/CD18

(2015) Osama A. Hamad et al.   THROMBOSIS AND HAEMOSTASIS

Complement System Part I – Molecular Mechanisms of Activation and Regulation

(2015) Nicolas S. Merle et al.   Frontiers in Immunology

Complement and Its Receptors: New Insights into Human Disease

(2014) V. Michael Holers   Annual Review of Immunology

Properdin Deficiency in Murine Models of Nonseptic Shock

(2014) N. D. Ivanovska et al.   JOURNAL OF IMMUNOLOGY

A Novel Mechanism of Complement Inhibition Unmasked by a Tick Salivary Protein That Binds to Properdin

(2014) K. R. Tyson et al.   JOURNAL OF IMMUNOLOGY

A New Map of Glycosaminoglycan and C3b Binding Sites on Factor H

(2014) C. Q. Schmidt et al.   JOURNAL OF IMMUNOLOGY

Properdin Plays a Protective Role in Polymicrobial Septic Peritonitis

(2014) C. M. Stover et al.   JOURNAL OF IMMUNOLOGY

Properdin Binds to Late Apoptotic and Necrotic Cells Independently of C3b and Regulates Alternative Pathway Complement Activation

(2014) W. Xu et al.   JOURNAL OF IMMUNOLOGY

Polyanion-Induced Self-Association of Complement Factor H

(2014) M. K. Pangburn et al.   JOURNAL OF IMMUNOLOGY

Protective Role for Properdin in Progression of Experimental Murine Atherosclerosis

(2014) Tanja Steiner et al.   PLoS One

A Novel Antibody against Human Properdin Inhibits the Alternative Complement System and Specifically Detects Properdin from Blood Samples

(2014) Diana Pauly et al.   PLoS One

Low-dose recombinant properdin provides substantial protection against Streptococcus pneumoniae and Neisseria meningitidis infection

(2014) Y. M. Ali et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Properdin has an ascendancy over factor H regulation in complement-mediated renal tubular damage

(2014) Seiji Nagamachi et al.   BMC Nephrology

Molecular Interactions between Complement Factor H and Its Heparin and Heparan Sulfate Ligands

(2014) Stephen J. Perkins et al.   Frontiers in Immunology

Myeloperoxidase influences the complement regulatory function of modified C-reactive protein

(2013) Peng-cheng Xu et al.   Innate Immunity

Neutrophil Elastase and Proteinase-3 Trigger G Protein-biased Signaling through Proteinase-activated Receptor-1 (PAR1)

(2013) Koichiro Mihara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tissue-Specific Host Recognition by Complement Factor H Is Mediated by Differential Activities of Its Glycosaminoglycan-Binding Regions

(2013) S. J. Clark et al.   JOURNAL OF IMMUNOLOGY

Identification of a Novel Mode of Complement Activation on Stimulated Platelets Mediated by Properdin and C3(H2O)

(2013) G. Saggu et al.   JOURNAL OF IMMUNOLOGY

Essential Role of Surface-Bound Complement Factor H in Controlling Immune Complex-Induced Arthritis

(2013) N. K. Banda et al.   JOURNAL OF IMMUNOLOGY

Rational Engineering of a Minimized Immune Inhibitor with Unique Triple-Targeting Properties

(2013) C. Q. Schmidt et al.   JOURNAL OF IMMUNOLOGY

Myeloperoxidase Directs Properdin-Mediated Complement Activation

(2013) Joseph O'Flynn et al.   Journal of Innate Immunity

Cyclosporine Induces Endothelial Cell Release of Complement-Activating Microparticles

(2013) B. Renner et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Circulating platelet–leukocyte aggregates in patients with inflammatory bowel disease

(2013) Yavuz Tekelioğlu et al.   Journal of the Chinese Medical Association

Properdin in complement activation and tissue injury

(2013) Allison M. Lesher et al.   MOLECULAR IMMUNOLOGY

Structural basis for the stabilization of the complement alternative pathway C3 convertase by properdin

(2013) M. Alcorlo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fibrinogen-specific antibody induces abdominal aortic aneurysm in mice through complement lectin pathway activation

(2013) H.-f. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dense Deposit Disease and C3 Glomerulopathy

(2013) Thomas D. Barbour et al.   SEMINARS IN NEPHROLOGY

Atypical Hemolytic Uremic Syndrome

(2013) David Kavanagh et al.   SEMINARS IN NEPHROLOGY

Bivalent and co-operative binding of complement Factor H to heparan sulfate and heparin

(2012) Sanaullah Khan et al.   BIOCHEMICAL JOURNAL

Structural and Functional Characterization of the Product of Disease-Related Factor H Gene Conversion

(2012) Andrew P. Herbert et al.   BIOCHEMISTRY

The tick-over theory revisited: Is C3 a contact-activated protein?

(2012) Bo Nilsson et al.   IMMUNOBIOLOGY

Factor H and Properdin Recognize Different Epitopes on Renal Tubular Epithelial Heparan Sulfate

(2012) Azadeh Zaferani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Properdin Is Critical for Antibody-Dependent Bactericidal Activity against Neisseria gonorrhoeae That Recruit C4b-Binding Protein

(2012) S. Gulati et al.   JOURNAL OF IMMUNOLOGY

The Role of Properdin in Zymosan- and Escherichia coli-Induced Complement Activation

(2012) M. Harboe et al.   JOURNAL OF IMMUNOLOGY

Combination of Factor H Mutation and Properdin Deficiency Causes Severe C3 Glomerulonephritis

(2012) A. M. Lesher et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Loss of Properdin Exacerbates C3 Glomerulopathy Resulting from Factor H Deficiency

(2012) M. M. Ruseva et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Antibody directs properdin-dependent activation of the complement alternative pathway in a mouse model of abdominal aortic aneurysm

(2012) H.-f. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Platelet-leukocyte deregulated interactions foster sterile inflammation and tissue damage in immune-mediated vessel diseases

(2012) Norma Maugeri et al.   THROMBOSIS RESEARCH

Abrogated RANKL expression in properdin-deficient mice is associated with better outcome from collagen-antibody-induced arthritis

(2012) Petya Dimitrova et al.   ARTHRITIS RESEARCH & THERAPY

Design and development of TT30, a novel C3d-targeted C3/C5 convertase inhibitor for treatment of human complement alternative pathway-mediated diseases

(2011) M. Fridkis-Hareli et al.   BLOOD

Complement activation on platelet-leukocyte complexes and microparticles in enterohemorrhagic Escherichia coli-induced hemolytic uremic syndrome

(2011) A.-l. Stahl et al.   BLOOD

Early and Transient Release of Leukocyte Pentraxin 3 during Acute Myocardial Infarction

(2011) N. Maugeri et al.   JOURNAL OF IMMUNOLOGY

The Critical Role of Complement Alternative Pathway Regulator Factor H in Allergen-Induced Airway Hyperresponsiveness and Inflammation

(2011) K. Takeda et al.   JOURNAL OF IMMUNOLOGY

Bleeding risk and reversal strategies for old and new anticoagulants and antiplatelet agents

(2011) M. LEVI et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Binding of factor H to tubular epithelial cells limits interstitial complement activation in ischemic injury

(2011) Brandon Renner et al.   KIDNEY INTERNATIONAL

Platelet-leukocyte interactions in thrombosis

(2011) Chiara Cerletti et al.   THROMBOSIS RESEARCH

Linkage Specificity and Role of Properdin in Activation of the Alternative Complement Pathway by Fungal Glycans

(2011) S. Agarwal et al.   mBio

Platelet–Leukocyte Interactions in Cardiovascular Disease and Beyond

(2010) Licia Totani et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Complement alternative pathway acts as a positive feedback amplification of neutrophil activation

(2010) L. Camous et al.   BLOOD

Native polymeric forms of properdin selectively bind to targets and promote activation of the alternative pathway of complement

(2010) Viviana P. Ferreira et al.   IMMUNOBIOLOGY

Native Properdin Binds toChlamydia pneumoniaeand Promotes Complement Activation

(2010) Claudio Cortes et al.   INFECTION AND IMMUNITY

Identification of Tubular Heparan Sulfate as a Docking Platform for the Alternative Complement Component Properdin in Proteinuric Renal Disease

(2010) Azadeh Zaferani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetic and therapeutic targeting of properdin in mice prevents complement-mediated tissue injury

(2010) Yuko Kimura et al.   JOURNAL OF CLINICAL INVESTIGATION

Molecular Intercommunication between the Complement and Coagulation Systems

(2010) U. Amara et al.   JOURNAL OF IMMUNOLOGY

Complement Component C3 Binds to Activated Normal Platelets without Preceding Proteolytic Activation and Promotes Binding to Complement Receptor 1

(2010) Osama A. Hamad et al.   JOURNAL OF IMMUNOLOGY

An Evaluation of the Role of Properdin in Alternative Pathway Activation on Neisseria meningitidis and Neisseria gonorrhoeae

(2010) S. Agarwal et al.   JOURNAL OF IMMUNOLOGY

Complement activation on platelets: Implications for vascular inflammation and thrombosis

(2010) Ellinor I. Peerschke et al.   MOLECULAR IMMUNOLOGY

Complement control protein factor H: The good, the bad, and the inadequate

(2010) Viviana P. Ferreira et al.   MOLECULAR IMMUNOLOGY

The role of properdin in murine zymosan-induced arthritis

(2010) Petya Dimitrova et al.   MOLECULAR IMMUNOLOGY

Complement: a key system for immune surveillance and homeostasis

(2010) Daniel Ricklin et al.   NATURE IMMUNOLOGY

Contribution of Chondroitin Sulfate A to the Binding of Complement Proteins to Activated Platelets

(2010) Osama A. Hamad et al.   PLoS One

Properdin: Emerging Roles of a Pattern-Recognition Molecule

(2009) Claudia Kemper et al.   Annual Review of Immunology

Platelet-associated complement factor H in healthy persons and patients with atypical HUS

(2009) C. Licht et al.   BLOOD

Monomeric CRP contributes to complement control in fluid phase and on cellular surfaces and increases phagocytosis by recruiting factor H

(2009) M Mihlan et al.   CELL DEATH AND DIFFERENTIATION

Dissociation of Pentameric to Monomeric C-Reactive Protein on Activated Platelets Localizes Inflammation to Atherosclerotic Plaques

(2009) Steffen U. Eisenhardt et al.   CIRCULATION RESEARCH

Mutations of Factor H Impair Regulation of Surface-bound C3b by Three Mechanisms in Atypical Hemolytic Uremic Syndrome

(2009) Markus J. Lehtinen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Factor H and Factor H-Related Protein 1 Bind to Human Neutrophils via Complement Receptor 3, Mediate Attachment to Candida albicans, and Enhance Neutrophil Antimicrobial Activity

(2009) J. Losse et al.   JOURNAL OF IMMUNOLOGY

The Binding of Factor H to a Complex of Physiological Polyanions and C3b on Cells Is Impaired in Atypical Hemolytic Uremic Syndrome

(2009) V. P. Ferreira et al.   JOURNAL OF IMMUNOLOGY

The down-stream effects of mannan-induced lectin complement pathway activation depend quantitatively on alternative pathway amplification

(2009) Morten Harboe et al.   MOLECULAR IMMUNOLOGY

The role of the anaphylatoxins in health and disease

(2009) Andreas Klos et al.   MOLECULAR IMMUNOLOGY

CD40 Ligand Promotes Mac-1 Expression, Leukocyte Recruitment, and Neointima Formation after Vascular Injury

(2008) Guohong Li et al.   AMERICAN JOURNAL OF PATHOLOGY

Factor H dysfunction in patients with atypical hemolytic uremic syndrome contributes to complement deposition on platelets and their activation

(2008) A.-l. Stahl et al.   BLOOD

Characterization of Complement Factor H Binding to Yersinia enterocolitica Serotype O:3

(2008) M. Biedzka-Sarek et al.   INFECTION AND IMMUNITY

Factor H-Binding Protein Is Important for Meningococcal Survival in Human Whole Blood and Serum and in the Presence of the Antimicrobial Peptide LL-37

(2008) K. L. Seib et al.   INFECTION AND IMMUNITY

Complement activation triggered by chondroitin sulfate released by thrombin receptor-activated platelets

(2008) O. A. HAMAD et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

The complement factor properdin induces formation of platelet-leukocyte aggregates via leukocyte activation

(2008) Johannes Ruef et al.   PLATELETS

The complement protein properdin binds apoptotic T cells and promotes complement activation and phagocytosis

(2008) Claudia Kemper et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

THE ROLE OF NEUTROPHILS IN SEVERE SEPSIS

(2008) José C. Alves-Filho et al.   SHOCK

Circulating platelet–leukocyte aggregates: A marker of microvascular injury in diabetic patients

(2007) I. Elalamy et al.   THROMBOSIS RESEARCH