Therapeutic potential of flavonoids in inflammatory bowel disease: A comprehensive review

Kaempferol, a phytoestrogen, suppressed triclosan-induced epithelial-mesenchymal transition and metastatic-related behaviors of MCF-7 breast cancer cells

(2017) Geum-A Lee et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Epigallocatechin-3-Gallate Inhibition of Myeloperoxidase and Its Counter-Regulation by Dietary Iron and Lipocalin 2 in Murine Model of Gut Inflammation

(2016) Beng San Yeoh et al.   AMERICAN JOURNAL OF PATHOLOGY

Morin: A Promising Natural Drug

(2016) Anna Caselli et al.   CURRENT MEDICINAL CHEMISTRY

Pharmacological Properties and Therapeutic Potential of Naringenin: A Citrus Flavonoid of Pharmaceutical Promise

(2016) Neha Rani et al.   CURRENT PHARMACEUTICAL DESIGN

Fisetin, a dietary flavonoid, ameliorates experimental colitis in mice: Relevance of NF-κB signaling

(2016) Bidya Dhar Sahu et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Treatment with kaempferol suppresses breast cancer cell growth caused by estrogen and triclosan in cellular and xenograft breast cancer models

(2016) Seung-Hee Kim et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Apigenin supplementation protects the development of dextran sulfate sodium-induced murine experimental colitis by inhibiting canonical and non-canonical inflammasome signaling pathways

(2016) Yazmín K. Márquez-Flores et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

(-)-Epigallocatechin-3-gallate decreases colonic inflammation and permeability in a mouse model of colitis, but reduces macronutrient digestion and exacerbates weight loss

(2016) Zachary T. Bitzer et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Tangeretin Inhibits IL-12 Expression and NF-κB Activation in Dendritic Cells and Attenuates Colitis in Mice

(2016) Su-Hyeon Eun et al.   PLANTA MEDICA

Ustekinumab in treatment of Crohn’s disease: design, development, and potential place in therapy

(2016) Parakkal Deepak et al.   Drug Design Development and Therapy

Flavonoids in Inflammatory Bowel Disease: A Review

(2016) Teresa Vezza et al.   Nutrients

The Dual Role of Neutrophils in Inflammatory Bowel Diseases

(2016) Odile Wéra et al.   Journal of Clinical Medicine

Kaempferol Inhibits Pancreatic Cancer Cell Growth and Migration through the Blockade of EGFR-Related Pathway In Vitro

(2016) Jungwhoi Lee et al.   PLoS One

Therapeutic efficacy of quercetin enzyme-responsive nanovesicles for the treatment of experimental colitis in rats

(2015) Ines Castangia et al.   Acta Biomaterialia

(−)-Epicatechin in the prevention of tumor necrosis alpha-induced loss of Caco-2 cell barrier integrity

(2015) Telma C. Contreras et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Health-promoting effects of the citrus flavanone hesperidin

(2015) Chaoyun Li et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Interaction of dietary compounds, especially polyphenols, with the intestinal microbiota: a review

(2015) Aleksandra Duda-Chodak et al.   EUROPEAN JOURNAL OF NUTRITION

Baicalein protects against polymicrobial sepsis-induced liver injury via inhibition of inflammation and apoptosis in mice

(2015) Anding Liu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Preventive effects of cranberry products on experimental colitis induced by dextran sulphate sodium in mice

(2015) Xiao Xiao et al.   FOOD CHEMISTRY

Wogonin suppresses inflammatory response and maintains intestinal barrier function via TLR4-MyD88-TAK1-mediated NF-κB pathway in vitro

(2015) Wenping Wang et al.   INFLAMMATION RESEARCH

Catechin-7-O- β -D-glucopyranoside isolated from the seed of Phaseolus calcaratus Roxburgh ameliorates experimental colitis in rats

(2015) Sung-Ho Kook et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Kaempferol and inflammation: From chemistry to medicine

(2015) Kasi Pandima Devi et al.   PHARMACOLOGICAL RESEARCH

The small intestinal mucosa acts as a rutin reservoir to extend flavonoid anti-inflammatory activity in experimental ileitis and colitis

(2015) Cristina Mascaraque et al.   Journal of Functional Foods

Chronic Inflammatory Disease and Osteopathy: A Systematic Review

(2015) Luca Cicchitti et al.   PLoS One

Morin, a Bioflavonoid Suppresses Monosodium Urate Crystal-Induced Inflammatory Immune Response in RAW 264.7 Macrophages through the Inhibition of Inflammatory Mediators, Intracellular ROS Levels and NF-κB Activation

(2015) Chitra Dhanasekar et al.   PLoS One

Lotus Leaf (Nelumbo nucifera) and its Active Constituents Prevent Inflammatory Responses in Macrophages via JNK/NF-κB Signaling Pathway

(2014) Shing-Hwa Liu et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Isoflavones: Chemistry, Analysis, Functions and Effects on Health and Cancer

(2014) Kwang-Pil Ko   Asian Pacific Journal of Cancer Prevention

Cooked navy and black bean diets improve biomarkers of colon health and reduce inflammation during colitis

(2014) Claire Zhang et al.   BRITISH JOURNAL OF NUTRITION

Concentrated grape juice (G8000™) reduces immunoexpression of iNOS, TNF-alpha, COX-2 and DNA damage on 2,4,6-trinitrobenzene sulfonic acid-induced-colitis

(2014) Patrícia Marchi et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Inflammatory bowel disease

(2014) Daniele Corridoni et al.   IMMUNOLOGY LETTERS

Targeting oxidative stress attenuates trinitrobenzene sulphonic acid induced inflammatory bowel disease like symptoms in rats: Role of quercetin

(2014) Dilip Dodda et al.   INDIAN JOURNAL OF PHARMACOLOGY

Chitosan–xanthan gum microparticle-based oral tablet for colon-targeted and sustained delivery of quercetin

(2014) Carla Caddeo et al.   JOURNAL OF MICROENCAPSULATION

Kaempferol suppresses bladder cancer tumor growth by inhibiting cell proliferation and inducing apoptosis

(2014) Qiang Dang et al.   MOLECULAR CARCINOGENESIS

Chemopreventive and Therapeutic Potential of “Naringenin,” a Flavanone Present in Citrus Fruits

(2014) Irfan Ahmad Mir et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Kaempferol inhibits gastric cancer tumor growth: An in vitro and in vivo study

(2014) HAIBIN SONG et al.   ONCOLOGY REPORTS

Protective effect of quercetin against acetic acid induced inflammatory bowel disease (IBD) like symptoms in rats: Possible morphological and biochemical alterations

(2014) Dilip Dodda et al.   Pharmacological Reports

Rutin has intestinal antiinflammatory effects in the CD4+ CD62L+ T cell transfer model of colitis

(2014) Cristina Mascaraque et al.   PHARMACOLOGICAL RESEARCH

Protective effect of naringenin on acetic acid-induced ulcerative colitis in rats

(2014) Salim S Al-Rejaie   WORLD JOURNAL OF GASTROENTEROLOGY

Fecal microbial metabolism of polyphenols and its effects on human gut microbiota

(2013) Shanthi G. Parkar et al.   ANAEROBE

Oligonol Inhibits Dextran Sulfate Sodium-Induced Colitis and Colonic Adenoma Formation in Mice

(2013) Hye-Won Yum et al.   ANTIOXIDANTS & REDOX SIGNALING

Where do health benefits of flavonoids come from? Insights from flavonoid targets and their evolutionary history

(2013) Ming-Feng Lu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Intestinal anti-inflammatory activity of luteolin: Role of the aglycone in NF-κB inactivation in macrophages co-cultured with intestinal epithelial cells

(2013) Yosuke Nishitani et al.   BIOFACTORS

Protective effect of naringenin against experimental colitis via suppression of Toll-like receptor 4/NF-κB signalling

(2013) Wei Dou et al.   BRITISH JOURNAL OF NUTRITION

Effect of natural polyphenols (Pycnogenol) on oxidative stress markers in children suffering from Crohn's disease – a pilot study

(2013) M. Koláček et al.   FREE RADICAL RESEARCH

A Pilot Study to Evaluate the Safety and Efficacy of an Oral Dose of (−)-Epigallocatechin-3-Gallate–Rich Polyphenon E in Patients With Mild to Moderate Ulcerative Colitis

(2013) Gerald W. Dryden et al.   INFLAMMATORY BOWEL DISEASES

Anti-oxidant activity and attenuation of bladder hyperactivity by the flavonoid compound kaempferol

(2013) Yaw-Bin Huang et al.   INTERNATIONAL JOURNAL OF UROLOGY

Effects of Bilberry (Vaccinium myrtillus) in Combination with Lactic Acid Bacteria on Intestinal Oxidative Stress Induced by Ischemia–Reperfusion in Mouse

(2013) Maja Jakesevic et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Quercetin-Loaded Microcapsules Ameliorate Experimental Colitis in Mice by Anti-inflammatory and Antioxidant Mechanisms

(2013) Carla F. S. Guazelli et al.   JOURNAL OF NATURAL PRODUCTS

Supplemental Naringenin Prevents Intestinal Barrier Defects and Inflammation in Colitic Mice

(2013) Tomoyo Azuma et al.   JOURNAL OF NUTRITION

Benefits of polyphenols on gut microbiota and implications in human health

(2013) Fernando Cardona et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Baicalein Prevents 6-Hydroxydopamine-Induced Mitochondrial Dysfunction in SH-SY5Y Cells via Inhibition of Mitochondrial Oxidation and Up-Regulation of DJ-1 Protein Expression

(2013) Yue-Hua Wang et al.   MOLECULES

Genistein Suppresses LPS-Induced Inflammatory Response through Inhibiting NF-κB following AMP Kinase Activation in RAW 264.7 Macrophages

(2013) Guiyuan Ji et al.   PLoS One

Baicalein Reduces Airway Injury in Allergen and IL-13 Induced Airway Inflammation

(2013) Ulaganathan Mabalirajan et al.   PLoS One

Flavonoid Bioavailability and Attempts for Bioavailability Enhancement

(2013) Surangi Thilakarathna et al.   Nutrients

Mechanisms of Inflammatory Responses in Obese Adipose Tissue

(2012) Shengyi Sun et al.   Annual Review of Nutrition

A randomized, double blinded, placebo-controlled clinical trial of silymarin in ulcerative colitis

(2012) Mansoor Rastegarpanah et al.   Chinese Journal of Integrative Medicine

Peracetylated (−)-Epigallocatechin-3-gallate (AcEGCG) Potently Suppresses Dextran Sulfate Sodium-Induced Colitis and Colon Tumorigenesis in Mice

(2012) Yi-Shiou Chiou et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Bilberry ingestion improves disease activity in mild to moderate ulcerative colitis — An open pilot study

(2012) Luc Biedermann et al.   Journal of Crohns & Colitis

A Low Dose of Fermented Soy Germ Alleviates Gut Barrier Injury, Hyperalgesia and Faecal Protease Activity in a Rat Model of Inflammatory Bowel Disease

(2012) Lara Moussa et al.   PLoS One

Soy Isoflavone Equol Perpetuates Dextran Sulfate Sodium-Induced Acute Colitis in Mice

(2011) Tohru SAKAI et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Dietary Kaempferol Suppresses Inflammation of Dextran Sulfate Sodium-Induced Colitis in Mice

(2011) Mi-Young Park et al.   DIGESTIVE DISEASES AND SCIENCES

Increasing Incidence and Prevalence of the Inflammatory Bowel Diseases With Time, Based on Systematic Review

(2011) Natalie A. Molodecky et al.   GASTROENTEROLOGY

Proanthocyanidins from grape seeds modulates the nuclear factor-kappa B signal transduction pathways in rats with TNBS-induced recurrent ulcerative colitis

(2011) Yan-Hong Wang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Inhibition of Ulcerative Colitis in Mice after Oral Administration of a Polyphenol-Enriched Cocoa Extract Is Mediated by the Inhibition of STAT1 and STAT3 Phosphorylation in Colon Cells

(2011) Isabel Andújar et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Green tea polyphenol epigallocatechin-3-gallate shows therapeutic antioxidative effects in a murine model of colitis

(2011) Markus Brückner et al.   Journal of Crohns & Colitis

A Review on the Dietary Flavonoid Kaempferol

(2011) J. M. Calderon-Montano et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Bilberries and their anthocyanins ameliorate experimental colitis

(2011) Heidi Piberger et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Proanthocyanidins from Grape Seeds Modulate the NF-κB Signal Transduction Pathways in Rats with TNBS-Induced Ulcerative Colitis

(2011) Xiaoli Li et al.   MOLECULES

Influence of dietary blueberry and broccoli on cecal microbiota activity and colon morphology in mdr1a−/− mice, a model of inflammatory bowel diseases

(2011) Gunaranjan Paturi et al.   NUTRITION

Anti-inflammatory effects of dietary phenolic compounds in an in vitro model of inflamed human intestinal epithelium

(2010) Thérèse Sergent et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Effect of kaempferol on lipid peroxidation and antioxidant status in 1,2-dimethyl hydrazine induced colorectal carcinoma in rats

(2010) Parthasarathy Nirmala et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Cyanidin-3-O-β-glucoside inhibits LPS-induced expression of inflammatory mediators through decreasing IκBα phosphorylation in THP-1 cells

(2010) Yinghui Zhang et al.   INFLAMMATION RESEARCH

Cyanidin-3-O-glucoside Protection against TNF-α-Induced Endothelial Dysfunction: Involvement of Nuclear Factor-κB Signaling

(2010) Antonio Speciale et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Evaluation of Antiproliferative, Anti-Type 2 Diabetes, and Antihypertension Potentials of Ellagitannins from Strawberries (Fragaria × ananassa Duch.) Using In Vitro Models

(2010) Marcia da Silva Pinto et al.   JOURNAL OF MEDICINAL FOOD

Pigmented Potato Consumption Alters Oxidative Stress and Inflammatory Damage in Men

(2010) Kerrie L. Kaspar et al.   JOURNAL OF NUTRITION

The Biochemistry, Chemistry and Physiology of the Isoflavones in Soybeans and their Food Products

(2010) Stephen Barnes   Lymphatic Research and Biology

Bioavailability of dietary flavonoids and phenolic compounds

(2010) Alan Crozier et al.   MOLECULAR ASPECTS OF MEDICINE

Targeting Inflammatory Pathways by Flavonoids for Prevention and Treatment of Cancer

(2010) Sahdeo Prasad et al.   PLANTA MEDICA

Oral treatment with genistein reduces the expression of molecular and biochemical markers of inflammation in a rat model of chronic TNBS-induced colitis

(2009) Jan Seibel et al.   EUROPEAN JOURNAL OF NUTRITION

Flavonoids as anti-inflammatory agents: implications in cancer and cardiovascular disease

(2009) Ana García-Lafuente et al.   INFLAMMATION RESEARCH

Isoflavones regulate innate immunity and inhibit experimental colitis

(2009) Masakazu Morimoto et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Anti-Invasive Activity of Anthocyanins Isolated from Vitis coignetiae in Human Hepatocarcinoma Cells

(2009) Dong Yeok Shin et al.   JOURNAL OF MEDICINAL FOOD

Quercetin Enhances Intestinal Barrier Function through the Assembly of Zonnula Occludens-2, Occludin, and Claudin-1 and the Expression of Claudin-4 in Caco-2 Cells

(2009) Takuya Suzuki et al.   JOURNAL OF NUTRITION

Suppressive Effect of an Isoflavone Fraction on Tumor Necrosis Factor-α-Induced Interleukin-8 Production in Human Intestinal Epithelial Caco-2 Cells

(2009) Hideo SATSU et al.   JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY

Oestradiol decreases colonic permeability through oestrogen receptor β-mediated up-regulation of occludin and junctional adhesion molecule-A in epithelial cells

(2009) Viorica Braniste et al.   JOURNAL OF PHYSIOLOGY-LONDON

Effect of glycosidation of isoflavones on their bioavailability and pharmacokinetics in aged male rats

(2009) Estatira Sepehr et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Modulating effect of Hesperidin on experimental murine colitis induced by dextran sulfate sodium

(2009) Lei Xu et al.   PHYTOMEDICINE

In utero and postnatal exposure to a phytoestrogen-enriched diet increases parameters of acute inflammation in a rat model of TNBS-induced colitis

(2008) Jan Seibel et al.   ARCHIVES OF TOXICOLOGY

Therapeutic effect and mechanism of proanthocyanidins from grape seeds in rats with TNBS-induced ulcerative colitis

(2008) Xiao-Li Li et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Enzyme-Assisted Processing Increases Antimicrobial and Antioxidant Activity of Bilberry

(2008) Riitta Puupponen-Pimiä et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Effects of Black Soybean [Glycine max (L.) Merr.] Seed Coats and Its Anthocyanidins on Colonic Inflammation and Cell Proliferationin Vitroandin Vivo

(2008) Jung-Mi Kim et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY