Established and emerging strategies to crack the genetic code of obesity
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Title
Established and emerging strategies to crack the genetic code of obesity
Authors
Keywords
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Journal
Obesity Reviews
Volume 20, Issue 2, Pages 212-240
Publisher
Wiley
Online
2018-10-24
DOI
10.1111/obr.12770
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Note: Only part of the references are listed.- Three siblings with Prader-Willi syndrome caused by imprinting center microdeletions and review
- (2018) Samantha N. Hartin et al. AMERICAN JOURNAL OF MEDICAL GENETICS PART A
- A fine-mapping study of central obesity loci incorporating functional annotation and imputation
- (2018) Xiaoyu Zhang et al. EUROPEAN JOURNAL OF HUMAN GENETICS
- Subcellular localization of MC4R with ADCY3 at neuronal primary cilia underlies a common pathway for genetic predisposition to obesity
- (2018) Jacqueline E. Siljee et al. NATURE GENETICS
- Loss-of-function variants in ADCY3 increase risk of obesity and type 2 diabetes
- (2018) Niels Grarup et al. NATURE GENETICS
- Loss-of-function mutations in ADCY3 cause monogenic severe obesity
- (2018) Sadia Saeed et al. NATURE GENETICS
- Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes
- (2018) Anubha Mahajan et al. NATURE GENETICS
- MC4R agonism promotes durable weight loss in patients with leptin receptor deficiency
- (2018) Karine Clément et al. NATURE MEDICINE
- Comprehensive review and annotation of susceptibility SNPs associated with obesity-related traits
- (2018) S.-S. Dong et al. Obesity Reviews
- Evidence for a strong genetic influence on childhood adiposity despite the force of the obesogenic environment
- (2018) Jane Wardle et al. AMERICAN JOURNAL OF CLINICAL NUTRITION
- Untangling the relationship between diet and visceral fat mass through blood metabolomics and gut microbiome profiling
- (2017) T Pallister et al. INTERNATIONAL JOURNAL OF OBESITY
- Whole-exome sequencing study reveals common copy number variants in protocadherin genes associated with childhood obesity in Koreans
- (2017) S Moon et al. INTERNATIONAL JOURNAL OF OBESITY
- Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity
- (2017) Valérie Turcot et al. NATURE GENETICS
- Genome-wide association study identifies 112 new loci for body mass index in the Japanese population
- (2017) Masato Akiyama et al. NATURE GENETICS
- Convergence between biological, behavioural and genetic determinants of obesity
- (2017) Sujoy Ghosh et al. NATURE REVIEWS GENETICS
- Prioritizing diversity in human genomics research
- (2017) Lucia A. Hindorff et al. NATURE REVIEWS GENETICS
- Mechanisms, Pathophysiology, and Management of Obesity
- (2017) Steven B. Heymsfield et al. NEW ENGLAND JOURNAL OF MEDICINE
- Genome-wide analysis identifies an african-specific variant in SEMA4D associated with body mass index
- (2017) Guanjie Chen et al. Obesity
- A systematic review of genetic syndromes with obesity
- (2017) Y. Kaur et al. Obesity Reviews
- Ethnic and population differences in the genetic predisposition to human obesity
- (2017) C. Stryjecki et al. Obesity Reviews
- Detection and quantification of inbreeding depression for complex traits from SNP data
- (2017) Loic Yengo et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Large meta-analysis of genome-wide association studies identifies five loci for lean body mass
- (2017) M. Carola Zillikens et al. Nature Communications
- CNV-association meta-analysis in 191,161 European adults reveals new loci associated with anthropometric traits
- (2017) Aurélien Macé et al. Nature Communications
- Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits
- (2017) Anne E. Justice et al. Nature Communications
- Exploration of haplotype research consortium imputation for genome-wide association studies in 20,032 Generation Scotland participants
- (2017) Reka Nagy et al. Genome Medicine
- Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults
- (2017) Mariaelisa Graff et al. PLoS Genetics
- Discovery and fine-mapping of adiposity loci using high density imputation of genome-wide association studies in individuals of African ancestry: African Ancestry Anthropometry Genetics Consortium
- (2017) Maggie C. Y. Ng et al. PLoS Genetics
- Evaluation of a melanocortin-4 receptor (MC4R) agonist (Setmelanotide) in MC4R deficiency
- (2017) Tinh-Hai Collet et al. Molecular Metabolism
- Neuroligin 2 nonsense variant associated with anxiety, autism, intellectual disability, hyperphagia, and obesity
- (2016) Daniel J. Parente et al. AMERICAN JOURNAL OF MEDICAL GENETICS PART A
- Is the $1000 Genome as Near as We Think? A Cost Analysis of Next-Generation Sequencing
- (2016) Kirsten J.M. van Nimwegen et al. CLINICAL CHEMISTRY
- The importance of gene-environment interactions in human obesity
- (2016) H. Reddon et al. CLINICAL SCIENCE
- Recent progress in genetics, epigenetics and metagenomics unveils the pathophysiology of human obesity
- (2016) M. Pigeyre et al. CLINICAL SCIENCE
- Whole-Exome Sequencing SuggestsLAMB3as a Susceptibility Gene for Morbid Obesity
- (2016) Hong Jiao et al. DIABETES
- Variants in the FTO and CDKAL1 loci have recessive effects on risk of obesity and type 2 diabetes, respectively
- (2016) Andrew R. Wood et al. DIABETOLOGIA
- De novo nonsense and frameshift variants of TCF20 in individuals with intellectual disability and postnatal overgrowth
- (2016) Johanna Schäfgen et al. EUROPEAN JOURNAL OF HUMAN GENETICS
- Novel Leptin Receptor Mutations Identified in Two Girls with Severe Obesity Are Associated with Increased Bone Mineral Density
- (2016) Sabine E. Hannema et al. Hormone Research in Paediatrics
- Discovery of rare variants for complex phenotypes
- (2016) Jack A. Kosmicki et al. HUMAN GENETICS
- Testing the role of predicted gene knockouts in human anthropometric trait variation
- (2016) Samuel Lessard et al. HUMAN MOLECULAR GENETICS
- Obesity and developmental delay in a patient with uniparental disomy of chromosome 2
- (2016) T Yu et al. INTERNATIONAL JOURNAL OF OBESITY
- Identification of a novel mutation confirms the implication of IFT172 (BBS20) in Bardet–Biedl syndrome
- (2016) Elise Schaefer et al. JOURNAL OF HUMAN GENETICS
- The genetic architecture of type 2 diabetes
- (2016) Christian Fuchsberger et al. NATURE
- Analysis of protein-coding genetic variation in 60,706 humans
- (2016) Monkol Lek et al. NATURE
- Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin
- (2016) Kaixin Zhou et al. NATURE GENETICS
- Identification of 15 genetic loci associated with risk of major depression in individuals of European descent
- (2016) Craig L Hyde et al. NATURE GENETICS
- A thrifty variant in CREBRF strongly influences body mass index in Samoans
- (2016) Ryan L Minster et al. NATURE GENETICS
- Multiethnic genome-wide meta-analysis of ectopic fat depots identifies loci associated with adipocyte development and differentiation
- (2016) Audrey Y Chu et al. NATURE GENETICS
- Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets
- (2016) Zhihong Zhu et al. NATURE GENETICS
- Integrative approaches for large-scale transcriptome-wide association studies
- (2016) Alexander Gusev et al. NATURE GENETICS
- Type 2 diabetes: genetic data sharing to advance complex disease research
- (2016) Jason Flannick et al. NATURE REVIEWS GENETICS
- Proopiomelanocortin Deficiency Treated with a Melanocortin-4 Receptor Agonist
- (2016) Peter Kühnen et al. NEW ENGLAND JOURNAL OF MEDICINE
- CNV analysis and mutation screening indicate an important role for theNPY4Rgene in human obesity
- (2016) Evi Aerts et al. Obesity
- C8orf37 is mutated in Bardet-Biedl syndrome and constitutes a locus allelic to non-syndromic retinal dystrophies
- (2016) Arif O. Khan et al. OPHTHALMIC GENETICS
- The phenotypic legacy of admixture between modern humans and Neandertals
- (2016) C. N. Simonti et al. SCIENCE
- New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk
- (2016) Yingchang Lu et al. Nature Communications
- A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape
- (2016) Janina S. Ried et al. Nature Communications
- Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels
- (2016) Tuomas O. Kilpeläinen et al. Nature Communications
- Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA
- (2016) Johannes Kettunen et al. Nature Communications
- Empirical evaluation of the Q-Genie tool: a protocol for assessment of effectiveness
- (2016) Z N Sohani et al. BMJ Open
- snpGeneSets : An R Package for Genome-Wide Study Annotation
- (2016) Hao Mei et al. G3-Genes Genomes Genetics
- Re: "The Association of Common Variants in PCSK1 With Obesity: A HuGE Review and Meta-Analysis"
- (2015) D. Meyre AMERICAN JOURNAL OF EPIDEMIOLOGY
- Detection of Chromosomal Aberrations in Clinical Practice: From Karyotype to Genome Sequence
- (2015) Christa Lese Martin et al. Annual Review of Genomics and Human Genetics
- GenoWAP: GWAS signal prioritization through integrated analysis of genomic functional annotation
- (2015) Qiongshi Lu et al. BIOINFORMATICS
- Assessing the quality of published genetic association studies in meta-analyses: the quality of genetic studies (Q-Genie) tool
- (2015) Zahra N. Sohani et al. BMC GENETICS
- Novel VPS13B Mutations in Three Large Pakistani Cohen Syndrome Families Suggests a Baloch Variant with Autistic-Like Features
- (2015) Muhammad Arshad Rafiq et al. BMC Medical Genetics
- From big data analysis to personalized medicine for all: challenges and opportunities
- (2015) Akram Alyass et al. BMC Medical Genomics
- The SickKids Genome Clinic: developing and evaluating a pediatric model for individualized genomic medicine
- (2015) S.C. Bowdin et al. CLINICAL GENETICS
- Targeted multi-gene panel testing for the diagnosis of Bardet Biedl syndrome: Identification of nine novel mutations across BBS1, BBS2, BBS4, BBS7, BBS9, BBS10 genes
- (2015) Asli Ece Solmaz et al. European Journal of Medical Genetics
- Contribution of common non-synonymous variants in PCSK1 to body mass index variation and risk of obesity: a systematic review and meta-analysis with evidence from up to 331 175 individuals
- (2015) K. T. Nead et al. HUMAN MOLECULAR GENETICS
- Gene-based meta-analysis of genome-wide association studies implicates new loci involved in obesity
- (2015) Sara Hägg et al. HUMAN MOLECULAR GENETICS
- A genome-wide association study of body mass index across early life and childhood
- (2015) N. M. Warrington et al. INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
- A novel interaction between the FLJ33534 locus and smoking in obesity: a genome-wide study of 14 131 Pakistani adults
- (2015) S Ahmad et al. INTERNATIONAL JOURNAL OF OBESITY
- Whole Exome Sequencing IdentifiesRAI1Mutation in a Morbidly Obese Child Diagnosed With ROHHAD Syndrome
- (2015) Vidhu V. Thaker et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Mutations inCOA3cause isolated complex IV deficiency associated with neuropathy, exercise intolerance, obesity, and short stature
- (2015) Elsebet Ostergaard et al. JOURNAL OF MEDICAL GENETICS
- New genetic loci link adipose and insulin biology to body fat distribution
- (2015) Dmitry Shungin et al. NATURE
- Integrative analysis of 111 reference human epigenomes
- (2015) Anshul Kundaje et al. NATURE
- A global reference for human genetic variation
- (2015) Richard A. Gibbs et al. NATURE
- Genetic studies of body mass index yield new insights for obesity biology
- (2015) Adam E. Locke et al. NATURE
- Germline gain-of-function mutations in AFF4 cause a developmental syndrome functionally linking the super elongation complex and cohesin
- (2015) Kosuke Izumi et al. NATURE GENETICS
- Structural forms of the human amylase locus and their relationships to SNPs, haplotypes and obesity
- (2015) Christina L Usher et al. NATURE GENETICS
- Genetic variance estimation with imputed variants finds negligible missing heritability for human height and body mass index
- (2015) Jian Yang et al. NATURE GENETICS
- A gene-based association method for mapping traits using reference transcriptome data
- (2015) Eric R Gamazon et al. NATURE GENETICS
- Endocrine disruptors and obesity
- (2015) Jerrold J. Heindel et al. Nature Reviews Endocrinology
- Human genotype–phenotype databases: aims, challenges and opportunities
- (2015) Anthony J. Brookes et al. NATURE REVIEWS GENETICS
- A New Initiative on Precision Medicine
- (2015) Francis S. Collins et al. NEW ENGLAND JOURNAL OF MEDICINE
- Genetic variants inLEP,LEPR, andMC4Rexplain 30% of severe obesity in children from a consanguineous population
- (2015) Sadia Saeed et al. Obesity
- Relationship between sleep duration and body mass index depends on age
- (2015) Michael A. Grandner et al. Obesity
- The role for adipose tissue in weight regain after weight loss
- (2015) P. S. MacLean et al. Obesity Reviews
- Genome-wide association study identifies novel genetic variants contributing to variation in blood metabolite levels
- (2015) Harmen H. M. Draisma et al. Nature Communications
- Rare variant association studies: considerations, challenges and opportunities
- (2015) Paul L Auer et al. Genome Medicine
- The Power of Gene-Based Rare Variant Methods to Detect Disease-Associated Variation and Test Hypotheses About Complex Disease
- (2015) Loukas Moutsianas et al. PLoS Genetics
- The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study
- (2015) Thomas W. Winkler et al. PLoS Genetics
- UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old Age
- (2015) Cathie Sudlow et al. PLOS MEDICINE
- Whole Exome Sequencing Identifies a Novel and a Recurrent Mutation inBBS2Gene in a Family with Bardet-Biedl Syndrome
- (2015) Yong Mong Bee et al. Biomed Research International
- Obesity genetics in mouse and human: back and forth, and back again
- (2015) Fereshteh T. Yazdi et al. PeerJ
- Second-generation PLINK: rising to the challenge of larger and richer datasets
- (2015) Christopher C Chang et al. GigaScience
- Identification of Two Cases of Ciliopathy-Associated Diabetes and Their Mutation Analysis Using Whole Exome Sequencing
- (2015) Min Kyeong Kim et al. Diabetes & Metabolism Journal
- CREBBPandEP300mutational spectrum and clinical presentations in a cohort of Swedish patients with Rubinstein-Taybi syndrome
- (2015) Josephine Wincent et al. Molecular Genetics & Genomic Medicine
- Contiguous mutation syndrome in the era of high-throughput sequencing
- (2015) Maéva Langouët et al. Molecular Genetics & Genomic Medicine
- Truncating Homozygous Mutation of Carboxypeptidase E (CPE) in a Morbidly Obese Female with Type 2 Diabetes Mellitus, Intellectual Disability and Hypogonadotrophic Hypogonadism
- (2015) Suzanne I. M. Alsters et al. PLoS One
- The Relationship Between Obesity and Exposure to Light at Night: Cross-Sectional Analyses of Over 100,000 Women in the Breakthrough Generations Study
- (2014) E. McFadden et al. AMERICAN JOURNAL OF EPIDEMIOLOGY
- The Association of Common Variants in PCSK1 With Obesity: A HuGE Review and Meta-Analysis
- (2014) Pieter Stijnen et al. AMERICAN JOURNAL OF EPIDEMIOLOGY
- Value of whole exome sequencing for syndromic retinal dystrophy diagnosis in young patients
- (2014) Ivan Prokudin et al. CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
- The genetics of fat distribution
- (2014) Dorit Schleinitz et al. DIABETOLOGIA
- Beneficial effect of a high number of copies of salivary amylase AMY1 gene on obesity risk in Mexican children
- (2014) María A. Mejía-Benítez et al. DIABETOLOGIA
- Deficiency of the bone mineralization inhibitor NPP1 protects mice against obesity and diabetes
- (2014) C. Huesa et al. Disease Models & Mechanisms
- Coffin–Siris Syndrome with obesity, macrocephaly, hepatomegaly and hyperinsulinism caused by a mutation in the ARID1B gene
- (2014) Mari-Anne Vals et al. EUROPEAN JOURNAL OF HUMAN GENETICS
- Exome sequencing followed by genotyping suggests SYPL2 as a susceptibility gene for morbid obesity
- (2014) Hong Jiao et al. EUROPEAN JOURNAL OF HUMAN GENETICS
- Atypical Alstrom syndrome with novel ALMS1 mutations precluded by current diagnostic criteria
- (2014) Jillian Casey et al. European Journal of Medical Genetics
- Chip-based direct genotyping of coding variants in genome wide association studies: Utility, issues and prospects
- (2014) Caroline M. Nievergelt et al. GENE
- Mutations in IFT172 cause isolated retinal degeneration and Bardet–Biedl syndrome
- (2014) Kinga M. Bujakowska et al. HUMAN MOLECULAR GENETICS
- IFT27, encoding a small GTPase component of IFT particles, is mutated in a consanguineous family with Bardet-Biedl syndrome
- (2014) M. A. Aldahmesh et al. HUMAN MOLECULAR GENETICS
- Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index
- (2014) Wanqing Wen et al. HUMAN MOLECULAR GENETICS
- A nonsense loss-of-function mutation in PCSK1 contributes to dominantly inherited human obesity
- (2014) J Philippe et al. INTERNATIONAL JOURNAL OF OBESITY
- Energy balance measurement: when something is not better than nothing
- (2014) N V Dhurandhar et al. INTERNATIONAL JOURNAL OF OBESITY
- Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study 2013
- (2014) Marie Ng et al. LANCET
- Pleiotropic genes for metabolic syndrome and inflammation
- (2014) Aldi T. Kraja et al. MOLECULAR GENETICS AND METABOLISM
- Data use under the NIH GWAS Data Sharing Policy and future directions
- (2014) NATURE GENETICS
- Low copy number of the salivary amylase gene predisposes to obesity
- (2014) Mario Falchi et al. NATURE GENETICS
- An atlas of genetic influences on human blood metabolites
- (2014) So-Youn Shin et al. NATURE GENETICS
- Sequencing depth and coverage: key considerations in genomic analyses
- (2014) David Sims et al. NATURE REVIEWS GENETICS
- A Form of the Metabolic Syndrome Associated with Mutations in DYRK1B
- (2014) Ali R. Keramati et al. NEW ENGLAND JOURNAL OF MEDICINE
- Genome-Wide Association Studies and Heritability Estimates of Body Mass Index Related Phenotypes in Bangladeshi Adults
- (2014) Molly Scannell Bryan et al. PLoS One
- Using genetically isolated populations to understand the genomic basis of disease
- (2014) Eleftheria Zeggini Genome Medicine
- Trans-ethnic genome-wide association studies: advantages and challenges of mapping in diverse populations
- (2014) Yun R Li et al. Genome Medicine
- Novel Approach Identifies SNPs in SLC2A10 and KCNK9 with Evidence for Parent-of-Origin Effect on Body Mass Index
- (2014) Clive J. Hoggart et al. PLoS Genetics
- Chromosome X-Wide Association Study Identifies Loci for Fasting Insulin and Height and Evidence for Incomplete Dosage Compensation
- (2014) Taru Tukiainen et al. PLoS Genetics
- Genome-wide meta-analysis of observational studies shows common genetic variants associated with macronutrient intake
- (2013) Toshiko Tanaka et al. AMERICAN JOURNAL OF CLINICAL NUTRITION
- Weight Loss after Gastric Bypass Is Associated with a Variant at 15q26.1
- (2013) Ida J. Hatoum et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Fine Mapping and Identification of BMI Loci in African Americans
- (2013) Jian Gong et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Long Runs of Homozygosity Are Enriched for Deleterious Variation
- (2013) Zachary A. Szpiech et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Small mosaic deletion encompassing the snoRNAs andSNURF-SNRPNresults in an atypical Prader-Willi syndrome phenotype
- (2013) Britt-Marie Anderlid et al. AMERICAN JOURNAL OF MEDICAL GENETICS PART A
- Clinical and genetic characterization of Bardet-Biedl syndrome in Tunisia: defining a strategy for molecular diagnosis
- (2013) O. M'hamdi et al. CLINICAL GENETICS
- Finding Novel Genes by Testing G × E Interactions in a Genome-Wide Association Study
- (2013) W. James Gauderman et al. GENETIC EPIDEMIOLOGY
- Post-GWAS: where next? More samples, more SNPs or more biology?
- (2013) P Marjoram et al. HEREDITY
- Next-Generation Sequence Analysis of Genes Associated with Obesity and Nonalcoholic Fatty Liver Disease-Related Cirrhosis in Extreme Obesity
- (2013) Glenn S. Gerhard et al. HUMAN HEREDITY
- Genetic Admixture and Obesity: Recent Perspectives and Future Applications
- (2013) José R. Fernández et al. HUMAN HEREDITY
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- (2013) L. Bian et al. HUMAN MOLECULAR GENETICS
- Novel locus including FGF21 is associated with dietary macronutrient intake
- (2013) Audrey Y. Chu et al. HUMAN MOLECULAR GENETICS
- A Homozygous Mutation in theTUBGene Associated with Retinal Dystrophy and Obesity
- (2013) Arundhati Dev Borman et al. HUMAN MUTATION
- Loss-of-function mutations in SIM1 contribute to obesity and Prader-Willi–like features
- (2013) Amélie Bonnefond et al. JOURNAL OF CLINICAL INVESTIGATION
- Rare variants in single-minded 1 (SIM1) are associated with severe obesity
- (2013) Shwetha Ramachandrappa et al. JOURNAL OF CLINICAL INVESTIGATION
- Exome sequencing of Bardet–Biedl syndrome patient identifies a null mutation in the BBSome subunitBBIP1(BBS18)
- (2013) Sophie Scheidecker et al. JOURNAL OF MEDICAL GENETICS
- The lactase persistence genotype is associated with body mass index and dairy consumption in the D.E.S.I.R. study
- (2013) Amel Lamri et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Truncating mutations of MAGEL2 cause Prader-Willi phenotypes and autism
- (2013) Christian P Schaaf et al. NATURE GENETICS
- A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry
- (2013) Keri L Monda et al. NATURE GENETICS
- Evaluating empirical bounds on complex disease genetic architecture
- (2013) Vineeta Agarwala et al. NATURE GENETICS
- Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture
- (2013) Sonja I Berndt et al. NATURE GENETICS
- Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset obesity
- (2013) Eleanor Wheeler et al. NATURE GENETICS
- The Genotype-Tissue Expression (GTEx) project
- (2013) John Lonsdale et al. NATURE GENETICS
- Genetic risk factors for BMI and obesity in an ethnically diverse population: Results from the population architecture using genomics and epidemiology (PAGE) study
- (2013) Megan D. Fesinmeyer et al. Obesity
- Pro12Ala variant of thePPARG2gene increases body mass index: An updated meta-analysis encompassing 49,092 subjects
- (2013) C. Galbete et al. Obesity
- Whole-Exome sequencing identifies novelLEPRmutations in individuals with severe early onset obesity
- (2013) Richard Gill et al. Obesity
- Whole exome sequencing identifies variation inCYB5AandRNF10associated with adiposity and type 2 diabetes
- (2013) Ke Huang et al. Obesity
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- (2013) Jonathan A. Mitchell et al. Obesity
- NovelLEPRmutations in obese Pakistani children identified by PCR-based enrichment and next generation sequencing
- (2013) Sadia Saeed et al. Obesity
- Rare Genomic Structural Variants in Complex Disease: Lessons from the Replication of Associations with Obesity
- (2013) Robin G. Walters et al. PLoS One
- Best Practices and Joint Calling of the HumanExome BeadChip: The CHARGE Consortium
- (2013) Megan L. Grove et al. PLoS One
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- (2013) M. Asai et al. SCIENCE
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- (2013) Daisy Rymen et al. PLoS Genetics
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- (2012) Peter M. Visscher et al. AMERICAN JOURNAL OF HUMAN GENETICS
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- (2012) Phi Yen Vu et al. AMERICAN JOURNAL OF MEDICAL GENETICS PART A
- Molecular Basis of Obesity: Current Status and Future Prospects
- (2012) Helene Choquet et al. CURRENT GENOMICS
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- (2012) Binod Neupane et al. EUROPEAN JOURNAL OF HUMAN GENETICS
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- (2012) Rick Twee-Hee Ong et al. EUROPEAN JOURNAL OF HUMAN GENETICS
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- (2012) Francesca Novara et al. European Journal of Medical Genetics
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- (2012) Julia S. El-Sayed Moustafa et al. HUMAN MOLECULAR GENETICS
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- (2012) Karani S. Vimaleswaran et al. HUMAN MOLECULAR GENETICS
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- (2012) Yiran Guo et al. HUMAN MOLECULAR GENETICS
- Challenges in reproducibility of genetic association studies: lessons learned from the obesity field
- (2012) A Li et al. INTERNATIONAL JOURNAL OF OBESITY
- Human SH2B1 mutations are associated with maladaptive behaviors and obesity
- (2012) Michael E. Doche et al. JOURNAL OF CLINICAL INVESTIGATION
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- (2012) Priya B. Shetty et al. JOURNAL OF HYPERTENSION
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- (2012) Vincent Marion et al. JOURNAL OF MEDICAL GENETICS
- X-exome sequencing identifies aHDAC8variant in a large pedigree with X-linked intellectual disability, truncal obesity, gynaecomastia, hypogonadism and unusual face
- (2012) Magdalena Harakalova et al. JOURNAL OF MEDICAL GENETICS
- FTO genotype is associated with phenotypic variability of body mass index
- (2012) Jian Yang et al. NATURE
- Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human
- (2012) Atsuhiko Ichimura et al. NATURE
- Extremely low-coverage sequencing and imputation increases power for genome-wide association studies
- (2012) Bogdan Pasaniuc et al. NATURE GENETICS
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- (2012) Yukinori Okada et al. NATURE GENETICS
- Meta-analysis identifies common variants associated with body mass index in east Asians
- (2012) Wanqing Wen et al. NATURE GENETICS
- Bayesian inference analyses of the polygenic architecture of rheumatoid arthritis
- (2012) Eli A Stahl et al. NATURE GENETICS
- Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits
- (2012) Jian Yang et al. NATURE GENETICS
- From patients to partners: participant-centric initiatives in biomedical research
- (2012) Jane Kaye et al. NATURE REVIEWS GENETICS
- Mining electronic health records: towards better research applications and clinical care
- (2012) Peter B. Jensen et al. NATURE REVIEWS GENETICS
- Loss-of-Function Mutations in MC4R Are Very Rare in the Greek Severely Obese Adult Population
- (2012) Konstantinos Rouskas et al. Obesity
- Quantile-Specific Penetrance of Genes Affecting Lipoproteins, Adiposity and Height
- (2012) Paul T. Williams PLoS One
- Genome-Wide Association for Abdominal Subcutaneous and Visceral Adipose Reveals a Novel Locus for Visceral Fat in Women
- (2012) Caroline S. Fox et al. PLoS Genetics
- The Metabochip, a Custom Genotyping Array for Genetic Studies of Metabolic, Cardiovascular, and Anthropometric Traits
- (2012) Benjamin F. Voight et al. PLoS Genetics
- Deletion of KDM6A, a Histone Demethylase Interacting with MLL2, in Three Patients with Kabuki Syndrome
- (2011) Damien Lederer et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Greater Impact of Melanocortin-4 Receptor Deficiency on Rates of Growth and Risk of Type 2 Diabetes During Childhood Compared With Adulthood in Pima Indians
- (2011) M. S. Thearle et al. DIABETES
- Heterozygous Mutations Causing Partial Prohormone Convertase 1 Deficiency Contribute to Human Obesity
- (2011) J. W. M. Creemers et al. DIABETES
- A Bivariate Genome-Wide Approach to Metabolic Syndrome: STAMPEED Consortium
- (2011) A. T. Kraja et al. DIABETES
- Health and economic burden of the projected obesity trends in the USA and the UK
- (2011) Y Claire Wang et al. LANCET
- Homozygosity for a novel missense mutation in the leptin receptor gene (P316T) in two Egyptian cousins with severe early onset obesity
- (2011) I. Mazen et al. MOLECULAR GENETICS AND METABOLISM
- Mirror extreme BMI phenotypes associated with gene dosage at the chromosome 16p11.2 locus
- (2011) Sébastien Jacquemont et al. NATURE
- Human metabolic individuality in biomedical and pharmaceutical research
- (2011) Karsten Suhre et al. NATURE
- Long-Term Persistence of Hormonal Adaptations to Weight Loss
- (2011) Priya Sumithran et al. NEW ENGLAND JOURNAL OF MEDICINE
- A Better Index of Body Adiposity
- (2011) Richard N. Bergman et al. Obesity
- Genetic Markers of Obesity Risk: Stronger Associations with Body Composition in Overweight Compared to Normal-Weight Children
- (2011) Andreas Beyerlein et al. PLoS One
- Mapping of disease-associated variants in admixed populations
- (2011) Daniel Shriner et al. GENOME BIOLOGY
- Admixture Mapping Comes of Age
- (2010) Cheryl A. Winkler et al. Annual Review of Genomics and Human Genetics
- GPR120 Is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-inflammatory and Insulin-Sensitizing Effects
- (2010) Da Young Oh et al. CELL
- Recurrent 200-kb deletions of 16p11.2 that include the SH2B1 gene are associated with developmental delay and obesity
- (2010) Ruxandra Bachmann-Gagescu et al. GENETICS IN MEDICINE
- Novel common copy number variation for early onset extreme obesity on chromosome 11q11 identified by a genome-wide analysis
- (2010) Ivonne Jarick et al. HUMAN MOLECULAR GENETICS
- Rare melanocortin-3 receptor mutations with in vitro functional consequences are associated with human obesity
- (2010) M. Mencarelli et al. HUMAN MOLECULAR GENETICS
- A new highly penetrant form of obesity due to deletions on chromosome 16p11.2
- (2010) R. G. Walters et al. NATURE
- A map of human genome variation from population-scale sequencing
- (2010) Richard M. Durbin et al. NATURE
- Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
- (2010) Elizabeth K Speliotes et al. NATURE GENETICS
- Common SNPs explain a large proportion of the heritability for human height
- (2010) Jian Yang et al. NATURE GENETICS
- New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
- (2010) Josée Dupuis et al. NATURE GENETICS
- Genome-wide association studies in diverse populations
- (2010) Noah A. Rosenberg et al. NATURE REVIEWS GENETICS
- Missing heritability and strategies for finding the underlying causes of complex disease
- (2010) Evan E. Eichler et al. NATURE REVIEWS GENETICS
- Genetic studies of common types of obesity: a critique of the current use of phenotypes
- (2010) M. J. Müller et al. Obesity Reviews
- The $1,000 genome, the $100,000 analysis?
- (2010) Elaine R Mardis Genome Medicine
- The Pro12Ala PPARγ2 Variant Determines Metabolism at the Gene-Environment Interface
- (2009) Sami Heikkinen et al. Cell Metabolism
- Ten Putative Contributors to the Obesity Epidemic
- (2009) Emily J. McAllister et al. CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
- Two British women studies replicated the association between the Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) and BMI
- (2009) Yin Yao Shugart et al. EUROPEAN JOURNAL OF HUMAN GENETICS
- Association of variants in the PCSK1 gene with obesity in the EPIC-Norfolk study
- (2009) T. O. Kilpelainen et al. HUMAN MOLECULAR GENETICS
- European lactase persistence genotype shows evidence of association with increase in body mass index
- (2009) J. Kettunen et al. HUMAN MOLECULAR GENETICS
- Multicenter dizygotic twin cohort study confirms two linkage susceptibility loci for body mass index at 3q29 and 7q36 and identifies three further potential novel loci
- (2009) J Kettunen et al. INTERNATIONAL JOURNAL OF OBESITY
- Genome-wide association study suggested copy number variation may be associated with body mass index in the Chinese population
- (2009) Bao-Yong Sha et al. JOURNAL OF HUMAN GENETICS
- Finding the missing heritability of complex diseases
- (2009) Teri A. Manolio et al. NATURE
- Large, rare chromosomal deletions associated with severe early-onset obesity
- (2009) Elena G. Bochukova et al. NATURE
- Targeted capture and massively parallel sequencing of 12 human exomes
- (2009) Sarah B. Ng et al. NATURE
- Reconstructing Indian population history
- (2009) David Reich et al. NATURE
- Exome sequencing identifies the cause of a mendelian disorder
- (2009) Sarah B Ng et al. NATURE GENETICS
- Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations
- (2009) David Meyre et al. NATURE GENETICS
- INPP5E mutations cause primary cilium signaling defects, ciliary instability and ciliopathies in human and mouse
- (2009) Monique Jacoby et al. NATURE GENETICS
- Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease
- (2009) David-Alexandre Trégouët et al. NATURE GENETICS
- Admixture Mapping of Obesity-related Traits in African Americans: The Atherosclerosis Risk in Communities (ARIC) Study*
- (2009) Ching-Yu Cheng et al. Obesity
- Consanguinity, human evolution, and complex diseases
- (2009) A. H. Bittles et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- MRAP and MRAP2 are bidirectional regulators of the melanocortin receptor family
- (2009) L. F. Chan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Potential etiologic and functional implications of genome-wide association loci for human diseases and traits
- (2009) L. A. Hindorff et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Genetic diagnosis by whole exome capture and massively parallel DNA sequencing
- (2009) Murim Choi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Admixture Mapping of 15,280 African Americans Identifies Obesity Susceptibility Loci on Chromosomes 5 and X
- (2009) Ching-Yu Cheng et al. PLoS Genetics
- Genome-Wide Association Studies in an Isolated Founder Population from the Pacific Island of Kosrae
- (2009) Jennifer K. Lowe et al. PLoS Genetics
- Prevalence of Melanocortin-4 Receptor Deficiency in Europeans and Their Age-Dependent Penetrance in Multigenerational Pedigrees
- (2008) F. Stutzmann et al. DIABETES
- Detailed phenotype–genotype study in five patients with chromosome 6q16 deletion: narrowing the critical region for Prader–Willi-like phenotype
- (2008) Maria Clara Bonaglia et al. EUROPEAN JOURNAL OF HUMAN GENETICS
- Preferential reciprocal transfer of paternal/maternal DLK1 alleles to obese children: first evidence of polar overdominance in humans
- (2008) Anne-Kathrin Wermter et al. EUROPEAN JOURNAL OF HUMAN GENETICS
- Estimation of significance thresholds for genomewide association scans
- (2008) Frank Dudbridge et al. GENETIC EPIDEMIOLOGY
- Estimation of the multiple testing burden for genomewide association studies of nearly all common variants
- (2008) Itsik Pe'er et al. GENETIC EPIDEMIOLOGY
- R125W coding variant in TBC1D1 confers risk for familial obesity and contributes to linkage on chromosome 4p14 in the French population
- (2008) D. Meyre et al. HUMAN MOLECULAR GENETICS
- The ADRB3 Trp64Arg variant and BMI: a meta-analysis of 44 833 individuals
- (2008) N Kurokawa et al. INTERNATIONAL JOURNAL OF OBESITY
- Prader-Willi phenotype caused by paternal deficiency for the HBII-85 C/D box small nucleolar RNA cluster
- (2008) Trilochan Sahoo et al. NATURE GENETICS
- Common nonsynonymous variants in PCSK1 confer risk of obesity
- (2008) Michael Benzinou et al. NATURE GENETICS
- Tbc1d1 mutation in lean mouse strain confers leanness and protects from diet-induced obesity
- (2008) Alexandra Chadt et al. NATURE GENETICS
- Integrated detection and population-genetic analysis of SNPs and copy number variation
- (2008) Steven A McCarroll et al. NATURE GENETICS
- Six new loci associated with body mass index highlight a neuronal influence on body weight regulation
- (2008) Cristen J Willer et al. NATURE GENETICS
- Genome-wide association studies for complex traits: consensus, uncertainty and challenges
- (2008) Mark I. McCarthy et al. NATURE REVIEWS GENETICS
- Brain-Derived Neurotrophic Factor and Obesity in the WAGR Syndrome
- (2008) Joan C. Han et al. NEW ENGLAND JOURNAL OF MEDICINE
- The Prevalence of Obesity in Ethnic Admixture Adults
- (2008) Cheryl L. Albright et al. Obesity
- Concept, Design and Implementation of a Cardiovascular Gene-Centric 50 K SNP Array for Large-Scale Genomic Association Studies
- (2008) Brendan J. Keating et al. PLoS One
- Mutations in ligands and receptors of the leptin–melanocortin pathway that lead to obesity
- (2008) I Sadaf Farooqi et al. Nature clinical practice. Endocrinology & metabolism
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