Ethnic and population differences in the genetic predisposition to human obesity

A systematic review of genetic syndromes with obesity

(2017) Y. Kaur et al.   Obesity Reviews

Association of Body Mass Index with DNA Methylation and Gene Expression in Blood Cells and Relations to Cardiometabolic Disease: A Mendelian Randomization Approach

(2017) Michael M. Mendelson et al.   PLOS MEDICINE

Analysis of Positive Selection at Single Nucleotide Polymorphisms Associated with Body Mass Index Does Not Support the “Thrifty Gene” Hypothesis

(2016) Guanlin Wang et al.   Cell Metabolism

Interindividual Variation in DNA Methylation at a Putative POMC Metastable Epiallele Is Associated with Obesity

(2016) Peter Kühnen et al.   Cell Metabolism

The importance of gene-environment interactions in human obesity

(2016) H. Reddon et al.   CLINICAL SCIENCE

Recent progress in genetics, epigenetics and metagenomics unveils the pathophysiology of human obesity

(2016) M. Pigeyre et al.   CLINICAL SCIENCE

Testing the role of predicted gene knockouts in human anthropometric trait variation

(2016) Samuel Lessard et al.   HUMAN MOLECULAR GENETICS

Mutations inC8ORF37cause Bardet Biedl syndrome (BBS21)

(2016) Elise Heon et al.   HUMAN MOLECULAR GENETICS

Prevalence and phenotypic characterization of MC4R variants in a large pediatric cohort

(2016) H Vollbach et al.   INTERNATIONAL JOURNAL OF OBESITY

Identification of a novel mutation confirms the implication of IFT172 (BBS20) in Bardet–Biedl syndrome

(2016) Elise Schaefer et al.   JOURNAL OF HUMAN GENETICS

Causal inference in obesity research

(2016) P. W. Franks et al.   JOURNAL OF INTERNAL MEDICINE

Early Clinical Diagnosis of PC1/3 Deficiency in a Patient With a Novel Homozygous PCSK1 Splice-Site Mutation

(2016) Bettina Härter et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Epigenome-wide association study of body mass index and the adverse outcomes of adiposity

(2016) Simone Wahl et al.   NATURE

A thrifty variant in CREBRF strongly influences body mass index in Samoans

(2016) Ryan L Minster et al.   NATURE GENETICS

CNV analysis and mutation screening indicate an important role for theNPY4Rgene in human obesity

(2016) Evi Aerts et al.   Obesity

Taking race out of human genetics

(2016) M. Yudell et al.   SCIENCE

Physical activity and genetic predisposition to obesity in a multiethnic longitudinal study

(2016) Hudson Reddon et al.   Scientific Reports

From big data analysis to personalized medicine for all: challenges and opportunities

(2015) Akram Alyass et al.   BMC Medical Genomics

Bardet-Biedl syndrome: Is it only cilia dysfunction?

(2015) Rossina Novas et al.   FEBS LETTERS

Epigenome-wide association study (EWAS) of BMI, BMI change and waist circumference in African American adults identifies multiple replicated loci

(2015) Ellen W. Demerath et al.   HUMAN MOLECULAR GENETICS

Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index

(2015) Janine F. Felix et al.   HUMAN MOLECULAR GENETICS

Seven Novel DeleteriousLEPRMutations Found in Early-Onset Obesity: a ΔExon6–8 Shared by Subjects From Reunion Island, France, Suggests a Founder Effect

(2015) Hélène Huvenne et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Leptin treatment: Facts and expectations

(2015) Gilberto Paz-Filho et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Current review of genetics of human obesity: from molecular mechanisms to an evolutionary perspective

(2015) David Albuquerque et al.   MOLECULAR GENETICS AND GENOMICS

A global reference for human genetic variation

(2015) Richard A. Gibbs et al.   NATURE

Genetic studies of body mass index yield new insights for obesity biology

(2015) Adam E. Locke et al.   NATURE

Population genetic differentiation of height and body mass index across Europe

(2015) Matthew R Robinson et al.   NATURE GENETICS

Genetic variance estimation with imputed variants finds negligible missing heritability for human height and body mass index

(2015) Jian Yang et al.   NATURE GENETICS

FTO Obesity Variant Circuitry and Adipocyte Browning in Humans

(2015) Melina Claussnitzer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genetic variants inLEP,LEPR, andMC4Rexplain 30% of severe obesity in children from a consanguineous population

(2015) Sadia Saeed et al.   Obesity

HIF3A association with adiposity: the story begins before birth

(2015) Hong Pan et al.   Epigenomics

Interactions between Obesity-Related Copy Number Variants and Dietary Behaviors in Childhood Obesity

(2015) Dandan Zhang et al.   Nutrients

Many obesity-associated SNPs strongly associate with DNA methylation changes at proximal promoters and enhancers

(2015) Sarah Voisin et al.   Genome Medicine

A population-based profile of 160 Australians with Prader-Willi syndrome: Trends in diagnosis, birth prevalence and birth characteristics

(2014) Tess Lionti et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Fine-scale human genetic structure in Western France

(2014) Matilde Karakachoff et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index

(2014) Wanqing Wen et al.   HUMAN MOLECULAR GENETICS

DNA methylation and body-mass index: a genome-wide analysis

(2014) Katherine J Dick et al.   LANCET

Obesity-associated variants within FTO form long-range functional connections with IRX3

(2014) Scott Smemo et al.   NATURE

Trans-ethnic genome-wide association studies: advantages and challenges of mapping in diverse populations

(2014) Yun R Li et al.   Genome Medicine

Fine Mapping and Identification of BMI Loci in African Americans

(2013) Jian Gong et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Evolutionary Perspectives on the Obesity Epidemic: Adaptive, Maladaptive, and Neutral Viewpoints

(2013) John R. Speakman   Annual Review of Nutrition

Congenital Proprotein Convertase 1/3 Deficiency Causes Malabsorptive Diarrhea and Other Endocrinopathies in a Pediatric Cohort

(2013) Martín G. Martín et al.   GASTROENTEROLOGY

Genetic Admixture and Obesity: Recent Perspectives and Future Applications

(2013) José R. Fernández et al.   HUMAN HEREDITY

Finding the missing heritability in pediatric obesity: the contribution of genome-wide complex trait analysis

(2013) C H Llewellyn et al.   INTERNATIONAL JOURNAL OF OBESITY

Exome Sequencing Finds a Novel PCSK1 Mutation in a Child With Generalized Malabsorptive Diarrhea and Diabetes Insipidus

(2013) Michael Yourshaw et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Severe obesity and diabetes insipidus in a patient with PCSK1 deficiency

(2013) Graeme R. Frank et al.   MOLECULAR GENETICS AND METABOLISM

A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry

(2013) Keri L Monda et al.   NATURE GENETICS

Genetic risk factors for BMI and obesity in an ethnically diverse population: Results from the population architecture using genomics and epidemiology (PAGE) study

(2013) Megan D. Fesinmeyer et al.   Obesity

Obesity genomics: assessing the transferability of susceptibility loci across diverse populations

(2013) Yingchang Lu et al.   Genome Medicine

A Systematic Mapping Approach of 16q12.2/FTO and BMI in More Than 20,000 African Americans Narrows in on the Underlying Functional Variation: Results from the Population Architecture using Genomics and Epidemiology (PAGE) Study

(2013) Ulrike Peters et al.   PLoS Genetics

Lack of red hair phenotype in a North-African obese child homozygous for a novelPOMCnull mutation: nonsense-mediated decay RNA evaluation and hair pigment chemical analysis

(2012) G. Cirillo et al.   BRITISH JOURNAL OF DERMATOLOGY

Molecular Basis of Obesity: Current Status and Future Prospects

(2012) Helene Choquet et al.   CURRENT GENOMICS

Alstrom Syndrome: Genetics and Clinical Overview

(2012) Jan D. Marshall et al.   CURRENT GENOMICS

Efficiency of trans-ethnic genome-wide meta-analysis and fine-mapping

(2012) Rick Twee-Hee Ong et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Bardet–Biedl syndrome

(2012) Elizabeth Forsythe et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Challenges in reproducibility of genetic association studies: lessons learned from the obesity field

(2012) A Li et al.   INTERNATIONAL JOURNAL OF OBESITY

Variants in CXADR and F2RL1 are associated with blood pressure and obesity in African-Americans in regions identified through admixture mapping

(2012) Priya B. Shetty et al.   JOURNAL OF HYPERTENSION

A case of early-onset obesity, hypocortisolism, and skin pigmentation problem due to a novel homozygous mutation in the proopiomelanocortin (POMC) gene in an Indian boy

(2012) Ching-Ngar Hung et al.   JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM

High prevalence of leptin and melanocortin-4 receptor gene mutations in children with severe obesity from Pakistani consanguineous families

(2012) Sadia Saeed et al.   MOLECULAR GENETICS AND METABOLISM

Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human

(2012) Atsuhiko Ichimura et al.   NATURE

Common variants at CDKAL1 and KLF9 are associated with body mass index in east Asian populations

(2012) Yukinori Okada et al.   NATURE GENETICS

Associations of Variants inFTOand NearMC4RWith Obesity Traits in South Asian Indians

(2012) Senthil K. Vasan et al.   Obesity

Loss-of-Function Mutations in MC4R Are Very Rare in the Greek Severely Obese Adult Population

(2012) Konstantinos Rouskas et al.   Obesity

Association between Common Polymorphism near the MC4R Gene and Obesity Risk: A Systematic Review and Meta-Analysis

(2012) Bo Xi et al.   PLoS One

Beyond the fourth wave of genome-wide obesity association studies

(2012) C H Sandholt et al.   Nutrition & Diabetes

The Metabochip, a Custom Genotyping Array for Genetic Studies of Metabolic, Cardiovascular, and Anthropometric Traits

(2012) Benjamin F. Voight et al.   PLoS Genetics

Clinical variability of genetic isolates of Cohen syndrome

(2011) S Douzgou et al.   CLINICAL GENETICS

Greater Impact of Melanocortin-4 Receptor Deficiency on Rates of Growth and Risk of Type 2 Diabetes During Childhood Compared With Adulthood in Pima Indians

(2011) M. S. Thearle et al.   DIABETES

Heterozygous Mutations Causing Partial Prohormone Convertase 1 Deficiency Contribute to Human Obesity

(2011) J. W. M. Creemers et al.   DIABETES

Relationship between adiposity and admixture in African-American and Hispanic-American women

(2011) R Nassir et al.   INTERNATIONAL JOURNAL OF OBESITY

Cohen Syndrome-associated Protein, COH1, Is a Novel, Giant Golgi Matrix Protein Required for Golgi Integrity

(2011) Wenke Seifert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Homozygosity for two missense mutations in the leptin receptor gene (P316T;W646C) in a Turkmenian girl with severe early-onset obesity

(2011) Nesibe Andiran et al.   JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM

Homozygosity for a novel missense mutation in the leptin receptor gene (P316T) in two Egyptian cousins with severe early onset obesity

(2011) I. Mazen et al.   MOLECULAR GENETICS AND METABOLISM

A rare variant in MYH6 is associated with high risk of sick sinus syndrome

(2011) Hilma Holm et al.   NATURE GENETICS

Obesity Prevalence in the United States — Up, Down, or Sideways?

(2011) Susan Z. Yanovski et al.   NEW ENGLAND JOURNAL OF MEDICINE

Fats, inflammation and insulin resistance: insights to the role of macrophage and T-cell accumulation in adipose tissue

(2011) Karen A. Harford et al.   PROCEEDINGS OF THE NUTRITION SOCIETY

Physical Activity Attenuates the Influence of FTO Variants on Obesity Risk: A Meta-Analysis of 218,166 Adults and 19,268 Children

(2011) Tuomas O. Kilpeläinen et al.   PLOS MEDICINE

Global prevalence and trends of overweight and obesity among preschool children

(2010) Mercedes de Onis et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

High incidence of Bardet Biedl syndrome among the Bedouin

(2010) Talaat I. Farag et al.   CLINICAL GENETICS

PRADER-WILLI SYNDROME IN A SWEDISH RURAL COUNTY: EPIDEMIOLOGICAL ASPECTS

(2010) Arne Åkefeldt et al.   DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY

From monogenic to polygenic obesity: recent advances

(2010) Anke Hinney et al.   EUROPEAN CHILD & ADOLESCENT PSYCHIATRY

High frequency of COH1 intragenic deletions and duplications detected by MLPA in patients with Cohen syndrome

(2010) Veronica Parri et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Natural selection at genomic regions associated with obesity and type-2 diabetes: East Asians and sub-Saharan Africans exhibit high levels of differentiation at type-2 diabetes regions

(2010) Yann C. Klimentidis et al.   HUMAN GENETICS

Fine mapping of the association with obesity at the FTO locus in African-derived populations

(2010) Mohamed T. Hassanein et al.   HUMAN MOLECULAR GENETICS

Genome-wide association of anthropometric traits in African- and African-derived populations

(2010) S. J. Kang et al.   HUMAN MOLECULAR GENETICS

Novel common copy number variation for early onset extreme obesity on chromosome 11q11 identified by a genome-wide analysis

(2010) Ivonne Jarick et al.   HUMAN MOLECULAR GENETICS

A new highly penetrant form of obesity due to deletions on chromosome 16p11.2

(2010) R. G. Walters et al.   NATURE

Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls

(2010)   NATURE

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

(2010) Elizabeth K Speliotes et al.   NATURE GENETICS

Body-Mass Index and Mortality among 1.46 Million White Adults

(2010) Amy Berrington de Gonzalez et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genome-Wide Association Study of Anthropometric Traits and Evidence of Interactions With Age and Study Year in Filipino Women

(2010) Damien C. Croteau-Chonka et al.   Obesity

Integrated Genetic and Epigenetic Analysis Identifies Haplotype-Specific Methylation in the FTO Type 2 Diabetes and Obesity Susceptibility Locus

(2010) Christopher G. Bell et al.   PLoS One

Different differences: The use of ‘genetic ancestry’ versus race in biomedical human genetic research

(2010) Joan H. Fujimura et al.   SOCIAL STUDIES OF SCIENCE

Allelic heterogeneity in inbred populations: The Saudi experience with Alström syndrome as an illustrative example

(2009) Mohamed A. Aldahmesh et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

FTOgene variation and measures of body mass in an African population

(2009) Branwen J Hennig et al.   BMC Medical Genetics

Is the thrifty genotype hypothesis supported by evidence based on confirmed type 2 diabetes- and obesity-susceptibility variants?

(2009) L. Southam et al.   DIABETOLOGIA

Genome-wide association study suggested copy number variation may be associated with body mass index in the Chinese population

(2009) Bao-Yong Sha et al.   JOURNAL OF HUMAN GENETICS

Finding the missing heritability of complex diseases

(2009) Teri A. Manolio et al.   NATURE

Reconstructing Indian population history

(2009) David Reich et al.   NATURE

Admixture Mapping of Obesity-related Traits in African Americans: The Atherosclerosis Risk in Communities (ARIC) Study*

(2009) Ching-Yu Cheng et al.   Obesity

Replication of Association Between a Common Variant Near Melanocortin-4 Receptor Gene and Obesity-related Traits in Asian Sikhs

(2009) Latonya F. Been et al.   Obesity

Mutational Analysis of the Pro-opiomelanocortin Gene in French Obese Children Led to the Identification of a Novel Deleterious Heterozygous Mutation Located in the α-Melanocyte Stimulating Hormone Domain

(2009) Beatrice Dubern et al.   PEDIATRIC RESEARCH

Admixture Mapping of 15,280 African Americans Identifies Obesity Susceptibility Loci on Chromosomes 5 and X

(2009) Ching-Yu Cheng et al.   PLoS Genetics

Cohen syndrome resulting from a novel large intragenicCOH1deletion segregating in an isolated Greek island population

(2008) Marianna Bugiani et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

The thrifty epigenotype: An acquired and heritable predisposition for obesity and diabetes?

(2008) Reinhard Stöger   BIOESSAYS

Ancestry Estimation and Correction for Population Stratification in Molecular Epidemiologic Association Studies

(2008) J. S. Barnholtz-Sloan et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Novel melanocortin 4 receptor gene mutations in severely obese children

(2008) Yung Seng Lee et al.   CLINICAL ENDOCRINOLOGY

Prevalence of Melanocortin-4 Receptor Deficiency in Europeans and Their Age-Dependent Penetrance in Multigenerational Pedigrees

(2008) F. Stutzmann et al.   DIABETES

Prader–Willi syndrome

(2008) Suzanne B Cassidy et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Increased constraints on MC4R during primate and human evolution

(2008) David A. Hughes et al.   HUMAN GENETICS

Thrifty genes for obesity, an attractive but flawed idea and an alternative perspective: the ‘drifty gene’ hypothesis

(2008) J R Speakman   INTERNATIONAL JOURNAL OF OBESITY

Unexpected Endocrine Features and Normal Pigmentation in a Young Adult Patient Carrying a Novel Homozygous Mutation in the POMC Gene

(2008) Karine Clément et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Prader-Willi phenotype caused by paternal deficiency for the HBII-85 C/D box small nucleolar RNA cluster

(2008) Trilochan Sahoo et al.   NATURE GENETICS

Common nonsynonymous variants in PCSK1 confer risk of obesity

(2008) Michael Benzinou et al.   NATURE GENETICS

Six new loci associated with body mass index highlight a neuronal influence on body weight regulation

(2008) Cristen J Willer et al.   NATURE GENETICS

DNA methylation landscapes: provocative insights from epigenomics

(2008) Miho M. Suzuki et al.   NATURE REVIEWS GENETICS

Association Analysis of the FTO Gene with Obesity in Children of Caucasian and African Ancestry Reveals a Common Tagging SNP

(2008) Struan F. A. Grant et al.   PLoS One

Correction of Population Stratification in Large Multi-Ethnic Association Studies

(2008) David Serre et al.   PLoS One