Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

Rare and low-frequency coding variants alter human adult height

(2017) Eirini Marouli et al.   NATURE

Genome-wide association study identifies 112 new loci for body mass index in the Japanese population

(2017) Masato Akiyama et al.   NATURE GENETICS

Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk

(2017) Helen R Warren et al.   NATURE GENETICS

Exome Genotyping Identifies Pleiotropic Variants Associated with Red Blood Cell Traits

(2016) Nathalie Chami et al.   AMERICAN JOURNAL OF HUMAN GENETICS

RVTESTS: an efficient and comprehensive tool for rare variant association analysis using sequence data: Table 1.

(2016) Xiaowei Zhan et al.   BIOINFORMATICS

The effect of phenotypic outliers and non-normality on rare-variant association testing

(2016) Paul L Auer et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

ZFHX3 knockdown increases arrhythmogenesis and dysregulates calcium homeostasis in HL-1 atrial myocytes

(2016) Yu-Hsun Kao et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Hypomorphism of Fto and Rpgrip1l causes obesity in mice

(2016) George Stratigopoulos et al.   JOURNAL OF CLINICAL INVESTIGATION

SOS2andACP1Loci Identified through Large-Scale Exome Chip Analysis Regulate Kidney Development and Function

(2016) Man Li et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Management of obesity

(2016) George A Bray et al.   LANCET

Role of Exchange Protein Directly Activated by Cyclic AMP Isoform 1 in Energy Homeostasis: Regulation of Leptin Expression and Secretion in White Adipose Tissue

(2016) Yaohua Hu et al.   MOLECULAR AND CELLULAR BIOLOGY

The genetic architecture of type 2 diabetes

(2016) Christian Fuchsberger et al.   NATURE

Analysis of protein-coding genetic variation in 60,706 humans

(2016) Monkol Lek et al.   NATURE

Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci

(2016) Chunyu Liu et al.   NATURE GENETICS

Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension

(2016) Praveen Surendran et al.   NATURE GENETICS

Hypothalamic AMPK: a canonical regulator of whole-body energy balance

(2016) Miguel López et al.   Nature Reviews Endocrinology

Proopiomelanocortin Deficiency Treated with a Melanocortin-4 Receptor Agonist

(2016) Peter Kühnen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Reappraisal of GIP Pharmacology for Metabolic Diseases

(2016) Brian Finan et al.   TRENDS IN MOLECULAR MEDICINE

The Zfhx3-Mediated Axis Regulates Sleep and Interval Timing in Mice

(2016) Edoardo Balzani et al.   Cell Reports

Skeletal muscle AMP-activated protein kinase γ1H151R overexpression enhances whole body energy homeostasis and insulin sensitivity

(2015) Milena Schönke et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The Regulatory Factor ZFHX3 Modifies Circadian Function in SCN via an AT Motif-Driven Axis

(2015) Michael J. Parsons et al.   CELL

The Hunger Genes: Pathways to Obesity

(2015) Agatha A. van der Klaauw et al.   CELL

Exchange protein directly activated by cAMP encoded by the mammalian rapgef3 gene: Structure, function and therapeutics

(2015) Upasana Banerjee et al.   GENE

Genetic studies of body mass index yield new insights for obesity biology

(2015) Adam E. Locke et al.   NATURE

A neural basis for melanocortin-4 receptor–regulated appetite

(2015) Alastair S Garfield et al.   NATURE NEUROSCIENCE

FTO Obesity Variant Circuitry and Adipocyte Browning in Humans

(2015) Melina Claussnitzer et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans

(2015) et al.   SCIENCE

The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

(2015) Thomas W. Winkler et al.   PLoS Genetics

Transcriptomic Identification of ADH1B as a Novel Candidate Gene for Obesity and Insulin Resistance in Human Adipose Tissue in Mexican Americans from the Veterans Administration Genetic Epidemiology Study (VAGES)

(2015) Deidre A. Winnier et al.   PLoS One

Update on obesity pharmacotherapy

(2014) George A. Bray et al.   Annals of the New York Academy of Sciences

RAREMETAL: fast and powerful meta-analysis for rare variants

(2014) S. Feng et al.   BIOINFORMATICS

EasyStrata: evaluation and visualization of stratified genome-wide association meta-analysis data

(2014) Thomas W. Winkler et al.   BIOINFORMATICS

Hypomorphism for RPGRIP1L, a Ciliary Gene Vicinal to the FTO Locus, Causes Increased Adiposity in Mice

(2014) George Stratigopoulos et al.   Cell Metabolism

Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index

(2014) Wanqing Wen et al.   HUMAN MOLECULAR GENETICS

Differential Regulation of Lipid Metabolism Genes in the Brain of Acetylcholinesterase Knockout Mice

(2014) Huang-Quan Lin et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Comparative gene array analysis of progenitor cells from human paired deep neck and subcutaneous adipose tissue

(2014) D. Tews et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

A polygenic burden of rare disruptive mutations in schizophrenia

(2014) Shaun M. Purcell et al.   NATURE

Obesity-associated variants within FTO form long-range functional connections with IRX3

(2014) Scott Smemo et al.   NATURE

Quality control and conduct of genome-wide association meta-analyses

(2014) Thomas W Winkler et al.   Nature Protocols

Interaction of Acetylcholinesterase with Neurexin-1β regulates Glutamatergic Synaptic stability in Hippocampal neurons

(2014) Yun-Yan Xiang et al.   Molecular Brain

Deletion of Atbf1/Zfhx3 In Mouse Prostate Causes Neoplastic Lesions, Likely by Attenuation of Membrane and Secretory Proteins and Multiple Signaling Pathways

(2014) Xiaodong Sun et al.   NEOPLASIA

Formation of Chimeric Genes by Copy-Number Variation as a Mutational Mechanism in Schizophrenia

(2013) Caitlin Rippey et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Beyond GWASs: Illuminating the Dark Road from Association to Function

(2013) Stacey L. Edwards et al.   AMERICAN JOURNAL OF HUMAN GENETICS

KSR2 Mutations Are Associated with Obesity, Insulin Resistance, and Impaired Cellular Fuel Oxidation

(2013) Laura R. Pearce et al.   CELL

Exchange protein activated by cAMP 1 (Epac1)-deficient mice develop β-cell dysfunction and metabolic syndrome

(2013) Alan K. L. Kai et al.   FASEB JOURNAL

Meta-analysis of gene-level tests for rare variant association

(2013) Dajiang J Liu et al.   NATURE GENETICS

A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry

(2013) Keri L Monda et al.   NATURE GENETICS

Best Practices and Joint Calling of the HumanExome BeadChip: The CHARGE Consortium

(2013) Megan L. Grove et al.   PLoS One

Cyclic AMP sensor EPAC proteins and energy homeostasis

(2013) Muayad Almahariq et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

zCall: a rare variant caller for array-based genotyping

(2012) Jacqueline I. Goldstein et al.   BIOINFORMATICS

Enhanced Leptin Sensitivity, Reduced Adiposity, and Improved Glucose Homeostasis in Mice Lacking Exchange Protein Directly Activated by Cyclic AMP Isoform 1

(2012) J. Yan et al.   MOLECULAR AND CELLULAR BIOLOGY

Exome sequencing and the genetic basis of complex traits

(2012) Adam Kiezun et al.   NATURE GENETICS

AMPK: a nutrient and energy sensor that maintains energy homeostasis

(2012) D. Grahame Hardie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Rare-Variant Association Testing for Sequencing Data with the Sequence Kernel Association Test

(2011) Michael C. Wu et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Safety and tolerability of donepezil 23 mg in moderate to severe Alzheimer's disease

(2011) Martin Farlow et al.   BMC Neurology

Genomic inflation factors under polygenic inheritance

(2011) Jian Yang et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Pooled Association Tests for Rare Variants in Exon-Resequencing Studies

(2010) Alkes L. Price et al.   AMERICAN JOURNAL OF HUMAN GENETICS

PheWAS: demonstrating the feasibility of a phenome-wide scan to discover gene-disease associations

(2010) J. C. Denny et al.   BIOINFORMATICS

METAL: fast and efficient meta-analysis of genomewide association scans

(2010) C. J. Willer et al.   BIOINFORMATICS

Effectiveness and tolerability of high-dose (23 mg/d) versus standard-dose (10 mg/d) donepezil in moderate to severe Alzheimer's disease: A 24-week, randomized, double-blind study

(2010) Martin R. Farlow et al.   CLINICAL THERAPEUTICS

The Melanocortin-4 Receptor: Physiology, Pharmacology, and Pathophysiology

(2010) Ya-Xiong Tao   ENDOCRINE REVIEWS

Cut-like Homeobox 1 (CUX1) Regulates Expression of the Fat Mass and Obesity-associated and Retinitis Pigmentosa GTPase Regulator-interacting Protein-1-like (RPGRIP1L) Genes and Coordinates Leptin Receptor Signaling

(2010) George Stratigopoulos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

(2010) Elizabeth K Speliotes et al.   NATURE GENETICS

Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge

(2010) Richa Saxena et al.   NATURE GENETICS

Melanocortin-4 Receptor Gene Mutations in a Dutch Cohort of Obese Children

(2010) Linda van den Berg et al.   Obesity

Profound Obesity Secondary to Hyperphagia in Mice Lacking Kinase Suppressor of Ras 2

(2010) Jean-Pierre Revelli et al.   Obesity

Proteomic characterization of the dynamic KSR-2 interactome, a signaling scaffold complex in MAPK pathway

(2009) Lin Liu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

KSR2 Is an Essential Regulator of AMP Kinase, Energy Expenditure, and Insulin Sensitivity

(2009) Diane L. Costanzo-Garvey et al.   Cell Metabolism

Evidence for beneficial effects of compromised gastric inhibitory polypeptide action in obesity-related diabetes and possible therapeutic implications

(2009) N. Irwin et al.   DIABETOLOGIA

Neuronal Protein Tyrosine Phosphatase 1B Deficiency Results in Inhibition of Hypothalamic AMPK and Isoform-Specific Activation of AMPK in Peripheral Tissues

(2009) B. Xue et al.   MOLECULAR AND CELLULAR BIOLOGY

Genetic ablation of acetylcholinesterase alters muscle function in mice

(2008) Alban Vignaud et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Prevalence of Melanocortin-4 Receptor Deficiency in Europeans and Their Age-Dependent Penetrance in Multigenerational Pedigrees

(2008) F. Stutzmann et al.   DIABETES

Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity

(2008) Gudmar Thorleifsson et al.   NATURE GENETICS

The Creb1 coactivator Crtc1 is required for energy balance and fertility

(2008) Judith Y Altarejos et al.   NATURE MEDICINE

High-throughput Screening of Mouse Knockout Lines Identifies True Lean and Obese Phenotypes

(2008) Robert Brommage et al.   Obesity

Vaccination against GIP for the Treatment of Obesity

(2008) Alma Fulurija et al.   PLoS One

Repression of the Transcription Factor Th-POK by Runx Complexes in Cytotoxic T Cell Development

(2008) R. Setoguchi et al.   SCIENCE