Loss-of-function mutations in ADCY3 cause monogenic severe obesity

Hepatic adenylate cyclase 3 is upregulated by Liraglutide and subsequently plays a protective role in insulin resistance and obesity

(2016) Y Liang et al.   Nutrition & Diabetes

Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index

(2015) Janine F. Felix et al.   HUMAN MOLECULAR GENETICS

A genome-wide association study of body mass index across early life and childhood

(2015) N. M. Warrington et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations

(2015) Jimmy Z Liu et al.   NATURE GENETICS

Genetic variants inLEP,LEPR, andMC4Rexplain 30% of severe obesity in children from a consanguineous population

(2015) Sadia Saeed et al.   Obesity

Many obesity-associated SNPs strongly associate with DNA methylation changes at proximal promoters and enhancers

(2015) Sarah Voisin et al.   Genome Medicine

Liraglutide as a Potentially Useful Agent for Regulating Appetite in Diabetic Patients with Hypothalamic Hyperphagia and Obesity

(2014) Takao Ando et al.   INTERNAL MEDICINE

Genome-wide association study of height-adjusted BMI in childhood identifies functional variant inADCY3

(2014) Evangelia Stergiakouli et al.   Obesity

A Gain-of-Function Mutation in Adenylate Cyclase 3 Protects Mice from Diet-Induced Obesity

(2014) Jeffrey L. Pitman et al.   PLoS One

Maternal preconception body mass index and offspring cord blood DNA methylation: Exploration of early life origins of disease

(2013) Xin Liu et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry

(2013) Keri L Monda et al.   NATURE GENETICS

From obesity genetics to the future of personalized obesity therapy

(2013) Julia S. El-Sayed Moustafa et al.   Nature Reviews Endocrinology

NovelLEPRmutations in obese Pakistani children identified by PCR-based enrichment and next generation sequencing

(2013) Sadia Saeed et al.   Obesity

High prevalence of leptin and melanocortin-4 receptor gene mutations in children with severe obesity from Pakistani consanguineous families

(2012) Sadia Saeed et al.   MOLECULAR GENETICS AND METABOLISM

Meta-analysis identifies common variants associated with body mass index in east Asians

(2012) Wanqing Wen et al.   NATURE GENETICS

Peripheral and Central GLP-1 Receptor Populations Mediate the Anorectic Effects of Peripherally Administered GLP-1 Receptor Agonists, Liraglutide and Exendin-4

(2011) Scott E. Kanoski et al.   ENDOCRINOLOGY

The importance of dietary modulation of cAMP and insulin signaling in adipose tissue and the development of obesity

(2010) Lise Madsen et al.   Annals of the New York Academy of Sciences

Adenylyl cyclase 8 is central to glucagon-like peptide 1 signalling and effects of chronically elevated glucose in rat and human pancreatic beta cells

(2010) B. Roger et al.   DIABETOLOGIA

A charged prominence in the linker domain of the cysteine-string protein Cspα mediates its regulated interaction with the calcium sensor synaptotagmin 9 during exocytosis

(2010) Frédéric Boal et al.   FASEB JOURNAL

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

(2010) Elizabeth K Speliotes et al.   NATURE GENETICS

Exendin-4 Protects  -Cells From Interleukin-1 -Induced Apoptosis by Interfering With the c-Jun NH2-Terminal Kinase Pathway

(2008) M. Ferdaoussi et al.   DIABETES

The Power of the Extreme in Elucidating Obesity

(2008) Philippe Froguel et al.   NEW ENGLAND JOURNAL OF MEDICINE